Concor in comparison with other analogue and synonym drugs: which is better?

For many years, cardiovascular diseases have held the palm among diseases that often lead to death. Moreover, stroke and heart disease are getting younger year by year.

The main risk factors are poor diet, stress, physical inertia, tobacco and alcohol use.

The danger of the disease is that it may not make itself felt for a long time, but may appear spontaneously. People suffering from CVD need early diagnosis and treatment with medications.

Doctors are increasingly prescribing Concor or Bisoprolol for the treatment of heart disease. Which is better and what is the difference between these medications? To resolve this issue, it is necessary to study the composition of both medications.

Bisoprol and Concor: what is the difference between them?

Bisoprolol and Concor are medications from the group of beta blockers that are widely used to treat hypertension and cardiovascular diseases: heart failure; coronary heart disease; heart rhythm disturbances; prevention of angina attacks.

Concor tablets

Concor and other bisoprolol preparations have significant advantages that have made them very popular among patients and doctors.

Characteristics of Concor

Bisoprolol is an adrenergic blocker that is used in the treatment of heart pathologies.
The medication is used:

• for diseases of the cardiovascular system;
• with ischemia;
• for hypertension;
• with manifestations of heart failure;
• for arrhythmia.

Concor is a selective adrenergic blocker, the principle of action of which is to act on the smooth muscle receptors of the bronchi and blood vessels, as well as to regulate metabolism.

The drug is prescribed:

• for hypertension;
• with increased fatigue;
• with cardiac ischemia;
• in case of vascular conduction disturbances;
• with angina pectoris;
• for chronic heart failure.

The drug is prescribed for hypertension, increased fatigue, and cardiac ischemia.

Compound

The composition of the medicines includes the main active ingredient – ​​bisoprol. That is why they act almost identically. Their effectiveness is at the same level.

Bisoprolol tablets

Contraindications for use and side effects are also similar. So what is the difference between Concor and Bisoprolol? They differ only in the manufacturer and price. Bisoprolol is a domestic analogue of Concor. When comparing Concor or Bisoprolol, the price difference is quite significant. The Russian drug costs slightly less than its foreign counterpart.

Table of drug differences

Although the two drugs have similar compositions, certain differences can still be noticed. To clearly demonstrate how the German Concor differs from the Russian Bisoprolol, we suggest that you familiarize yourself with the table of differences. Perhaps she will help you finally make your choice.

After reviewing the table, we can conclude that there are still certain differences between the drugs. Moreover, if we compare these two drugs, then Concor has significantly more additives. After all, manufacturers use a special film for the product. This is where most of the additives are found. Although there are very few of them in the composition itself. The price of the drugs also differs. As you can see, Bisoprolol is a cheaper analogue of Concor. However, both remedies are very effective and are used quite often.

Advantages

The advantages of the drugs over other drugs are the following:

• It is enough to take Concor and Bisoprolol once a day. One tablet will provide the patient with stable blood pressure for a day;
• taking medications does not depend on food intake;
• These beta blockers have fewer side effects than their predecessors;
• medications do not affect potency in men;
• affordable price.
• Bisoprolol and Concor are metabolically neutral drugs. They do not affect the metabolism of cholesterol, triglycerides and glucose in the blood. They are safely prescribed to patients with type 2 diabetes and the elderly.

And yet, many patients are concerned with the question: Bisoprolol and Concor - which is better? Some patients benefit from the more expensive original Concor, while others can trust their health exclusively to domestic medicine. The choice of drug for treatment remains with the patients.

Comparison of side effects of Concor Cor and Metoprolol ratiopharma

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Concor Cor has almost the same level of adverse events as Metoprolol ratiopharma. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Concor Cor are similar to Metoprolol ratiopharm: how quickly the body recovers after taking it and whether it recovers at all.

How do medications for hypertension work?

The drugs in question for hypertension act much more consistently than other medications and keep blood pressure at the desired level.
Daily blood pressure monitoring showed that after taking Bisoprolol or Concor tablets, the blood pressure remains normal in the morning of the day following administration.

Other beta blockers reduced or completely stopped their hypotensive effect 4 hours before taking the next dose of the drug.

These medications can effectively control blood pressure and heart rate not only at rest, but also during exercise. In this regard, they work better than, for example, Metoprolol. The most important feature of drugs is the stability and uniformity of their action throughout the day.

