Askofen is a drug that has antipyretic and analgesic effects.
The main components of the drug are: acetylsalicylic acid, phenacetin, caffeine. This medicine is available in the form of tablets, its effect is due to the characteristics of 3 basic active ingredients. Thus, phenacetin helps reduce pain, eliminate inflammation, and reduce body temperature. Caffeine, in turn, affects the spinal cord, increasing its reflex excitability. This component increases performance, reduces drowsiness, increases physical activity, and almost completely eliminates physical fatigue. The action of acetylsalicylic acid is aimed at reducing pain, eliminating inflammation and reducing body temperature. In general, Askofen can be called an analgesic, anti-inflammatory and antipyretic agent.
Pharmacodynamics and pharmacokinetics
A combined drug whose effectiveness is ensured by its constituent components.
Acetylsalicylic acid has a noticeable analgesic, antipyretic and anti-inflammatory effect, inhibits platelet aggregation .
Paracetamol also exhibits antipyretic and analgesic effects.
Caffeine increases reflex excitability of the spinal cord, stimulates respiratory and vasomotor functions, dilates blood vessels , muscles, heart, brain, kidneys, and reduces platelet aggregation . In addition, taking caffeine helps reduce drowsiness and fatigue, increase performance, and so on.
As a result of oral administration, almost 90% of the drug is absorbed. In this case, the maximum concentration of substances in the serum is achieved at different times: paracetamol - within an hour, caffeine - 2.5 hours, acetylsalicylic acid - 1-2 hours.
Almost 80% of the acidic active substances are eliminated from the body by the kidneys.
pharmachologic effect
Askofen-P tablets have a direct effect on blood vessels, contribute to the narrowing of vascular walls and increase blood pressure. Productive absorption into the systemic circulation is observed, with acetylsalicylic acid reaching its maximum concentration in plasma after 1-2 hours. Caffeine takes longer to be absorbed; the indicated time interval is at least 2.5 hours. 80% of the active components are excreted by the kidneys; metabolism is observed in the liver. The composition of Askofen tablets is gentle, but the course of treatment must be previously agreed with a doctor.
Askofen-P during pregnancy
It should be noted that this drug is not recommended for use during pregnancy, especially in the 1st and 3rd trimester. A one-time use of the medicine in the 2nd trimester of pregnancy is allowed, but if it is clearly established that it will not cause harm to the fetus.
As is known, taking the drug in the first trimester can cause fetal malformation in the form of cleft palate caused by the teratogenic effect of acetylsalicylic acid.
In the third trimester, there remains a possibility of inhibition of labor, closure of the ductus arteriosus in the unborn baby, causing vascular hyperplasia in the lungs and hypertension in the circulatory vessels.
How does taking Askofen affect blood pressure?
Many patients have a question: “Is Askofen capable of lowering blood pressure or increasing it?” The instructions for the drug do not contain information about whether this drug has an effect on blood pressure.
However, if Askofen cannot lower blood pressure, then the presence of caffeine in its composition forces many hypotensive patients to take note of this medicine. Reviews from patients suffering from low blood pressure who have used the drug indicate that, in addition to the actions stated in the instructions, Askofen increases blood pressure
.
Doctors believe that the concentration of caffeine in the drug is quite small to stimulate the central nervous system, but is sufficient to normalize vascular tone and accelerate blood circulation. This suggests that Askofen increases blood pressure, helping to get rid of the symptoms accompanying hypotension.
However, experts advise not to abuse the drug to treat low blood pressure, since there are more effective means for this. If you have hypotension, you should not self-medicate based on reviews from people who do not have a medical education.
Askofen is a cheap combination medicine that contains caffeine, acetylsalicylic acid and paracetamol, has an analgesic, tonic and anti-inflammatory effect. The combination of acetylsalicylic acid and paracetamol has a strong effect on pain centers, eliminating it regardless of location and nature. The caffeine in the drug affects the overall tone of the body and increases reflexes. Also, the components of the drug affect the functioning of the hypothalamus, which leads to a decrease in fever. This drug is the best remedy if you need to maintain working capacity, but at the same time you are in pain. The drug is available without a prescription in the form of tablets that cost about ten rubles.
Contraindications for use
- intolerance to the drug or its components;
- various gastrointestinal lesions;
- disorders of the liver or kidneys;
- abnormalities in the functioning of the respiratory system, for example, with asthma;
- dissecting aortic aneurysm;
- some disorders of the nervous and cardiovascular system;
- age less than 15 years;
- lactation, pregnancy and so on.
Side effects
When treated with this drug, various problems may arise in the gastrointestinal tract in the form of: anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative damage, bleeding. liver or kidney failure, tachycardia and increased blood pressure is also possible
Long-term use of the medication causes: dizziness, tinnitus, headache, hypocoagulation, various undesirable syndromes and liver dysfunction .
