Nicotinic acid for atherosclerosis: how it affects blood vessels

Nicotinic acid, or a medication with acid - niacin. There are also medicines in the form of B3, or medicines of vitamins PP.

Nicotinic acid is a biological organic compound that takes an active part in the oxidation of fat molecules in the human body and regulates lipid metabolism.

With the help of medications with nicotinic acid for systemic atherosclerosis, it is possible to regulate the cholesterol index in the blood.

Nicotinic acid is not only a vitamin for the human body, but also a medicinal substance for the treatment of metabolic disorders and the pathology of atherosclerosis.

Vitamins of group B (B3) perfectly fight hypertension, gently lowering blood pressure.

In case of atherosclerosis, medications with nicotinic acid reduce the concentration of cholesterol in the blood and stop the growth of atherosclerotic plaques in the bloodstream, stopping the progression of the disease.

Nicotinic acid is not only a vitamin

Indications for use

If you suspect the development of systemic atherosclerosis and a high cholesterol index, the doctor must prescribe medications that contain nicotinic acid.

Also, drugs with this vitamin PP are prescribed for the following pathologies of the blood flow system and cardiac organ:

In case of coronary heart disease, nicotine dilates blood vessels, which prevents the progression of cardiac ischemia;
For coronary insufficiency;
With the development of pathology, thrombosis;
In the post-infarction period;
In the post-stroke period;
For varicose veins;
With familial hereditary hyperglycemia;
In pathology, diabetes mellitus with a high cholesterol index.

Nicotinic acid is prescribed when it is necessary to obtain the following medicinal therapeutic effect:

To reduce low-density lipoproteins in the blood;
To reduce triglycerides;
To stabilize blood glucose and blood pressure;
To reduce the viscosity of blood plasma;
To bring the patient out of an apathetic state, or from a state of depression;
To achieve therapeutic treatment for nicotine and alcohol addiction;
To strengthen the immune system;
For the treatment of intestinal motility and the entire digestive tract.

A nicotinic acid

Scientific evidence

You should not take nicotinic acid for cholesterol without a doctor’s recommendation. Previously, it was believed that the simultaneous use of statins and vitamin B increases the concentration of good cholesterol even more significantly. But recent studies have shown that this advantage is negligible.

Most doctors do not recommend taking niacin if you have high cholesterol. The exception is cases of intolerance to statins. First, you should try changing your lifestyle: quit smoking, switch to proper nutrition, increase physical activity.

The effectiveness of niacin has been proven for the following diseases and pathologies:

Increased cholesterol levels. Supplements are available in dosages of 500 and 250 mg. However, significant levels of vitamin B will be required to lower cholesterol levels, which is why it is a second-line drug but is often used against elevated triglycerides.
Treatment and prevention of niacin deficiency, as well as pellagra, which is manifested by dermatitis, impaired functioning of the gastrointestinal tract and deterioration in the conduction of brain impulses into muscle cells.

Some studies have confirmed the effectiveness of niacin in improving joint flexibility, reducing pain and swelling in arthrosis. Some patients are able to reduce their pain medications.

People who consume large doses of niacin through food and multivitamins have a reduced risk of developing Alzheimer's disease. However, there is no evidence that taking the vitamin prevents the disease.

With atherosclerosis, the walls of blood vessels lose their elasticity, which leads to heart attacks in men and heart disease due to ischemia. Vitamin B helps prevent another heart attack.

The substance preserves the health of blood vessels, therefore it is used in the prevention of nuclear cataracts or darkening of the central part of the lens. The dilation of small blood vessels improves the duration of erection and serves to prevent erectile dysfunction. Research shows that taking niacin lowers phosphate levels and increases calcium concentrations in people with end-stage kidney disease and also helps normalize micronutrient balance on dialysis.

The drug is prescribed against acne, eczema, intestinal diseases, and helps with conditions associated with dysfunction of the nervous system: depression, dizziness, migraine, motion sickness.

Vitamin B works best in combination with other vitamins and microelements:

in combination with beta-carotene and selenium, vitamin C and E, which are antioxidants, a significant increase in the level of good cholesterol is achieved;
chromium helps lower blood sugar, virtually eliminating the side effect of the substance;
together with nettle, goji berries, coenzyme Q10, L-arginine, vitamin B helps normalize blood pressure;
Zinc helps the body produce niacin on its own.

You should not combine vitamin B intake with herbs that can harm liver health: comfrey, mint oil, borage. When combined with cloves, garlic, ginger and ginseng, it increases the risk of bleeding by slowing down blood clotting.

Effect of nicotinic acid on blood vessels

The mechanism of action of medications that contain nicotinic acid is as follows:

If a slight increase in the cholesterol index is observed in the patient’s body, then a minimum dose of nicotinic acid is prescribed; if cholesterol is very high, then its average dosage is prescribed.

If the patient has severe liver disease, then when the synthesis of high molecular density lipoproteins is activated, the liver cells begin to work actively and a malfunction of the liver organ may occur.

Liver cells and bile acids also need to utilize molecules of low-density lipoproteins that are present in the human body due to genetic hereditary hypercholesterolemia, or from bad habits, poor diet and unhealthy lifestyle.

In addition to reducing the lipoprotein index, niacin properties reduce elevated triglycerides in the blood by inhibiting the process of lipolysis.

Patients who have low stomach acidity, after prescribed treatment with niacin, observe improved digestion and the disappearance of unpleasant and painful symptoms in the stomach after eating.