For severe hypertension, combinations of Bisoprolol with other medications are prescribed: diuretics, ACE inhibitors, and other drugs for hypertension. It was found that the blood pressure lowering effect of Concor and Bisoprol remained stable over the 3 years that the study continued.

Medicines, even without combination with other medications, provide the desired effect in patients suffering from mild or moderate hypertension.

pharmachologic effect

Manufacturer: Ozone (Russia)
Release form: tablets

Active ingredient: metoprolol

Analogs: Bisoprolol, Anaprilin, Betalok zok

Metoprolol belongs to the group of selective beta-blockers. Based on the chemical composition, there are 2 forms of the drug: Metoprolol tartrate and Metoprolol succinate. The medication reduces the frequency and severity of angina attacks, lowers blood pressure and restores the rhythm of heart contractions.

Under the influence of the drug, the need for oxygen in the cellular structures of the myocardium decreases, and the tolerance of the heart muscle to physical activity increases.

Treatment of chronic heart failure

Both medications are useful for chronic heart failure of various origins.

The drugs significantly reduce the risk of sudden death, the frequency of re-hospitalization, and also improve the quality of life of patients.

If you have the slightest ailment associated with increased blood pressure, such as frequent headaches and dizziness, spots flashing before your eyes, as well as if you experience aching or stabbing pain in the sternum, shortness of breath, it is important to consult a doctor in a timely manner.

Timely consultation with a doctor will significantly reduce the risk of stroke and heart attack.

How to take beta blockers correctly?

For different diseases and depending on the patient’s condition, the dosage of drugs may be different:

• for hypertension, the initial dose is 5 mg per day, gradually increasing it to 10 mg per day;
• for coronary heart disease, the dosage ranges from 2.5 to 10 mg per day. It is selected strictly individually until the pulse rate reaches 50-60 beats per minute;
• for chronic heart failure, medications are prescribed in addition to therapy with diuretics and ACE inhibitors. The initial dose is 1.25 mg per day.

For elderly patients, the dosage of medications is prescribed on a general basis. Treatment of heart diseases with beta blockers and their dosage can only be prescribed by a doctor!

Features of taking medications

When taking a medicinal product containing bisoprolol fumarate, the following aspects must be taken into account:

• both drugs can be taken both before and after meals;
• You should not abruptly stop treatment; hypertension may worsen;
• it is necessary to begin treatment of chronic heart failure with a lower dose;
• patients taking the drug with a diagnosis of coronary heart disease require constant monitoring;
• when planning an operation, it should be taken into account that the use of bisoprolol fumarate reduces the risk of developing arrhythmia and myocardial ischemia;
• people suffering from obstructive respiratory diseases are recommended to start treatment with bisoprolol with a minimum dose;
• The drug is prescribed to a person with psoriasis with caution.

From the above it follows that it is necessary to select a drug based on individual characteristics: age, concomitant pathologies. It is always necessary to assess the risk to the body as a whole.

Prescription during pregnancy

During the period of bearing a child, the prescription of bisoprolol fumarate is possible only when the benefit of taking it is higher than the risk of complications for the fetus. Beta blockers reduce uteroplacental blood flow, this is fraught with intrauterine growth retardation, spontaneous abortion and premature birth are possible. During treatment, constant monitoring of blood flow and fetal growth is necessary. If indicators worsen, alternative treatment should be considered.

You can read more about the use of Concor during pregnancy here.

Interaction with alcohol

When bisoprolol is consumed with alcohol, its effect is completely blocked, and the disease worsens and atrial fibrillation develops. In the event of loss of consciousness, people around you will probably consider this to be a banal manifestation of intoxication and will not provide emergency assistance.

What do doctors prescribe more often?

Before purchasing this or that product, you should listen to the opinions of professionals.

Comment from a cardiologist of the highest category : “Concor is an analog drug, that is, a new substance that has undergone a large number of different studies and was patented by a German pharmaceutical company. In turn, Bisoprolol is a generic (copy), that is, a reproduced medicine. And although its therapeutic relationship with the original has been confirmed, the company producing such products does not have a license. It should be remembered that generic drugs are less effective (approximately 5-15%), this is due to cheaper production technology.

Concor: benefits and harms during pregnancy and lactation

It is Concor that is most often prescribed to expectant mothers for the treatment of arterial hypertension.