Askofen tablets, instructions for use (Method and dosage)
As the instructions for use of Askofen-P indicate, these tablets are prescribed to be taken after meals 2-3 times a day in an amount of 1-2 pieces. In this case, the maximum daily dosage should not exceed 6 pieces, and the break should be less than 4 hours.
Considering the indications for the use of Askofen, you need to observe some features of administration:
- It is better to take the tablets with milk, regular warm or mineral water;
- patients with impaired renal or liver function need to increase the interval between taking the medicine - from 6 hours.
In addition, the course of pain therapy should not exceed 5 days and treatment of fever should not exceed 3 days. In other cases, the duration of treatment and dosage is determined by the doctor.
General information about the drug
To eliminate pain of moderate intensity, according to international recommendations, combination medications are used. They contain substances that enhance the effect of the main components. These drugs have antipyretic and anti-inflammatory effects, which allows them to act on the cause of unpleasant symptoms.
Drug group, INN, scope of application
In accordance with the latest international pharmacological classification of drugs, Askofen P is included in the group of combined analgesics-antipyretics. According to the ATC classification, it has code N02B A51, a group of various combinations of acetylsalicylic acid without psycholeptics. International unclassified name – Acidum Acetylsalicylici + Paracetamol + Caffeinum.
In most cases, the use of Askofen P is resorted to when monocomponent drugs are ineffective and there is severe pain, which significantly impairs a person’s psycho-emotional state and ability to work.
Release forms and prices for the drug, average in Russia
Askofen P is an inexpensive painkiller that is produced by a Russian pharmaceutical company in tablet form. Each tablet has a flat-cylindrical shape with a dividing strip on one side.
The color can vary from white to light cream, mild marbling is allowed, and there is no specific smell. Sold in cardboard packages containing 1 or 2 blisters of 10 tablets. Sold in pharmacies without a doctor's prescription.
The average price for package No. 10 differs in different regions, as shown in the table.
Compound
The drug contains two non-steroidal anti-inflammatory substances in different quantities (200 mg) - acetylsalicylic acid (the more common name is aspirin) and paracetamol. Their active effect is enhanced by 40 mg of caffeine.
Potato starch, talc, low molecular weight polyvinylpyrrolidone, silicone, petroleum jelly, citric acid monohydrate, calcium stearate and stearic acid are used as a base to give shape and color, as well as to protect active ingredients from environmental influences.
Pharmacodynamics and pharmacokinetics
Acetaminophen (paracetamol) and acetylsalicylic acid (aspirin) belong to the group of non-steroidal anti-inflammatory drugs. The mechanism of action of paracetamol is associated with blocking the action of both forms of the cyclooxygenase enzyme, which leads to a decrease in the concentration of inflammatory mediators - prostaglandins. The antipyretic and analgesic effect of acetaminophen is due to its effect on the thermoregulation and pain centers located in the hypothalamus.
Effects of Askofen P
Aspirin has a local anti-inflammatory and analgesic effect by inhibiting the synthesis of prostaglandins in peripheral tissues. Reduces exudation, swelling and hyperthermia in inflamed tissues, reduces the permeability of capillary walls.
The antiaggregation effect of acetylsalicylic acid is associated with an irreversible blocking of the activity of the enzyme cyclooxygenase type 1 and a decrease in the production of thromboxane A2, a mediator of platelet aggregation and degranulation.
Caffeine is a strong adaptogen and psychostimulant. Strengthens the anti-inflammatory and antipyretic properties of the main components, has a general tonic effect on the body, reduces drowsiness and fatigue, and increases working capacity.
After oral administration, the expected clinical effect occurs after 15-20 minutes. Absorption of the components occurs in the stomach and small intestine within 30 minutes. It is excreted from the body in the urine after metabolism in the liver.
Analogs
One of the popular domestic analogues of the drug is Citramon Ultra from the Russian company Obolenskoye FP. The average price for 10 tablets is from 82 rubles. Available in packs of 10, 15 and 30 tablets. Capsules Citramon-ExtraCap, Pharmstandard, Russia are also in demand. They have a faster and longer lasting effect. Price – from 88 rubles for 10 capsules.
The most expensive is the imported product. An increased dosage (0.25 g of aspirin, 0.5 g of paracetamol and 65 mg of caffeine) allows you to get the fastest and most long-lasting clinical effect. The product effectively eliminates signs of inflammation, fever, and relieves pain. Packages of 16 tablets are available in pharmacy chains and cost from 193 rubles.
Overdose
In case of overdose, the following may occur:
- nausea, vomiting, pain in the gastrointestinal tract;
- sweating, pale skin;
- tachycardia;
- tinnitus;
- drowsiness, collapse, convulsive state;
- bronchospasm, breathing problems and so on.
If there is a suspicion of poisoning , then you need to urgently call for medical help. Usually the victim's stomach is washed and adsorbents are prescribed.