The progression of brain cell encephalopathy, which is provoked by systemic atherosclerosis, is reduced.

The use of B vitamins, which include nicotinic acid, in the treatment of the nervous system, has a satisfactory effect not only on the central nervous system, but also reduces mental and emotional disorders.

In addition to the effect of medications with nicotinic acid on the nervous system and on the reduction of total cholesterol, the concentration of which in the blood is higher than normal, as well as its low molecular weight fractions, the property of niacin is that this medication can be used as a means of dilating the vascular lumen.

In the arteries, due to the vasodilating effect of nicotinic acid, the lumen increases and, with the help of increased blood speed in the arteries, excess cholesterol molecules are washed out of them, which reduces the risk of systemic pathology atherosclerosis.

With a decrease in atherosclerotic neoplasms on the endothelium of the arteries, their membranes thicken, and the volume of fibrin in the arterial membranes decreases, which significantly reduces the growth of cholesterol plaques and damage to the arterial membranes by systemic atherosclerosis.

Nicotinic acid preparations, together with statins, are leaders among medications in the drug treatment of atherosclerotic changes in the bloodstream system and the progression of non-stenotic and stenotic atherosclerosis.

In addition to the treatment of systemic atherosclerosis, nicotinic acid medications are prescribed to stimulate the functioning of the adrenal glands.

When taking the medication niacin, the production of hormones that strengthen the immune system increases and increases the body's defenses to resist allergic agents that try to invade the human body.

When taking the medication niacin, hormone production increases

Nicotinic acid as a cosmetic product

Trichologists say that poor circulation in the scalp leads to insufficient nutrition of the hair follicles.
As a result, hair follicles move from the active phase to the sleep phase. This directly affects the condition and appearance of the curls. The hair loses its former volume, the hair begins to actively fall out, becomes brittle, lifeless, and unruly. Nicotinic acid can dilate blood vessels, thereby accelerating blood circulation in the scalp. That is why it is used in the fight against baldness and to accelerate hair growth. The product is applied to the scalp. It is more convenient to immediately buy the product in liquid form: nicotinic acid tablets will have to be crushed and mixed with water. And nicotinic acid from practical bottles is already ready for use.

You can literally feel the fact that nicotinic acid dilates the peripheral vessels of the scalp. After applying the product, many people experience a slight burning sensation and the scalp turns slightly red.

Take precautions: before using nicotinic acid for your hair for the first time, check whether it causes you an allergic reaction. Apply the product to the crook of your elbow and wait a couple of minutes. If the skin begins to become covered with red spots and itches, wash off the nicotinic acid with water.

In the treatment of atherosclerosis, the problem of damage to cerebral vessels is of particular importance. The vessels of the cerebral basin are thin, the branches here have practically no collaterals, so any blockage of the vessel threatens the development of an immediate stroke. The death of parts of the brain can leave a person disabled even if medical help arrives. Therefore, drugs for the treatment of atherosclerosis must be taken in full, and selected very carefully, taking into account the individual patients.

Drug therapy for cerebral atherosclerosis is based on the prescription of several groups of drugs. Lipotropic drugs and lipid-lowering agents are required. Patients cannot do without taking vasodilators, which are also indicated in the treatment of the disease. Nootropics are prescribed - drugs to activate cerebral circulation, multivitamin medications. If there is no result, surgical intervention is performed.

Niacin deficiency

With a deficiency of vitamin PP in the human body, the following pathologies are observed:

Nervous and mental overexcitation and depression;
Soreness in the head;
Circling in the head;
Memory loss;
Confusion;
Decreased intellectual abilities;
Pathologies on the skin - rash, peeling of the epidermis, dryness of the epidermis, inflammatory red spots on the skin, itching of the skin, pain when the temperature changes;
Nausea, which can provoke vomiting from the stomach;
Severe diarrhea or constipation.

Nicotine enters the human body not only after taking medications that contain this component, but also through food.

The following foods are rich in vitamin B3, or PP, that a person consumes almost every day:

Meat of fatty and non-fatty varieties;
Salo;
Fermented milk products;
Bread and bakery products;
Cereal products;
Sea and river fish;
Poultry meat;
Bean products;
All varieties of nuts;
Vegetable oils;
Energy drinks that contain large amounts of B vitamins.

Nicotine for blood vessels is used not only in the treatment of atherosclerosis, but also has a complex effect on many organs and systems in the body.

It is necessary to take niacin only as prescribed by your doctor, because this drug is included in the category of medications that are not intended for self-medication, because niacin has a number of side effects that can be aggravated by its improper use.

You should take niacin only as prescribed by your doctor.

Mechanism of action and use in medicine

The chemical effect of niacin is quite diverse in relation to organs and systems:

Its main property is that it is able to block spontaneous lipolysis and thereby reduce the amount of free fatty acids released into the blood;
B vitamins are also used to reduce cholesterol produced by the liver;
In addition to its direct effect on the processes of cholesterol metabolism in the body, nicotinic acid is capable of dilating spasmodic vessels, which is the prevention of atherosclerosis and tissue ischemia;
The use of nicotinic acid has a beneficial effect on the rheological properties of blood, making it more fluid, increasing the speed and volume of blood flow, enhancing microcirculation and, as a consequence, blood supply in tissues and organs;
It is capable of lysing atherosclerotic plaques in high concentrations, therefore it is used as a method of treating atherosclerosis;
It enhances the motor function of the gastrointestinal tract and the secretory function of the gastric glands;
Stimulates the production of serotonin in the brain, thereby improving mood and vitality;
Nicotinic acid also has an anabolic effect, regulating the level of growth hormone in the blood, thereby having a hypoglycemic effect, since growth hormone indirectly increases the level of glucose in the blood and is an insulin antagonist.

