Does Detralex increase blood pressure? [Reviews ⋆ Analogs] Details about the influence

Pathogenesis of cerebrovascular accident in cervical osteochondrosis

Vascular compression
Vascular disorders are based on two main factors: compression of the spinal cord vessels (especially the vertebral and basilar arteries) and damage to the vasomotor center located in the medulla oblongata.

Compression of blood vessels in osteochondrosis is usually caused by the development of disc protrusion, intervertebral hernia and the appearance of osteophytes (bone spines). With gradual compression of the above-mentioned vessels that supply blood to the spinal cord and brain, compensation of blood circulation occurs due to developed collaterals. With acute compression, a picture of ischemic cerebral stroke may develop.

Damage to the vasomotor center causes disruption of the innervation of the entire circulatory system, including the brain. The tone of blood vessels is disturbed, their inner lining thickens, paresis of the microcirculatory system occurs, as a result of which metabolism slows down.

Clinical picture of vascular disorders in this pathology

Stages of vascular blood flow disturbance:

Initial (stage of dyscirculatory encephalopathy) - patients at this stage usually complain of dizziness, headache, decreased attention, tinnitus, unsteadiness of gait, increased fatigue, sleep disturbance. During the examination, the doctor reveals small manifestations of peudobulbar and spastic-atrophic syndrome.
Subcompensation (stage of pronounced neurological changes) - patients develop a significant impairment of mental activity (memory deteriorates, thinking is impaired, the ability to control actions and speech decreases, emotional lability, apathy, lethargy develops), a slowdown of all mental processes, disturbances in walking and the vestibular system (nausea , vomiting, dizziness), pseudobulbar, bulbar, amyotraphic and spastic-atrophic syndromes.
Decompensation (the stage of irreversible changes in the central nervous system) - at this stage, the symptoms of the disease reach their climax. Such patients can no longer care for themselves and require constant care.

Medicine “Detralex”: side effects

The use of the drug can cause damage to some body systems:

from the digestive tract: nausea, turning into vomiting, diarrhea, dyspepsia. Less common are cases of colitis;

Sometimes neurological disorders appear - headache, general malaise, dizziness

from the nervous system: pain in the head, dizziness, systemic malaise;
allergic manifestations: itching, rash, urticaria. In extreme and rare cases, angioedema has been reported.

There is no information about the occurrence of an overdose from the drug.

It is extremely rare to develop adverse reactions, these include:

dyspeptic symptoms;
the occurrence of vegetative-vascular dystonia.

If such conditions are identified, specific therapy is not required; it is enough to reduce the dose of the drug or temporarily stop taking it.

This drug is usually well tolerated by patients even after long-term use. However, if used incorrectly or due to the individual characteristics of the body, side effects can sometimes still occur in patients drinking Detralex. Most often this is nausea and vomiting. The patient may also feel pain in the epigastric region. Sometimes patients taking this medicine also develop diarrhea.

In some cases, the drug "Detralex" also produces side effects on the nervous system. This usually manifests itself in the form of dizziness. In addition, the patient's general health may deteriorate.

Most often, when taking Detralex, the side effects are not too obvious. If nausea or, for example, headache occurs, doctors do not even usually recommend stopping the course of treatment started with this medication. After some time, all unpleasant symptoms usually disappear. Only if you are allergic to any of its components.

Detralex does not cause any side effects on the heart during the course. It can have a negative effect mainly only on the gastrointestinal tract and nervous system. This drug does not affect other organs in any way.

These are the side effects and contraindications that the drug Detralex has. Unfortunately, studies of the effect of this drug on the body in case of overdose have not been conducted. In this regard, the product is considered relatively safe. However, if an overdose is suspected, the patient should still rinse the stomach just in case.

