Use of aspirin in the treatment of diseases and possible side effects

Beneficial effect on blood vessels

Many people have a question: Aspirin dilates or constricts blood vessels. The use of this drug has a dilating effect; it prevents platelets from sticking together, that is, it does not allow a blood clot to form in the vessels and block the blood flow in them. Thus, Aspirin protects patients from stroke and heart attack.

Acetylsalicylic acid eliminates platelet activity for no more than a week. However, doctors recommend daily use of the drug. This is due to the fact that platelets are produced by the bone marrow every day, and in the morning. Aspirin is not able to affect a fresh portion of platelets. It only affects old production. Therefore, doctors recommend taking the drug daily, preferably in the morning.

Important! Aspirin does not affect blood viscosity; it prevents the formation of blood clots.

Aspirin dilates blood vessels in the brain

Aspirin is often prescribed by doctors for colds and many other diseases. The popularity of the drug is explained by its numerous therapeutic properties. The tablets reduce fever, eliminate hangovers, and help with cardiovascular pathologies. However, it is very important to know whether Aspirin increases or decreases blood pressure.

Therapeutic effect of the drug

Acetylsalicylic acid belongs to the category of anti-inflammatory drugs, produces antipyretic, analgesic and antiaggregation effects. The tablets reduce the production of inflammatory mediators - prostaglandins.

As a result, the inflammatory process decreases and disappears. The medicine is very effective for rheumatic processes in the body.

It affects the areas of the brain responsible for thermoregulation processes and pain sensations, thereby reducing temperature and eliminating pain.

The drug prevents platelets in the blood from sticking together, thinning the blood fluid. For this reason, the vessels relax and the pain disappears.

Doctors often prescribe medicine to patients prone to blood clots to prevent the development of stroke and heart attack.

The drug can reduce the risk of miscarriages and helps patients with cataracts and migraines. But how does Aspirin affect blood pressure - does it increase or decrease?

Effect on blood pressure

Scientists from Spain conducted studies to find out whether Aspirin increases or decreases blood pressure. To obtain the data, they prescribed the drug to one group of patients at bedtime for three months.

Others took the medication in the morning, while others followed other recommendations to lower blood pressure. In the first group of patients, blood pressure stopped increasing. There were no changes for the rest.

Doctors were surprised by the results and began to recommend Aspirin to prevent high blood pressure.

In general, medical experts are of the opinion that Aspirin does not lower or increase blood pressure. But the drug thins the blood well and improves its movement through the vessels. Aspirin reduces vascular tone.

As a result of the dilation of blood vessels, the rate of blood flow decreases and the pressure decreases. To reduce blood viscosity, the minimum dose of the drug is sufficient. For a cold, the patient takes a much larger amount of medicine.

Therefore, drugs with lower dosages are produced for hypertensive patients. They have much fewer side effects.

Purpose of the drug

Doctors do not prescribe Aspirin for high blood pressure, but they do prescribe it to prevent possible complications. The drug helps prevent the development of heart attack and stroke. For hypertensive patients, Aspirin alone is not enough, but for patients with cerebral vascular pathologies, the medication is quite enough. The medicine can dilate blood vessels and stop headaches.

Doctors do not recommend medicine for high blood pressure. “Aspirin” is actively used by cardiologists and is included in standard treatment regimens for pathologies of the heart and blood vessels. Doctors also prescribe it in the postoperative stage after various interventions to prevent the formation of complications.

It is not advisable to take acetylsalicylic acid continuously. For patients with high blood pressure, the medicine helps well if cardiovascular pathologies are detected. In such situations, Aspirin reduces blood pressure. In other situations, therapy with this remedy does not make sense.

If the pressure has increased, in order to reduce it, doctors prescribe other medications: Cardiomagnyl, Aspecard. But their constant use is possible if there is a mortal danger:

• in a post-infarction state;
• there are blood flow disorders in the brain;
• atherosclerosis was detected.

To reduce potential risks, the cardiologist determines which disorder in the body increases blood pressure. Then he prescribes the drug and determines an effective treatment regimen.

For hypotension

With low blood pressure, Aspirin can only help the patient in eliminating headaches. Hypotension occurs due to:

• stress;
• sedentary lifestyle;
• psycho-emotional stress.

As a rule, eliminating these factors is enough to solve the problem.

Side effects

Aspirin does an excellent job of preventing the formation of blood clots. But the medicine is not without negative effects.

• for peptic ulcers of the gastrointestinal organs;
• for bronchial asthma;
• during the period of bearing a child;
• children under 12 years old.

In patients with ulcerative formations, Aspirin can lead to bleeding. The drug injures the gastric mucosa, therefore it is contraindicated for gastritis, colitis, and erosions. And in people with bronchial asthma it can provoke bronchospasm.

In children under 12 years of age, the medicine can cause the development of Reye's syndrome, a disorder of the brain and liver. The drug is not prescribed to pregnant women due to the possible risk of bleeding and causing miscarriage in the first or last trimester of pregnancy.

Aspirin is also not prescribed to nursing women, since it is concentrated in breast milk in large quantities, which is unacceptable for an infant.

Why is the medicine not approved for regular use?

