CAPOTENE OR CORINTHAR: which is better and what is the difference (differences in compositions, reviews from doctors)

Pharmacological action of the drug

Potassium ions under the influence of Corinfar penetrate in smaller quantities through the cell membrane.

Due to this, the smooth muscles that compress the blood vessels relax. Due to this effect, the lumen of blood vessels expands.

Additionally, the pressure on the walls of blood vessels is also reduced. Muscle tissue requires less oxygen for consumption, which reduces energy costs. All this helps to reduce blood pressure.

Based on this, the drug is aimed at the following:

• Providing a hypotensive effect on the body;
• improving the functioning of the lateral branches of blood vessels;
• supplying the myocardium with blood by improving blood flow;
• increased coronary blood flow.

It is very important that the effect of the drug Corinfar at high blood pressure does not affect the veins, does not change the load that is placed on the muscle fibers during contraction, and does not contribute to the development of orthostatic collapse. The effect can be observed after taking the tablet after 20 minutes

Its duration is 4-6 hours.

What is the difference?

Medicines belong to different pharmacotherapeutic groups and have different compositions.

Use only as directed by a doctor

Corinfar is a German long-acting nifedipine, which is available in tablet form of 10 or 20 mg. The main pharmacological effect is to selectively block the transport channels of calcium ions between the membranes of myocardial cells and the vascular wall, which increases the oxygen content in the myocardium (antianginal effect) and reduces blood pressure.

The use of Corinfar normalizes the flow of calcium ions that occurs in various diseases, especially arterial hypertension. Coronary blood flow increases, oxygen content in the myocardium increases, without affecting the venous vessels. It has no effect on the functioning of the sinoatrial and AV nodes, and reduces the force of heart contractions. Due to the expansion of arteries in the periphery, the total resistance of blood vessels in the periphery and the myocardial oxygen demand decreases. There is an increase in renal blood flow.

After taking Corinfar, the effect is achieved within 20 minutes (sublingually even faster), lasting up to 6 hours. With long-term use (2-3 months), tolerance to the action of the drug develops (the body stops responding to it properly, the effectiveness is greatly or almost completely reduced), so the use of high doses (40 mg or higher) should be avoided during long-term therapy. In general, as already mentioned, Corinfar and Capoten are drugs for emergency action in isolated cases, and their constant use, for example, during crises, is dangerous by provoking strokes.

Frequent side effects are possible: increased heart rate, arrhythmias, swelling of the ankles and legs, headache, dizziness, arthritis. Rarely, deterioration of cardiac activity (requires discontinuation of the drug).

Russian Capoten, which contains the active ingredient captopril, a first-generation ACE inhibitor, is available in tablet form of 25 mg. The main difference between Capoten and Corinfar is in the mechanism of action and is based on the transformation of the hormone angiotensin, which is responsible for regulating the width of the lumen of blood vessels.

56 tablets of 25 mg

A decrease in hypertension is noted half an hour to an hour after administration. The duration of the sustained hypotensive effect depends on the dose taken and reaches optimal levels within several weeks.

Possible side effects: orthostatic hypotension, tachycardia, peripheral edema, bronchospasm.

Often (about 5-6% of cases, usually in women) it can cause a dry cough due to the accumulation of bradykinin, usually disappearing a few days after discontinuation of the drug. If the cough is difficult to stop, then the drug must be discontinued.

What is the difference

Indications and contraindications

The drug "Corinfar", which is based on nifedipine, is able to dilate blood vessels, increase blood flow and relax the heart muscle. It is indicated for use in hypertension and chronic angina. The main disadvantage of Corinfar is a large number of contraindications, including:

• hypersensitivity to the components of the drug;
• decreased blood pressure;
• decompensated CHF;
• extreme degree of left ventricular failure;
• unstable angina;
• narrowing of the aortic opening in the valve area;
• acute form of myocardial infarction;
• pregnancy, lactation period.

In addition, individuals who have been diagnosed with severe tachycardia or bradycardia, impaired renal and liver function, insufficient cerebral circulation, severe arterial hypertension and mitral valve stenosis should be approached with special caution when treating hypertension with Corinfar.

It is important to exercise caution when using Corinfar for persons under 18 years of age.

Even people with type 1 diabetes can take this drug.

"Capoten" includes an active component - captopril, which has a pronounced antianginal and hypotensive effect, which allows its use in the period after a heart attack, accompanied by disturbances in the functioning of the left ventricle. In addition, “Capoten” is indicated for type I diabetes, which affects the kidneys, high blood pressure and heart failure. Unlike Corinfar, it has fewer restrictions on its use and is therefore safer. Capoten is not prescribed in case of hypersensitivity to it, angioedema, as well as problems in the functioning of the kidneys and liver, hyperkalemia and obstructed blood outflow. It should not be taken by women during pregnancy and nursing mothers.