Indications for use

varicose veins of the legs;
varicocele (in men);
heaviness in the legs;
swelling of the lower extremities;
haemorrhoids;
nutritional disorders of the tissues of the lower extremities in people who suffer from diabetes;
ulcers on the lower extremities that develop due to tissue nutritional disorders;
thrombophlebitis. For thrombophlebitis, Detralex is prescribed to eliminate the symptoms of the disease, as well as stimulate blood flow and eliminate stagnation of blood and lymph;
prostatitis. Detralex for prostatitis is used as an adjuvant in complex treatment to normalize the outflow of blood and lymph, and relieve swelling in the affected area.

Does Detralex increase blood pressure?

"Detralex" is a drug made from plant substances, mainly flavonoids.

"Detralex" and blood pressure are frequent companions, but the use of the drug to treat hypertension is unacceptable.

The administration of the drug is preceded by hypotension, often with accompanying varicose veins, swelling of the extremities and hemorrhoids. The medicine is used for course therapy lasting from 1 to 2 months.

Method of action

Does Detralex increase blood pressure, and due to what properties:

the drug has a venotonic effect;
angioprotective effect is noted;
after taking the drug, the ability of veins to stretch decreases and vascular tone increases, this leads to the elimination of blood stagnation in the veins;
"Detralex" from pressure reduces the permeability of vascular membranes;
eliminates the tendency of capillaries to fragility;
enhances resistance functions;
improves the quality of blood microcirculation;
accelerates the flow of lymph throughout the body.

"Detralex" is a modern pharmaceutical medicine consisting of components of plant origin - flavonoids

With prolonged use, it reduces the manifestation of symptoms in chronic venous insufficiency. Mainly used to prevent ischemia of the extremities of functional origin.

The drug belongs to angioprotectors - this is a medicinal group that can improve vascular function. "Detralex" has an antioxidant effect due to the elimination of the unwanted effects of free radicals.

The presence of these substances in the body damages the membranes of blood vessels. The drug has an anti-inflammatory effect due to its ability to block the development of prostaglandins (substances that provoke inflammation).

Additionally, the drug restores blood flow in the capillaries and provides protection against thrombosis.

To a greater extent, the drug "Detralex" is excreted through feces (86%), and the remaining 14% is eliminated in the urine. The half-life cycle will take 11 hours. During its stay in the body, the drug is converted into metabolites, as evidenced by the presence of phenolic acid in the urine.

Doctors have doubts whether Detralex can increase blood pressure; most are inclined to believe that the effect occurs, but taking the drug only to normalize blood pressure is inappropriate. The effect on blood pressure is due to increased vascular tone, but the effect is low.

Special instructions:

in case of recurrence of hemorrhoids, the use of the drug "Detralex" is carried out only in combination with the use of other drugs to eliminate pathologies of the anal passage;
Do not exceed a 2-month course of therapy without a doctor’s prescription.
If there is no symptomatic effect from the drug, an examination by a proctologist is carried out and the method of treatment is changed;
When circulatory abnormalities occur in the veins, lifestyle must be reviewed to achieve maximum impact.
Doctors recommend avoiding exposure to the sun and not staying under it for a long time, avoiding standing for long periods of time and reducing body weight, especially if you are obese. You should take short walks and use compression garments to improve blood circulation.

Doctors recommend wearing compression garments in parallel with Detralex

Analogs

Based on the active components, complete analogues of the drug include “Venozol” and “Venarus”. Relative analogues, which have only partially similar composition, are Vasoket and Phlebodia 600.

The doctor has the right to replace Detralex with other venotonic drugs; this drug group includes:

"Ginkor Fort";
"Troxevasin";
"Venorutin";
"Antistax."

Price

The price offer of chain pharmacies for a small package is about 700 rubles, and for a large one – 1300 rubles.

pharmachologic effect

Detralex belongs to the pharmacological group of drugs that have capillary and vein-strengthening properties and contain flavonoids. The mechanism of action of the active substances of the medicinal product provides the following forms of pharmacological action:

normalization of the tone of blood vessels - veins, capillaries;
vascular protection;
strengthening the walls of blood vessels;
stimulation of microcirculation, especially in the extremities;
normalization of venous pressure;
decreased permeability of vascular walls;
improvement of lymph outflow;
normalization of blood rheology. The drug effectively thins the blood.