Chronic use of blood thinners can pose a danger to the health and life of the patient. These drugs change the structure and composition of blood fluid. They prevent platelets from sticking together, and some of the platelet cells are destroyed by the drugs.

Taking Aspirin is dangerous for people suffering from diseases of the blood clotting system and hemophilia. If it is necessary to prescribe Aspirin to such patients, this is done with great caution, and the use of the drug should be monitored by a doctor.

Restrictions on taking Aspirin exist for people who have the following diagnoses:

• thrombocytopenia;
• hemorrhagic diathesis;
• hypoprothrombinemia;
• anemia.

Pharmaceuticals produce many drugs that have similar effects to Aspirin, but have much fewer negative effects. You should not use Aspirin for prophylaxis: it can pose a serious threat to health. It is also pointless to use Aspirin when blood pressure fluctuates: the drug does not change this indicator in any way.

What dilates the blood vessels of the brain? Such information will be useful for both young people and older people. As can be seen from medical statistics, the need to use special medications arises in many people.

You can prevent problems by including foods that dilate blood vessels in your diet - this will allow you to maintain your health in good condition without resorting to synthetic drugs.

Let's try to consider what dilates the blood vessels of the brain, which options are more effective, and which are the safest.

It is important!

If a person suffers from diseases associated with insufficient blood supply to the brain, in certain situations the doctor may prescribe special tablets.

You will need to follow his instructions very precisely, without adjusting the recommended program, without canceling it or replacing the prescribed remedy. But in the absence of a medical recommendation, you cannot abuse drugs.

If you often experience a headache or other symptoms indicating a lack of blood supply, you need to see a doctor as soon as possible in order to identify the cause of the disease and fight it.

Attempts to cure symptoms if they are associated with pathology using home methods will not lead to success; you should not count on it. You need to treat your health with extreme care and attention.

Well, if unpleasant sensations rarely bother you, then you need to know what dilates the blood vessels of the brain, and have a suitable remedy on hand so that if such a situation occurs, you quickly provide yourself with first aid.

Relevance of the problem

Changes in the quality of the circulatory system of the brain are often observed due to age, which affects a variety of organs and systems. However, as can be seen from medical statistics, at present the problem has become significantly younger and worries not only middle age, but also boys and girls.

Almost any person who abuses alcoholic beverages or tobacco products knows firsthand which pills dilate blood vessels in the brain. The problem is relevant for those who lead an inactive life, move little, eat salty, fatty foods, and are overweight.

To summarize: an impressive percentage of our society, to one degree or another, faces the unpleasant consequences of impaired blood circulation. Doctors are calling: if you suspect serious abnormalities, there is no need to delay, you should immediately visit a doctor in order to preserve your health and quality of life.

Vessels: what affects?

What dilates the blood vessels of the brain, which contributes to the reduction of the lumen? There are quite a lot of factors associated with diet, physical activity, bad habits, the opportunity to relax and recuperate. Stressful situations have an extremely negative impact on the human body.

To optimize the activity of the circulatory system, heart, brain, you need to exclude fat, fried foods, salt, add greens, vegetables, dairy, and fish to your diet.

Vegetable oils (olive, flax, sunflower) will bring benefits - however, they are not suitable for frying, but are suitable only as a salad dressing. To improve the quality of your blood, you should pamper yourself with berries and fruits.

If the body receives vitamins and minerals in the quantities it needs, this has a positive effect on all organs, including blood vessels, brain, and heart.

Source: https://ogomeopatii.ru/aspirin-rasshirjaet-sosudy-golovnogo-mozga/

Reception scheme

It is known that the drug Aspirin dilates blood vessels and is widely used as a prophylaxis for people with heart disease over 45 years of age . However, its daily dose should not exceed 100 mg. If the patient needs blood thinning, then the daily dose can range from 50 to 320 mg.

The exact dosage is prescribed by the doctor, based on the person’s condition. For example, in the presence of cardiosclerosis, Aspirin is taken 2 times a week, 200 mg. over the course of a month. To improve the condition after a heart attack, the duration of use is increased to six months, while the dosage of Acetylsalicylic acid varies from 160 to 320 mg. per day. Doctors usually prescribe taking ¼ tablet of Aspirin in the morning.

Advice: to ensure that Aspirin does not irritate the stomach, it is better to drink it with plenty of milk.

Aspirin prevents stroke in atrial fibrillation

To prevent cerebral strokes due to the formation of blood clots in patients with atrial fibrillation, aspirin is used (50 mg per day or even 100 mg once a week is sufficient) or other medications to thin the blood or reduce its clotting. But this can only be used as prescribed by a doctor, like any other medicine.

Links to studies:

• www.ncbi.nlm.nih.gov/pubmed/24474959
• www.ncbi.nlm.nih.gov/pubmed/26197188
• www.ncbi.nlm.nih.gov/pubmed/25988464
• www.ncbi.nlm.nih.gov/pubmed/27339487

Interaction with other drugs

Despite the beneficial effects of Aspirin on blood vessels, this drug can not only be beneficial, but also harmful. Therefore, you should not prescribe it yourself; you need to consult your doctor. If you need to take pills for a long time, which lasts for more than one year, then you need to regularly monitor your blood and stool tests. In addition, it is important to consider the interaction of Aspirin with other medications.