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Correct use

When choosing a medicine for high blood pressure, ease of use is of no small importance.

Thus, Corinphan tablets should be taken orally, immediately after meals, with the required amount of clean water. The dosage is selected by a specialized cardiologist individually for each patient, depending on the diagnosis and its severity, but usually no more than 10 mg is prescribed in the first days of treatment for 2-3 doses. With a weakly expressed hypotensive effect, the dose is increased to 20 mg twice a day.

Both medications require water to take.

Regarding “Capoten”, it should also be drunk after meals and washed down with water. The initial dose is 12.5 mg in the morning and evening. If necessary, the dosage is increased to 25 mg and in extreme cases - to 50 mg 2-3 times a day. To quickly bring your blood pressure back to normal and stabilize it, you can simultaneously use “Capoten” and “Corinfar” or any other antihypertensive drug.

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Bad influence

When taking the compared medications, the patient may experience various adverse events, which are almost identical for both drugs. Thus, against the background of the use of “Kapoten” and “Corinfar” the following may occur:

• hot flashes;
• heart rhythm disturbances;
• drowsiness or, conversely, difficulty falling asleep, increased fatigue, dizziness, pain in the temples and the back of the head;
• depression;
• sensory disturbance;
• tremor;
• narrowing of the bronchi;
• pulmonary edema;
• dermatitis, itching, rash on the skin;
• urge to vomit, stool disturbances;
• dry mouth;
• muscle pain;
• deterioration of kidney function;
• an increase in the volume of urine excreted.

While taking Capoten, a person may experience a dry cough.
Separately, "Capoten" can provoke "angina pectoris", cardiac arrest, impaired blood flow in the brain, shortness of breath, dry cough and inflammation of the nasal mucosa. In addition, taking nifedipine can cause the development of various autoimmune diseases. When treating high blood pressure with Corinfar, there is a chance of dermatitis, cramps, swelling of the joints, as well as increased gas formation and thickening of the gums.

Features of the composition

The pharmaceutical product Corinfar has a specific release form - tablets with an unusual design, covered with a yellowish coating. Each unit contains 10 mg of the active component, that is, nifedipine. In addition to the main component, the drug contains additional elements:

• microcrystalline cellulose,
• lactose,
• starch,
• Magnesium stearate
• povidone,

During the production process of the medicine, tablets are packaged in blisters of 10 units, and are also packaged in bottles of 50 or 100 units. The glass of the bubbles is brown, which protects the medicine from light.

Important point! If the patient takes the medicine for more than three months, addiction may occur. The clinical effect after taking the tablets is observed quickly, after about 20 minutes, and the duration of action is about 6 hours.

Side effects

The following table will tell you about the side effects of Nifedipine and the frequency of their occurrence.

Most undesirable effects are transient (transient) in nature and are quickly eliminated when the medication is discontinued.

Similarities of means

Corinfar and Kapoten have the following similarities:

1. Both medications are used to treat hypertension and chronic heart failure.
2. Antihypertensive drugs are prohibited in patients who are breastfeeding.
3. Both drugs must be stored at temperatures up to 25 degrees for 5 years from the date of release.
4. During therapy with antihypertensive drugs, care must be taken when driving vehicles and operating machinery that may be potentially dangerous.
5. Medicines should not be taken if you are intolerant to their composition or have a narrowing of the aortic mouth.
6. While taking both medications, there may be a decrease in all blood cells, cardiac arrhythmia, drop in blood pressure, hot flashes, muscle and joint pain, increased daily diuresis and mammary glands, liver and kidney dysfunction, swelling of the extremities, blurred vision, dizziness, headache, drowsiness, depression, bronchospasm, pulmonary edema, gingival hyperplasia, dry mouth, diarrhea, nausea, vomiting, impotence.

What to do after a hypertensive crisis

A sharp exacerbation of hypertension is a signal from the body that it is necessary to take serious care of your health. If this time the crisis was successfully managed without a stroke or heart attack, then you should not hope that you will continue to be as lucky. Therefore, consult a doctor as soon as possible. The doctor will first send you to the laboratory for tests, conduct a thorough examination of the various systems of your body, and then prescribe treatment. After suffering a hypertensive crisis, patients, as a rule, no longer need to be convinced for a long time that carefully following the doctor’s recommendations is in their interests.