What kind of remedy is this?

Detralex is a strong drug that belongs to the group of venotonic and angioprotective medications. The main healing components are hesperidin (a group of ioflavonoids) and diosmin (a bioflavonoid).

They are both known to be of plant origin. The powerful medicinal effect of these ingredients is aimed at completely eliminating congestion of various etiologies, which can be traced in the vessels.

Constant use of this medicine significantly reduces the fragility of capillaries, and with the so-called systematic use, microcirculation in the smallest vessels significantly improves. Arteries, veins and capillaries become more flexible, and the outflow of lymph in the patient’s body also improves.

The pharmacological drug Detralex is presented in the form of yellow-pink tablets in a special film coating. About 75% of the active components of the drug are excreted by the body along with excrement. And the rest is released when the bladder is emptied.

As a rule, the process of complete elimination of the ingredients of the drug takes about 12 hours from the moment of administration. Metabolic processes associated with the absorption of the drug provoke the appearance of phenolic acid in the urine.

Detralex is an angioprotector that significantly improves the performance of the circulatory system.

It also has a strong antioxidant effect. As is known, the use of this product is an effective prevention of the appearance of free radicals, which significantly damage the integrity of the walls of blood vessels.

The medicine is also distinguished by its unique anti-inflammatory effect, which is based on preventing the appearance of prostaglandins (fatty physiologically active components). The flavonoids contained in its composition prevent the occurrence of blood clots and minimize the risk of sudden strokes. So does Detralex increase blood pressure or, on the contrary, lower it?

Instructions for use

The drug, as described by the manufacturer, is recommended to be taken orally with food. The prescribed dose is swallowed whole, without being crushed beforehand. You should drink enough water (at least 60 ml).

Method of use in the treatment of disorders of the venous and lymphatic systems

Therapeutic dose - 2 tablets per day. The daily dosage should be distributed as follows: one tablet in the morning (before lunch) and the second tablet in the afternoon (preferably in the evening). After 7 days of using the drug, they switch to the next course of treatment: 2 tablets per day once. The duration of administration (monthly courses are possible), method of administration and doses are selected individually and may differ from those recommended by the manufacturer.

Dosage regimen for hemorrhoids

The course of treatment for this pathology is as follows: 6 tablets per day (morning, lunch and evening), 2 tablets per dose for the first 4 days. The next 3 days - 4 tablets per day (in two doses). Treatment of the disease is continued with a maintenance dose of the drug - 2 tablets per day. The duration of the course of treatment during which Detralex should be taken depends on the degree and severity of the disease and is selected only by the doctor.

The importance of vitamins in osteochondrosis

Cervical osteochondrosis is considered to be one of the most insidious diseases. As it develops, the body is depleted, causing a person to become lethargic and open to new diseases. To restore immunity and fill the body with useful nutrients, doctors, in addition to medications to combat the main symptoms, prescribe taking vitamin complexes. In addition, many of the vitamins are involved in restoring natural regeneration processes, and some of the vitamins (group B) help calm nervous irritation, normalize the natural metabolism of calciferol and help eliminate edema.

Treatment of cerebral circulatory disorders in cervical osteochondrosis

Treatment of this syndrome depends, first of all, on the cause that caused it, be it a prolapsed disc or its complete rupture, and is aimed at how to improve blood supply to the brain in case of cervical osteochondrosis.

Surgical intervention consists of excision of the affected intervertebral disc (laminectomy), restoration of blood flow through the vertebral and basilar arteries; If necessary, angioplasty of these vessels is performed.

