Telzap, 80 mg, film-coated tablets, 30 pcs.

Telzap is an antihypertensive drug that is often prescribed to patients with high blood pressure.

This drug has a number of advantages: high efficiency, safety, less pronounced side effects, affordable price.

This medicine for high blood pressure has a prolonged effect.

The result of treatment should be assessed after 4-6 weeks of use.

Letters from our readers

Topic: Grandma's blood pressure has returned to normal!

From: Christina ( [email protected] )

To: Administration otgipertonii.ru

Christina, Moscow

My grandmother’s hypertension is hereditary - most likely, I will have the same problems as I get older.

I accidentally found an article on the Internet that literally saved my grandmother. She was tormented by headaches and had a repeated crisis. I bought the course and monitored the correct treatment.

After 6 weeks she even started talking differently. She said that her head no longer hurts, but she still takes pills for blood pressure. I am sending a link to the article

Indications for use

According to the instructions for use, Telzap is prescribed to people with essential arterial hypertension.

It is also taken by patients with an increased risk of mortality from cardiovascular diseases:

• with type 2 diabetes mellitus, which is combined with myocardial damage;
• if there is a history of coronary heart disease of the 2nd degree, strokes, thrombosis of peripheral arteries.

It is recommended that you consult your doctor before taking this drug.

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Special Recommendations

Telmisartan is prescribed with increased caution to patients with renovascular hypertension, which is caused by stenosis of both renal arteries or stenotic kidney disease, which is the only one left in the body. The fact is that Telmisartan can increase the risk of hypotension and renal failure. In patients with moderate kidney disease, creatinine and electrolyte levels in the blood should be regularly monitored.

Particular care must be taken when prescribing the drug to patients with low BCC or a lack of sodium in the body in the case of treatment with diuretic medications, insufficient intake of salt into the body, with frequent diarrhea and vomiting. The doctor separately evaluates Telmisartan treatment for patients with aortic or mitral stenosis, hypertrophic cardiomyopathy, moderate liver disease and coronary artery disease.

It is worth thinking about the need for Telmisartan for patients with peptic ulcers of the intestines and stomach, especially if the ailments are aggravated, with other pathologies of the digestive organs. When using the drug, there is a possible risk of gastric or intestinal internal hemorrhage.

Effect on blood pressure

The action of this drug is aimed at a gentle and gradual reduction in blood pressure. This occurs due to the effect on angiotensin receptors of the ATI subtype.

The drug blocks specific proteins, eliminates the influence of aldosterone, but does not disrupt the exchange of potassium ions.

Telzap reduces both systolic and diastolic pressure, but does not interfere with heart function.

Telmisartan does not alter bradykinin metabolism. Therefore, an important advantage of the medicine is the absence of unpleasant side effects such as diarrhea and dry cough.

Withdrawal syndrome usually does not develop after abrupt cessation of use. However, within 2-3 days the pressure returns to its original level. This explains why blood pressure rises when Telzap 80 mg is excluded from the drug regimen.

Telmisartan is used only for long-term treatment (at least 4 weeks). It cannot be used to relieve symptoms of hypertensive crisis.

Instructions for use

The tablets are taken once a day with 100-150 ml of water, regardless of meals.

The starting dose for people with arterial hypertension is usually 40 mg per day. If the medicine does not show its effect, the dose is increased to 80 mg. A decision to increase the amount should be made no earlier than a month after the start of therapy.

If the effect of treatment is insufficient even at the maximum dose, it is necessary to add a diuretic (hydrochlorothiazide is most often used). To prevent mortality from heart disease, Telzap is prescribed in a daily dose of 80 mg.

Patients are advised to regularly monitor the tonometer readings and record the data obtained in a special diary. This is especially important in the first weeks of therapy, as changes in the dose and frequency of the antihypertensive drug may be required.

For people with severe renal impairment, the maximum daily dose is 20 mg of telmisartan (half a tablet once a day).

Release form

The product is available in tablet form. They are white or light yellow in color and have an elongated or round flat-cylindrical shape.

Depending on the pharmaceutical company, they are produced in cardboard packages that contain blisters or plastic jars. Blisters come in 5, 7, 10, 20 pcs., jars - 10, 20, 28, 30, 40, 50, 100 pcs.

Side effects

Despite its high effectiveness, the blood pressure medicine Telzap has a number of side effects.

These include:

• decrease in the amount of hemoglobin and platelets;
• increased potassium levels in the blood;
• decreased glucose concentration;
• hearing impairment;
• decreased heart rate;
• allergic rashes, erythema, skin itching;
• pain in muscles and joints;
• digestive disorders, changes in taste, increased gas formation;
• mood lability, rarely – anxiety;
• changes in the normal functioning of the kidneys and liver;
• drowsiness;
• dizziness, short-term loss of consciousness.

The patient needs to carefully monitor his condition. The appearance of any negative changes in the body may indicate the ineffectiveness of therapy.

Kinetic properties

Telmisartan is well absorbed from the digestive system. Maximum bioavailability reaches 60 percent. Having taken a dose of 80 mg, you should expect the maximum concentration of the active component after one hour. The drug actively interacts with blood proteins, mainly with high acidity glycoprotein and albumin.

The components of the drug are distributed in relatively equal quantities throughout the tissues of the body. The metabolism of Telmisartan occurs in the liver through conjugation with glucoronic acids. In this way, acyl glucuronide is produced in an inactive form, which is excreted in the bile. In the feces, 85 percent of Telmisartan remains unchanged and 10 percent of the glucuronide. No more than 2 percent of the drug is excreted through the kidneys.

The elimination rate is low, the half-life lasts up to 31 hours in women, and up to 21 hours in male patients.

The hypotonic effect becomes noticeable three hours after consumption, the effect will linger for a day. The stability of the drug's effect is observed after 4-8 weeks of therapy. If you stop using Telmisartan, after a while the pressure will return to its original values.

Important! In patients with renal failure at the stage of hemodialysis, a decrease in the amount of Telmisartan in the blood is observed. With this disease, the active substance binds to blood proteins and does not leave the body during dialysis. If the patient suffers from kidney dysfunction, then the duration of elimination of the drug substances remains unchanged.

In the presence of liver failure, the perfect bioavailability of the drug components increases to 100 percent.

Contraindications

The drug has a number of contraindications, which are indicated in the instructions for use.

Telzap blood pressure tablets should not be taken in the following cases:

• during pregnancy and lactation;
• with idiosyncrasy (hereditary intolerance) to fructose;
• if you are allergic to any components of the drug;
• with cirrhosis of the liver (type C according to the international Child-Pugh classification);
• with stagnation of bile or inflammatory diseases of the gallbladder and ducts;
• patients with type 2 diabetes mellitus when taken simultaneously with aliskiren;
• together with antihypertensive drugs from the group of ACE inhibitors.

For some conditions, a drug is prescribed only when the benefit of treatment is greater than the risk of negative consequences for the patient. Such situations include:

• decreased sodium concentration in the blood;
• increased potassium content in blood plasma;
• hypertrophic cardiomyopathy;
• Conn's syndrome;
• narrowing of the renal arteries of both kidneys;
• kidney transplant;
• long-term use of potent diuretics;
• heart failure;
• mild liver dysfunction;
• mitral valve stenosis.

In these situations, the patient using Telzap should be under the supervision of a doctor.

Compound

Telmisartan tablets contain different concentrations of the active ingredient - 40 or 80 mg. The active ingredient of the drug is telmisartan. Depending on the dose, the amount of additional substances also varies.

Caustic soda is also known by another name - sodium hydroxide.

Overdose

The patient must know the symptoms of excessive use of the drug in order to avoid serious health problems.

Main signs of overdose:

• severe hypotension (low blood pressure values ​​are individual, they depend on the pressure at which the patient feels well);
• increase in the number of heart contractions;
• dizziness;
• changes in laboratory parameters (increased creatine content);
• impaired filtration and reabsorption of urine.

It is important to remember that therapy for this condition is quite complex and includes gastric lavage, taking antacids, and single use of hypertensive drugs. To avoid this, you must strictly follow your doctor's recommendations on the dosage of the medicine.

Telzap Plus 80 + 12.5 mg

Telzap 80 mg is available for sale with instructions for use. It is convenient to use when prescribing a high therapeutic dose.

Active ingredients

One tablet contains 80 mg of telmisartan and 25 mg of hydrochlorothiazide. The first substance lowers blood pressure, and the second has a diuretic effect and enhances the effect of the first. Additional substances: sodium hydroxide, sorbitol, magnesium stearate. On the oblong tablet of dosage 80/12.5 mg the number 81 appears.

Indications

A dosage of 80 mg is indicated in the absence of effect from treatment with a dose of 40 mg, in patients with a persistent increase in blood pressure to high levels.

Contraindications in the instructions for use for Telzap 80 mg:

• taking ACE inhibitors;
• intolerance to the components of the drug;
• taking Aliskiren for diabetes;
• liver pathologies;
• cholestasis, gallbladder pathology;
• hypokalemia and hypercalcemia;
• pregnancy;
• age up to 18 years.

Instructions for use

Telzap Plus is used for treatment in cases where there is no effect from the use of telmisartan 40 or 80. Telzap Plus 40 mg/12.5 mg is prescribed if blood pressure is not controlled only with telmisartan 40 mg. Dosage 80 mg/12.5 mg - patients whose blood pressure is not controlled at a dose of telmisartan 80 mg.

A dose of 80 +12.5 mg is taken once a day according to the instructions for use. One tablet is taken with water and blood pressure is monitored. In the event of an excessive drop in blood pressure, the dose is reduced and the symptoms of overdose are eliminated.

Reception features:

• patients with renal failure while taking Telzap Plus undergo periodic kidney examinations;
• in case of liver failure, the daily dose is limited to 40 mg/12.5 mg.

The safety of taking the drug under 18 years of age has not been established. Elderly patients do not require dose adjustment; it is used according to the instructions for use.

Analogs

Identical in active substance:

• Mikardis plus;
• Telpres plus;
• Telsartan N.

They differ in prices, which depend on the manufacturer.

Interaction with other drugs

Telzap does not interact positively with all drugs, so caution should be exercised when treating with these medications.

Antihypertensive drugs

Telmisartan enhances the effect of other blood pressure medications. Co-administration with ACE inhibitors is strictly contraindicated as it can cause an uncontrolled drop in blood pressure.

Digoxin

The medication increases the concentration of digoxin in the blood by 50%.

Lithium preparations

Telzap increases the lithium content in plasma, contributing to its toxic effect on the body.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

All NSAIDs inhibit the hypotensive effect of telmisartan. In addition, simultaneous use of these tablets often leads to kidney failure. Patients should drink enough fluids and have regular blood tests for creatinine.

Diuretics

With long-term use of thiazide diuretics or furosemide together with this drug, the risk of hypovolemia increases. A sharp drop in blood pressure numbers is also possible.

Pharmacokinetics of Telmisartan

The active ingredients of the blood pressure drug Telmisartan are quickly absorbed, reaching the gastrointestinal tract. The bioavailability of the drug is about 50% and, unlike other blood pressure medications, food intake does not affect this factor.

The main active ingredient Telmisartan is more than 99% bound to plasma proteins. The half-life is approximately 20 hours. Most of the drug is excreted from the body through the intestines and around the kidneys (about 2%).

Analogs

There are a number of medicines whose active ingredient is also telmisartan:

• Telsartan;
• Telmista;
• Telpres;
• Mikardis.

You can replace Telzap with analogues only after consulting a doctor!