If you had a hypertensive crisis, this means that the disease has gone far enough. Therefore, lifestyle changes and proper diet may not be enough to reduce blood pressure to an acceptable level. If the doctor prescribes you medications for hypertension, there is nothing you can do, you will have to carefully swallow the pills every day, without missing the time of taking them. Side effects from medications, of course, exist, but the threat of a new exacerbation of the disease is even worse.

The more experience a patient has with hypertension, the higher his blood pressure rises during an exacerbation. At the first stage of hypertension, a significant deterioration in well-being can result from an increase in pressure to only 140/90 mm. rt. Art. If hypertension is left untreated, the body gradually “gets used” to life with consistently high blood pressure. Then the symptoms that we listed above are noted already with truly menacing numbers on the tonometer. In some patients, blood pressure during a crisis may rise to 220/120 mmHg. Art. and even higher. This usually leads to irreversible complications: heart attack, stroke, kidney damage, and blurred vision due to hemorrhage in the vessels of the eye.

Contraindications for use

As indicated in the instructions attached to the drug Capoten, this drug is not allowed to be taken by patients with hypertension, who also have the following points:

• stenosis or obstructive changes in the aorta that interfere with the normal flow of blood from the left ventricle;
• hypersensitivity to the drug;
• stenosis of the arteries of both or a single kidney;
• serious problems with the liver or kidneys;
• hyperkalemia;
• postoperative period following kidney transplantation;
• angioedema.

• hypersensitivity to nifedipine and other 1,4-dihydropyridine derivatives;
• low pressure (less than 90);
• cardiogenic shock or collapse;
• heart failure at the decompensation stage, severe aortic stenosis;
• extensive heart attack (first month);
• first trimester of pregnancy;
• period of breastfeeding;
• unstable angina;
• co-administration of this drug with Rifampicin.

In severe cases, this remedy can be used at short intervals to achieve a sustainable decrease in pressure.

When taking Capoten frequently, it is very important to closely monitor blood pressure and use it no more than once every half hour. If after an hour the patient does not feel relief, it is necessary to call an ambulance

The drug Corinfar has a good effect on the patient’s body, providing a faster and stronger effect. However, taking this drug may cause significant side effects, such as increased heart rate, severe headaches, and hot flashes.

As can be understood from the above information, Capoten tablets have a smaller list of contraindications than Corinfar. The first drug is not recommended for people suffering from kidney disease, as well as for women during pregnancy.

A hypertensive crisis is a sudden sharp increase in blood pressure by more than 30 mm Hg from a person’s normal “working” pressure. It is accompanied by an increase in the volume of circulating blood or a sharp spasm of blood vessels. This may include dizziness, headache, nausea, sweating, chest pain, panic and fear of death. No one is immune from this condition. Therefore, drugs that help quickly cope with high blood pressure are in great demand. Most often, Corinfar and Kapoten are used to relieve a crisis. Which of these drugs is preferable? In order to get an answer to this question, you need to know all the differences and features of each drug.

Comparisons and differences

Corinfar and Kapoten have the following differences:

Corinfar and Capoten are not complete analogues; each medication has its own characteristics, so the doctor must decide which antihypertensive drug is best, taking into account the patient’s health condition.

Medicine and healthComment

Nifedipine

The drug is produced in the form of coated tablets. 30 tablets (10 mg), 50 tablets (10, 20 mg) per package.

The therapeutic effect is achieved due to the active substance - nifedipine .

The drug is a calcium channel blocker. Thanks to this property, antianginal and hypotensive effects are achieved. There is a decrease in the tension of the smooth muscles of tubular formations and expansion in the arteries. Peripheral vascular resistance decreases and blood pressure drops.

It has been proven that with long-term treatment with the drug, atherosclerotic plaques stop forming in the coronary vessels.

In the first days of treatment, it may cause tachycardia . The medicine has an enhanced effect on the removal of sodium and water from the body.

Patients with Rhine syndrome may experience decreased vascular spasms in the extremities. In persons with neurogenic hypertension, the progression of the syndrome of impairment of all renal functions slows down.

The use of the drug in complex therapy of the syndrome caused by decompensated dysfunction of the myocardium (chronic stage) leads to an improvement in the functioning of the heart muscle. Its size is significantly reduced.

The dosage is selected individually, depending on the degree of the disease. To avoid irritation of the gastrointestinal mucosa, Nifedipine is taken with or after meals. The usual dose is 1 tablet up to 3 times . In some cases - 2 tablets up to 2 times . The maximum dose should be no more than 40 mg .

The dosage needs to be adjusted in elderly patients, those undergoing treatment for liver failure, and patients with impaired cerebral circulation (severe form).

If the dose is exceeded, the following symptoms may appear: decreased blood pressure, skin hyperemia, headache attacks, bradycardia.