Drug therapy:

Antiplatelet agents and drugs that improve blood microcirculation - acetylsalicylic acid, clopidogrel, dipyridamole, pentoxifylline, chimes, thiotriazoline;
Diuretics and osmodiuretics - indicated for acutely developing process, help reduce cerebral edema (mannitol, furasemide);
Antioxidants – drugs that reduce lipid peroxidation and destruction of nerve cell membranes (vitamin E, Mexidol);
Neuroleptics - this group of drugs causes an antiemetic and sedative effect, reduces the degree of cognitive impairment, emotional disorders (aminazine, etaparazine);
Tranquilizers - suppress the emotional manifestations of cerebral circulatory disorders, improve sleep, reduce apathy, depression (seduxen, afobazole, meprobanate, phenozepam);
Antihypertensive drugs of central action (cardura, physiotens, reserpine) - effectively reduce pressure in the cerebral blood supply system, reduce cerebral edema;
Low molecular weight dextrans - promote blood thinning (hemodilution) and improve cerebral blood flow (reopolyglucin);
Calcium channel blockers (cinnarizine, stugeron) – prevent the entry of calcium ions into the nerve cell, thereby improving metabolic processes in it, increase the resistance of neurons to ischemic conditions, and eliminate cerebral vasospasm;
Nootropic drugs - improve metabolic processes in the brain, restore thinking, memory, speech, help the brain more easily tolerate ischemia and hypoxia (piracetam, fezam, citicoline, ceraxon, cerebrolysin);
Vasoactive substances - dilate brain vessels, improve cerebral blood supply and rheological properties of blood, outflow of venous blood, prevent aggregation of red blood cells and platelets (Cavinton, Vinpocetine, Ginkgo biloba, Tanakan);
Histaminergic drugs are synthetic analogues of the mediator histamine, activate histamine receptors in the inner ear, reduce the manifestations of vestibular disorders (dizziness, unsteadiness of gait), promote better conduction of electrical impulses along nerve fibers (betahistine, betaserc, vestibo);
Venotonics – improve intracranial outflow of venous blood, restore blood circulation in the microcirculatory system, have an angioprotective effect (phlebodia, diosmin, detralex);
Vitamin complexes - improve metabolic and energy processes in nerve cells, reduce brain hypoxia, promote the restoration of cognitive functions (cytoflavin, milgamma, neurobex).

Physiotherapy

Non-drug treatment methods are general preventive and are indicated for patients with cervical osteochondrosis during the period of remission of the disease. They include:

Lifestyle changes - first of all, quitting smoking and drinking alcohol, controlling arterial hypertension, hyperlipidemia, compensation for diabetes mellitus, diet, weight loss, reducing sedentary time, increasing physical activity;
Therapeutic gymnastics, including a set of specially selected exercises, morning exercises, dosed walking, running;
Swimming, yoga, Pilates;
Massage – classic, acupressure, vibration and so on.

Drugs for localizing the pathological process at the lumbar level

Osteochondrosis of the lumbar spine is manifested by the following symptoms:

chronic aching pain in the lumbar region and/or lower extremities;
feeling of body aches;
sensitivity disorders of the skin of the legs, periodic “tingling”;
chilliness of the lower extremities;
a sharp decrease in tolerance to physical activity.

All these symptoms are a consequence of the presence of an obstruction to blood flow at the lumbar level. Therefore, there is a need to dilate the corresponding vessels. For this purpose, as a rule, angioprotectors or biogenic stimulants that have a pronounced vasodilating effect are prescribed. Let's consider those that are most often recommended for use by patients.

Trental

The drug belongs to the group of angioprotectors, therefore, it has the ability to protect blood vessels from various types of adverse effects. In addition, Trental has the ability to expand pathologically narrowed vessels and optimize blood flow in their lumens. This medication acts primarily on arteries, arterioles and capillaries, therefore activating blood flow to tissues.

The active ingredient of this drug is pentoxifylline. There is another drug with the same name (Pentoxifylline). It can be considered as an analogue of Trental.

Trental is available in tablet form and also in solution form. In this case, patients suffering from lumbar osteochondrosis are more often prescribed to take the tablet form of the drug. The dosage is selected individually and usually involves taking Trental 2-3 times a day in the amount of 2-4 tablets. A combination of two dosage forms is also possible.

