An effective drug Mexidol for cerebral vessels: action, effect, application regimen

One of the best antioxidants on the market now is Mexidol . This drug was synthesized in early 1980 in Russia. It can help with various diseases ranging from vegetative-vascular dystonia to coronary heart disease.

It also comes in two forms in the form of tablets and injections, each of which is suitable for a specific type of person. The drug can act as monotherapy or be part of an integrated approach.

In an article on a similar topic, we tell you what Askofen helps with.

Detailed description

• Mexidol has the active ingredient ethylmethylhydroxypyridine succinate , which is present both in tablets and ampoules.
• purchase the drug in pharmacies only with a doctor’s prescription; he can prescribe either tablets or injections, sometimes they are combined, but if there are contraindications for the tablet form, the injectable form is used.
• Injections have the advantage not only that they are less toxic in this form, they also increase the effectiveness of the medicine.
• The composition contains other excipients; it is important to study the instructions for intolerance to any component.
• It is also very important to know all the side effects of Mexidol; if any of them appear, you should immediately consult a doctor.
• But the medicine is well tolerated , the only drawback may be its slight toxicity when taking tablets, so for long courses only injections are always used.

Also see instructions for use of Anaprilin, prices, reviews, analogues.

Composition, properties, release forms

The drug contains the active substance – ethylmethylhydroxypyridine succinate. Mexidol also contains the following auxiliary components:

• food coloring E71;
• milk sugar;
• artificial polymer;
• carmellose sodium;
• talc;
• food emulsifier E572;
• macrogoal

Mexidol is a universal drug that has a positive effect on neuroses. It helps to dissolve cholesterol plaques on the walls of blood vessels. When using the drug, plasma membrane lipids are restored, learning ability increases, since Mexidol affects memory and mental activity. In addition to the fact that the drug helps normalize blood pressure, it significantly reduces the level of bad cholesterol in the blood.

The drug has a positive effect on the body: it relieves headaches, mood swings and palpitations. Mexidol reduces signs of hypertension, arrhythmia, tachycardia and vasomotor instability.

Mexidol is available in tablets and injections. The tablets are intended for oral administration and weigh 125 g each. The package contains 10 or 90 round tablets of white or cream color.

High blood pressure injections are intended for intravenous or intramuscular administration. The solution is yellow or transparent. At the pharmacy you can buy ampoules with a volume of 2 to 5 ml.

Pharmacological properties

The main substance has a positive effect on blood vessels, increases dopamine levels in the brain and has other beneficial effects. One of its main effects is to improve the metabolism in the brain, it helps deliver more nutrients to the brain, thus increasing the performance of a person.

Other effects of Mexidol:

• it has an antitoxic effect, so it perfectly removes alcohol and any other neurotoxic intoxication;
• with its help, the effect of tranquilizers and antidepressants, as well as other drugs that affect the psyche, is enhanced, this allows you to reduce the dosage of the main drug;
• it improves sleep cycles and has a slight calming effect, especially if fears act as VSD syndrome;
• improves myocardial functioning.

All properties apply to both tablets and Mexidol injections .

It is very important that it improves the energy metabolism of the cell and also lowers the level of total cholesterol.

A doctor may prescribe it as a preventive measure for certain diseases or to treat a simple form of a disease.

Find out more about the effective heart drug Carmidol here.

The main effect of the drug Mexidol is to narrow or dilate blood vessels?

The peculiarity of the action of this drug, in contrast to traditional drugs that directly affect the vessels or receptors of the nervous system, is a fundamentally different point of application. Mexidol changes the course of metabolic processes. This manifests itself in the form of the following biological reactions:

• activates signal transmission through the neural network;
• normalizes blood lipid composition;
• protects cell membranes from destruction by free radicals;
• enhances the synthesis of substances for energy production.

In this regard, the drug can have a positive effect on all processes that are accompanied by insufficient blood flow to the organs (ischemia), without directly affecting vascular tone.

The pharmacological effects of Mexidol are:

• high resistance to stress, reducing its consequences;
• calming effect without drowsiness and muscle weakness;
• improvement of memorization, it eliminates memory impairment after injury, intoxication;
• reduction of seizures, trembling of limbs in Parkinson's disease;
• protection of tissues from oxygen deficiency;
• increased concentration;
• increased performance;
• reducing the toxic effects of alcohol;
• preventing the formation of blood clots and atherosclerotic plaques;
• sleep restoration;
• counteracting age-related processes of reducing the ability to learn, store and reproduce information;
• normalization of emotional state.