Sometimes these symptoms act as side effects. They are joined by: dizziness, nausea, tachycardia, swelling in the legs.

Shelf life up to 3 years .

When are they appointed?

We studied the instructions for use of the drugs and found that their scope of action varies. There is only one similarity - both drugs are prescribed for high blood pressure:

1. The initial dose of Capoten is 12.5 mg (1/2 tablet). If necessary, the dosage of the medication is gradually increased. The maximum daily dose is 150 mg.
2. Corinfar is started with 10 mg (1 tablet) 2-3 times a day. According to indications, the dosage is doubled. The maximum daily dose is 40 mg.
3. Capoten is prescribed not only for hypertension. It is also used in other situations:
4. complex therapy of chronic heart failure;
5. left ventricular dysfunction after myocardial infarction;
6. diabetic nephropathy.

Corinfar is used only for arterial hypertension and angina pectoris. The drug has no other indications.

Complicated hypertensive crises and their treatment

In a situation where a patient has a complicated hypertensive crisis, the doctor needs to quickly decide how to act. What drugs should I use? Should they be administered to the patient intravenously or in the form of tablets orally? What is your target blood pressure level? What should be the optimal rate of its reduction? In order to make an informed decision on all these issues on the spot, the doctor must have not only good “theoretical” training, but also practical experience. Moreover, finding out the exact numbers of the patient’s blood pressure does not help much in making a diagnosis. It is much more important to correctly interpret the patient’s symptoms and complaints in order to recognize what complications he has. This emergency physician skill is a "mixture of science and art."

Distribution of complications of hypertensive crisis by frequency

The doctor's immediate actions are to:

• reduce the load on the left ventricle of the heart;
• improve blood flow in the coronary (supplying the heart) vessels;
• eliminate acute heart failure;
• normalize the volume of circulating blood and plasma, if it is increased;
• influence the causes of excessive narrowing of the lumen of blood vessels;
• restore blood supply to the brain (especially if the patient has seizures).

If it is obvious that the patient has developed certain complications of a hypertensive crisis, then therapy should be carried out intensively, through intravenous administration of drugs. In the event of aortic aneurysm dissection, blood pressure should be reduced very quickly. Namely, by 25% of the initial value in 5-10 minutes, and then to the target level of “upper” pressure of no more than 110-100 mm Hg. st

In case of acute disorders of cerebral circulation, on the contrary, the pressure is reduced very slowly and carefully. In case of a hypertensive crisis, which turns out to be complicated, the patient is hospitalized, but emergency medical care is provided at home and is still taken to the hospital.

First aid for hypertension

If your blood pressure is high, you should:

1. Stop physical activity.
2. Take a comfortable position, sitting or reclining.
3. Take one tablet: Capoten (25 mg) or Corinfar (10 mg).
4. Measure blood pressure every 20-30 minutes.
5. If after an hour the pressure does not drop below 180/100 mmHg. Art., take another tablet - Kapoten or Corinfar.
6. If after repeating the pill there is no effect, call an ambulance.
7. If the pressure rises after 30 minutes while taking the drug, chest pain, severe headaches, and confusion appear, call an ambulance.

Corinfar acts faster - the effect occurs 20 minutes after taking the drug and lasts up to 5-6 hours. The maximum concentration of nifedipine in the blood is achieved after 1.5-2 hours.

The hood works more slowly - the pressure drops after 30-40 minutes. The maximum concentration in the blood was observed after 1-1.5 hours. The effect lasts up to 4-6 hours. Eating slows down the effect of captopril by 30%.

Kapoten

Available in tablet form (25 or 50 mg). The manufacturing company determines the shape and appearance of the tablets.

The main active substance is captopril , which expands the lumens in blood vessels and reduces blood pressure.

The medicinal product is classified as an ACE inhibere. Its effect prevents the formation of angiotensin ||. By doing this, the gaps in the arteries and veins increase, and the pressure drops.

The therapeutic effect occurs after an hour. 75% of the substance is absorbed. Excreted by the urinary system. Patients with elevated levels of urea and creatinine should consult a physician.

The dosage is determined individually, depending on blood pressure and symptoms of the disease. The main thing is not to exceed 150 mg per day . The time of administration does not depend on food consumption.

Capoten can be harmful in case of hypersensitivity to captopril, ACE inhibitors, persons with a hereditary predisposition to Quincke's edema, and liver and kidney dysfunction.

The drug is not prescribed to pregnant and lactating women.

There is a danger of overdose, which leads to a sharp decrease in blood pressure. Treatment consists of hemodialysis and the introduction of plasma expanders.