Aspirin, when used over a long period of time, can weaken the effect of medications used to treat gout and diuretics. It has been noted that it enhances the effect of hormones, hypoglycemic medications, anticoagulants, and anti-inflammatory drugs. If Aspirin is taken simultaneously with cytostatics, it increases the side effects of the latter and can cause gastric bleeding.

What are the dangers of long-term use of aspirin?

The reason for the danger of long-term use of acetylsalicylic acid is its non-selectivity (non-selectivity). That is, in addition to inactivating platelets, the drug also negatively affects the production of substances that protect various organs and tissues (stomach, liver, kidneys, bone marrow). The most dangerous consequence of long-term use of aspirin is gastric ulcer, which is often complicated by perforation and bleeding.

Therefore, if a patient is prescribed aspirin for continuous use, the patient must undergo an annual endoscopic examination of the stomach, duodenum, and take a general blood test and stool test for the Gregersen reaction. These examinations will help to identify possible complications from the gastrointestinal tract in a timely manner. In some cases, the simultaneous use of aspirin and drugs that restore the stomach wall (omeprazole, pantoprazole, ranitidine, etc.) is justified.

Contraindications to taking Aspirin

Aspirin should not be taken for the following concomitant conditions:

• for gastrointestinal diseases;
• hemophilia;
• decreased blood clotting;
• renal failure;
• increased sensitivity;
• Reye's syndrome;
• bronchial asthma.

In addition, daily use of Aspirin as a prophylaxis for vascular thrombosis is not recommended for persons:

• those under 45 years of age with risk factors;
• over 45 years of age in the absence of risk factors;
• suffering from diabetes mellitus, hypertension with vessels not affected by atherosclerosis.

With proper use and regular consultation with a doctor, with the help of Aspirin you can avoid such an unpleasant phenomenon as vascular thrombosis.

Sources:

Vidal : https://www.vidal.ru/drugs/aspirin__1962 GRLS : https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGu >

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Aspirin is not the best medicine for the heart

A recent study suggests that aspirin may reduce the risk of heart attack, but may also cause severe bleeding.

Doctors and pharmacists are well aware that the preventive properties of cardiac aspirin are based on its ability to prevent blood clotting.

But the average pharmacy visitor who wants to protect the heart with advertised over-the-counter aspirin is not always aware of the other side of this coin - the risk of bleeding.

Not many people have heard about the effect of acetylsalicylic acid on the mucous membrane of the gastrointestinal tract.

A new study has found that aspirin, while reducing the risk of heart attack and stroke, may also increase the risk of potentially dangerous bleeding.

Researchers from Imperial College London and King's College in the UK analyzed data from 13 clinical trials involving more than 164,000 participants without cardiovascular disease aged 53 to 74 years.

The researchers wanted to find out whether aspirin prevents cardiovascular events in this age group, and also clarify the risk of bleeding requiring hospitalization.

The results, published in the Journal of the American Medical Association, point to two key points.

Firstly

If you've never had a heart attack (primary prevention), regular low-dose aspirin does prevent the risk of heart attack, stroke, and—most importantly—reduces mortality.

Secondly

, in secondary prevention (after previous cardiovascular events), taking aspirin has no effect on mortality and is associated with a high risk of bleeding. Simply put, it does not save life, but it adds problems.

“We end up with more people with severe bleeding that require hospitalization than people who are saved from heart attacks and strokes,” says Dr. Salman Arein, a professor of cardiology at the University of Texas McGovern Medical School.

Dr. Arein explains that aspirin is a strong antiplatelet agent that interferes with the “gluing” of platelets.

Although platelets can be involved in the formation of a fatal blood clot in a cerebral artery, they prevent us from literally bleeding to death at the slightest cut in the skin or, especially, damage to internal organs. Therefore, long-term use of low-dose aspirin increases the risk of bleeding. This drug becomes even more dangerous if taken at the same time as popular anticoagulants. For example, with warfarin.

A drop of tar in a barrel of aspirin

In general, some authoritative experts in the field of cardiovascular diseases argue that all people over 40 can safely start taking aspirin. And, nevertheless, today these are only individual expert opinions that are not supported by real evidence. What do the largest organizations in the field of drug safety think about this?

In 2014, the FDA (Food and Drug Administration), an organization that we know as the Food and Drug Administration in the United States, analyzed a fairly large list of clinical studies conducted in various countries around the world and came to interesting conclusions. Aspirin has shown phenomenal effectiveness in the secondary prevention of strokes and heart attacks in people who have previously suffered episodes of these diseases. However, it had no effect on the incidence of new cardiovascular events, except for increasing the risk of developing specific complications (bleeding, gastric ulcers, kidney problems).

Therefore, they concluded that this drug should not be recommended for widespread use, even in cases where a person is at high risk (diabetes mellitus, unfavorable heredity). Dr. Robert Temple, FDA's deputy director for clinical research, said in a statement: "The benefits of taking daily aspirin without a history of vascular accidents have not been established, but the risks are present."