We recommend reading the article about medications for the blood vessels of the head. From it you will learn about the prescription of drugs for dilating blood vessels, treating migraines, strengthening and restoring the walls of blood vessels, and the use of venotonics.

And here is more information about the treatment of cerebral atherosclerosis.

Indications for use

This drug has one of the widest indications for use; it can be part of the treatment of many diseases, and can cope with some on its own. In some cases, it enhances the effect of other medications.

There are also acute conditions, after which taking Mexidol is vital, these include a previous myocardial infarction.

A more detailed list of indications for use:

• consequences of acute circulatory disorders in the brain;
• suffered traumatic brain injuries and concussions;
• vegetative-vascular dystonia;
• cardiac ischemia;
• intoxication with alcohol or psychotropic substances;
• neurotic disorders;
• glaucoma.

The list of diseases is incomplete. It is possible that this antioxidant can have a positive effect in other serious diseases.

If you have one of these conditions, do not try to purchase the medicine yourself as it may cause complications for you, so always consult your doctor before starting treatment.

Will the drug help with vasospasm, heart problems?

Mexidol is used to treat any manifestations of insufficient blood supply to tissues. It improves organ function during ischemic damage by enhancing energy production and preventing cell destruction.

In case of disturbances of coronary blood flow, its effect is manifested in reducing the strength and frequency of attacks of pain in the heart, shortness of breath, improving exercise tolerance, and increasing the contractility of the heart muscle.

During myocardial infarction, the following changes occur under the influence of the drug:

• the area of ​​necrosis decreases;
• bioelectrical activity is restored;
• blood flow in the affected area improves;
• the consequences of ischemia are reduced;
• the reaction to nitrates and vasodilators increases.

Myocardial infarction is one of the indications for the use of the drug Mexidol.
After taking Mexidol, patients with impaired cerebral hemodynamics showed positive dynamics, which manifested themselves in the form of:

• restoration of emotional state;
• improving motor and coordination function;
• reduction of autonomic disorders (fluctuations in blood pressure, pulse rate, sweating, feeling of fear);
• improved sleep;
• reducing complaints of headache, hearing and vision impairment;
• restoration of sensitivity;
• normalizing memory, increasing attentiveness and pace of work.

This is confirmed by data from additional types of research. After a week's course of treatment with Mexidol, the ECG, electroencephalogram, and data obtained from ultrasound of the vessels of the heart and brain begin to return to normal.

In patients receiving this drug, blood viscosity and cholesterol levels decrease.

Instructions for use with dosages

Since Mexidol is a rather dangerous medicine that can cause serious side effects (especially in tablets), it is necessary to carefully select the dosage based on individual characteristics.

Many people are interested in what medications Mexidol is prescribed with; only a doctor can answer this question; it is only known that this medicine enhances the effect of sedatives and also helps treat serious illnesses. If everything is in order with your health, then the dosages recommended by the manufacturer are suitable.

The company recommends the following dosages:

1. Tablet form applied internally

   
   ry at a dosage of 125 or 250 mg (1-2 tablets) 3 times a day for 2-6 weeks, maximum daily dose 800 mg. They always start with a minimum dosage , they do this not only to check the body’s reaction, but also so that the drug can begin to accumulate and does not cause side effects. After finishing, it is also gradually interrupted.

2. Injections are dosed slightly differently ; they can enter the body through an intravenous drip or through an intramuscular injection. start using it with minimal dosages of 0.05-0.1 g 1-3 times a day, the maximum daily dose is 0.8 g. The maximum dosage is achieved in the treatment of atherosclerotic dementia and reaches 0.4 g once a day.

You should choose the appropriate method of administration based on your characteristics, and the doctor always recommends intramuscular administration, since it is more effective and does not require special skills, you can even do it yourself, but for people, tablets are always preferable, since they do not raise questions and are easier are used.

Using Mexidol intravenously , you need to dilute it with a special solution.