Capoten can cause adverse reactions in the form of: anemia, thrombocytopenia, the appearance of blood in the urine, tachycardia, acidosis, weight loss, aphthous stomatitis, abdominal pain. From the skin: rashes, itching.

General information about drugs

Important to remember! You can take medication for the treatment of hypertension only after consultation with your doctor. Self-medication is dangerous due to the development of side symptoms and can negatively affect the course of the disease.

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Contraindications

For all its usefulness, Captopril has contraindications. It is better to refuse the drug in the following cases:

• pregnancy;
• lactation;
• age under 18 years;
• angioneurotic neurosis;
• angioedema;
• aortic stenosis;
• insufficient blood circulation in the brain;
• cardiac ischemia;
• coronary insufficiency;
• period after kidney transplant;
• cardiovascular and cerebrovascular pathologies;
• hypersensitivity to, to Captopril in particular;
• severe connective tissue diseases of an autoimmune nature;
• inhibition of bone marrow hematopoiesis;
• hepatic or renal dysfunction;
• Na+ restricted diet;
• decrease in blood volume: diarrhea, vomiting, etc.;
• elderly age;
• development of Quincke's edema;
• cardiogenic shock;
• severe heart defects.

The following side effects may occur more often than others:

• constant fatigue, asthenia, paresthesia;
• loss of appetite;
• jaundice (in isolated cases);
• acidosis, hyponatremia;
• kidney dysfunction;
• dry, barking cough;
• skin rash;
• anemia, thrombocytopenia;
• tachycardia, severe hypotension, peripheral edema;
• bronchospasm, serum pathology, lymphadenopathy;
• agranulocytosis.

If complications occur, you should immediately see a doctor and tell him about the symptoms that have appeared.

When drugs should not be prescribed

Memo for an emergency doctor

An emergency physician can choose a treatment strategy for a hypertensive crisis only after carefully collecting information. What questions to ask:

• How long has the patient suffered from hypertension?
• What are his usual and maximum blood pressure levels?
• When did the current hypertensive crisis begin? How long has it been going on?
• What blood pressure pills had the patient already taken before the ambulance arrived?
• What medications for hypertension does the patient take regularly?
• Maybe the crisis arose due to skipping or stopping medications that lower blood pressure? If yes, which drugs?

You should also ask about concomitant and past cardiovascular diseases, cerebrovascular accidents, kidney problems, and the presence of diabetes mellitus.

If a patient complains of shortness of breath, pain in the heart, or has heart rhythm disturbances, an ECG must be done. If changes in the final part of the ventricular complex are detected (decrease or elevation of the ST segment, formation of a symmetrical negative T wave), this indicates acute coronary syndrome.

There are different classification options for hypertensive crises. For the practical work of an emergency physician, it is enough to distinguish between hyperkinetic and hypokinetic hypertensive crisis.

Hyperkinetic hypertensive crisis

Hyperkinetic hypertensive crisis - is formed mainly due to an increase in cardiac output (too intense work of the heart). In this case, the total peripheral vascular resistance does not change at all or increases slightly. In such a situation, systolic (upper) blood pressure increases, but diastolic (lower) blood pressure remains stable or changes little.

A hyperkinetic hypertensive crisis usually develops quickly and lasts no more than 2-4 hours. Accompanied by an increase in pulse rate, tachycardia (palpitations), sweating, sometimes the patient's skin turns red and becomes covered with spots. Often ends with polyuria - copious urine output.

Hypokinetic hypertensive crisis

Hypokinetic hypertensive crisis occurs due to high total peripheral vascular resistance. In this case, cardiac output decreases to one degree or another. This type of hypertensive crisis usually occurs in patients with a long history of hypertension who have been poorly treated, and therefore their target organs are damaged.

A hypokinetic hypertensive crisis develops slowly, over several days or even weeks, and is severe. Both systolic and diastolic blood pressure are increased. Moreover, the increase in diastolic pressure is often more significant. The patient experiences a loss of strength, pale skin, and often develops complications with the heart or brain.

Different drugs are used to treat hyperkinetic and hypokinetic crises, which we will discuss in detail in the next section of this page.

Which is better when compared with other drugs

Let's try to compare Nifedipine with other medications with antihypertensive or similar effects. Long-term therapy sometimes requires rotation of the drugs used, so familiarization with the most common medications will not be superfluous.

Amlodipine

The basis of white cylindrical Amlodipine extended-release tablets is amlodipine besylate, a substance belonging to the second generation BMCC.
This is also a dihydropyridine derivative, the effect of which is to block calcium channels, reducing the transmembrane penetration of Ca ions into the cell. According to the instructions for use, it has not only a hypotensive, but also an anti-ischemic effect. Available in dosages of 5 and 10 mg, it contains lactose. When comparing which is better - Nifedipine or Amlodipine, you need to remember the duration of action of both drugs.