Any beta blockers reduce blood flow in the placenta, and this negatively affects the development of the unborn baby.

It is recommended to stop taking Concor 3 days before the expected due date.

After the birth of the child, he needs to be carefully examined. The newborn may experience symptoms of bradycardia and hypoglycemia.

The active ingredient Concor is not excreted into breast milk, but its use while feeding a baby is not recommended. If you still need to take the medicine, doctors insist that you stop breastfeeding.

Which is better to choose Concor or Bisoprolol?

Modern pharmaceuticals launch new drugs almost every six months, but not everything new is good. What medications should I take? And in what cases? Which drug has fewer side effects?

Concor

Concor is a drug prescribed to patients suffering from surges in blood pressure. It comes in the form of white tablets. The main indication for use is coronary heart disease, prevention of angina pectoris, blood pressure surges, and chronic heart failure.

The drug has a number of main contraindications, they should be taken into account when prescribing treatment:

1. Any forms of bronchial asthma.
2. A sharp decrease in blood pressure.
3. Shock caused by heart rhythm disturbances.
4. Circulatory disorders.
5. Caution should be taken concomitantly with other inhibitor drugs.
6. Age up to 18 years.
7. Kidney failure.

I would like to make a separate point about taking Concor during pregnancy and breastfeeding. Self-prescription of this drug is impossible. The doctor prescribes treatment with this medicine if the benefits to the mother outweigh the consequences for the development of the fetus.

The tablets should be taken before or after breakfast with a small amount of liquid; for proper absorption, it is not recommended to chew the drug or grind it into powder.

Taking this drug requires constant monitoring by your doctor, so you can adjust the ideal dose for the patient. It is recommended to begin treatment with small doses, then gradually increase, but provided that the previous dose of the drug was well tolerated by the patient.

Bisoprolor

This medication is available in the form of white tablets. It is aimed at treating angina pectoris, persistent high blood pressure, and is also used in complex therapy for recovery after a heart attack.

The drug has the following contraindications:

• Any forms of bronchial asthma.
• Shock caused by heart rhythm disturbances.
• Circulatory disorders.
• Refunds up to 18 years of age.
• Liver failure.
• Pregnancy and lactation period.
• Any other individual intolerance to bisoprolor and other components included in its composition.
• It is necessary to use with caution with other drugs, because may cause a severe allergic reaction.

The drug should be used only after a doctor's prescription. Before taking it, it is necessary to completely exclude acute heart failure.

And also the attending physician should adjust the dosage, start with the lowest dose, gradually increasing, and monitor the patient’s condition.

Bisoprolor should be taken in the first half of the day with plenty of water, without tying the medication to breakfast.

The medication has a wide range of side effects, such as dizziness, nausea, heart failure, headache, a sharp drop in blood pressure and many others. If you feel worse, you should stop taking it and consult a doctor immediately. In case of acute drug poisoning, rinse the stomach and call an ambulance.

In fact, if you conduct a comparative analysis of the components included in these drugs, you can conclude that these are almost identical drugs.

Bisoprolor is part of Concor and is its main pharmaceutical component, i.e. Concor is a more expensive analogue. The principle of their effect on blood pressure is absolutely the same.

As described above, these are analogue drugs. Their main difference is the manufacturer. Bisoprolor is a domestic medicine, well known to the older generation, because has been assigned to them for many years. Concor is a newer analogue of its works in Germany. Another difference is the price. Due to foreign production, the price of concor is several times higher.

It is believed that the effects of Concor are gentler on the body, and some patients complain that it is ineffective for them; in fact, this is the individual tolerance of the drug. Concor contains additional components in the form of calcium magnesium and titanium dioxide.

These drugs are good because they can be used by older people without causing serious harm to health. But taking it during pregnancy is different: bisoprolor cannot be used in its pure form during this period, but Concor is most often prescribed to pregnant women suffering from cardiovascular diseases and high blood pressure.

It must be taken into account that drugs of this class affect blood flow to the placenta, which means the development of the fetus may be at risk. Therefore, only a doctor can prescribe these medications, and also adjust the correct dosage so as not to harm either the mother or the baby.