Thus, the use of nicotinic acid in medical practice is quite wide: it is used not only for high cholesterol, which prevents the development of heart and vascular diseases, but can also regulate blood circulation in the body, which serves as a treatment method for existing pathologies, for example, atherosclerosis.

In addition, niacin is widely used in psychiatric practice to treat depression, schizophrenia, alcohol and nicotine addiction.

Side effects

Nicotinic acid is prescribed with caution for ulcerative pathologies of the stomach and intestines. Even a minimal dosage for peptic ulcers can cause serious complications in the body.

If there is a need to prescribe nicotinic acid, then you need to select drugs that contain components that reduce the effect of acid on the digestive tract.

The drug niacin has the following side effects:

Pathology hyperemia. With this pathology, there is an increased amount of blood in the arteries of the circulatory system, which causes redness of areas on the skin, in the arteries of which hyperemia develops. This pathology is expressed not only visually on the skin, but also in severe burning, itching of the skin and pain in these areas of the skin;
The disease is gout . Nicotine has the properties of increasing the volume of uric acid in the body, which can lead to pathologies such as gout;
Damage to liver cells. The drug niacin has a detrimental effect on liver cells. If liver cells are damaged, this can happen from taking medications in large doses. Also, such a negative effect often occurs when self-medicating and when taking pills for a long period of time, which increases the production of enzymes by liver cells;
Visual organ. With excessive doses, niacin reduces vision, which leads to fogginess in the eyes, redness of the mucous membrane of the visual organ, as well as burning in the eyes and severe tingling;
If nicotine is taken incorrectly, blood sugar increases or decreases. The patient’s body reacts to this drug individually, but after stopping taking medications with nicotinic acid for atherosclerosis, blood sugar is restored within normal limits.

If a medication with nicotinic acid is prescribed for the drug therapy of systemic atherosclerosis for the first time, a decrease in the blood pressure index can be observed.

But the pressure returns to normal levels after a few days from the moment of taking it.

All negative effects on the patient’s body manifest themselves when the maximum permissible doses are used in treatment.

Hyperemia

Liver damage

Gout

Adverse reactions

It is prohibited to take nicotinic acid if you have a gastric or duodenal ulcer in the acute stage. During remission, the vitamin can enter the body only with the drug Enduracin and its analogues. They contain substances that protect the mucous membrane of the digestive organs from the effects of acid.

Although niacin clears the body of cholesterol and speeds up metabolism, it increases appetite, which can lead to weight gain. It is quite easy to avoid this if you eat a healthy diet and exercise. It is also recommended to include foods rich in vitamin B15, milk and cabbage dishes in your diet.

When taking products containing niacin for the first time, adverse reactions may occur in the form of skin flushing, urticaria, and a drop in blood pressure. These phenomena are absolutely safe for health and soon go away on their own, without the use of medications. People with hypotension should be careful, as even a slight decrease in pressure can lead to fainting. If you initially take the drug in small quantities and gradually increase the dose, adverse reactions can be avoided.

Individuality of taking medications

At the initial stages of treatment of systemic atherosclerosis with the drug nicotinic acid, it is necessary to constantly donate blood to measure blood glucose and liver enzymes.

Niacin has a positive effect on the body and helps prevent the progression of atherosclerosis, but the drug with nicotinic acid is not well tolerated by patients, especially by elderly patients.

Many elderly patients experience glucose tolerance, which, when taking this medication, can negatively affect the performance of the endocrine system.

Also, women experience strong hot flashes, men also feel such hot flashes during the treatment of atherosclerosis, but their frequency and intensity are much less.

Those patients who are treating atherosclerosis with nicotinic acid and feel constant hot flashes and they bring severe discomfort to life refuse therapy with medications of this pharmacological group.

When used in the treatment of atherosclerosis, nicotine can significantly reduce the blood pressure index.
In order not to reduce blood pressure very strongly and sharply, the doctor prescribes a dosage of no higher than 50.0 - 60.0 milligrams per day.

Gradually, the body gets used to the components of the drug, and the dosage increases to 4.0 - 5.0 grams per day. After the prescribed dose of 5.0 grams, constant monitoring of blood parameters - cholesterol and glucose, as well as blood pressure and liver transminases - is prescribed.

If liver enzymes are activated above normal, then the dosage is reduced and atherosclerosis is treated with a dose of nicotinic acid within 2.0 grams per day. Treatment of atherosclerosis lasts 60 days, then a break in therapy is taken for six months.

The diet should be maintained during the medication course and should not be stopped during the break.

The most important

Atherosclerosis of cerebral vessels is a serious pathology that can lead to serious consequences. If an attack of cerebrovascular accident caused by atherosclerotic plaques in the cerebral vessels is not removed, patients are at risk of a stroke. Various groups of medications will help to cope with the problem, and primarily drugs for activating cerebral blood supply, lipotropic agents, vitamins, and agents for lowering lipid levels. If you treat the disease comprehensively and consult a doctor in a timely manner, you can avoid the terrible consequences of atherosclerosis.