Andipal

Instructions for use Andipala calls this drug a combined analgesic drug, the active core of which consists of a non-narcotic analgesic (metamizole sodium), an antispasmodic (papaverine), a vasodilator (bendazole or dibazole) and a barbiturate (phenobarbital). A slight vasodilating effect has an effect on the smooth muscle layer of the walls of blood vessels; the indications for use include migraines, all kinds of colic and other pain syndromes. The section of the instructions for use on interactions talks about the ability of Andipal tablets to enhance the hypotensive effect of BMCC, ACE inhibitors, nitrates and other antihypertensive drugs. Therefore, it is not correct to compare Nifedipine or Andipal, which is better.

Ginipral

Ginipral tablets are prescribed for the threat of premature termination of pregnancy (uterine tone), starting from the 20th week. Today this medicine is difficult to find in pharmacies, and you can often hear that Nifedipine is prescribed to women instead of Ginipral. This is where their question arises - which is better, Ginipral or Nifedipine. If we compare these medications in terms of their effect on the tone of the uterus, then without a doubt Ginipral is preferable. But some women (it has been noticed that they have hypertension) tolerate Nifedipine well. Others, judging by the reviews, advise to refrain from taking it, as they are faced with side effects. This means that you need to select a medication individually. We should not forget that these medications, according to their instructions for use, have completely different indications for use, so it is wrong to talk about their interchangeability.

What is the composition of Corinfar and Capoten

The difference between these drugs is really great. First of all, it consists of what substance acts as the main one in such means. The action of Corinfar is based on the properties of a substance called nifepidin. Its main ability is to block calcium channels. In turn, Capoten is made on the basis of captopril. In fact, this medicine is often called exactly that. When captropil enters the body, it blocks ACE and prevents blood vessels from contracting to a pathological state. Thus, Kapoten helps relieve vascular spasms and avoid increased pressure on them. This mechanism allows the drug to be used for the treatment of hypertension.

How Corinfar and Kapoten work

If the composition of the drugs differs, then their effect on the body is approximately the same. Ultimately, medications help to quickly reduce blood pressure, and with long-term use they provide lasting changes in the condition. Because of this, both drugs can be used to treat hypertension and not just as an emergency intervention. True, Capoten also has one more effect - it protects against complications that can arise from diabetes. Therefore, we can say that this drug is even more practical.

Kapoten or Corinfar: which is better, reviews, difference

For high blood pressure, experts often prescribe Capoten or Corinfar. Which is better and more effective? Which drug has fewer side effects? Those who are faced with arterial hypertension ask the above questions.

Corinfar begins to act within 20-40 minutes from the moment the tablet is taken orally, and Capoten - after 30-60 minutes. The effect lasts up to 6 hours. With constant use of Corinfar (2-3 months), resistance to the action of nifepidine develops.

The difference between popular antihypertensive drugs is great. First of all, it lies in their composition.

The action of Corinfar is based on the properties of nifepidin. This active substance blocks calcium channels, increases coronary blood flow and lowers blood pressure.

Capoten, whose work is based on the action of captopril, blocks ACE, which prevents blood vessels from contracting to pathological conditions. Thanks to the vasodilating effect, renal blood flow increases, the load on the heart decreases, and complications of the cardiovascular system in diabetes mellitus decrease.

Unlike Corinfar, Capoten relaxes the walls of venous vessels, reduces the secretion of aldosterone by the adrenal glands, and lowers pressure in the right side of the heart and pulmonary arteries. In turn, Corinfar demonstrates low effectiveness in terms of restoring heart rhythm.

Antihypertensive medications are recommended to be taken for arterial hypertension.

In combination with other drugs, Corinfar helps with variant or tension angina.

Capoten is prescribed for impaired renal function (nephropathy), which develops against the background of type 1 diabetes mellitus, and insufficiency of the left ventricle (post-infarction period).

In combination with combination treatment, Capoten is used for chronic heart failure.

Both drugs should not be taken if:

• low blood pressure,
• any allergic reactions to the active substance,
• breastfeeding,
• pregnancy (Corinfar in the 1st trimester),
• under 18 years of age,
• severe failure of the liver and kidneys (Corinfar is possible, but with caution).

You should avoid Capoten if you have high potassium levels, lactose intolerance, renal artery stenosis, or the presence of one kidney.

Corinfar is not recommended for arterial valve stenosis, acute heart attack and heart failure.

If you compare the instructions for medications, Capoten has a smaller list of side effects.