So, to summarize, we can say that these two drugs are practically no different from each other, with the exception of the country of origin and price, but they have a number of advantages in relation to other analogues:

1. Availability. They can be easily found at your nearest pharmacy and are also affordable.
2. It should be used once a day, without being tied to your diet.
3. Gentle effect on the body.
4. Can be used by elderly people, as well as patients suffering from diabetes.
5. Possible use during pregnancy.

Interaction between alcohol and Bisoprolol

Alcoholic drinks can affect the functioning of any medication.

This is due to the fact that both alcohol and medications undergo processing in the liver, and this negatively affects its work.

Bisoprolol and Concor should not be combined with alcoholic beverages.

During their interaction, the functioning of the heart is disrupted. In this case, arrhythmia and pain in the heart area occur. Alcohol can significantly increase blood pressure. Even a small dose of alcohol during therapy can cause a sedative effect: a feeling of emotional depression, severe lethargy.

Concomitant use of alcohol and beta blockers can be fatal!

Comparison of the safety of Concor Cor and Metoprolol ratiopharma

The safety of a drug includes many factors.

At the same time, in Concor Cor it is quite similar to Metoprolol ratiopharm. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Concor Cor, as well as Metoprolol ratiopharma, we look at which organ is the metabolizing organ and how critical the effect on it is.

The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Concor Cor does not have any risks when used, just like Metoprolol ratiopharma.

Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Concor Cor and Metoprolol ratiopharma.

Analogs

There are many analogues of these drugs available on the pharmacy market:

1. Biprol;
2. Bisogamma;
3. Niperten;
4. Bisoprolol-Lugal;
5. Bisoprolol-Prana;
6. Bisoprolol-ratiopharm.

Each manufacturer of Bisoprolol analogues tries to convince doctors that their drug meets international quality standards and is not inferior in its effect to the original Concor.

Every doctor has his own opinion on this matter. When prescribing a drug, he is guided by practical experience and the patient’s condition.

What is the difference?

Concor is an original drug that has undergone numerous clinical efficacy studies. It has a wide range of indications and is used even in patients with other chronic diseases, but only taking into account a preliminary examination.

Niperthene has the same properties, but acts as an analogue. Has low price parameters.

Contraindications

The list of contraindications for both drugs is almost the same:

• cardiogenic shock;
• bradycardia;
• atrioventricular block II and III degrees;
• sick sinus syndrome;
• hypotension;
• hypersensitivity to beta blockers;
• respiratory tract diseases, pulmonary emphysema, severe forms of bronchial asthma.

Beta blockers are prescribed with caution for liver and chronic renal failure, myasthenia gravis; disorders of the thyroid gland, diabetes mellitus; depression, psoriasis.

Side effects

Bisoprolol and Concor are tolerated by patients much better than older generation beta blockers.

Side effects when taking beta blockers are still possible and they manifest themselves in the following:

• from the central nervous system: weakness, fatigue, dizziness, headaches, nightmares, anxiety;
• from the senses: vision problems, conjunctivitis, dry and sore eyes;
• from the cardiovascular system: bradycardia, rapid heartbeat, cardiac arrhythmias, arterial hypotension;
• from the digestive system : nausea, abdominal pain, constipation or diarrhea;
• from the endocrine system: weakened thyroid function;
• allergic reactions: rash, urticaria, itchy skin.

When taking medications, blood test parameters may change: thrombocytopenia, increased activity of liver enzymes ALT, as well as bilirubin levels.

Video on the topic

Specialist on what is better: Concor Ilm Bisoprolol, what is the difference between the drugs:

Bisoprolol and Concor are modern selective drugs from the group of beta blockers. They have proven high effectiveness in the treatment of hypertension and cardiovascular diseases. Side effects are relatively rare and are well tolerated by patients. It is these medications that lower blood pressure to the desired level, reduce the frequency of angina attacks and manifestations of heart failure. Timely treatment with beta blockers prescribed by a doctor will reduce the risk of stroke and heart attack. The difference between Concor and Bisoprolol is only in the manufacturer and price. Bisoprol is a domestic drug. In Russia, it is included in the Federal program of preferential drug provision for patients.

Comparison of addiction between Concor Cor and Metoprolol ratiopharma

Like safety, addiction also involves many factors that must be considered when evaluating a drug.

So, the totality of the values ​​of such parameters as “syndrome o” in Concor Cor is less than the similar values ​​in Metoprolol ratiopharma. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible.