Prevention of thrombosis, heart attack and stroke by taking Aspirin

Indications for taking the medicine

Thrombosis is not a rare disease and can occur in anyone. However, this does not mean that everyone should take aspirin to prevent the disease. Due to the existing risks of gastric bleeding, the medication is indicated only for those whose risk of thrombosis is quite high. First of all, this applies to persons:

• survivors of myocardial infarction, ischemic stroke or transient ischemic attack (ministroke);
• with a diagnosis of coronary heart disease, angina or intermittent claudication;
• with atherosclerosis of the carotid artery (according to ultrasound);
• after stenting or coronary artery bypass surgery.

The listed indications increase the risk of thrombosis, so the use of aspirin in these situations is appropriate according to the recommendations of a doctor. If you have no known risk of cardiovascular disease, then taking the medicine may cause more complications than benefits. Indeed, in addition to the bleeding already mentioned, the drug can cause heartburn, allergies and abdominal pain.

Mechanism of action of Aspirin

Drinking aspirin to prevent blood clots is a method approved by almost all world-famous therapeutic schools. Aspirin contains everything necessary for the prevention of blood clots in blood vessels and the elimination of provoking factors during thrombosis to be successful.

Anti-clot tablets work according to the following principle:

• prevent platelets and red blood cells from sticking together;
• with high levels of cholesterol in the blood, formations are prevented from forming on the vascular walls;
• against blood clots, aspirin has a double effect, simultaneously reducing the production of prostaglandins, as a reaction to the existing inflammation and eliminating the inflammatory process;
• the antispasmodic effect of the drug prevents or eliminates the development of spasm, which is invariably present at the initial stage of development of stenosis and thrombosis with clots.

Taking Aspirin against blood clots in blood vessels has a multivariate effect. For men, it is useful in preventing heart attack; in women, it is consistently effective in preventing thrombosis and stroke.

Aspirin is used to prevent cardiovascular pathologies immediately after the onset of menopause, when the protective mechanism of the reproductive period decreases.

Taking the drug for men is recommended after reaching a critical age, and invariably helps to avoid a heart attack.

Aspirin is the main drug for the treatment of thrombosis

Based on data from controlled studies and meta-analysis, modern therapeutic standards, aspirin is recognized as a mandatory treatment for patients with chronic ischemic heart disease, atherosclerotic vascular lesions of other locations, secondary prevention of myocardial infarction, and prevention of thromboembolic exacerbations in patients with atrial fibrillation at low or moderate risk.

The mechanism of action of aspirin is the irreversible inhibition of COX by acetylation of amino acids, as a result of which the synthesis of thromboxane A2 is limited, megakaryocytes are inhibited and platelet dysfunction is formed. Because platelets become unable to regenerate cyclooxygenase, the effect of aspirin lasts for as long as they last (approximately 10 days).

A serious limitation of aspirin is its specificity for COX, and, accordingly, a less pronounced effect on other pathways of platelet activation. Therefore, aspirin is able to prevent aggregation induced by thrombin and partially inhibits aggregation induced by adenosine diphosphate (ADP) and high doses of collagen.

The pathogenetic justification for the advisability of using thienopyridines and other alternative antiplatelet agents in addition to aspirin has recently been the phenomenon of “aspirin resistance,” which can lead to loss of the antiplatelet effect of the drug and an increase in the likelihood of atherothrombotic events. Clinical studies have used aspirin doses ranging from 50 to 1200 mg per day, and such a wide dose range has not demonstrated significant differences in the clinical effectiveness of aspirin. Taking this into account, in cardiological practice aspirin is used mainly in small doses, which significantly reduces the possibility of gastrointestinal bleeding as a side effect of aspirin therapy. Aspirin absorption exceeds 80%, this drug has a wide metabolism. However, only the “mother” drug significantly affects platelet function.

Side effects of aspirin include hemorrhages, hypersensitivity, skin rashes, alopecia and purpura. Absolute contraindications to aspirin therapy are active peptic ulcer disease, hypersensitivity (in particular, “aspirin asthma”) and thrombocytopenia. Relative contraindications are a history of peptic ulcer or dyspepsia, a tendency to bleeding, and concomitant therapy with indirect anticoagulants.

Healthy lifestyle to prevent cardiovascular diseases

Daily physical activity and a healthy diet are the easiest and at the same time very effective prevention of thrombosis and are beneficial for overall health.

Unfortunately, due to their profession, as well as for other reasons, people are often forced to spend a lot of time sitting or standing without changing posture, which affects the condition of the body and can lead to stagnation of blood, greatly increasing the risk of blood clots. Since few people have the opportunity to change their field of activity, they need to do therapeutic exercises, exercise regularly and simply be physically active.

If you have a sedentary job, set aside 5 minutes every hour for a break - just walking a little to warm up is enough.

Movement is life, and to maintain vein tone, it is useful to walk, run in the morning, ride a bike, do cardio exercises, walk at a moderate pace every day, and dance. However, it should be noted that it is necessary to avoid sports that place a heavy load on the arch of the foot: weightlifting, aerobics, squash, tennis and some others, since they provoke venous diseases. It is best to consult a doctor about this.

It is important to maintain a water regime agreed with your doctor, choosing clean water without gas or impurities, and eating right.

The list of products recommended in this case is quite simple and at the same time rich; you can create a delicious, varied menu from it. It should include:

• cereals;
• dairy products;
• lean meat and fish;
• vegetable oils;
• fresh vegetables and fruits.

Products with a large amount of vitamin E, as well as those rich in flavonoids, the leader among which are red grapes, will be very useful; you can replace them with grape juice or dry red wine (daily intake - up to 100 mg). The daily diet should contain soluble and insoluble plant fibers that promote normal intestinal function and lower cholesterol levels, foods containing a lot of Omega-3 - this will reduce blood viscosity and triglyceride levels.

The following food products should be especially noted:

• fish fat;
• tomatoes;
• oatmeal;
• berries;
• grape;
• lemons;
• ginger;
• olive and linseed oils;
• beets.

You need to eat less very salty, fatty and fried, smoked, white bread, meat broths, sausages, cream, lentils, chocolate and other confectionery products containing a lot of fat, be careful with bananas and mangoes, rose hips, chokeberries, and some herbs (nettle, St. John's wort, valerian, corn silk, millennial). You should eat no more than three egg yolks per week.

It is recommended to stop drinking alcohol and smoking, or at least keep them to a minimum.

Other drugs for antiplatelet therapy

Dipyridamole, which is mainly used in combination with aspirin, is one of the most effective means of secondary prevention of ischemic cerebrovascular accidents. The mechanism of action of this drug is the inhibition of phosphodiesterase, which limits the inactivation of cyclic adenosine monophosphate (AMP), the level of which is increased in platelets, as a result of which the activation of cytoplasmic second messengers is reduced.

Dipyridamole also provokes a surge of prostacyclin and inhibits the formation of thromboxane A2. Due to its effect on these pathways, the drug reduces platelet aggregation and adhesion. However, its effect does not last long, and to achieve sustainable suppression of platelet function, repeated use of the drug or administration of its forms with a slow release of the active substance is necessary. In addition, the use of high doses of dipyridamole is associated with a certain risk of “steal syndrome” in stenotic coronary arteries.

Thienopyridine derivatives - ticlopidine and clopidogrel - are modern antiplatelet therapy that can be used as alternative drugs or as an addition to aspirin. The scope of clinical use of these drugs includes secondary prevention of cerebrovascular events of ischemic origin, treatment of coronary artery disease, including endovascular interventions on the coronary arteries, as well as treatment of atherosclerotic lesions in various areas of the vascular bed.

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The mechanism of action of thienopyridine derivatives is the inhibition of platelet aggregation induced by its agonists, in particular platelet activating factor and collagen, as well as a dramatic decrease in the binding of ADP to purinoceptors on the surface of platelets. Apparently, this mechanism is independent of cyclooxygenase. In this case, the platelet response to the action of thrombin, collagen, fibrinogen, and von Willebrand factor is disrupted. Under the influence of thienopyridines, activation of glycoprotein (GP) receptors, an important stage in the formation of platelet aggregates, is prevented to a certain extent. In addition, the release of various thromboinducing substances, growth and migration factors, and proinflammatory cytokines from platelet granules, cytoplasm and membrane structures is inhibited. The optimal effect on platelet function is achieved after several days of oral administration of thienopyridines.

Clopidogrel, a drug that combines a powerful antiplatelet effect and the safety of long-term use, the effectiveness of which is assessed in a number of large controlled studies, is now attracting much attention among modern ATCs. The effectiveness of this drug in addition to aspirin or as an alternative therapeutic agent has been convincingly proven in the treatment and re-prevention of acute coronary syndromes, during revascularization procedures, as well as in atherosclerotic destruction of various areas of the vascular bed

Healthy lifestyle to prevent cardiovascular diseases

Daily physical activity and a healthy diet are the easiest and at the same time very effective prevention of thrombosis and are beneficial for overall health.

Unfortunately, due to their profession, as well as for other reasons, people are often forced to spend a lot of time sitting or standing without changing posture, which affects the condition of the body and can lead to stagnation of blood, greatly increasing the risk of blood clots. Since few people have the opportunity to change their field of activity, they need to do therapeutic exercises, exercise regularly and simply be physically active.

If you have a sedentary job, set aside 5 minutes every hour for a break - just walking a little to warm up is enough.

Movement is life, and to maintain vein tone, it is useful to walk, run in the morning, ride a bike, do cardio exercises, walk at a moderate pace every day, and dance. However, it should be noted that it is necessary to avoid sports that place a heavy load on the arch of the foot: weightlifting, aerobics, squash, tennis and some others, since they provoke venous diseases. It is best to consult a doctor about this.

It is important to maintain a water regime agreed with your doctor, choosing clean water without gas or impurities, and eating right.

The list of products recommended in this case is quite simple and at the same time rich; you can create a delicious, varied menu from it. It should include:

• cereals;
• dairy products;
• lean meat and fish;
• vegetable oils;
• fresh vegetables and fruits.

Scheme and rules of admission

Aspirin against vascular thrombosis is recommended for daily use by women over 40 years of age and men over 45 years of age (if there are indications for use). The daily dosage ranges from 75 mg to 100 mg.

When prescribing the drug in order to reduce blood thickening, its daily dosage will be 50-320 mg (determined individually for each patient).

This blood clot medicine should not be taken unless the stomach is full of food (to prevent bleeding). Aspirin can be used during or immediately after a meal. It is recommended to drink plenty of water, or preferably jelly. The latter contains starch, which envelops the wall of the stomach and thereby prevents the negative effects of the acid contained in the drug on it.

The pharmacological industry produces enteric-coated Aspirin: Aspirin Cardio, Thrombo ACC. These medications must be consumed entirely. They cannot be chewed and/or divided into pieces.

Sudden withdrawal of a prescribed medication can provoke a “ricochet effect” - the sudden appearance of dangerous pathologies:

• thrombosis;
• heart attack;
• stroke.

This situation will especially affect patients who already have a history of cardiovascular diseases or have undergone surgical interventions in the heart area. In these situations, you should never stop taking the drug yourself. This should be done by the attending doctor.

It is best to take medication against blood clots for preventive purposes in the evening. At this time, the maximum possible effective interaction of the drug component with platelets occurs.

In addition to directly affecting platelets and preventing blood clots, Aspirin has other beneficial effects. These include a 43% reduction in the likelihood of developing colon cancer and a 36% reduction in stomach cancer (compared to the control group).

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Admission rules

Aspirin for thrombophlebitis or deep vein thrombosis should be taken as follows:

• Twice a day, 1/2 tablet of the drug, crushed to a powder state. This dosage regimen is recommended in the first month of therapy; after this period, you need to drink 1/4 tablet per day before bed.
• You should take the medicine during or immediately after a meal.
• An excellent way to prevent possible harm to the gastrointestinal tract from the acid contained in the drug is to drink the medicine with milk, oatmeal jelly and other enveloping liquid that does not contain acid.
• While taking the tablets, which are coated with a special coating, you cannot chew them; you must swallow them whole.
• In order to minimize the harmful effects of the drug on the gastrointestinal tract, doctors advise taking the medicine in the form of instant tablets.
• All forms of the drug must be washed down with plenty of clean, still water.
• If the patient is scheduled for surgery, therapy should be suspended 5-7 days before the intervention.

Indications and contraindications for use

Thrombosis is part of the pathogenesis of many different diseases. A formed blood clot can cause the development of myocardial infarction, stroke, and chronic heart failure. Blood clots in the veins are complications of the recovery period after surgery and malignant neoplasms.

Thrombosis and thrombophlebitis are quite common pathological processes. But this does not mean that taking Aspirin is indicated for everyone without exception.

The main indications for prescribing this drug against blood clots will be:

• previous diseases: heart attack, stroke or micro-stroke;
• established diagnosis: angina pectoris, intermittent claudication, coronary heart disease;
• the presence of atherosclerosis of the carotid artery (confirmed by instrumental diagnostic methods);
• conditions after surgical interventions: stenting or coronary artery bypass grafting.

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All these pathological conditions contribute to a significant increase in the body’s ability to cause thrombosis. Therefore, prescribing this drug in these cases on the recommendation of a doctor will be justified.

Self-administration of Aspirin is strictly prohibited, since in addition to its positive effects on the body, this drug also has a number of negative features. These include:

• increased risk of stomach bleeding;
• abdominal pain;
• allergic reaction;
• heartburn.

Before prescribing this drug, in some cases, an additional examination of the body must be carried out: gastroscopy, blood test. If Aspirin is used for a long time, it is necessary to monitor hemostasis indicators and examine stool for the presence of hidden bleeding.