Contraindications include: pregnancy and lactation, individual intolerance to the components of the medication, internal bleeding of any location, including hemorrhagic stroke.

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Possible side effects include:

dyspeptic symptoms;
facial hyperemia;
heart rhythm disturbances;
headache;
dizziness;
expressed anxiety.

The cost of this medication in pharmacies in Moscow and St. Petersburg varies widely, depending on the number of tablets in the package, the dosage of the active substance, and also on the manufacturer. The price of 60 tablets varies between 450-2,000 rubles.

Release form and dosage composition

The presented medicine is produced in the form of specially coated tablets of 30 and 60 pieces in one package.
The main therapeutic properties of the drug are due to its main component - diosmin; one tablet contains about 450 milligrams. The molecule significantly increases the tone of the muscle layer of the vascular wall. As a result, the drug not only helps to improve hemodynamic parameters in the lower extremities, but also reduces inflammation during phlebitis. In addition to diosmin, the composition includes the following components:

hesperidin – about 50 milligrams;
magnesium stearate;
gelatin;
cellulose;
macrogol;
hypromellose.

The drug is available in tablet form, coated on the outside. Each dragee contains 2 active substances: diosmin (450 g) and hesperidin (50 g). Blisters are used to pack tablets, each containing 15 pieces. The cardboard packaging holds 2 or 4 blisters.

The active ingredients of Detralex are hesperidin and diosmin. This medicine is produced in the form of film-coated tablets. The active components of the drug are micronized. Therefore, they penetrate into the blood very quickly. These tablets begin to act within half an hour after taking them. After 11 hours, the medicine is excreted from the body in urine and feces.

The active substance of the drug "Detralex" diosmin has a beneficial effect on vascular tissue, reducing their permeability and strengthening. Doctors call ordinary vitamin P hesperidin. Its main purpose is to reduce the sensitivity of problem areas. This substance also relieves inflammation.

As auxiliary components, the drug "Detrolex" contains magnesium stearate, gelatin, talc, cellulose, macrogol 6000, sodium laurisulfate. These tablets are supplied to pharmacies and clinics in blisters. The latter are packed in cardboard boxes in twos or one. Each tablet of Detralex contains 450 mg of diosmin and 50 mg of hesperidin.

Detralex for hypertension

Is it possible to take Detralex for hypertension?

Doctor, hello. Almost three years ago I had a cava filter installed. I took warfarin, then switched to aspirin. Five months ago my legs began to swell. Now the swelling is absolutely terrible.

The doctor said that my vena cava filter was clogged and nothing could be done. Is this really true? Yes, I am many years old, but the whole point is that I still have a grandson in my arms and I need to somehow hold on for at least a little longer. Perhaps in Moscow they are performing operations to remove the filter. Filter "crown". I would be very grateful for.

Symptoms of cerebrovascular accident The human brain is a unique organ, the control center of all the capabilities of the human body. The functioning of neuronal brain cells requires a significant expenditure of energy, which the brain receives through the circulatory system. The structural features and anastomosis of the cerebral arteries, forming a closed circle of Willis, provide unique blood circulation in the “command post” and the intensity of metabolic processes. Due to circulatory disorders, atherosclerotic vascular lesions often result in a disproportion between the need and delivery of blood to the brain. In this situation. for example, even a slight change in blood pressure can lead to the development of ischemia of the area of the brain supplied by the affected vessel and then, through a whole chain of biochemical reactions, to the death of neurons.

Combating co-occurring disorders

The development of osteochondrosis in the neck occurs against the background of increased irritability of the patient. This is completely justified, since a significant part of the symptoms interfere with normal life activities and cause a strong feeling of discomfort. For example, for most people with advanced forms of the disease, it is very difficult to simply turn the head left and right. In addition, sleep often deteriorates sharply, the patient is in a state of chronic fatigue, and even with constant pain.