Japanese scientists came to similar conclusions, who conducted the largest clinical trial JPPP (Japanese Primary Prevention Project) in the period 2005-2007. They analyzed the medical records of about 15 thousand patients who received low-dose aspirin for the purpose of primary prevention of stroke and heart attack and came to similar conclusions. The number of patients in whom the likelihood of developing a heart attack was significantly reduced was decent, but the high frequency of various severe bleedings negated this good indicator. For other key indicators (acute myocardial infarction and sudden mortality), no positive results were obtained at all.

Body weight is an important factor when taking aspirin

Today in pharmacies, as a rule, you can buy cardiac aspirin in doses of 75 or 100 mg per tablet. This is considered the “gold standard” for heart attack prevention. But the “one size fits all” principle does not work here. The study, published in The Lancet, calls for body weight to be taken into account.

Researchers analyzed data from nine clinical trials and found that the recommended dose of 75 to 100 milligrams of aspirin per day protected only those patients who weighed up to 154 pounds (70 kilograms).

Individuals with greater body weight required aspirin doses of 300 mg/day or even higher to provide a statistically significant preventive effect.

It is not surprising, because body weight affects the distribution of the drug in the body.

History of the drug

Acetylsalicylic acid is a medicinal product that is produced on the basis of essential oils of acetic acid. The drug has analgesic, antipyretic, anti-inflammatory and vasodilating effects on the human body.

Salicylic acid was first obtained in 1838 in Italy by the chemist R. Piria. And in 1874, the world's first factory for the production of salicylic acid was opened in the German city of Dresden.

Since 1897, after Felix Hoffmann managed to obtain acetylsalicylic acid in its pure form, it became possible to use the drug for medical purposes.

The main raw material for the production of the drug was willow bark, and it was from it that this acid was extracted.

Aspirin first went on sale in 1899 as a drug that has an antipyretic effect. When used by people, it was observed that it not only lowers body temperature, but also relieves pain and has anti-inflammatory properties. In addition, the drug dilates blood vessels and thins the blood.

This drug is used all over the world to this day, and it gained its popularity due to its wide spectrum of action and affordable price for tablets.

Elderly people can only get hurt

The ASPREE study examined the preventive effect of regular 100 mg aspirin versus placebo. The project involved about 19 thousand older Australians and Americans aged 70 years and over who did not have cardiovascular disease, dementia or disability. The researchers found no evidence that aspirin had any preventive effect.

Although participants taking aspirin showed a higher risk of bleeding.

Obviously, aspirin is not the best medicine for the heart today. The ASPREE study also found that the risk of death from any cause in this age group was higher with aspirin than with placebo.

Statins as an alternative to aspirin

So, should you take aspirin to reduce your risk of heart attack or stroke?

This is a difficult question if you are familiar with the scientific facts. But there is an alternative that is strongly recommended by some foreign cardiologists. These are drugs from the statin group (atorvastatin, rosuvastatin).

“With the introduction of statins to lower cholesterol, aspirin may no longer be considered the best preventive option in people without a history of cardiovascular disease,” is the professional opinion of Dr. Robert Segal, an American cardiologist and founder of LabFinder.

According to another expert, Dr. Arein, statins inhibit the formation of cholesterol plaques in the arteries, and they are “proven to be effective in preventing heart attacks and strokes.”

“Statins are most effective for secondary prevention—to prevent second and third events. Therefore, all patients who have had a heart attack and ischemic stroke (caused by a blood clot) should take statins for as long as they can tolerate them,” Dr. Arein told local media.

However, Segal warns that statins are strictly contraindicated during pregnancy, lactation, and severe liver disease. Let us add that many medications cannot be combined with statins.

Aspirin constricts or dilates blood vessels

Aspirin is often prescribed by doctors for colds and many other diseases. The popularity of the drug is explained by its numerous therapeutic properties. The tablets reduce fever, eliminate hangovers, and help with cardiovascular pathologies. However, it is very important to know whether Aspirin increases or decreases blood pressure.

How to treat?

The health of cerebral vessels is one of the key factors of health. Together with the health of heart vessels. If you do not monitor the condition of blood vessels, the consequences can be stroke and heart attack. Why does this cause such serious consequences?

The vessels pump blood, which contains nothing less than life. It delivers oxygen and nutrition to the brain. If the vessel ceases to perform its function, areas of the brain without nutrition dry out and die.

Various factors lead to vasoconstriction.

There is no need to worry - you just need to take action. And one of the ways to avoid the risk of strokes and heart attacks is the use of drugs that dilate blood vessels, which ensures that they perform their function properly.

In addition, the performance of blood vessels guarantees the presence of a “combat” memory and a tenacious mind.

The nature of the decrease in vascular performance lies in poor nutrition, psycho-emotional stress, nervous stress, due to wear and tear of the circulatory system in old age.

There are drugs available that are intended to expand the vascular channels for pumping blood directly to the head, separately to the blood vessels of the heart, substances for working under conditions of high blood pressure, to increase blood supply to the extremities, for arthrosis of the joints, and for salt deposition (osteochondrosis) of the neck.

If the cause of vascular malfunction in terms of blood pumping is atherosclerosis, that is, partial or varying degrees of blockage of the lumen of blood vessels with atherosclerotic plaques, then the function of dilating blood vessels is taken over by drugs whose action is based on dissolving and washing out these plaques from the vessels.