The most common contraindications to prophylactic use of Aspirin for thrombosis are the presence of the following pathological conditions:

• asthma;
• gastritis;
• active gastric ulcer;
• duodenal ulcer;
• hypersensitivity to the components of the drug;
• diathesis;
• kidney disease (the medicine is excreted in the urine);
• liver diseases;
• thrombocytopenia.

Pregnancy and breastfeeding are also restrictions on the use of this drug.

Scope of use

The medication is recommended to be taken for the treatment of the following ailments and painful symptoms:

1. To lower body temperature in case of viral, respiratory, infectious diseases.
2. In order to relieve pain.
3. For arthritis, vasculitis, Kawasaki disease, arteritis and other rheumatic ailments.
4. For the prevention and treatment of thrombosis and thrombophlebitis of various forms of localization, including thrombus formation in the deep vessels of the lower extremities.

Aspirin against blood clots is prescribed, among other things, under the following circumstances:

• If there is a history of previous heart attacks or strokes.
• With diagnoses such as ischemic disease, angina pectoris.
• With intermittent claudication, that is, pain in the lower legs due to blockage of large vessels in the calf area.
• During postoperative therapy after installation of shunts and stents on vessels of various locations.

Dosage and rules of administration

Oddly enough, the effect of aspirin depends on its dosage. In large quantities it can lower the temperature, and in small quantities it can thin the blood. Therefore, the drug is produced today in different dosages and in different dosage forms.

When aspirin is prescribed for the prevention of thrombosis, we are talking about its constant use throughout life. The dose of the medicine is small, no more than 100 mg per day. It is best to take it before bed, since it is at night that the number of platelets increases, creating a risk of blockage of blood vessels.

The aspirin tablet we are used to is too large to use as a whole for prevention. Therefore, it must either be divided into quarters, or buy other products containing the required amount of the substance. Some products are available in a soluble coating. However, there is no point in overpaying for it - after all, they show the same percentage of side effects.

If the medicine is prescribed for treatment, the dosage of aspirin is increased 3 times and is up to 300 mg per day. However, taking larger amounts of the drug is not recommended, since its high content in the blood can only worsen the situation. For medicinal purposes, it is recommended to chew the tablets and place them under the tongue for rapid absorption of the active ingredients.

If you have a high risk of thrombosis and you are taking the drug as prescribed by a doctor, then the decision to stop using it should also be made by a specialist, and not arbitrarily. Therefore, if you suspect any side effects, such as stomach pain, please consult your doctor.

Rules for taking aspirin:

1. Under no circumstances should you exceed the prescribed dose.
2. You should take the tablet half an hour after eating. Taking the medicine on an empty stomach is extremely dangerous as it can cause stomach damage.
3. It is not advisable to combine aspirin with other medications.
4. You cannot combine taking medication with drinking alcohol.

This medicine, like many others, has its contraindications. The use of aspirin for the prevention of thrombosis is not recommended for persons:

• with a diagnosis of asthma, gastritis, diathesis or ulcers;
• with weakened or painful kidneys and liver;
• during pregnancy and lactation.

If you have any contraindications for taking aspirin, then you can play it safe and replace it with regular consumption of blood thinning products.

Atherothrombosis is the main reason for prescribing Aspirin

Atherothrombosis is a relatively new term denoting a specific condition that develops in the human body. According to large-scale studies, it has been proven that after atherosclerosis, atherothrombosis begins to progress in the human body.

The problem is so widespread that more than a quarter of all deaths recorded in the modern world are a consequence of the development of a process progressing in the body.

Aspirin dissolves blood clots that already exist in blood vessels

There is even a separate medical scientific publication of the same name dedicated to aspects related to this pathology:

• therapeutic schools have long known about the effectiveness of Aspirin for the prevention of thrombosis, heart attacks and strokes;
• its antiplatelet properties turned out to be in demand in the treatment process after a proven connection between the formation of thrombosis in blood vessels and the presence of atherosclerotic plaques;
• There was recorded documentary evidence of the formation of thrombosis on their invaded surfaces.

Aspirin for blood clots is just one of the many uses of acetylsalicylic acid, which has been successfully used in medicine for over 130 years. The results of a scientific conference dedicated to the 125th anniversary of aspirin convincingly showed that the answer to the question of whether it is possible to take aspirin for blood clots is clearly positive if there are no contraindications. Every person who has reached a certain age can use ASA for preventive purposes.

Aspirin advantages and disadvantages

Aspirin. - perhaps one of the most famous and most commonly used drugs in the world. Despite its more than century-long history of existence (acetylsalicylic acid was obtained in 1899), its industrial production is increasing, and its scope of application in various areas of medicine is expanding. Its dosage forms are also changing, as the positive and negative effects of aspirin are studied.

Aspirin belongs to the group of non-steroidal
anti-inflammatory drugs (NSAIDs)
, the name of which makes clear their main effect - suppression of inflammation. It also acts as an antipyretic and analgesic. Hence the wide range of uses of aspirin: for rheumatic diseases, various types of pain, migraines, neuralgia, fever due to viral infections.

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Recently, the effect of aspirin has been actively studied in the treatment of colorectal cancer, as well as Alzheimer's disease.

Based on the antiplatelet effect of aspirin, it is prescribed for thrombophlebitis, cerebrovascular accidents, to prevent fatal consequences of coronary heart disease (including myocardial infarction), and for arterial hypertension in pregnant women with a high risk of eclampsia. Aspirin is also used in cardiovascular surgery and in invasive cardiology (stenting and angioplasty). In addition to the antiplatelet effect, aspirin has a number of other positive effects on the cardiovascular system: protects the inner lining of blood vessels (endothelium); increases the production of nitric oxide (NO), which is a powerful factor in vasodilation, and, therefore, improves their patency; slows down the formation of atherosclerotic plaques, protecting low-density lipoproteins from oxidation.

An undoubted advantage for practical use is the ability to take aspirin for prophylactic purposes only once a day

at a dose significantly lower (50-325 mg) than for the treatment of inflammatory diseases, where the daily dose can reach 4-5 g in several doses.

Side effects

Like all drugs, aspirin also has undesirable effects, which are caused by the main mechanism of its action - a violation of the synthesis of prostaglandins. When taking aspirin, the amount of beneficial prostaglandins involved in protecting the gastric mucosa from hydrochloric acid decreases, which can lead to irritation and inflammation of the mucosa with the formation of ulcers, up to the development of gastric bleeding.

Tinnitus, dizziness, hearing loss, thrombocytopenia may also occur.

Aspirin should be used with caution in patients with bronchial asthma and diabetes. In children under 14 years of age, it can provoke the development of Reye's syndrome (damage to the brain and liver)

Contraindications

• hypersensitivity to the drug, aspirin asthma, hemorrhagic diathesis, dissecting aortic aneurysm, acute diseases of the gastrointestinal tract (peptic ulcer, erosions) acute renal failure, liver failure, gout, nephrolithiasis (urolithiasis), pregnancy, breastfeeding

Preventing unwanted effects

For long-term use, preference should be given to

• enteric forms of aspirin (the active substance is released in the intestinal lumen, bypassing the stomach); soluble drugs with the addition of alkaline buffers; dosage forms for intravenous or intramuscular administration, the aspirin patch has been actively developed in recent years.