Nicotinic acid, vitamin PP or vitamin B3 is a unique substance that takes part in various types of metabolism in the human body. Everyone knows the beneficial properties of nicotinic acid, which, by the way, has nothing to do with tobacco. Benefits include improving liver function, gastrointestinal tract, lowering blood sugar levels, in addition, this vitamin helps heal wounds and ulcers. However, few people know that nicotinic acid is beneficial for blood vessels. It is this beneficial property of vitamin PP that we will talk to you about in our article.

Universal nicotinic acid: why is it prescribed in cardiology, cosmetology

The drug is used for the prevention and treatment of vitamin PP (B3) deficiency, atherosclerosis, spasm of the cerebral, coronary and peripheral arteries, and neuropathy. High doses and long-term use disrupt liver function and metabolic processes. It is recommended to include cottage cheese in your diet when using Nicotinic acid.

The benefits and harms of nicotinic acid

This medication has vitamin activity and is involved in the reactions of tissue respiration, the formation of proteins, fats and the breakdown of glycogen reserves in the liver and muscles. The presence of nicotinic acid in the blood accelerates the processes of oxidation and energy production. The main medicinal properties include:

prevention of progression of atherosclerosis;
improved blood flow;
expansion of peripheral, coronary and cerebral vessels;
reduction of manifestations of intoxication;
improving the functioning of the liver, stomach and intestines (in small doses);
acceleration of wound healing and ulcerative defects;
restoration of impulse conduction in nerve fibers.

Nicotinic acid is called an antipellagric agent, since its deficiency results in a complex of “three D” symptoms: skin lesions (dermatitis), persistent diarrhea (diarrhea) and dementia (dementia).

When taking high doses of the drug, redness of the skin of the face and torso, dizziness, hot flashes, numbness in the extremities occurs, with increased sensitivity to Nicotinic acid, blood pressure decreases significantly, a disturbance in the rhythm of heart contractions, nausea and vomiting, and persistent itching of the skin may occur. When examining patients who have been taking this drug for a long time, they find:

increased levels of glucose and uric acid in the blood;
fatty liver;
increased body weight associated with impaired carbohydrate and fat metabolism;
damage to the mucous membrane of the stomach, duodenum and small intestine.

One of the side effects is accelerated hair growth when applied externally. It is used by cosmetologists to treat baldness.

We recommend reading the article about the treatment of cerebral atherosclerosis. From it you will learn about the prescription of complex therapy, the effectiveness of the use of vitamins, fibrates and statins, the choice of drugs and symptomatic therapy.

And here is more information about the treatment of dyslipidemia.

Indications for use

Nicotinic acid is used to treat pellagra, and is also prescribed for prophylactic purposes in conditions that may be accompanied by hypovitaminosis of vitamin PP:

strict diets, monotonous food;
parenteral administration of nutritional mixtures;
decreased secretion of pancreatic enzymes;
disruption of absorption processes in the intestine;
sudden weight loss;
gastric resection;
hereditary pathology with insufficient absorption of tryptophan (Hartnup disease);
nonspecific ulcerative colitis;
enteropathy, enerocolitis;
recurrent diarrhea;
long-term infectious diseases;
acute and chronic inflammatory liver diseases;
malignant neoplasms;
increased thyroid function;
constant stress.

During pregnancy and lactation, nicotinic acid is used with caution, but it can be prescribed to women during such periods with smoking, drug dependence, and multiple births. This drug is part of the complex therapy of atherosclerosis, ischemia of the brain and lower extremities.

Nicotinic acid is indicated for obliterating endarteritis, polyneuropathy, Raynaud's disease, spasm of blood vessels, biliary tract, ureters, neuritis of the facial nerve, gastritis with insufficient production of hydrochloric acid, as well as for long-term non-scarring wounds and ulcers, alcohol and drug intoxication.

Why is it prescribed for cardiac problems?

Under the influence of Nicotinic acid, the production of low-density lipoprotein complexes, which provoke the development of atherosclerosis, decreases.

The anti-atherogenic effect is also manifested by the normalization of total cholesterol (after a month), triglycerides (on the first day of administration).

The level of high-density lipoproteins increases, which protect the lining of the arteries from plaque attachment.

A course of medication prevents the progression of myocardial ischemia and blockage of the arteries supplying internal organs.

This medicine is used to treat patients with heart disease also due to the following actions:

has a vasodilating effect;
activates systemic blood circulation and microcirculation;
prevents the formation of blood clots.

The drug is indicated for angina pectoris, especially with the vasospastic variant of its course, dyslipidemia, and angiopathy.

Use of tablets, intramuscular

You should take the tablets strictly after meals. Many patients, when taken on an empty stomach, experience severe redness of the skin and hot flashes, abdominal pain and heartburn. The prophylactic dose is 25 - 50 mg, and for pellagra it is increased to 100 mg. The maximum daily dose is 500 mg.

For some patients suffering from atherosclerosis, the doctor may recommend a gradual increase in dosage - from 50 mg after dinner with the daily addition of 50 mg to 2 - 3 g of Nicotinic acid per day, provided that it is well tolerated. The drug is administered intravenously for ischemic stroke, 1 ml of 1% solution per day. Droppers with medicine are prescribed daily or every other day in an amount of 10 to 15.

Intramuscular and subcutaneous injections can cause severe pain, so they are most often not used, replacing Xanthinol with nicotinate.

Contraindications

The use of nicotinic acid is not recommended for the following conditions:

increased sensitivity;
peptic ulcer;
liver failure;
gout;
urolithiasis disease;
malignant hypertension;
progressive circulatory failure.

There are a number of diseases for which this drug can be prescribed, but in small doses, short courses, under the constant supervision of a doctor, subject to laboratory monitoring of liver function. These include:

gastritis with preserved acidity;
hepatitis;
diabetes;
chronic alcoholism.

Large doses are prohibited for pregnant women and during breastfeeding. It should be taken into account that long-term treatment with Nicotinic acid (atherosclerosis, pellagra) should be carried out against the background of the inclusion of cottage cheese in the diet, prophylactic intake of Methionine, Espa-lipon, Essentiale or their analogues to protect the liver from damage.

We recommend reading the article about medications for the blood vessels of the head. From it you will learn about which drugs are best to take and when, about herbal preparations with complex effects and about contraindications that you need to know about.

And here is more information about what is better: fibrates or statins.

Nicotinic acid is used to improve metabolism, prevent the occurrence and progression of the formation of cholesterol plaques, especially if high blood cholesterol is combined with an increase in triglycerides.

The drug dilates blood vessels, improves blood rheology and inhibits the formation of blood clots.

Indicated for angina pectoris, spasms of the cerebral, coronary and peripheral arteries, as well as for patients who experience an increased need for vitamin PP.

Long-term use of high doses is accompanied by impaired liver function, so it is recommended to take hepatoprotectors and a diet with regular consumption of cottage cheese.

Watch the video about the effect of nicotinic acid:

Source: //CardioBook.ru/nikotinovaya-kislota-dlya-chego-naznachayut/

Use of tablets, intramuscular

Intramuscular and subcutaneous injections can cause severe pain, so they are most often not used, replacing Xanthinol with nicotinate.

What vitamins are needed for brain vessels

What food should contain and what vitamins should be present in it to improve the functioning and strengthen the blood vessels of the brain.

Vitamins and minerals related to antioxidants are of great importance for the brain. These vitamins include vitamin A, C, E, P, and selenium.

Vitamin P. Vitamin P or rutin belongs to flavonoids, which are considered one of the most powerful antioxidants, strengthens the walls of blood vessels, makes them elastic, reduces the fragility and permeability of capillaries. This vitamin can be found in black currants, red and black rowan berries, citrus fruits, green tea, beer, rose hips and other foods.

Vitamin C is also a powerful antioxidant, important for the production of collagen and some hormones, participates in hematopoiesis, and has anti-stress properties. This vitamin helps remove toxins from the body and normalizes metabolism.

Vitamin A and carotene (provitamin A), which is found in carrots, including carrot juice, cabbage, watermelons, cod liver and other products.

Vitamin E is an antioxidant found in many vegetable oils, nuts, legumes and other foods.

Vitamin D, which is better known as a vitamin essential for the skeletal system, prevents the development of brain tumors.

B vitamins make up a whole group of vitamins and are essential for brain function. We can highlight some vitamins of this group, the most important for the blood vessels of the brain, and primarily vitamin B12, but they work best in combination.

If we talk about the most significant vitamins from group B, then in addition to vitamin B12, these are vitamin B1, B2, B3, B4, B5, B6, B9.

Vitamin B1 or thiamine helps improve memory and coordination, relieves anxiety, depression, fatigue, and insomnia.

Vitamin B2 or riboflavin improves mental reaction, relieves drowsiness, weakness, and prevents headaches.

Vitamin B3 or nicotinic acid helps concentrate, improves memory, and gives vigor.

Vitamin B4 or choline plays an important role as a mediator in the brain, important for good memory and the development of intelligence.

Vitamin B5 or pantothenic acid ensures the transmission of impulses between brain cells and improves memory.

Vitamin B6 or pyridoxine is responsible for intelligence and memory, relieves irritability, anxiety and anxiety.

Vitamin B9 or folic acid relieves fatigue, apathy, and improves memory.

Vitamin B12 or cobalamin improves memory and prevents dementia. This vitamin is especially important for older people, as it can prevent the development of Alzheimer's disease.

L-arginine is an amino acid and improves the tone of blood vessels, mental abilities, and delays the development of Alzheimer's disease.

Alpha lipoic acid is an antioxidant and the only antioxidant supplement that can easily enter the brain prevents strokes.

Coenzyme Q10 stimulates cellular metabolism, is an antioxidant, prevents the formation of atherosclerotic plaques and can significantly improve brain health.

Flavonoids are a whole family of antioxidants that are present in fruits and vegetables and improve vascular tone.

Omega-3 fatty acids improve brain function and mood.

Phosphatidylserine is a phospholipid that stimulates brain cells and improves memory. Phospholipids can only be obtained by humans from food or in the form of dietary supplements; they are present mainly in meat and fish; some amounts are found in dairy products and some vegetables.

Iron is an important mineral involved in the transport of oxygen to cells, including brain cells. Lack of oxygen causes fatigue, drowsiness, and decreased productivity.

Magnesium is involved in more than 300 biochemical processes in the body and is necessary to maintain the functioning of the nervous system and regulate blood pressure.

Vitamins for cerebral atherosclerosis

Atherosclerosis is a condition where blood vessels become clogged with so-called atherosclerotic plaques. As a result, blood circulation is impaired due to blockage of blood flow to vital organs.

