Indian Enam or domestic Enap - which medicine for blood pressure is more effective?

Author of the article: Marina Dmitrievna

2017.12.15

418

Drugs

Our cardiovascular system tends to quickly respond to unsatisfactory living conditions: bad habits (nicotine, alcohol), dirty atmosphere and water, stressful situations, poor quality nutrition (deficiency of vitamins and excess of fat-containing foods). All this wears it out ahead of time.

Important! The cause of cardiovascular pathologies is often hypertension (otherwise known as arterial hypertension), which consists of a persistent increase in blood pressure. Its development leads to a hypertensive crisis, stroke or heart attack. The manifestation of high blood pressure is characteristic of angina pectoris, ischemic heart disease, tachycardia, arrhythmia and other diseases of the heart and blood vessels.

High blood pressure
To normalize blood pressure, strengthen blood vessels and stimulate cardiac activity, effective and proven antihypertensive drugs Enam and Enap are often prescribed; what is the difference between them, and which is better, we will look at this article.

What to choose: Enam or Enap?

To normalize blood pressure, strengthen blood vessels and stimulate cardiac activity, doctors often prescribe antihypertensive drugs, for example, Enam or Enap. These drugs belong to the group of ACE inhibitors, and they have the same mechanism of action. However, there are differences between medications.

To normalize blood pressure, strengthen blood vessels and stimulate cardiac activity, doctors often prescribe antihypertensive drugs, for example, Enam or Enap.

Comparison of safety of Enam and Enap

The safety of a drug includes many factors.

At the same time, in Enam it is quite similar to Enap. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing metabolism in Enam, as well as in Enap, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Enam does not have any risks when used, just like Enap.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Enam and Enap.

Characteristics of Enam

This is an antihypertensive drug that is produced in tablet form. The main component is enalapril maleate. The drug inhibits the angiotensin-converting enzyme, as a result of which the activity of the ACE enzyme decreases and the production of angiotensin-II decreases. The medication has a diuretic effect and effectively reduces blood pressure, and also reduces the load on the myocardium in heart failure.

In addition, Enam has the following properties:

• stimulates the respiratory function of the body;
• increases blood circulation in the small circle;
• normalizes blood flow in the vessels of the kidneys.

This drug prevents the development of diabetic nephropathy and increases renal blood flow, thereby reducing cardiac mortality. The maximum concentration of the drug is observed 4 hours after taking it. The medicine acts for 24 hours, after which it is excreted by the kidneys.

Indications for use:

• arterial hypertension;
• chronic heart failure (in complex therapy).

Contraindications include:

• angioedema;
• decreased kidney function;
• pregnancy;
• breast-feeding;
• mitral and aortic stenosis;
• excessive sensitivity to the components of the product.

Enam has a diuretic effect and effectively reduces blood pressure, and also reduces the load on the myocardium in heart failure.
Caution should be exercised when taking medication for the following diseases:

• hypovolemia;
• renal artery stenosis;
• decreased kidney function;
• heart failure;
• violation of water-salt balance;
• cardiac ischemia;
• disturbance of cerebral blood flow.

Enam is most often well tolerated, but sometimes the following side effects may develop:

• rhinorrhea, dry cough, shortness of breath, glossitis, pharyngitis;
• myocardial infarction, bradycardia;
• constipation, diarrhea, indigestion, epigastric pain, pancreatitis, dry mouth, nausea;
• change in taste, stomatitis;
• depression, ringing in the ears, sleep disturbance, headache;
• decrease in the amount of hemoglobin, neutropenia;
• bronchospasm, itching of the skin, urticaria;
• increased sweating, Raynaud's syndrome, baldness, agranulocytosis.

In case of overdose, arterial hypotension may develop.

Comparison of the effectiveness of Enam and Enap

The effectiveness of Enam is quite similar to Enap - this means that the ability of the medicinal substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Enam is more pronounced, then using Enap even in large doses will not achieve this effect.

Also, the speed of therapy - an indicator of the speed of therapeutic action - in Enam and Enap are approximately the same. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.

Action of Enap

This is an antihypertensive drug that is produced in tablet form. The main component is enalapril maleate. The mechanism of action of the drug is based on inhibition of ACE activity, resulting in reduced pressure and load on the myocardium. The medication dilates the arteries, but does not increase the heart rate. When pressure decreases under the influence of Enap, cerebral circulation is not impaired. The drug also increases blood supply to the coronary and renal blood flow.