Recommendations for admission

• for prophylactic purposes, aspirin is taken at the same time

after meal

it is advisable to wash down the drug with alkaline mineral water or milk within 30 minutes after taking the medicine; it is advisable not to take a horizontal position for patients who are planning surgery; you should stop taking aspirin 5-10 days before

And remember, no matter how perfect a drug may seem, a doctor must prescribe and discontinue it!

Therapeutic properties

Aspirin for thrombosis is prescribed by doctors in different cities. This medication is available to almost every patient, although it has a pronounced effect on the blood count.

The medicine contains acetylsalicylic acid. This substance not only relieves fever and has an analgesic effect, but also thins the blood. Aspirin is an antiplatelet agent that can prevent the process of platelets and red blood cells sticking together, which slows down the formation of blood clots and promotes the dissolution of small clots.

This anticoagulant began to be prescribed to patients with vascular pathologies relatively recently. Previously, this active substance was valued for its anti-inflammatory and analgesic effects. Only in the 80s did they begin to use it in patients who had suffered a heart attack, stroke, ischemic attacks, or oxygen deprivation.

The use of aspirin to thin the blood during thrombosis

Aspirin for deep vein thrombosis can also have a positive therapeutic effect. Its action is determined by the following properties:

• The main component protects the vascular endothelium;
• Increases the production of nitric oxide, due to which the blood vessels dilate and their patency is optimized;
• Stops the formation of vascular plaques during atherosclerotic changes.

The dosage of the drug is determined by the doctor. The medication can be used for both therapeutic and prophylactic purposes.

Medicines that help thin the blood

Most often, in the treatment of thrombosis, drugs that thin the blood are prescribed:

• Heparin or Warfarin. They contain the enzyme thrombin, similar to that produced by leeches. One of the most inexpensive and effective medications. However, their use is possible only under the supervision of a doctor;
• Xa-Rivaroxaban is an innovative blood thinner. The therapeutic effect is due to selective inhibition of the action of blood viscosity factor;
• Trental – helps thin the blood, regulates its viscosity;
• Curantil is a German medicine that reduces coagulation;
• Eskzan - thins the blood, restores the elasticity of the walls of veins and arteries, prevents the penetration of fluids beyond the vascular bed;
• Phenilin is a highly effective medicine. However, it has a large number of contraindications, so it is rarely prescribed;
• Acetylsalicylic acid is used for the prevention of heart attack and stroke in older patients, as well as in the treatment of thrombosis of the lower extremities. The advantage of the drug is its affordable price;
• Multivitamin complexes can compensate for the lack of magnesium, zinc, selenium, and lecithin. Increase the tone of veins, strengthen the vascular wall.

Whether it is worth taking antibiotics for thrombosis is decided by the attending physician after conducting clinical studies, identifying the cause of the inflammatory process and making a diagnosis.

Medicinal properties

Acetylsalicylic acid belongs to the category of non-steroidal anti-inflammatory drugs. In addition, the product has an antipyretic and analgesic effect, and therefore the scope of its application is quite wide.

By the 1980s, researchers had established that aspirin dissolves blood clots and also helps prevent recurrent blood clots.

In addition to its blood-thinning effect, aspirin helps against blood clots in blood vessels in the following ways:

• Strengthens the internal endothelium of blood vessels.
• Prevents cholesterol deposition on the walls of veins and capillaries.
• Promotes uniform expansion of the vascular lumen.

Having established these properties, doctors began to use aspirin against blood clots to prevent heart attacks, strokes and other serious diseases resulting from vascular thromboembolism of varying degrees of localization.

How to take Aspirin for thrombosis?

Aspirin for thrombosis is the most accessible, cheapest and very effective drug in a number of drugs that can thin the blood and prevent the formation of blood clots. The formation of blood clots in the lumen of blood vessels is a normal protective reaction of the body. The ability of blood to form clots prevents bleeding from wounds. Thrombosis is already a pathology and can threaten human life.

How to take aspirin to prevent blood clots » Blood thinning

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Acetylsalicylic acid (aspirin) is one of the most popular drugs with a wide spectrum of action. It can be used as an antipyretic, analgesic and anti-inflammatory agent.

Experts often prescribe aspirin to thin the blood for patients suffering from pathologies of the cardiovascular system. It is important to know how to take the medicine correctly so as not to cause harm to the body.

Action

Aspirin is prescribed in small doses to prevent blood thickening. At the same time, it is necessary to distinguish between the concepts of “propensity to form blood clots” and “increased viscosity”.

When the ratio of plasma volume and the number of formed elements is violated, the blood begins to thicken.

Such conditions do not develop as an independent disease, but are a consequence of various pathological processes in the body.

When blood flow slows down, which is facilitated by high blood viscosity, the risk of microclot formation increases significantly, which can cause blockage of blood vessels.

It is worth noting that the anti-aggregation properties of the drug do not change the viscosity of the blood fluid, but only prevent thrombus formation, affecting platelets in such a way that they prevent them from sticking to each other and adhering to the damaged surface.

Does aspirin thin or thicken?

It is incorrect to say that the use of aspirin reduces coagulation or thins the blood, despite the fact that such conclusions are not so rare in the medical literature. It is important to understand how this medication actually works.

• viscosity - is directly related to liquefaction or thickening;
• coagulability - a predisposition to form clots;
• adhesion.

These concepts are often confused with each other, since they all participate in the process of blood clot formation.

Acetylsalicylic acid (ASA) is a drug that helps reduce cell aggregation. Thanks to this, the following happens:

• improvement of microcirculation;
• decreased ability to thrombosis;
• increased bleeding time.

It is precisely because of the presence of these properties that the drug is recommended for patients with cardiac pathologies.

What type of drug thins the blood?

There are several types of medicine:

In most cases, aspirin Cardio is prescribed to elderly people as a preventive measure for the development of pathologies of the heart and blood vessels.

It must be taken with extreme caution and only with a doctor's prescription.

For younger people, with thickening and increased viscosity, it is better to use plain or American aspirin. However, you still shouldn’t get carried away with pills. It is better if the drinking regime is adjusted . In case of excessive loads, it is permissible to take the drug in small doses.

Rules for taking medication and daily dosage

Many people are interested in the question of how to quickly restore blood viscosity with aspirin. To achieve the maximum effect without harming the body, you must strictly follow the specialist’s instructions and follow all the rules of administration:

• aspirin, which has a special coating, must not be chewed or broken, it must be swallowed completely;
• Chewable tablets should not be swallowed whole;
• the dosage form intended for resorption is placed under the tongue for complete dissolution;
• The medication should be taken only after meals with plenty of liquid.

Only a doctor can determine the dosage of the drug. When ASA is prescribed for prophylaxis, no more than 100 milligrams are allowed per day.