Atherosclerosis leads to many health problems, including dementia.

To reduce the risk of developing atherosclerosis, nutrition and its balance are of paramount importance. But we don’t always follow the rules and diet. To replenish the body with the necessary vitamins and minerals, you can use dietary supplements and vitamin complexes. What should they include?

First of all, antioxidants. These are vitamins with such properties, minerals, flavonoids.

Vitamin B3 – niacin can reduce the level of bad cholesterol in the body. It is often prescribed by doctors for this problem.

There are also a number of dietary supplements derived from plants that will help reduce the risk of developing atherosclerosis and assist in treatment.

Such dietary supplements should contain:

Vitamins B12 and B4

The diet should contain more fresh vegetables and fruits, grains, legumes, unrefined oils, nuts, and seeds. Trans fats should be avoided

Vitamins for brain vessels names

Almost all well-known manufacturers of vitamin preparations and supplements have vitamins for the brain in their line. Therefore, it makes no sense to list the names of these vitamin complexes. Any pharmacist will recommend them to you.

Among the cheap domestic drugs, ascurutin should be noted. Ascurutin is a vitamin complex that includes rutin and ascorbic acid, i.e. vitamin C. It is often prescribed to strengthen blood vessels.

The dietary supplement “Ginkgo Biloba” is not in short supply and is sold in almost every pharmacy. There are more expensive supplements that include the extract of this plant.

Of course, taking vitamins and dietary supplements alone will not completely get rid of the problem. An important role in the normal functioning of the brain is played by nutrition, daily routine, giving up bad habits, and regular physical activity.

Disturbances in the normal functioning of the brain lead to headaches, unreasonable fears, and depression.

And vitamins can only help maintain health, memory and a clear mind for many years.

Sources:

http://www. sportobzor. ru/vitaminy-i-mineraly/nikotinovaya-kislota-dlya-sosudov. html

http://otzovik. com/review_2940843.html

http://ekolekar. com/vitaminy-dlya-sosudov-golovnogo-mozga. html

Indications

Indications for the use of nicotinic acid are the following conditions:

High level of atherogenic substances in the blood: cholesterol, high-density lipoproteins, triglycerides;
Lack of nicotinic acid in the body;
Gastrointestinal motility disorders, intestinal malabsorption syndrome and other gastrointestinal diseases;
Neuritis of the facial nerve;
Cardiovascular diseases;
Ischemic cerebral circulatory disorders;
Dermatitis, pellagra;
The body’s increased need for niacin during cancer, pregnancy, infectious diseases, stress, etc.

Vitamins for brain vessels

Our modern, active lifestyles often involve hectic work schedules and intense emotional stress. Modern people are much more and more often exposed to various stressful situations than our grandmothers. Stress, irritation, depression, anxiety have become inevitable and practically the norm for many people. All this naturally puts a lot of stress on the brain. Therefore, in addition to rational, proper nutrition, a modern person must additionally take vitamin complexes for the blood vessels of the brain. What vitamins and minerals must be in such complexes that will help strengthen the blood vessels of the brain and help it cope with heavy loads, protect the brain from degradation and aging.

Vitamins are involved in many processes occurring in the human body and are extremely important. For proper functioning, it is necessary to saturate it with the necessary vitamins, including for normal brain function. A person receives most of the necessary vitamins from food. But, unfortunately, situations in life are different. Our diet is not always balanced. Often, many people simply snack on the go, whatever comes to hand, so to speak. This affects not only the brain, but the entire body as a whole.

Nicotinic acid for high blood pressure

Nicotinic acid (vitamin PP, vitamin B3, nicotinamide, niacin, antiallergic vitamin) is a pyridine derivative, participates in redox processes, the metabolism of fats, purine bases, is part of the enzymes of cellular respiration, glycolysis, protein synthesis (NAD, NADP), promotes the breakdown of nutrients in the intestines, stimulates the production of thyroxine, reduces blood glucose levels and activates the adrenal glands.

Insufficient amounts of the vitamin cause pellagra (damage to the skin, gastrointestinal tract, dementia). The daily requirement of an adult for vitamin B3 is 15-20 mg.

Vitamin PP is found in high concentrations in yeast, nuts, tomatoes, fatty fish, dairy products, and meat.

Nicotinic acid (NA) provokes the release of prostacyclin (Pg I2). This is a local hormone produced by the endothelium of the vascular wall, which affects the tone of smooth muscles and reduces platelet aggregation.

The vasodilatory effect is most pronounced in the heart, kidneys, brain and lungs.

This is due to the uneven distribution of pyridonucleotides in organs (from largest to smallest - liver (depot) > brain > myocardium > kidneys > skeletal muscles > red blood cells).

The coenzymes NAD and NADP are vital for all types of metabolism. The process of transformation of NAD into NADP and vice versa is accompanied by the release of 150 kJ/mol of energy necessary for cellular metabolism.

Patients suffering from hypertension experience generalized vascular spasm, proliferation of the smooth muscle layer and thrombus formation. The lumen of blood vessels, especially the heart and kidneys, also narrows, and oxygen supply to tissues decreases. In response to hypoxia, minute blood volume increases due to increased blood pressure and increased heart rate.

Prostacyclin blocks this link in the pathogenesis of hypertension, but it undergoes rapid breakdown into inactive metabolites. Therefore, the effect of administering nicotinic acid is short-term.