With long-term use of the medication, the following beneficial effects are observed:

• the myocytes of the artery walls decrease;
• the hypertrophy of the left ventricle of the myocardium decreases, and the development of its dilatation slows down;
• myocardial blood circulation improves;
• prevents the occurrence of heart failure.

The drug does not allow platelets to stick together and has a slight diuretic effect. The maximum concentration of the drug is observed 1 hour after taking it, and the therapeutic effect lasts for a day.

Indications for use:

• arterial hypertension;
• essential hypertension;
• chronic heart failure;
• prevention of coronary ischemia in patients with left ventricular dysfunction.

The indication for use of Enap is arterial hypertension.
The daily dose of the drug is 10-20 mg/day, taken 2 times a day.

Contraindications include:

• history of Quincke's edema;
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption syndrome;
• idiopathic angioedema;
• excessive sensitivity to the components of the product;
• pregnancy;
• breast-feeding;
• age up to 18 years.

Caution should be exercised when taking medication for the following diseases and conditions:

• renal artery stenosis;
• cardiac ischemia;
• hypertrophic obstructive cardiomyopathy;
• primary hyperaldosteronism;
• after a kidney transplant;
• hyperkalemia;
• renal failure;
• inhibition of hematopoiesis;
• diabetes;
• systemic pathologies of connective tissue.

During treatment with Enap, there is a risk of side effects:

• lymphadenopathy, autoimmune diseases, pancytopenia, inhibition of hematopoiesis, decreased hemoglobin and hematocrit, neutropenia, anemia;
• hypoglycemia;
• depression, sleep disturbance, vertigo, severe excitability, insomnia, drowsiness, headache;
• Raynaud's syndrome, myocardial infarction, stroke, cardiac arrhythmia, angina pectoris, chest pain, severe low blood pressure;
• blurred vision, tinnitus, change in taste;
• diarrhea, dry mouth, anorexia, vomiting, constipation, flatulence, nausea;
• cough, rhinitis, shortness of breath, bronchospasm, sore throat;
• rash, erythroderma, urticaria, baldness, itching, increased sweating, Quincke's edema;
• oliguria, gynecomastia, impotence, renal failure, proteinuria, renal dysfunction;
• muscle cramps.

In case of an overdose, blood pressure may drop significantly, collapse, bradycardia, and palpitations may develop.

Difference between drugs

What is the difference between Enap and Enalapril? These drugs have the same effect on the human body with hypertension. After all, their main purpose is to normalize high blood pressure. They help improve the functioning of the cardiovascular system, due to which the load on the heart is significantly reduced. Enap and Enalapril are also effective medications for the prevention of heart disease.

These drugs normalize high blood pressure with the help of the active substance – enalapril maleate, which is contained in both Enap and Enalapril. Therefore, the difference between them is extremely insignificant.

The only difference between these medications is the manufacturer. They do not differ in their effect on the body:

• the effect of the drugs is the same;
• both drugs have a fairly small number of side effects, so their use is well tolerated in the treatment of hypertension;
• have almost the same composition.

Is it possible to replace Enap with Enalapril? In some cases, with hypertension, the use of these medications alternates. This contributes to maximum effectiveness of the active substance.

Important to remember! Before lowering blood pressure due to hypertension using these medications, you should consult a specialist! Also, you should not determine the dosage of medications yourself, as this may worsen the patient’s condition.

Doctors' opinion

Tatyana, 54 years old, therapist, Moscow: “The drug Enam helps to reduce high blood pressure, but it is considered a potent drug, so it is forbidden to exceed the recommended dose. After taking the medication, the patient is under my supervision for about 3 hours, because arrhythmia often develops.”

Victoria, 49 years old, therapist, Yaroslavl: “I most often prescribe the drug Enap in the early stages of arterial hypertension. It should be taken once a day, and the duration of treatment is determined individually. The medication has many side effects, so if necessary, I replace it with another drug.”

Comparison of side effects of Enam and Enap

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Enap has more adverse effects than Enam. This implies that the frequency of their occurrence is low in Enap and low in Enam. Frequency of manifestation is an indicator of how many cases of an undesirable effect from treatment are possible and registered. The undesirable effect on the body, the strength of influence and the toxic effect of drugs are different: how quickly the body recovers after taking it and whether it recovers at all. When using Enap, the body's ability to recover faster is higher than that of Enam.

Video on the topic

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To summarize, we can confidently say that Enalapril and Enap are prominent representatives of effective antihypertensive drugs that gently lower blood pressure, normalize cardiac activity and prevent the development of heart failure.

It is important to remember that these drugs should not be taken without consulting a specialist who will prescribe the patient adequate dosages of the medication, taking into account the degree of complexity of his illness, the presence of contraindications to use and complications from other organs.

What is better anyway?

To answer the question unambiguously: “Enap” or “Enalapril” - which is better?” — it will be very difficult, because both of these drugs have the same active substance. There is no difference between the two drugs. Perhaps the only difference is the price. But, as practice has shown, each patient chooses the drug that suits him personally.

Although each of these drugs has one active ingredient, the additional components are different, which means that in each individual case two almost identical drugs can act differently. Therefore, you need to carefully choose the drug.

Medicine Enap instructions for use, compatibility of Enap with alcohol

According to the instructions for use of the drug Enap, alcohol provokes an increase in the hypotensive effect of the tablets. That is why drinking alcohol during treatment is prohibited. In addition, it is necessary to undergo examinations. Their frequency is determined by the doctor.

It should be borne in mind the likelihood of developing hypotension in people with severe renal disease, as well as heart failure, caused by taking diuretics or a salt-free diet.

According to the instructions for use of the drug Enap, an overdose of this antihypertensive drug, as well as inappropriate use and abuse of it, is fraught with: a significant decrease in pressure, chest pain, angina pectoris, fainting and presyncope, dizziness, arrhythmia, heart attack, weakness, depression, paresthesia, confusion, sleep disturbances, shortness of breath, anorexia, xerostomia, tinnitus, rashes, itching, urticaria, dysphonia, decreased libido, glossitis.

In case of overdose, symptoms often appear six hours after oral administration of the drug. If there is a strong decrease in blood pressure, the appearance of tachycardia, a feeling of your own heartbeat, cough, convulsions, or bradycardia, immediately seek qualified help.

First aid in case of overdose:

1. Place the patient in a horizontal position.
2. The head end should be slightly lowered.
3. Give the patient activated charcoal (one tablet per ten kilograms of weight).
4. Call a doctor.

In the hospital, the patient's stomach is washed.
If the case is severe, intravenous administration of a 0.9% sodium chloride solution is prescribed. People with bradycardia are advised to have a pacemaker installed. To prevent the occurrence of the above symptoms, Enap, the instructions for use of which are contained in the package, should be taken only with a doctor's prescription.

The most popular analogues of the active ingredient include: Envilipril, Invoril, Ednit, Myopril, Enalapril, Renitek, Envas, Enam, Berlipril, Vazolapril, Corandil.

The average cost of Enapa is 430 rubles, Enapa N is 600 rubles, Enapa NL is 160-400 rubles, Enapa R is 600 rubles.

Reviews from people who have taken and are taking the drug are direct confirmation of its effectiveness. In addition, now you know the answer to a fairly common question: “Does Enap lower or increase blood pressure?” But you shouldn’t take pills without your doctor’s knowledge. The medicine Enap, instructions for use of which are presented in the package, is one of the most effective drugs that helps normalize blood pressure, as well as improve the condition.

Valeria, 51 years old, pensioner

“I’ve been taking Enap for a long time. An excellent medicine that helps normalize blood pressure and maintain it at a normal level. I did not observe any side effects as such, at most drowsiness or dizziness. But this is nothing compared to the therapeutic effect of Enap.”

Igor, 49 years old, conductor

“I was diagnosed with arterial hypertension a long time ago. Whatever I didn’t take. I had to go to the doctor when practically nothing helped, when the pressure dropped for a short period of time. The doctor prescribed me to take Enap tablet once a day. I will say this, this drug is the best. No need to take pills in bulk, just one a day. Now the pressure is practically not a concern. Excellent medicine."

Margarita, 57 years old, pensioner

“Heart problems in old age are, in my opinion, basically normal. I was diagnosed with hypertension seven years ago. I started taking Enap relatively recently. The pressure does not fluctuate, the condition and health are normal. I take an Enap tablet once a day, at the same time.”