Despite their mild effect, blood pressure pills can cause drowsiness, sleep disturbances, depression, dizziness, and hot flashes. Also, when taking Capoten, the patient runs the risk of experiencing rashes, disturbances in heart rhythm, kidney function and sensitivity, tremors of the limbs, dry cough, and inflammation of the liver.

Adverse reactions when taking Corinfar include: swelling, fainting, fatigue, headache, drowsiness, tremor, dizziness. Patients may also complain of bronchospasms, rashes, dermatitis, itching, nausea, joint swelling, muscle pain, anaphylactic reactions, impaired renal function, bowel movements, gait and swallowing.

Although Kapoten has a mild effect, it effectively fights hypertension. Often, when taking it, no additional drugs are required, the action of which is aimed at eliminating adverse reactions. But in the case of Corinfar, it is difficult to do without other medications. Since the latter can increase the heart rate, it should not be taken if the rate is above 85 beats per minute.

Corinfar lowers blood pressure faster, but this cannot be called an advantage. The fact is that the drug can significantly lower blood pressure, which can worsen the patient’s general condition. And Capoten lowers blood pressure quickly, but the hypotensive effect still occurs gradually. Therefore, it is also considered as an emergency treatment for high blood pressure. It is enough to take Capoten in several doses (an interval of at least 30 minutes) so that a sufficient concentration of captopril normalizes blood pressure, despite high levels.

In case of hypertensive crisis, which is better - Kapoten or Corinfar? The drugs are not specialized antihypertensive drugs during a crisis. It is recommended to take Capoten or Corinfar under the supervision of the attending physician in the case of complex therapy. To avoid side effects and overdose, medications should be taken according to instructions, according to the recommendations of a specialist. It is not worth putting Corinfar or Capoten under the tongue to accelerate the hypotensive effect, since resorption can lead to a burn of the oral mucosa.

Currently, there are many drugs that can replace Capoten and Corinfar. They differ in pricing policy, speed of onset of the hypotensive effect, pharmacology, duration of maintaining normal blood pressure levels, and effectiveness. Each drug is selected depending on the patient’s age, the presence of chronic diseases, and the severity of pathologies. Analogs of Kapoten and Corinfar include:

• Hypernik, Fenigidin, Nicardia,
• Prestarium, Amprilan, Vasolong,
• Ramipril, Accupro, Coverex,
• Zokardis, Blockordil, Gopten,
• Adalat, Nifesan, Kordafen,
• Enap, Parnavel.

To protect yourself from the development of undesirable effects, entrust the choice of a drug for high blood pressure to a specialized specialist who must study the characteristics of the body and the patient’s medical history. Taking into account contraindications, the necessary remedy will be prescribed.

Clara, 52 years old In case of sudden hypertensive “suppository”, when blood pressure jumps, I use Corinfar. However, during the next such incident, he was not nearby. That evening we were visiting relatives. Upper blood pressure went off scale almost 200 points. A friend gave me a Capoten tablet, I immediately put it under my tongue. Although it dissolved quickly, it tasted unpleasant. After 10 minutes, I put my hands in hot water, did acupressure, and drank Corvalol. Then I measured my blood pressure, it dropped to 170 points, and an hour later it almost returned to normal. I slept with peace of mind, but in the morning I didn’t feel well. Maybe because I put the pill under my tongue. Kapoten, although it acts as an ambulance in a crisis, I still give preference to Corinfar. Evgeniy, 43 years old. What is better to take for high blood pressure? This question actually worries many hypertensive patients who rely only on traditional medicine. Capoten or Corinfar should be prescribed individually. The first drug is suitable for some, and the second option is more suitable for others. But still, Kapoten is a less dangerous remedy. The only pity is that its effectiveness may not be sufficient. Therefore, before starting therapy, you should visit your doctor. Personally, I and my body like Kapoten. On rare occasions I use its cheap analogue Captopril. Section: Medicines

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Which medicine is better

It is quite difficult to give an exact answer as to which is better, Corinfar or Kapoten. Still, the body’s reaction to drugs of this kind is often individual and difficult to predict. Therefore, only a doctor can prescribe a specific medicine. He must take into account the characteristics of the human body and determine possible contraindications. However, if desired, it will be possible to identify certain differences in the effects of the drugs. They can be listed as follows.