To resolve blood clots and with high plasma density, the daily dose should not exceed 300-500 milligrams.

The tablets are taken once a day at the same time. The most suitable period is around seven o'clock in the evening. It is at this time that the body begins to prepare for rest, which promotes better absorption of the medicine.

It is prohibited to use the product on an empty stomach, as the risk of developing gastric ulcers increases.

The duration of treatment depends on a number of factors and is determined solely by a specialist.

According to most scientists, taking 75 mg of aspirin daily throughout life helps reduce the risk of heart attack, stroke and cancer. However, the possibility cannot be ruled out that regular use of the medication may cause other health problems.

Using aspirin to thin the blood in pregnant women

Almost every woman during pregnancy turns to her doctor with the question of whether it is possible to take aspirin during pregnancy.

It is worth saying that in the first and third trimesters it is better to avoid taking the medicine, as this may threaten miscarriage. Also, the effect of acetylsalicylic acid negatively affects the development of the fetus.

Therefore, they try to prescribe this drug only in exceptional situations.

If the use of tablets is necessary, for example, when the blood density is high, then the doctor can select the minimum dosage that will not harm the baby and the expectant mother. However, if possible, it is better to refuse this medication or replace aspirin with another drug.

Analogs

The choice of ASA substitutes as a blood thinner must be approached with caution. It is highly not recommended to replace it yourself. To do this, you need to seek help from a specialist who will select the most optimal option.

In most cases, Aspeter acts as an analogue of aspirin. It has anti-inflammatory, antipyretic and analgesic effects, as well as antiplatelet properties.

It is prescribed for preventive purposes to reduce the risk of heart attacks, dilute blood fluid and prevent blood clots.

Another substitute is Asafen, which helps reduce the risk of thrombosis, as well as prevent cerebrovascular accidents. The medication is taken only as prescribed by a doctor and under his strict supervision.

Side effects

Excessive doses of ASA cause side effects. Among the most common are:

• development of allergies;
• pathologies of the gastrointestinal tract, accompanied by nausea, vomiting, pain, stomach ulcers, bleeding;
• swelling of the kidneys or liver;
• nephritis;
• renal failure;
• dizziness;
• noise in ears;
• weakness.

If these symptoms occur, the medication should be stopped.

Contraindications for use

Absolute contraindications to taking acetylsalicylic acid:

• age up to 12 years;
• hypersensitivity to components;
• predisposition to the development of bleeding.

• asthma;
• pathology of the stomach in a chronic form at the acute stage;
• liver and kidney failure;
• pregnancy period;
• hemophilia;
• the period of the preparatory stage for the operation;
• breast-feeding.

You need to take the medicine especially carefully when:

• hypovitaminosis K;
• thrombocytopenia;
• anemia;
• gout;
• simultaneous treatment with anticoagulants.

Before deciding to treat with aspirin, you need to make sure that there are no obstacles to this.

European guidelines on the use of aspirin for thromboprophylaxis

Aspirin

Potent anticoagulants are generally considered mandatory for the prevention of venous thromboembolism (VTE) after most surgical procedures. However, iatrogenic complications may occur and overcome the benefit of prophylaxis. In addition, accelerating postoperative rehabilitation may reduce the risk of VTE.

Nowadays, some surgeons suggest using aspirin instead of potent anticoagulants to prevent VTE after various surgical procedures, especially after orthopedic procedures, mainly hip and knee replacements.

Efficacy of aspirin in the prevention of venous thromboembolism

Nowadays, aspirin is widely used to prevent arterial thrombotic events (stroke or myocardial infarction). It is one of the main ones in the preventive treatment of patients with cardiovascular diseases. Aspirin is inexpensive, does not require monitoring, and does not accumulate in patients with renal failure.

The classic primary activity of aspirin is the persistent inactivation of the cyclooxygenase activity of prostaglandin H synthase 1 (COX-1). Higher doses of aspirin inactivate the cyclooxygenase activity of prostaglandin H synthase 2 (COX-2), resulting in decreased prostacyclin levels and a potential prothrombotic effect.

Other important mechanisms of action of aspirin have been proposed. Aspirin may interfere with thrombin formation. It may act on tissue factor expression on monocytes/macrophages, leading to disruption of prothrombinase formation on platelets, resulting in decreased activation of factor V and decreased thrombin generation. Aspirin may also reduce thrombin formation by acylation of prothrombin and platelet membrane components.

Chromatin (usually DNA) structures called neutrophil extracellular traps (NECs) are released from neutrophils. They are thought to increase bacterial killing activity and the inflammatory response of neutrophils. Neutrophil extracellular traps may act as a basis for thrombus formation, highlighting the association with VTE. Activated platelets induce neutrophils to release their nuclear material as NPP.

Treatment with aspirin can prevent the formation of NVL. So, aspirin can indirectly prevent the formation of a blood clot that is associated with neutrophil extracellular traps. Aspirin reduces the number of endothelial and platelet microparticles in patients with coronary artery disease after 8 weeks of daily use of 100 mg aspirin.

Low doses of aspirin can also change the size of fibrin fibers, while leading to the formation of thicker fibers and larger network pores, increasing clot permeability, also seen with direct oral anticoagulants. Aspirin may interfere with fibrinogen acylation and cause increased clot lysis, although this has not been demonstrated in all clinical settings, such as diabetes. Aspirin also inhibits the activation of factor XII, which can lead to decreased fibrin clot stability.

Is aspirin effective for the prevention of deep vein thrombosis and pulmonary embolism in orthopedic surgery?

Since 2012, it has been recommended that aspirin be used in patients undergoing total femur arthroplasty or total knee arthroplasty for 10 to 14 days. Aspirin is also recommended for 10 to 14 days in patients undergoing surgery for a femur fracture. These recommendations are broadly based on the Pulmonary Embolism Prevention Trial, which compared 160 mg of aspirin per day with placebo. This study included 17,444 patients undergoing hip fracture and hip replacement surgery. There was a 28% reduction in the risk of developing symptoms of deep vein thrombosis (DVT).

One systematic review was published in 2020, including three meta-analyses and three prospective randomized controlled trials of 46,254 patients who underwent total hip arthroplasty, total knee arthroplasty, and hip fracture. Although some results are conflicting, aspirin remains more effective than placebo in the primary prevention of VTE.

There is no data on the effectiveness of aspirin for orthopedic procedures other than total hip arthroplasty, total knee arthroplasty, and hip fracture surgery. Because the risk of developing DVT and pulmonary embolism after other orthopedic procedures is lower than after total hip arthroplasty, total knee arthroplasty, and hip fracture surgery, aspirin may be considered effective. Procedures on cancer patients (femur, pelvic bone, spinal column) should still be considered at high risk for thrombosis.

Multiple studies have found insufficient moderate-to-severe risk evidence that aspirin is more or less effective than low-molecular-weight heparin, warfarin, or dabigatran for the prevention of VTE in total knee arthroplasty or total hip arthroplasty.