Video on the topic

Does the drug Mexidol lower blood pressure or not? What effect can be expected from taking it? Answers in the video:

In general, Mexidol is a modern drug characterized by a number of positive properties. First of all, it is worth noting its high medicinal effectiveness and wide application profile. In addition, this drug has no side effects and does not cause health problems even with long-term use.

Another undoubted advantage is the high variability of the effective combination of Mexidol with other somatic drugs. The active substances used do not cause addiction or allergic reactions, and the variety of forms of the drug and methods of its administration allow for effective treatment of various groups of patients.

The information on the MyMedNews.ru website is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment.

MyMedNews.ru

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Contraindications

Like many similar drugs, Mexidol has its own list of contraindications, which can only be violated if the expected benefit of the drug is higher than the harm. There are also individual contraindications that are not listed in the instructions; only your attending physician can identify them.

Detailed list of contraindications:

1. drug intolerance;
2. pregnancy;
3. acute liver failure;
4. acute renal failure.

• For tablets, the requirements for the condition of the liver and kidneys are much higher, since they are involved in the absorption of the active substance into the blood, so even with chronic diseases of these organs, it is worth considering other forms.
• Also, no studies on the consequences of taking and prescribing the drug Mexidol to pregnant women . Therefore, the medicine in any form is not prescribed during pregnancy, and is sometimes avoided during lactation.
• For individual intolerance , people who often suffer from allergies and cannot tolerate many other medications should be examined by a doctor. Your doctor will likely prescribe the minimum dosage to test your body's response. If everything is in order, a full course will be prescribed.

Side effects

These unpleasant consequences of this drug are mild and most often appear in tablets. These may be standard side effects such as nausea and vomiting or serious liver damage and the onset of an acute illness.

As a rule, healthy people almost never experience acute conditions that require urgent hospitalization.

Common side effects are treated symptomatically, that is, their manifestations are eliminated, sometimes this does not even require discontinuation of Mexidol.

List of side effects from the instructions:

• nausea;
• dry mouth and mucous membranes;
• drowsiness;
• allergic reactions;
• kidney and liver damage;
• skin itching.

All side effects usually appear during the first week; in the future, only serious consequences associated with damage to internal organs may appear, but this happens extremely rarely.

Also, after the injection, various problems may develop, for example, infection at the injection site and further development of inflammation, so you should be careful during injections.

Mexidol-info

Contraindications to the use of Mexidol.

Possible side effects: sleep disturbances - insomnia/drowsiness...

Mexidol is an original Russian-made drug.

The spectrum of action of Mexidol is very wide. Today, when the pharmacological industry produces an endless number of drugs, it is quite difficult to find a drug that does not have side effects and contraindications.

Nootropic and cerebroprotective, antihypoxic and anticonvulsant, antiparkinsonian, vegetotropic, tranquilizing, antistress effects ... And all this is Mexidol - the drug we are talking about in this article.

Experiments on animals have shown that Mexidol prolongs life under various types of hypoxia. Moreover, this effect is much better manifested in Mexidol than in drugs such as Pyritinol ( Encephabol ) and Piracetam.

Mexidol produces a significant anti-alcohol effect, has a geroprotective (corrects processes characteristic of aging of the body) and anti-atherogenic (prevents the occurrence of pathological changes in blood vessels and the aorta) effect .

However, like any chemical drug, Mexidol has side effects on the body and has contraindications for its use.

What side effects does Mexidol have on the body?

Fortunately, the drug itself is characterized by low toxicity; There are few side effects from its use. Experiments on animals have shown that even when using the maximum permissible therapeutic doses of Mexidol, no significant side effects occur.

In treatment, it is very important that the medication does not have a negative effect on the liver. And Mexidol has this property. Moreover, the drug has a hepatoprotective effect (protects the liver).

Maybe Mexidol changes heart rate, electrocardiogram, blood pressure (BP), hemodynamics? The answer is negative!

Experiments on animals have shown that Mexidol also has no effect on urination, salivation and defecation, respiration and blood composition.

T.A. Voronina in the article “Mexidol: main effects...” (Moscow, 2005) writes that in animal experiments the negative aspects of Mexidol are manifested as follows : Mexidol inhibits motor activity and upsets coordination of movements. Moreover, these phenomena do not appear in all experimental animals and only when using high doses of Mexidol (over three hundred mg/kg) with intraperitoneal administration of the drug and when Mexidol is administered orally in doses exceeding four hundred mg/kg.

It is important that with long-term treatment with Mexidol (from two to three months), the effect of the drug does not decrease and, at the same time, no undesirable manifestations are observed.

In addition, after long-term treatment with Mexidol, withdrawal symptoms do not appear!

Mexidol has a pronounced therapeutic effect. You can read about the drug Mexidol and its dosages for certain diseases in the article “Mexidol - indications for use” .

Mexidol is a low-toxic medication, so cases of overdose (if the instructions are followed) are unlikely.

Acceptable side effects in the form of sleep disturbances (drowsiness or insomnia) disappear quickly : within 24 hours.

For more complex cases of drug overdose and the interaction of Mexidol with other drugs, read the article “Mexidol - instructions” .

In some cases, intravenous jet administration of Mexidol may cause dryness of the oral mucosa, a metallic taste, a sore throat... It is not necessary to discontinue treatment with Mexidol in such cases. Gradually the negative effects weaken. It is recommended to administer the drug more slowly. Occasionally, there are other side effects : nausea, allergic reactions, heartburn, increased gas formation...

When treating with Mexidol, those who suffer from bronchial asthma and suffer from hypersensitivity to sulfites should be very careful. Patients with high/low blood pressure should be prescribed Mexidol with caution.

Mexidol has contraindications, but they are few.

This is hypersensitivity to the components of Mexidol, acute dysfunction of the kidneys and liver. Moreover, it should be noted : the liver does not have pain receptors (sometimes the liver lining hurts, but more often the adjacent organs). This is a question that readers sometimes ask in their letters (can the liver hurt because of the medicine - because of Mexidol in particular). Mexidol has hepatoprotective properties.

The following should be noted : there have been no strictly controlled experiments with the use of Mexidol in pregnant women and during lactation, as well as in children. Therefore, treatment with Mexidol for pregnant women and women breastfeeding is contraindicated.

Treatment of children with Mexidol

The following fact should be taken into account : although there is not yet official permission for the use of this drug in children, there are recommendations for the use of Mexidol in certain cases. What are these cases, read in the article “Mexidol and children” .

On our website you can read reviews readers about the drug Mexidol, the price of this medication, as well as reviews about Mexidol analogues , questions about the compatibility of Mexidol with a number of other drugs (as well as here , here , here , here , here , and here ); with the treatment of alcoholism , alcoholic and diabetic polyneuropathy with Mexidol and other issues of the use of Mexidol in the treatment of patients.

It is very important that the drug is original and not a fake , because Often side effects occur precisely when using a counterfeit drug. By the way, a counterfeit can be a counterfeit of both an expensive drug and a cheap one; may even be sold in pharmacies or may be used by a medical institution.

For our part, we must try to do everything in our power to distinguish a fake. Read about it here , here and here .

Often, readers in their letters ask us the question: “How to help a child if he has eaten Mexidol tablets?”

Firstly, let’s answer in a trivial way : do everything to prevent this from happening, i.e. hide medications from children - and the further/higher the better!

Secondly, general rules for drug poisoning:

1. Give the child plenty of room temperature water to drink (do not give the child mineral water, but give any liquid without carbon dioxide).

2. Tilt the child’s upper body and press on the root of the tongue (try to induce vomiting).

3. Give the child activated carbon (a must have in any family!).

You carry out all these manipulations before the ambulance arrives, which you call immediately upon discovery of the pills eaten by the child. You should take the medicine container with you to the hospital.

Under no circumstances should you give your child milk, castor oil, or saline solution (do not give anything other than what is written above).

Interaction with other drugs

• How the drug interacts with other drugs is of interest to many. As a rule, when taking Mexidol with any other medicine, it enhances its effect or simply performs its function.
• Increased effects occur when taking psychotropic and sedative drugs. In such cases, it is prescribed to reduce the dosage of the former.
• It also often acts as part of complex treatment of coronary heart disease and further maintenance of therapy.
• As a preventive measure for learning disabilities, it is sometimes prescribed along with nootropics. In this case, the saturation of the brain with nutrients will increase significantly and the effect of increased memory will be revealed for a while, along with the effect of increased perception of information.
• Another important effect is to reduce the toxic effect of ethyl alcohol when taking Mexidol.