By activating fibrinolysis, nicotinamide improves microcirculation of heart tissue, reducing the load on the myocardium. Vitamin PP affects lipid metabolism - it blocks the synthesis of very low density lipoproteins (VLDL) by hepatocytes, reduces cholesterol and triglyceride levels. Normalization of the lipid profile inhibits the development of atherosclerotic plaques that narrow the lumen of blood vessels.

In hypertension, nicotinic acid reduces blood pressure by inhibiting excitation processes in the brain, which eliminates the stress component of the pathogenesis of the disease.

Due to its ability to improve microcirculation and cerebral blood flow, nicotinic acid is widely used in intensive care for acute ischemic cerebrovascular accidents.

Is the drug used for arterial hypertension?

The vasodilating effect of administration lasts no more than 20-25 minutes (acid half-life is 40 minutes), which does not allow routine use of the medicine for high blood pressure.

Nevertheless, it is advisable to include it in the complex therapy of patients with hypertension in combination with:

obliterating atherosclerosis or endarteritis;
diabetic or hypertensive angioretinopathy;
trophic changes in the skin;
hypertensive encephalopathy;
chronic cerebrovascular insufficiency, a history of transient ischemic attacks;
IHD;
atherosclerosis, hyperlipidemia;
liver dysfunction, cirrhosis;
chronic cephalgia and migraine.

How nicotinic acid is used in the treatment of hypertension: doses and course duration

Nicotinic acid is available in the form:

ampoules with 1% solution of nicotinic acid, 1 ml;
powder for injections;
tablets;
“Sodium Nicotinate” solution 0.1%;
extended-release tablets – “Enduracin”;
combination drugs - “Nikoshpan” (“nicotine” with “Drotaverine”).

The dosage of the drug is individual for each case.

Tablet forms should be taken after meals, starting with low doses and gradually increasing them over three to four weeks until therapeutic doses. The starting amount is 50-100 mg twice a day.

To treat atherosclerosis, high doses of the drug (1-3g/day) are used. If there are no adverse reactions, take 500-1000 mg of NK one time. Long-term use of nicotine can cause tolerance to the medicine. To prevent such reactions, a break of three to five days after a month of use is recommended. They also practice a course of treatment - four weeks on, four weeks off.

Injectable forms of vitamin PP are administered:

intravenously in a hospital setting, in a slow stream or drip;
intramuscularly (Nicotinamide and Nicotinate are less painful);
subcutaneously;
intradermally.

"Enduracin" releases the active substance over a long period of time, which creates a stable concentration of the drug in the blood. The initial dose is 500 mg/day per dose for 7 days, then 1000 mg in 2 divided doses for another week and, starting from the 3rd week, 1500 mg in 3 divided doses. The duration of the course is 1-2 months with a break of 4 weeks, then it is repeated for 2-3 months.

Contraindications to the use of nicotinic acid:

exacerbation of gastric and duodenal ulcers;
decompensated liver dysfunction;
type 2 diabetes mellitus with uncontrolled blood glucose levels;
gout, hyperuricemia;
metabolic syndrome;
advanced stage of atherosclerosis;
pregnancy and lactation period.

Possible side effects:

allergy;
feeling of heat on the skin, hyperemia of the upper body;
dizziness, orthostatic hypotension;
hyperglycemia;
paresthesia;
fatty liver degeneration (with long-term use of high doses in combination with other lipid-lowering drugs).

Recommendations for using nicotinic acid:

systematic control of glycemia, liver transaminases (ALT, AST), urea, uric acid;
to reduce side effects, take tablet forms with food;
separate the use of medication and the use of caffeinated drinks, especially hot ones;
the drug is incompatible with alcohol;
avoid visiting saunas and taking hot baths;
use with extreme caution in patients with rhythm disturbances taking nitrates, β-blockers and Ca2+ channel antagonists;
potentiates the effect of antithrombotic drugs;
it is recommended to increase the consumption of foods containing methionine (hard cheese, eggs, various types of fish, beef, turkey);
with long-term therapy, NC increases the consumption of ascorbic acid.

conclusions

Nicotinic acid is used for medical purposes and in cosmetology, dermatology, and trichology. By accelerating glycolysis, vitamin PP helps in weight loss.

The drug is not compatible with vitamins B1, B6, B12, theophyllines, salicylates, tetracycline, sympathomimetics and hydrocortisone.

The medicine should not be taken without prior consultation with your doctor.

Source: //cardiograf.com/terapiya/medicamentoznoe/nikotinovaya-kislota-pri-gipertonii.html

Review: Lekhim Nicotinic Acid Tablets - I didn’t expect it. with spasms of cerebral vessels

And so, in connection with the diagnosis - osteochondrosis and spasms of the blood vessels in the head, constant headaches and poor general health and inhibition, a neurologist prescribed a whole course of treatment for me.

One of the drugs is nicotinic acid.

The price of nicotine is simply ridiculous - for 50 tablets only 7.50 UAH. It's about the same as a bottle of still water.

The tablets are small, sour, and easy to swallow.

I took it 3 times a day, 1 tablet. But when I realized that I was forgetting to take it at lunch, I decided to switch to 2 in the morning, 1 in the evening. And then it all began.