Nutrition Help

Atherosclerosis does not consist of an increased amount of cholesterol in food - which, for a minute, is the raw material for the production of testosterone in men and sex hormones in women. And the increased content of LDL - low-density lipoproteins, which retain excess cholesterol in the blood.

If the amount of HDL ingested from food - high-density lipoproteins , which wash out such plaques, is greater than the LDL content, no matter how much cholesterol is in food, it simply does not linger in the blood. It is washed out by excess HDL.

These high-density lipoproteins include fish oil containing Omega-3 fatty acids and olive oil. There are also Omega-6 and Omega-9 fatty acids.

It is important that your food contains a lot of Omega-3, fatty fish such as mackerel are considered good sources.

The second aspect of nutrition that affects the retention of plaques is the consumption of sweets along with fatty foods. You need to use them separately, with a time interval.

The third aspect is to eliminate trans fats. Spread, margarine, refined “oils”, which are not oils, but hydrogenated products of synthetic origin.

These are fats that do not exist in nature . To give them the necessary properties - so that they do not smell, so that they do not burn, they take natural fats and artificially “sculpt” molecules onto them, and obtain artificially synthesized chemicals that do not exist in nature. You don't need to eat them. This process is called hydrogenation.

The vessel is like a hose. It should be hard, durable, but at the same time elastic and allow everything that is needed to pass through it. So that there are no delays.

Spasm is excessive tension on a vessel when it is “twisted” or “squeezed” or “squeezed.”

Source: https://BoliGolovnie.ru/varikoz/aspirin-suzhaet-ili-rasshirjaet-sosudy.html

Other ways to protect yourself from heart attack and stroke

“The latest study supports the idea that aspirin should be used with caution in patients with risk factors for coronary heart disease and stroke, and that lifestyle changes and risk factor modification may be a safer strategy for preventing the event,” Dr. Arein said.

Among the simplest ways to protect against heart attack:

• Regular physical activity • Healthy diet low in saturated fat • Strictly limiting refined sugars and simple carbohydrates • Quitting smoking and minimizing secondhand smoke • Maintaining body mass index within healthy limits • Effectively controlling hypertension and diabetes

Aspirin is not the best medicine for the heart. Without a healthy lifestyle, no medications will provide reliable protection against heart attack and stroke.

Konstantin Mokanov: Master of Pharmacy and professional medical translator

Contraindications for the use of aspirin

Aspirin should not be used in patients with allergies to salicylates or anti-inflammatory drugs. In addition, special caution should be exercised in patients suffering from asthma or bronchospasm.

Due to the negative effects on the stomach and intestines, use with caution in patients suffering from:

• peptic ulcer
• diabetes mellitus
• gastritis

Even when none of these conditions are present, aspirin may increase the risk of stomach bleeding , especially if taken in combination with alcohol or warfarin.

Patients suffering from hemophilia or other blood clotting disorders should not take aspirin or other salicylates.

Aspirin has been shown to cause hemolytic anemia in patients with glucose-6-phosphate dehydrogenase enzyme deficiency, especially when taken in large doses.

The use of aspirin in cases of dengue fever is not recommended due to the increased tendency of bleeding.

Patients suffering from kidney disease, hyperuricemia or gout should not use aspirin because this drug reduces the kidneys' ability to remove uric acid and therefore may worsen these diseases.

The use of Aspirin for cardiovascular diseases

Numerous cardiac studies around the world have been devoted to studying the effects of Aspirin (acetylsalicylic acid). The uniqueness of this drug lies in the fact that it reliably reduces mortality from myocardial infarction (up to 70%) among patients with cardiovascular diseases. Long-term use of acetylsalicylic acid has been proven to improve the long-term prognosis for the patient's life.

Aspirin is a revolutionary drug that is recognized by the world's leading cardiologists as the drug of choice in the treatment and prevention of various diseases of the cardiovascular system.

I recently read an article that talks about the drug Choledol for cleaning blood vessels and getting rid of CHOLESTEROL. This drug improves the general condition of the body, normalizes the tone of the veins, prevents the deposition of cholesterol plaques, cleanses the blood and lymph, and also protects against hypertension, strokes and heart attacks.

I’m not used to trusting any information, but I decided to check and ordered a package. I noticed changes within a week: the constant pain in my heart, heaviness, and pressure surges that had tormented me before receded, and after 2 weeks they disappeared completely. Try it too, and if anyone is interested, below is the link to the article.

For whom Aspirin is contraindicated?

Aspirin for the prevention of cardiovascular pathologies is recommended to patients in order to eliminate the risk of vascular thrombosis, ischemic stroke and myocardial infarction. In most cases of cardiac pathologies, risks to the patient's life are caused by blockage of blood vessels with a blood clot. For the purpose of prevention, it is necessary to take a small dose of the drug daily. It is not recommended to take aspirin for the prevention of cardiovascular diseases in any dosage:

• people without prerequisites for the occurrence of cardiovascular pathology;
• men up to forty-five years old and women up to fifty-five years old;
• for hypertensive patients or diabetics, if the patients’ vessels do not show signs of atherosclerosis.

Aspirin is prescribed for the prevention of cardiovascular diseases with extreme caution to patients with the following diseases:

• with hypersensitivity to the main component – ​​acetylsalicylic acid;
• if the patient is diagnosed with hemophilia, since the drug can thin the blood;
• when diagnosing hemorrhagic diathesis in a sick person;
• during an exacerbation of a stomach ulcer or gastritis;
• it is contraindicated for patients with urolithiasis or acute renal failure;
• during pregnancy or lactation.

However, Aspirin for the prevention of cardiovascular diseases is recommended to patients in all clinical cases if the benefits of its action far outweigh the risks from the gastrointestinal tract. Acetylsalicylic acid can cause adverse reactions:

• risk of stomach bleeding;
• heartburn;
• epigastric pain;
• allergic reactions.

Recently, doctors have developed cardioaspirin - a special drug that is broken down not in the stomach, but in the duodenum. Its absorption occurs much more slowly - the drug reaches its highest concentration in the blood after three to four hours. Thus, enteric forms cause less harm to the susceptible gastric mucosa, which means they can be used with little or no concern. Another advantageous difference between the new product and other drugs is that it contains the optimal dosage of aspirin for the prevention of heart disease.

The benefits and harms of acetylsalicylic acid

Aspirin is an effective antiplatelet agent and nonsteroidal anti-inflammatory drug (NSAID). The active ingredient of this drug, acetylsalicylic acid, belongs to the group of cyclooxygenase (COX) enzyme inhibitors. This enzyme is involved in the production of active biocompounds in the human body (thromboxane, prostaglandins, prostacyclins).

Platelet COX promotes the synthesis of thromboxane, which increases their “stickiness” (aggregation) and triggers the process of thrombus formation. COX in the cells of the vascular walls is involved in the biosynthesis of prostacyclins, which dilate blood vessels. Acetylsalicylic acid in small doses suppresses platelet COX, but does not affect this enzyme in the cells of the vascular walls, thereby improving blood microcirculation.

In addition to its antiplatelet properties, the drug suppresses the biosynthesis of prostaglandins in the body, due to which it has the following effects:

• antipyretic (antipyretic);
• anti-inflammatory;
• painkiller.

The primary indication for the use of Aspirin is various cardiovascular diseases, for which it is taken as a single agent or as part of complex treatment. But the wide range of effects of this medication allows you to take the drug for other pathologies and conditions.

Indications for its use are:

• 
  cardiovascular pathologies (coronary heart disease (CHD), blood flow disorders in the brain, thrombosis, thrombophlebitis, prevention of complications after heart surgery, before long-term surgical interventions, flights);

• conditions after cerebral strokes and acute myocardial infarction;
• pain syndromes (neuralgia, migraines, muscle, joint, dental and menstrual pain);
• febrile conditions and diseases accompanied by hyperthermia (rheumatism, sinusitis, tonsillitis, other infectious and inflammatory processes).

Along with its therapeutic properties, the use of the drug has a number of side effects, which limits its use. With prolonged use without appropriate medical supervision, stomach ulcers and gastric bleeding may occur. Their occurrence is explained:

• 
  inhibition of the thrombus formation process;

• irritant effect on the mucous membrane of the gastrointestinal tract;
• suppression of the biosynthesis of prostaglandins, which have a healing effect on microtraumas of the mucous membrane of the stomach and duodenum.

Considering this side effect of the drug, absolute contraindications for its use are:

• history of ulcerative processes in the stomach or duodenum;
• hemophilia, thrombocytopenia;
• blood diseases accompanied by a deficiency of coagulation factors;
• portal hypertension syndrome or venous congestion in the systemic circulation.

Acetylsalicylic acid can cause allergic reactions (angioedema, skin reactions - rash, itching, urticaria). Patients with bronchial asthma need to take this drug according to special desensitizing regimens (with increasing doses).

Aspirin is excreted in the urine, so it is contraindicated for patients with impaired renal excretory function. Long-term use of acetylsalicylic acid can inhibit hematopoiesis, which can lead to anemia. It is also prohibited for pregnant women to drink this drug, especially in the first trimester, due to its teratogenic effect.

It is dangerous for children under 12 years of age to take this medication for viral infections due to the risk of developing Reye's syndrome, a dangerous disease that occurs with the rapid development of fatty liver and hepatic encephalopathy.

Aspirin for the prevention of cardiovascular diseases

Aspirin for the prevention of cardiovascular diseases is included in all international recommendations. This is due to the proven effectiveness of the drug in low doses.

Atherothrombosis is the main reason for prescribing Aspirin

Atherothrombosis is a pathology in which the patient develops an atheromatous plaque covered by a thrombus. It is this formation that is diagnosed in most patients with vascular pathologies.

The process of thrombus formation on the surface of atheroma is the result of activation of platelets and a series of coagulation reactions. At the initial stage, platelet adhesion begins in the damaged area of ​​the vessel, that is, the process of their gluing occurs in the place where the vessel is damaged and lacks epithelium.

In the next phase of aggregation, platelets stick together and a primary plug is formed. Such blood clots are not yet tightly attached and with the blood flow they usually spread throughout the body, clogging small vessels.

Larger blood clots can cause severe cardiac pathologies, including death.

Mechanism of action of Aspirin

Aspirin is the first antiplatelet drug to be successfully used in medical practice. Thanks to its capabilities, it has become the basis for the prevention and treatment of atherothrombosis and actively prevents the development of complications associated with vascular pathology.