An approximate list of drugs with which it can be used:

1. In the treatment of VSD: sedative herbal preparations;
2. serious tranquilizers, for example, phenezepam.

There are many combinations, which only a qualified specialist can help you learn more about, but it is worth noting that Mexidol is compatible with many medications. You just need to be careful when using multiple medications in tablets, as this can seriously harm the liver.

Mexidol for prevention

• This medicine may b

  
  be prescribed by a therapist for the prevention and normalization of a person’s condition. It is able to effectively increase mental activity, as well as restore the sleep-wake cycle.

• Due to the fact that the drug improves blood circulation in the brain, the risk of stroke is significantly reduced.
• Also, the course of vascular dystonia syndrome improves significantly, until all symptoms disappear during use. Many people note that after taking Mexidol prophylactically, they forgot about the problem for many years.
• Preventive medication should not last more than a month; it is best to use the drug in reduced dosages, reducing the number of doses to 2 times a day.
• The positive effect , which can be noticed, appears only after 2 weeks of regular use. If you suffered from any mental illness, for example, a disrupted sleep cycle, then during this period the situation should improve significantly or positive dynamics will appear.

How to use the drug correctly?

The use of Mexidol in tablets and injections for injections is significantly different.

• Pills. The drug should be taken 2-3 times a day, 375-750 mg. The maximum volume should not exceed 6 tablets or 800 mg. The course of treatment is 14 days. The dosage is standard for any type of pressure. It is important to take into account that abruptly stopping the drug can cause harm to the body, so stopping therapy is possible only gradually.
• Injections. The solution is administered using injections or droppers, after diluting the drug with an isotonic sodium chloride solution. Injections should be given within 7 minutes, the dropper speed should be 50-60 drops per minute. Do not exceed the maximum dosage per day – 1200 mg. In case of pressure surges, use the solution by introducing a dropper of 200-500 mg of Mexidol 4 times a day. After this period, administer the drug 2 times a day in the same way.

Taking the drug will help you get rid of severe pain in the temples and back of the head. Most reviews from heart specialists are positive, as they claim that for hypertension and hypotension, Mexidol helps stabilize blood pressure.

Mexidol analogues and their cost

Almost every medicine has more expensive or cheaper analogues, Mexidol in tablets and injections was no exception. First, it’s worth understanding the current cost of this medicine in pharmacies.

The cheapest option would be to buy 30 tablets at a price of about 300 rubles; 10 ampoules of 2 ml each cost 500 rubles. The prices provided are average, but most likely, Mexidol will cost more in most pharmacies.

Mexidol has several analogues, some of them will be more affordable, the effectiveness can only be judged by individual reviews.

List of analogues:

1. Actovegin. This drug is a more expensive analogue of Mexidol, which has a different active ingredient. For 50 tablets you will need to pay more than 1.5 thousand, and for 5 injections of 5 ml - 600 rubles.
2. Neurox. It is a complete analogue of Mexidol with a similar price (sometimes you can find an injection solution a little cheaper), but there are also capsules that will help avoid side effects such as nausea and vomiting.
3. Piracetam . Not a complete analogue, but it has a similar principle that improves cerebral circulation. For 30 tablets of 800 mg you will have to pay about 100 rubles.

Not all similar medications are provided. In most cases, with indirect analogues, Mexidol can be used together and increase the effectiveness of both drugs.

Mexidol or Picamilon, what is the difference?

Both medications are available in tablets and ampoules with solution, and also improve blood circulation in the brain. Mexidol has a beneficial effect on metabolism in neurons, protects membranes and improves them. Picamilon dilates blood vessels in the brain.

Medicines can be prescribed for overload, asthenia, alcoholism, and emotional instability. Mexidol helps the myocardium, therefore it is used as part of complex therapy for heart attacks; It is also administered for inflammation in the abdominal cavity, normalizes the consequences of traumatic brain injuries, and improves vision by working with the optic nerve and retina.

Any of the two medications cannot be prescribed for renal failure, and Mexidol is not indicated for acute liver problems. Adverse reactions differ in the nature of their effect on the nervous system: Picamilon can cause agitation and anxiety, while another drug becomes a source of drowsiness.

Also, Picamilon is less present in the body: half of it leaves the body in about an hour, while the second medication can be found in the blood within 4 hours. Since the drugs differ in their mechanisms of action, they are sometimes prescribed together for better effect.