1. Capoten has a smaller list of side effects. That is, it acts on the body much “softer” than Corinfar. Despite its mild effect, Capoten fights hypertension quite effectively. And often it is not necessary to prescribe any other remedy aimed at eliminating its side effects. In the case of Corinfar, not everything is so rosy. To minimize the negative consequences of using such a drug, it is sometimes very difficult to do without taking other drugs.
2. Corinfar, in turn, can cause quite serious side effects. Most often these are an increase in heart rate, fever, migraine, and indigestion. It is also important to consider a serious limitation when taking this drug. It consists in the fact that the patient’s heart rate should be a maximum of 85 beats. per minute If your heart rate is higher, you should not take Corinfar.
3. Capoten, although capable of quickly reducing pressure, still does not act immediately. But it can still be considered as an emergency aid. You just need to take a few tablets one after another. There should be at least 30 minutes between doses. With a gradual increase in the concentration of captopril in the body, pressure decreases.
4. Corinfar acts very quickly and helps to dramatically reduce blood pressure after just one tablet. And this is not always an advantage, since such a drug can lower blood pressure too much, which also leads to a worsening of the condition.

It becomes clear that the difference between these drugs is quite large. But it’s still impossible to say for sure which one is better.

As noted earlier, it is incredibly important to consult with a specialist to find the appropriate medication. Therefore, you should not rely only on yourself or on the recommendations of friends.

It is also important to make sure that there are no contraindications to a particular drug. By the way, they also differ.

How do they work?

1. "Corinfar" belongs to the class of selective calcium channel blockers. The active ingredient is nifedipine. The mechanism of action is based on the fact that nifedipine, like other calcium antagonists, slows down the penetration of calcium ions into the muscle cells of blood vessels and the heart. The selectivity of Corinfar lies in the fact that it acts primarily on blood vessels.

The drug has antianginal and hypotensive effects. The therapeutic effect is caused by the dilation of the arteries as a result of a decrease in their tone and a decrease in the ability of platelets to stick together.

1. "Capoten" belongs to the ACE inhibitors. The active ingredient is captopril. It inhibits the activity of angiotensin-converting enzyme, which promotes the transformation of angiotensin I into angiotensin II, which constricts blood vessels and increases blood pressure.

Captopril reduces total peripheral vascular resistance, afterload and preload on the heart, and reduces left ventricular hypertrophy with long-term use.

What is the speed of action of the drugs?

When taking Corinfar, the clinical effect occurs within twenty minutes. The duration of the therapeutic effect is four to six hours. Metabolized by the liver. The main part of the metabolites (80%) is excreted by the kidneys, the remaining part is excreted along with bile.

The maximum concentration of captopril in the blood is reached on average after an hour. The half-life is about three hours. Approximately 95% of the substance is excreted in the urine.

What does it help with?

Capoten is taken not only for hypertension. It can be part of complex therapy for other heart pathologies. Treatment with this drug is carried out exclusively under the supervision of the attending physician - the dosage and schedule of administration are usually completely individual. The official instructions for use do not mention that it can be used to relieve hypertensive attacks.

In general, in addition to cases of arterial hypertension, Capoten is taken in the following cases. The dosage and frequency of administration depends on the type of disease:

• kidney pathologies leading to increased blood pressure;
• heart failure with weak action of cardiac glycosides;
• nephropathy arising from diabetes mellitus.

It is safe to take Capoten for high blood pressure only under the supervision of a specialist, since the condition may worsen if used incorrectly. It is also worth noting that before starting therapy, it is necessary to establish the exact cause of hypertension and whether there are other pathologies of the cardiovascular system, liver, or kidneys.

Important! In most cases, Capoten is taken together with other antihypertensive drugs: diuretics, calcium receptor blockers and other medications. .

Composition and mechanism of action

Normalization of pressure is achieved by dilating the arteries.
Corinfar prevents the penetration of K ions into vascular cells and the muscle layer of the heart muscle. The components of the medicine dilate the arteries without changing the tone of the veins, and also reduce the oxygen demand of the heart and reduce the load on the contracting myocardium. "Capoten" prevents the conversion of angiotensin I into a protein that provokes an increase in blood pressure.

The pharmaceutical industry produces many antihypertensive drugs. This is explained by the prevalence of hypertension. However, the wide range of blood pressure medications often confuses patients. Which medicine do you prefer? What, for example, will allow you to quickly achieve the desired therapeutic effect: “Corinfar” or “Capoten”?

Both drugs are well known in the medical community and are popular among people suffering from hypertension. But this does not mean that they are analogues.

"Corinfar"

• In addition to hypertension, Corinfar is prescribed for the treatment of angina: tension and spontaneous.

"Kapoten"

• "Capoten" is prescribed for the treatment of high blood pressure either as a separate drug or in combination with other antihypertensive drugs (most often with thiazide diuretics).

Other indications:

• chronic heart failure (CHF);
• myocardial infarction, when the functions of the left ventricle are impaired, but the patient’s condition remains stable;
• nephropathy caused by insulin-dependent diabetes mellitus.