The active ingredient in Aspirin is acetylsalicylic acid. The antiaggregation effect of the drug is dose-dependent, i.e. The expected effect does not occur at any concentration of the substance. In the course of research, it was found that small concentrations of the substance are enough to achieve an antiplatelet result.

In addition to blocking blood clots, acid has the following effects:

• affects lysine in the fibrinogen molecule;
• loosens fibrin threads;
• suppresses pro-inflammatory cytokines;
• normalizes the level of C-reactive protein.

For whom Aspirin is contraindicated?

Aspirin for the prevention of cardiovascular pathologies is recommended to patients in order to eliminate the risk of vascular thrombosis, ischemic stroke and myocardial infarction.

In most cases of cardiac pathologies, risks to the patient's life are caused by blockage of blood vessels with a blood clot. For the purpose of prevention, it is necessary to take a small dose of the drug daily.

It is not recommended to take aspirin for the prevention of cardiovascular diseases in any dosage:

• people without prerequisites for the occurrence of cardiovascular pathology;
• men up to forty-five years old and women up to fifty-five years old;
• for hypertensive patients or diabetics, if the patients’ vessels do not show signs of atherosclerosis.

Aspirin is prescribed for the prevention of cardiovascular diseases with extreme caution to patients with the following diseases:

• with hypersensitivity to the main component – ​​acetylsalicylic acid;
• if the patient is diagnosed with hemophilia, since the drug can thin the blood;
• when diagnosing hemorrhagic diathesis in a sick person;
• during an exacerbation of a stomach ulcer or gastritis;
• it is contraindicated for patients with urolithiasis or acute renal failure;
• during pregnancy or lactation.

However, Aspirin for the prevention of cardiovascular diseases is recommended to patients in all clinical cases if the benefits of its action far outweigh the risks from the gastrointestinal tract. Acetylsalicylic acid can cause adverse reactions:

• risk of stomach bleeding;
• heartburn;
• epigastric pain;
• allergic reactions.

Recently, doctors have developed cardioaspirin - a special drug that is broken down not in the stomach, but in the duodenum. Its absorption occurs much more slowly - the drug reaches its highest concentration in the blood after three to four hours.

Thus, enteric forms cause less harm to the susceptible gastric mucosa, which means they can be used with little or no risk.

Another advantageous difference between the new product and other drugs is that it contains the optimal dosage of aspirin for the prevention of heart disease.

Who should take Aspirin?

Taking acetylsalicylic acid is advisable for the following categories of patients:

• for those who have previously been diagnosed with myocardial infarction;
• in patients with ischemic stroke;
• if patients have ischemic transient attacks (mini-strokes);
• if a person is diagnosed with coronary heart disease, angina pectoris;
• if the patient is suspected of developing a myocardial infarction;
• for the prevention of thromboembolism when a person is undergoing surgery;
• patients after coronary artery bypass surgery.

If a person meets at least one point, the doctor prescribes acetylsalicylic acid, including it in the drug therapy regimen to support the functioning of the heart and blood vessels.

How to take Aspirin as a preventative measure

Doctors recommend how to take cardiac aspirin for prevention:

• The dose should not exceed 160 mg per day . This is the limit even with the most complex pathologies.
• The recommended dosage is from 75 to 120 mg per day .

Aspirin Cardio is available in dosages of 100 or 300 mg, i.e. one tablet is enough to provide the required daily dose.

The drug Trombo ACC contains 75 mg of acetylsalicylic acid, which is the lowest limit to meet the patient's acid needs.

At the initial stage, on the recommendation of a doctor, patients start with these dosages, increasing it if necessary.

Analogs of Aspirin Cardio are:

• Acekor Cardio (100 mg of active ingredient in one tablet);
• Godasal (100 mg);
• Thrombolec Cardio (100 mg);
• Akard (75 or 150 mg);
• Cardiomagnyl (75 mg);
• Cardiomagnyl Forte (150 mg);
• Cardisave (75 or 150 mg);
• Lospirin (75 mg);
• Magnicor (75 mg).

Patients usually take Aspirin Cardio or Thrombo ACC. It is worth noting that such drugs are effective and fully fulfill their intended purpose. There is no point in purchasing an expensive analogue that will have the same effect.

Note! Do not take the drug at the same time as alcoholic beverages.

To avoid adverse reactions, do not take the tablets on an empty stomach - take the drug either during meals or immediately after. Do not split or chew the tablets; swallow them whole.

Take the medicine with plenty of water. Can be administered intravenously or intramuscularly to avoid the passage of the drug through the gastrointestinal tract.

In rare cases, patients experience an overdose of Aspirin:

• temperature rises;
• breathing problems occur;
• cough appears;
• the skin turns pale;
• urination decreases;
• a state of stupor or overexcitation occurs;
• there are pains in the heart;
• pulse quickens.

The most dangerous stage of poisoning is the appearance of swelling of the lungs, which quickly worsens. When foaming at the mouth appears, such patients can rarely be saved. Death occurs from kidney and liver failure, pulmonary edema, and paralysis of vital centers of the brain. If signs of Aspirin poisoning appear, induce vomiting or give the patient activated charcoal.