Interaction
Simultaneous treatment with Askofen-P leads to increased effects of heparin , reserpine, indirect anticoagulants, steroid hormones and some hypoglycemic agents . It is also likely that the effectiveness of furosemide, spironolactone , and antihypertensive and anti-gout drugs , which help remove uric acid from the body, will decrease.
An increase in side effects of glucocorticosteroids , methotrexate sulfonylurea derivatives , as well as non-steroidal anti-inflammatory drugs and non-narcotic analgesics was noted.
It is not recommended to combine this medicine with barbiturates , antiepileptic drugs, zidovudine, rifampicin and alcohol-containing drinks, because there is a possibility of developing a hepatotoxic effect.
The effect of paracetamol increases the elimination period of chloramphenicol by almost 5 times. As for caffeine, it helps accelerate the absorption of ergotamine.
Combination therapy with Salicylamide and other stimulants of microsomal oxidation promotes the production of toxic metabolites of paracetamol , which negatively affect liver function.
Simultaneous use with Metoclopramide enhances the absorption of paracetamol . Repeated use can increase the effect of anticoagulants.
special instructions
Do not use with other products containing paracetamol or acetylsalicylic acid. Do not exceed the indicated doses. Use the drug with caution in case of a history of gastrointestinal ulcers, including chronic or recurrent peptic ulcer disease or a history of gastrointestinal bleeding, while using anticoagulants, impaired renal and/or liver function. Concomitant liver diseases increase the risk of liver damage from paracetamol. The risk of overdose is higher in patients with non-cirrhotic alcoholic hepatitis. During surgical operations
(including dental) the use of drugs containing acetylsalicylic acid may increase the likelihood of occurrence/intensification of bleeding due to inhibition of platelet aggregation for some time after the use of acetylsalicylic acid.
The drug slows down the removal of uric acid from the body, which can cause an acute attack of gout. During treatment, it is not recommended to drink excessive amounts of drinks that contain caffeine (in particular coffee, tea). This can cause sleep disturbances, tremors, a feeling of tension, irritability, and discomfort in the chest due to increased heartbeat. During treatment you should refrain from drinking alcoholic beverages. During pregnancy and breastfeeding.
Do not use during pregnancy and breastfeeding.
Children.
The drug is not used in children under 14 years of age due to the risk of developing Reye's syndrome (hyperpyrexia, metabolic, nervous system and mental disorders, vomiting, liver dysfunction) with hyperthermia due to viral diseases.
Analogs
Level 4 ATC code matches:
Acetylsalicylic acid
Aspirin-S
Citropak
Aspirin
Citramon
Coficil-Plus
Farmadol
Cefekon N
Aquacitramon
Upsarin UPSA
Citrapack
Alca Prim
Thrombopol
Citrapar
The following drugs also have a similar effect: Orafen, Flexen, Diclovit, Artrosilene, Bofen and others.
Reviews about Askofen-P
As numerous patient reviews left on various forums show, this drug is an excellent, inexpensive and effective combination remedy. Many users have been taking Askofen tablets for a long time, which does not reduce the therapeutic effect, since they use them periodically.
At the same time, some patients ask what Askofen-P helps best with and how often can it be used? To this, experts answer that the tablets have equivalent analgesic, antipyretic and anti-inflammatory effects. However, when these unwanted symptoms do not disappear quickly, you need to consult a doctor.
In addition, there are many features and contraindications to taking this medicine. For example, Askofen Darnitsa is capable of exacerbating the manifestation of asthma more than other forms, causing the development of severe allergic reactions.
Does Ascofen increase or decrease blood pressure?
This drug is often taken by people suffering from arterial hypotension , that is, low blood pressure, in order to get rid of this disease. However, they claim that such treatment was recommended to them by a doctor. Most patients are satisfied with the effect produced.
Of course, this combination of substances includes a small dosage of caffeine , which is not capable of having a stimulating effect on the central nervous system, but normalizes cerebral vascular tone and accelerates blood flow. Therefore, patients with high blood pressure should take these pills with caution, and people with low blood pressure should still not abuse such therapy.
Indications and contraindications
These tablets are often taken for various pain syndromes. That is, Askofen will help with headaches, calm migraines, neuralgia, arthralgia, myalgia. In addition, it will reduce severe pain during menstrual periods. But at the same time, Askofen has both indications and contraindications for use, which should be taken into account when purchasing a medicine.
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The instructions for the drug prohibit its use in case of the following ailments:
- tendency to gastrointestinal bleeding,
- stomach and duodenal ulcers,
- renal-liver failure,
- hypocoagulation,
- portal hypertension,
- asthma,
- some of the heart and nervous system diseases.
Pregnant women should avoid taking the medication and should not drink Ascophen during lactation. Those whose body cannot tolerate any of its components should also be careful with it.
Children under 15 years of age are also not recommended to use these tablets.
Askofen-P price, where to buy
This medicine is available to almost all patients, since in Russian pharmacies its price starts from 14 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Askofen-P painkiller tablet.
20 pcs. Pharmstandard-Leksredstva OJSC 63 rub. order
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