There was a feeling that there was a tingling sensation on my face, like goosebumps on my body, then on my hands, I didn’t understand why or what it was connected with. I got scared, rushed to get an MRI of my head - everything was fine, and then my friend told me to look at the side effects. So, I reviewed a lot, well, every drug can have an adverse reaction, I’ve never had this before. The rush of blood felt very good, urticaria. Everything goes by quite quickly, but the feeling is not the most pleasant, I’ll tell you.

I began to pay attention to when this numbness appeared and came to the conclusion that it was after taking nicotinic acid. I won’t cancel it, just 1 piece again. I'll drink. So keep in mind that this happens.

I’ll show you a couple of photos of what happened to me in the morning after taking 2 pieces at once. It was as hot as a sunburn on my face, arms, neck and upper back. And “goosebumps”, itchy skin especially on the head.

Well, it's logical. After all, nicotinic acid is used in ampoules to accelerate hair growth and strengthen hair follicles by rubbing into the scalp, and they make hair sprays with it. It improves blood circulation and increases blood flow. Everything is clear, but since there are a lot of drugs, it was difficult to navigate.

Nicotinic acid for face and skin

Nicotine is a real find for those who care about their skin. Vitamin B3 takes part in almost all internal processes, which has a positive effect on the skin. The beneficial substance has a complex effect:

Gives the skin a natural tone and relieves signs of fatigue.
Effectively fights sagging.
Slows down the aging process.
Removes age spots.
Prevents the formation of subcutaneous tumors.
Removes excess water from the body - removes swelling on the face and body.
Effectively fights acne, acne and other skin inflammations.
Provides protection from harmful ultraviolet rays.
Normalizes sebum production.
Actively participates in the production of essential hormones.

Due to the unique effect of vitamin B3, it is often prescribed before plastic surgery. The substance makes the skin elastic and ensures rapid recovery after surgical intervention.

Features of application

Lipotropic medications such as cholite or vitamin B12 should be used simultaneously with the prescription of the vitamin, since one of the side effects of niacin is increased appetite and impaired weight control in patients. Control of physical activity and diet are also recommended, a set of physical exercises and a split diet with plenty of low-fat dairy products, vegetables and fruits, and control of the consumption of simple carbohydrates and fats are prescribed.

To avoid redness, itching and heat, you should take Aspirin at a dose of 325 mg simultaneously with taking nicotinic acid, with a difference of half an hour, while Aspirin is drunk first. You should also not drink hot drinks such as tea or coffee while taking the drug.

According to some data, the daily dose for lowering cholesterol should not be more than 2000 mg, since exceeding it is fraught with the development of toxic hepatitis. Additional monitoring of liver function is carried out and inclusion of “Methionine” or products that contain it, for example, cottage cheese, in the therapeutic list.

What foods contain nicotinic acid?

Vitamin B3, niacin, nicotinamide or nicotine is a unique substance that can be obtained not only from drugs, but also from various foods with proper nutrition. Most of it is contained in the following names:

Cereals, grains and legumes. These products contain all B vitamins. Anyone who eats side dishes and cereals from various cereals, grains and legumes every morning will never lead their body to a deficiency of nutrients. The highest levels of niacin are in split peas, buckwheat, beans, lentils, oatmeal, barley flour, barley, etc.
Nuts and dried fruits. This is an excellent way to comprehensively compensate for the lack of healthy fats and carbohydrates in the body. Nuts and dried fruits are great for those on a diet. If you have a deficiency of niacin, experts recommend paying attention to peanuts, sesame seeds, sunflower seeds, cashews, hazelnuts, pistachios, etc.
Mushrooms. It is not for nothing that this product is placed in a separate group. Mushrooms can boast a high nicotine content. The concentration depends on the variety. Therefore, experts recommend trying different types, not limiting yourself to the most common oyster mushrooms and champignons. The most vitamin B3 is found in porcini mushrooms, honey mushrooms, boletuses, russula, champignons, and chanterelles.
Dairy products. Many people are opponents of these products, which is supported by the opinion of some doctors that they are harmful to the gastrointestinal tract. But to maintain the balance of nicotinic acid, it would not be superfluous to eat a piece of hard/semi-hard cheese, snack on curd mass, condensed milk, yogurt or kefir.
Eggs. They contain an incredible amount of vitamins and microelements, including a lot of nicotinamide. Not only the usual chicken eggs, but also any other bird eggs, such as quail eggs, are suitable as its source.
Meat and meat products. There is definitely a place to roam here. If you cannot imagine your life without barbecue or baked chicken, then there will definitely not be any deficiency of nicotinic acid. The largest amount of vitamin is found in turkey, rabbit, chicken, beef and pork.
Fish and seafood. This is a great alternative for those who for some reason do not eat meat. The concentration of the beneficial substance depends on the selected product. Most of it is found in mackerel, Atlantic salmon, chum salmon, pink salmon, bream, herring, etc.
Fruits and berries. This category is relevant for vegetarians. If you lack vitamin B3, you should lean on dried peach, banana, pomegranate, cherry, melon, grapefruit, etc.
Vegetables and herbs. Fresh foods also contain a lot of vitamin B3. However, vegetables and herbs are not suitable for combating deficiency. The existing concentration is not enough, but for prevention you can add garlic, potatoes, spinach, turnips, broccoli, carrots, and rutabaga to your diet.

Interesting fact. Liquid dairy products have an interesting trend: the lower the fat content of kefir, fermented baked milk, and yogurt, the more nicotinamide they contain.