The incidence of DVT in total knee arthroplasty may be reduced with rivaroxaban, but there are insufficient data to demonstrate its effect on the incidence of symptomatic deep vein thrombosis. Some studies have noted concerns about bleeding complications and the relative ineffectiveness of aspirin. They then suggested that aspirin could be considered an alternative to other thromboprophylactic agents after total hip arthroplasty and total knee arthroplasty.

Another study randomized 170 knee arthroscopy patients to one of two groups: those who took aspirin or those who took placebo. There were no cases of VTE identified in the entire population.

Is aspirin as effective as other agents for the prevention of DVT and pulmonary embolism in orthopedic surgery?

In the recommendations of the ASSR 2012. recommended the use of low molecular weight heparin instead of aspirin in patients undergoing total knee arthroplasty, total femoral arthroplasty, and femoral fracture surgery. These recommendations are based on two low-quality studies (1 published article and 1 abstract) involving 469 patients. The pooled results showed an increased risk of symptomatic DVT (relative risk, 1.87; 95%, 1.3 to 2.7) in the aspirin group.

Three systematic reviews have been published since 2012. The study included 8 prospective randomized controlled trials involving 1408 patients. All studies were published before 2012. There was no difference in the incidence of DVT between aspirin and anticoagulants. There was a nonsignificant trend in favor of anticoagulants after surgery for femoral fracture. The risk of bleeding was lower with aspirin, with a slight trend favoring aspirin after arthroplasty. The incidence of thromboembolism was too low to generate reliable estimates. Compared with anticoagulants, aspirin may be associated with a higher risk of DVT following femoral fracture, although the incidence of bleeding was significantly lower.

Analysis of 21 studies involving 34,764 patients. For prophylactic treatment, low molecular weight heparin (13,590 patients), oral factor Xa inhibitors (6,609 patients), oral direct thrombin inhibitors (5,965 patients), indirect factor Xa/IIa inhibitors (3,444 patients), aspirin (2,427 patients), warfarin (489 patients) were used. ), mobile compression device (199 patients) and placebo (2041 patients). Across all studies, the estimated incidence of pulmonary embolism was 0.21% and remained unchanged over the 17 years covered by the study. The authors suggested that no prophylactic treatment could significantly reduce the risk of pulmonary embolism.

How is aspirin tolerated for the prevention of DVT and pulmonary embolism in orthopedic surgery?

A study on the prevention of pulmonary embolism found no difference between aspirin and placebo. Since 2012, two systematic studies have been published.

• The first study included 8 prospective randomized controlled trials involving 1408 patients. The risk of bleeding was lower with aspirin than with anticoagulants after femoral fracture, with a slight trend favoring aspirin after arthroplasty.
• The second study included one meta-analysis, 5 prospective randomized controlled trials, and 1 prospective study involving 9599 patients. Concluded that aspirin may reduce the risk of bleeding, despite conflicting results.

What are the indications for the use of aspirin in the prevention of DVT and pulmonary embolism?

Since 2012, ACC guidelines have recommended aspirin for the prevention of DVT and pulmonary embolism after total knee arthroplasty, total femoral arthroplasty, and femoral fracture surgery. However, some studies have shown concern about the increased risk of DVT.

In patients at increased risk of bleeding, ASCP does not recommend any pharmacological prophylaxis. It is recommended to use devices with intermittent pneumatic compression.

Prospective cohort studies suggest that use of a rapid recovery program after total knee arthroplasty and total hip arthroplasty may be associated with a low risk of DVT, regardless of the type of prophylaxis.

We analyzed 1977 patients who underwent primary total femoral arthroplasty, total knee arthroplasty, or simultaneous double knee arthroplasty in a standardized fast-track fashion. Patients received pharmacological DVT prophylaxis with low molecular weight heparin 6-8 hours after surgery until discharge. All remissions and deaths within 30–90 days were analyzed using the national health registry and with particular attention to clinical DVT, pulmonary embolism, and sudden death. Three deaths (0.15%) were related to the coagulation process and a total of 11 clinical DVTs (0.56%) and 6 pulmonary emboli (0.30%) were identified. Over the past 2 years, in a study of 854 patients who were mobilized within four hours of surgery, with a prophylaxis duration of 1 to 4 days, the mortality rate was 0% and the incidence of DVT was 0.60% after total knee arthroplasty; 0.51% after total femoral arthroplasty and 0% after bilateral total knee arthroplasty.

Pulmonary embolism occurred in 0.30% of patients after total knee arthroplasty; 0% after total femoral arthroplasty and 0% after bilateral total knee arthroplasty. These data suggest that the risk of clinical DVT and fatal pulmonary embolism after total femoral arthroplasty and total knee arthroplasty after fast-track surgery is low.

We studied 4924 consecutive cases of total femur arthroplasty and total knee arthroplasty. DVT prophylaxis included the use of low molecular weight heparin or factor Xa inhibitors only during hospitalization when the length of stay was less than 5 days. Symptomatic thromboembolic events were observed in 0.84% ​​of patients; DVT in 0.41% during 90-day follow-up 5 cases of pulmonary embolism (0.11%) and DVT (0.30%). There were 4 surgical-related deaths, of which 1 (0.02%) was due to pulmonary embolism and 6 (0.13%) were of unknown cause. Data show that the incidence of thromboembolic events is low in patients with fast-track surgery with a length of stay of 5 days or less.

The panel believes that the lower risk of symptomatic DVT following the above procedures, followed by an enhanced recovery program and lower risk of bleeding, may offset the possible higher incidence of DVT following prophylaxis with aspirin than with other pharmacologic agents.

ACCP recommends the use of intermittent compression devices (ICDs) in combination with an antithrombotic agent in patients undergoing major orthopedic surgery. This recommendation was based on 5 studies with more than 2400 patients, 70% of which showed a reduction in the incidence of DVT with the use of PPC devices.

A prospective randomized trial was conducted in 275 patients undergoing total knee arthroplasty under epidural anesthesia, comparing PKP prophylaxis associated with enoxaparin versus aspirin. All patients underwent ultrasound within 3-5 days after surgery and a repeat ultrasound 4-6 weeks after surgery. The overall rates of DVT in the enoxaparin and aspirin group were 14.1% and 17.8%.

What should be the dose and how long should aspirin treatment last for the prevention of DVT and pulmonary embolism in orthopedic surgery?

There is a considerable range of doses (from 75 to 1000 mg per day) and duration of treatment (from 2 days to 6 weeks). In the current literature there are no clear recommendations regarding the dose and duration of treatment.

Efficacy/safety relationship of aspirin in surgery

One randomized, double-blind study was conducted in patients undergoing general elective surgery. The use of aspirin was compared with heparin. A dose of 500 mg aspirin was compared with a dose of 5000 IU unfractionated heparin once daily. This study included 1210 patients. Diagnosis of the primary outcome of DVT was based on mandatory Doppler ultrasound. There was no significant difference between DVT and pulmonary embolism rates.

Based on these data, it can be concluded that aspirin may reduce the risk of DVT and pulmonary embolism in patients undergoing general surgical procedures.

Is aspirin appropriate for the prevention of VTE in the perioperative period?

Several authors still recommend against using aspirin for VTE prophylaxis. Aspirin is less effective than low molecular weight heparin and the newer direct anticoagulants. More attention should be paid to the risk of bleeding.

Aspirin, in combination with early patient activation, may be offered to moderate-risk orthopedic patients and to selected high-risk patients undergoing total femoral arthroplasty and total knee arthroplasty, or to patients with a femoral fracture at high risk of bleeding. OPC should be used if aspirin is prescribed as the only pharmacological agent. But current literature cannot provide a rationale for a precise recommendation (dose, duration of treatment, follow-up parameters).

Literature

1. https://journals.lww.com/ejanaesthesiology/Fulltext/2018/02000/European_guidelines_on_perioperative_venous.7.aspx?fbclid=IwAR3O0hZ0uNGCA-fb4SxPXv7hyZdqnzxLZ2X5i5_VRY7zAy5ep0jgGXypLmA
2. https://journals.lww.com/ejanaesthesiology/Fulltext/2018/02000/European_guidelines_on_perioperative_venous.9.aspx?fbclid=IwAR0rKcP5NIyGGOHNziOmIsSaUeyVjRAsHgLO4d3NxA-C7SGI9XSbT9x-uzQ

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Rules of application

If Aspirin against blood clots is prescribed for prevention, its daily use is 75-100 mg. Treatment involves a dosage of 300 mg. In this case, the course of drug therapy should be prescribed only by a specialist.

There are recommendations for the use of pharmacological agents that must be followed:

• You cannot change the prescribed dosage yourself.
• The medication should not be used on an empty stomach. This treatment may lead to stomach problems. The optimal treatment option is to take the medication 30 minutes after eating.

It is not allowed to use the medicine simultaneously with other NSAIDs. Such treatment can cause internal bleeding or other unwanted effects from the body.

Aspirin Cardio - indications for treatment and prevention, how to take and contraindications, reviews

Many patients who are prescribed cardiac aspirin are dismissive of this medicine, believing that it is unlikely to help with their diseases, because coated aspirin, according to general ideas, can only relieve headaches and help with high fever.
However, cardiologists prescribe Aspirin Cardio for arterial hypertension, hypertension, in order to improve the functioning of the heart by clearing blood vessels from blood clots and plaques, so it is important to follow the recommendations of your doctor when he prescribes taking aspirin for the heart. Aspirin is based on acetylsalicylic acid, which inhibits the synthesis of prostaglandin enzymes. Prostaglandins are involved in the inflammatory process by being responsible for the production of platelets.

Under the influence of salicylate, platelets lose their ability to aggregate and coagulate, and stop sticking to each other in the bloodstream, forming blood clots.

This mechanism of action of Aspirin Cardio determines the use of this drug as an antiplatelet and anticoagulant drug.

Aspirin from the heart contains acetylsalicylic acid as the main active ingredient. To prevent the medicine from corroding the gastric mucosa when taken, the drug tablets are coated, which dissolves only when absorbed by the intestines. Coated aspirin contains the following auxiliary components:

• fine crystalline cellulose powder;
• corn starch.

The shell, which protects the stomach from the negative effects of the main element of the medication, contains the following substances:

• a copolymer of ethyl acrylate and methacrylic acid;
• sodium lauryl sulfate;
• talc;
• triethyl citrate;
• polysorbate.

Release form

The pharmaceutical industry produces medicine in the form of tablets. Each of them may contain 100 mg or 300 mg of acetylsalicylic acid.

The tablets are round in shape, convex on both sides; if you cut them, you can see that inside there is a white, finely crystalline substance, surrounded on all sides by a white shell. The blister may contain 10 or 14 tablets packed in a cardboard box.

It is accompanied by instructions for use, which must be read before taking cardiac aspirin to ensure there are no contraindications.

Aspirin Cardio - indications for use

If the results of tests and examinations of the patient demonstrate a tendency to blood clots, which can pose a danger to the health and life of the patient, then doctors must prescribe Aspirin Cardio. The list of ailments for which the drug is used is extensive:

• Initial preventive measures to prevent the development of myocardial infarction in the presence of aggravating factors (diabetes mellitus type 1 or 2, obesity, pathologically elevated levels of lipids in the blood, arterial hypertension, old age, smoking, a history of primary myocardial infarction).
• Recorded unstable angina, threatening exacerbation of coronary artery disease and heart attack.
• Stable angina, when the patient complains of chronic attacks of pain under the shoulder blade or behind the sternum, high blood pressure.
• Preventive measures to prevent stroke if the patient has insufficient oxygen supply to the brain.
• Acute cerebral ischemia, threatening stroke, which can be avoided with timely treatment.
• Prevention of blood clots after invasive surgery related to blood vessels (coronary bypass surgery, stenting and angioplasty of the aorta, arteries, veins, endarterectomy and angioplasty of the carotid arteries).
• Prevention of the development of thrombosis and thromboembolism of the pulmonary artery and deep veins in conditions of prolonged immobility and bed rest of the patient after extensive abdominal surgery.

The medicine has an impressive list of contraindications; you should definitely familiarize yourself with it to know that the cardiac drug will not harm your health when taken. Aspirin for the heart should not be taken if you have the following ailments:

• bronchial asthma that developed as a result of taking other NSAIDs, complicated by nasal polyps;
• intolerance to acetylsalicylic acid, allergy to other components of aspirin;
• exacerbation of stomach and duodenal ulcers, bleeding;
• hemophilic hereditary or acquired diseases, hemorrhagic diathesis;
• pregnancy in the first and last trimester, lactation;
• age up to 15 years;
• dysfunction of the liver or kidneys, expressed in insufficient functioning of the organs;
• insufficiency of the heart muscle in the stage of decompensation;
• co-administration of the drug with Methotrexate, if the dosage of the latter exceeds 15 mg per week.

Directions for use and dosage

Many patients do not know how to take Aspirin Cardio correctly and stop taking the medicine when they feel better. The use of the drug is calculated for a period of up to 1 month. Depending on the ailments that the patient suffers from, the dose and frequency of taking salicylate is as follows:

• for the prevention of initial myocardial infarction - every other day, 1 tablet of 100 or 300 mg;
• for the prevention of secondary myocardial infarction, in case of suspected stroke and impaired blood supply to the brain - every day, 1 tablet of 100 or 300 mg;
• for unstable angina - chew 1 tablet, the sooner the better, to prevent the development of a heart attack, take 200-300 mg of the drug every day for the next month;
• preventive measures to prevent pulmonary embolism - 100 mg Cardio Aspirin daily or 300 every other day;
• prevention of thrombosis - 100-200 mg of medication daily.

special instructions

If the patient is planning an operation, he will have to stop using aspirin for at least a week, since the medication thins the blood.

This medicine should be taken with extreme caution if you have gout, as well as decreased excretion of uric acid, urinary deficiency, a history of stomach or duodenal ulcers, bronchial asthma, or hypersensitivity to drugs.

During pregnancy

It is allowed to take salicylate only in the 2nd trimester of pregnancy. In the early stages of gestation, taking cardiac aspirin may be accompanied by a risk of intrauterine pathologies of fetal development, and in the last months of pregnancy, when taking salicylic acid, there is a high risk of intracranial hemorrhages in the baby and inhibition of labor.

In childhood

For children under 15 years of age, heart aspirin can be prescribed only if other NSAIDs have been proven ineffective. You should drink the drug carefully, monitoring the reaction of the child’s body.

If the medicine causes uncontrollable vomiting or fever, then this may indicate the presence of Rayet's syndrome: you should immediately stop taking the medicine, informing your doctor about the occurrence of this side effect.

In cases of impaired renal and liver function

Severe renal failure with creatinine clearance less than 30 ml/hour is a contraindication to the use of the drug. If creatinine clearance is more than 30 ml/hour, the drug should be taken with caution. A diagnosis of class B and C liver dysfunction, a tendency to develop cirrhosis and hepatosis are considered a contraindication for the use of salicylates.

Drug interactions

Before your doctor prescribes cardiac aspirin, tell him or her about all the medications you take regularly.

Concomitant use with Ibuprofen, magnesium hydroxide, serotonin uptake inhibitors increases the risk of hemorrhagic effusions and bleeding. Combined use with Methotrexate negatively affects the hematopoietic system, reducing blood sugar.

The effect of drugs for gout or arterial hypertension may be reduced when taken simultaneously with salicylic acid.

Side effects

Inhibition of platelet adhesion, anticoagulant and antiplatelet effects of the drug cause side effects from various body systems, manifested in the following symptoms:

• Central nervous system: dizziness, headache, tinnitus, hearing impairment.
• Circulatory organs: increased number of nasal and gastrointestinal bleeding, the appearance of hematomas, cerebral hemorrhages, bleeding gums, hemolytic anemia, hemolysis.
• Gastrointestinal tract: nausea, heartburn, vomiting, pain in the stomach or liver, exacerbation of peptic ulcer, liver dysfunction.
• Endocrine system: increased sweating, rash, urticaria, itching, allergic rhinitis, bronchospasm, rarely - anaphylactic shock or Quincke's edema.

Overdose

Doctors have found that intoxication occurs as a result of taking salicylate in a concentration of more than 100 mg per kg of weight in one day.

In this case, the patient develops confusion, dizziness, breathing problems, convulsions, accompanied by involuntary vomiting.

If such signs are present, you should immediately call an ambulance, rinse the patient’s stomach, and give activated charcoal or another sorbent. Treatment of severe poisoning is carried out in a hospital setting.

Aspirin from the heart has many analogues, the active ingredient of which is acetylsalicylic acid. These include:

• Acylpyrine;
• Acsbirin;
• Asprovit;
• Acecardole;
• Acenterine;
• Cardiopyrin;
• Ascopirin;
• Aspicor;
• Anopyrine;
• Thrombo ACC;
• Thrombopol;
• Thrombogard 100;
• Fluspirin.

Price

Cardiac aspirin is produced by the German company Bayer. Depending on the markups on the drug, the price of tablets varies widely, however, the medicine is one of the affordable medications that are dispensed by pharmacies without prescriptions. How much Aspirin Cardio costs can be seen in the table:

Reviews

Nikolay, 65 years old

I have atherosclerosis of the extremities, my legs hurt very badly. The doctor prescribed taking cardiac aspirin every day for two months. I felt improvement after a week, my legs began to obey, the pain began to go away. A month later, at the appointment, the doctor noted a persistent improvement, blood tests were normal. I feel good.

Anna, 60 years old

I suffer from obesity and diabetes. One day I felt terrible pain in my chest, immediately chewed a Cardio Aspirin tablet, and waited for the ambulance to declare a heart attack. After hospitalization and treatment I feel better, the doctor prescribed me to drink acetylsalicylic acid for a month to prevent acute ischemia from developing.

Sergey, 55 years old

I didn’t think that acetylsalicylic acid would help with heart disease, however, when I went to the doctor with complaints of chest pain, it turned out that I had stable angina. The cardiologist prescribed me to take the medicine for a month with complex therapy with other drugs. The pain has gone away, I feel better, my tests are normal.

Source: https://sovets.net/12785-aspirin-kardio.html

Aspirin Cardio - indications for treatment and prevention, how to take and contraindications, reviews

· You will need to read: 7 minutes

Many patients who are prescribed cardiac aspirin are dismissive of this medicine, believing that it is unlikely to help with their diseases, because coated aspirin, according to general ideas, can only relieve headaches and help with high fever. However, cardiologists prescribe Aspirin Cardio for arterial hypertension, hypertension, in order to improve the functioning of the heart by clearing blood vessels from blood clots and plaques, so it is important to follow the recommendations of your doctor when he prescribes taking aspirin for the heart.

Aspirin Cardio - instructions for use

Aspirin is based on acetylsalicylic acid, which inhibits the synthesis of prostaglandin enzymes. Prostaglandins are involved in the inflammatory process by being responsible for the production of platelets.

Under the influence of salicylate, platelets lose their ability to aggregate and coagulate, and stop sticking to each other in the bloodstream, forming blood clots.

This mechanism of action of Aspirin Cardio determines the use of this drug as an antiplatelet and anticoagulant drug.

Compound

Aspirin from the heart contains acetylsalicylic acid as the main active ingredient. To prevent the medicine from corroding the gastric mucosa when taken, the drug tablets are coated, which dissolves only when absorbed by the intestines. Coated aspirin contains the following auxiliary components:

• fine crystalline cellulose powder;
• corn starch.

The shell, which protects the stomach from the negative effects of the main element of the medication, contains the following substances:

• a copolymer of ethyl acrylate and methacrylic acid;
• sodium lauryl sulfate;
• talc;
• triethyl citrate;
• polysorbate.

Contraindications

The medicine has an impressive list of contraindications; you should definitely familiarize yourself with it to know that the cardiac drug will not harm your health when taken. Aspirin for the heart should not be taken if you have the following ailments:

• bronchial asthma that developed as a result of taking other NSAIDs, complicated by nasal polyps;
• intolerance to acetylsalicylic acid, allergy to other components of aspirin;
• exacerbation of stomach and duodenal ulcers, bleeding;
• hemophilic hereditary or acquired diseases, hemorrhagic diathesis;
• pregnancy in the first and last trimester, lactation;
• age up to 15 years;
• dysfunction of the liver or kidneys, expressed in insufficient functioning of the organs;
• insufficiency of the heart muscle in the stage of decompensation;
• co-administration of the drug with Methotrexate, if the dosage of the latter exceeds 15 mg per week.