If a patient stops taking aspirin for the prevention of cardiovascular diseases, the dose is not abruptly stopped - this provokes a “rebound effect”, i.e. causes the same effects for which the drug was originally taken. Therefore, the end of therapy is a separate scheme, which is signed by the doctor, and it must be followed strictly.

Aspirin is available from pharmacies without a prescription. Cardiac Aspirin is not prescribed for children. Certain drugs can be used in adolescents from the age of 15, for example, Cardiomagnyl, Aspirin Cardio is allowed from the age of 16, and Thrombo ACC is allowed from the age of 18

Interaction of Aspirin with other drugs

When taking Aspirin simultaneously with other medications, it affects their effect. The following reactions have been established:

• if you take Aspirin together with anticoagulants, the drug enhances their effect and provokes increased bleeding;
• Aspirin can both enhance the therapeutic effect of non-steroidal anti-inflammatory drugs and their side effects;
• when taking Aspirin and Methotrexate simultaneously, the negative effect of the latter drug increases;
• Aspirin can enhance the hypoglycemic effect of sulfonylureas;
• if you take Aspirin along with corticosteroids, the likelihood of gastrointestinal bleeding increases;
• the drug can weaken the effect of Furosemide, spirinolactone and some antihypertensive drugs;
• If you use more than 3 g of Aspirin, then while taking antacids in a person’s blood, the level of salicylates decreases.

With proper use of acetylsalicylic acid in recommended doses and safe forms, the substance can become the basis for primary and secondary prevention of cardiovascular diseases in patients with a high risk of developing cardiopathy or existing diagnoses.

16329 Gulmira Sadzykova 01/02/2018

Source: https://profilaktika-zabolevanij.ru/lekarstva/aspirin-dlya-profilaktiki-serdechno-sosudistyx-zabolevanij/

Rules and regimens for taking the drug

Aspirin for the prevention of vascular thrombosis is indicated for use by women over 40 years of age and men over 45 years of age. Moreover, its daily preventive dose is about 75-100 mg.

Aspirin is a blood thinner prescribed for patients with cardiovascular disease. The dosage ranges from 50 to 320 mg per day. How much and in what dosage it is indicated to take this drug is determined by the doctor individually for each patient. For example:

To clean VESSELS, prevent blood clots and get rid of CHOLESTEROL, our readers use a new natural drug recommended by Elena Malysheva. The preparation contains blueberry juice, clover flowers, native garlic concentrate, rock oil, and wild garlic juice.

• for post-infarction cardiosclerosis, Aspirin for blood thinning is prescribed 125-250 mg twice a week for at least 1 month;
• To improve the long-term prognosis after acute myocardial infarction, Aspirin is prescribed for a period of at least 6 months at a dose of 160-325 mg per day.

Aspirin is included in many standard treatment regimens for cardiovascular diseases. For example, the use of Aspirin at a dose of 325 mg 2 times a day is indicated for unstable angina after discontinuation of Heparin in order to prevent the development of withdrawal syndrome.

Given the large number of contraindications and side effects, self-administration of Aspirin is prohibited. Before prescribing it, a doctor’s consultation is required, and, if necessary, additional research methods (blood tests, gastroscopy). When taking the medication for a long time, it is necessary to monitor hemostasis and examine stool for occult blood.

When taking Aspirin simultaneously with other medications, it should be taken into account that it has the property of enhancing or weakening the effects of certain medications:

• weakens the effect:

  
  diuretics (Furosemide, Spironolactone);

• anti-gout drugs (Probenecid, Sulfinpyrazone);
• enhances actions:
  anticoagulants (Heparin, Coumarin);
• corticosteroids (Prednisolone, Kenalog, Hydrocortisone);
• hypoglycemic drugs (Maninil, Diabeton, Amaryl);
• NSAIDs (Ibuprofen, Paracetamol).

With the simultaneous administration of Aspirin and cytostatics (Methotrexate), an increase in the side effects of the latter is observed.

If patients have contraindications or side effects, it is recommended to replace Aspirin with Ticlopidine.

Materials used in the article:

https://medbe.ru/news/serdtse-i-sosudy/aspirin-ne-luchshee-lekarstvo-dlya-serdtsa/

https://proinsultmozga.ru/sosudy/preparaty-02/kak-prinimat-aspirin-dlya-profilaktiki.html

https://zavorota.ru/spina/bol-poseredine.html

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Indications for prophylactic use of aspirin in Russia

In our country, protocols and standards for the management of patients with cardiovascular diseases provide for special groups of people who are indicated for constant use of a prophylactic dose of aspirin (75-100 mg):

• Acute cerebral circulation (stroke) of ischemic type,
• Post-acute myocardial infarction,
• Angina pectoris of exertion and rest,
• Previous surgery: coronary artery bypass grafting and coronary artery stenting,
• Heart rhythm disturbances (fibrillation, fluttering),
• Patients who do not have cardiovascular diseases, but are at risk for their occurrence: diabetes mellitus, hereditary hypercholesterolemia, genetic predisposition, etc.

Indeed, the vast majority of people at an appointment with a cardiologist in Russia receive a recommendation to take a prophylactic dose of aspirin daily for an indefinite period of time (that is, for life). This has been the case for many years, but recent scientific evidence casts doubt on the need for this preventive measure.