To restore peace of mind and relieve irritation from the nerve roots located in the area of inflammatory processes, sedatives are prescribed. In some cases, when the patient has a sleep disorder, sleeping pills are prescribed. For mild options, doctors usually use herbal ones - valerian, motherwort and various herbs.

If nervous irritation has developed into prolonged depression, then more serious medications may be prescribed: Gidazepam, Donormil and Barboval. (And also: Cavinton for cervical osteochondrosis).

If the patient develops partial numbness and muscle spasms, then relaxing medications are prescribed to combat these secondary manifestations of osteochondrosis in the neck area. With their help, tight muscles relax and blood circulation is restored. This group of medications includes Cyclobenzaprine, Tizanidine and Baclofen.

When the arteries are compressed, a sharp disruption of the normal blood supply occurs, which causes malfunctions in the functioning of internal organs. To correct the situation, the patient is prescribed to take vasodilators. With their help, blood circulation is restored, pain is reduced, inflammation and swelling disappear.

Ancillary drugs

The main drugs for the treatment of osteochondrosis are given above. However, the disease is not cured only with injections and tablets.

The following are known among the most effective auxiliary means.

Applying compresses with painkillers.
Therapeutic patches that are attached directly to the affected area.
The use of the method of oriental medicine - acupuncture, which directly affects the nerve centers.
Use of magnets. Despite the fact that Western medicine does not recognize this method of treatment, many patients use it to treat symptoms of osteochondrosis.

The first two methods still have some scientific basis and are often prescribed as part of a therapeutic complex that helps to quickly eliminate unpleasant symptoms during exacerbations of osteochondrosis. At the same time, the last two methods are considered quite extreme and do not always bring positive results, so you should not rely heavily on them and, at the same time, you should not believe everyone who promises to conduct a high-quality acupuncture session. (And also: signs of osteochondrosis of the cervical spine).

More effective will be traditional treatment, the complex of which consists of taking medications, taking massage courses, performing exercises in a physical therapy group, and so on. All these components are prescribed by the doctor after studying the structural features of the patient’s body and the specifics of developing osteochondrosis.

In addition, it will help you create a daily routine so that it includes a place for exercise and simple warm-up during working hours.

When fighting osteochondrosis, you can count on a quick recovery only when all the instructions of an experienced specialist are strictly followed. Moreover, the entire course of treatment should take place under the slogans of “consistency” and “regularity.” If there are interruptions in the process or it is abandoned at the first improvement in physical condition, then a new exacerbation of the disease can soon be expected.

Due to the specific nature of osteochondrosis, which can progress very quickly, the start of treatment should not be delayed if there are characteristic symptoms of the disease. Here it is necessary to remember that sometimes after the first signs appear, the disease tends to subside, but this does not mean that it has passed.

Once you start treatment, you should not independently make changes to the dosage of medications or add/exclude them from the list of required medications. In addition, it is necessary to monitor your reaction to all medications, as some of them can cause allergic effects.

We must not forget for a moment the importance of human health. As a result, fear and laziness, which are causing delays in going to the doctor, should be discarded

After all, such a disease of the cervical spine, when it becomes severe, can cause disability or even death, so it is worth treating it with full responsibility!

Does Detralex increase or decrease blood pressure?

Let's consider how Detralex acts on the human cardiovascular system: does it increase blood pressure or not, why is this drug needed and who will benefit from it?

Detralex is a venotonic drug of plant origin, used to normalize blood circulation and increase vascular tone. It is taken in courses lasting 1-2 months. Available in tablet form.

Composition and pharmacological properties

A drug from the group of venotonic and angioprotective agents. The main active components are hesperidin and diosmin, which are of plant origin.

These substances provide:

eliminating congestion in veins and blood vessels;
reducing capillary fragility;
increased microcirculation in small vessels;
removing excess fluid from the body.

When taking the medicine systematically, the plasticity of veins and blood vessels increases, and lymph outflow improves. Blood circulation is normalized, the risk of thrombus formation is reduced, and reliable prevention of the development of varicose veins, hemorrhoids, and thrombophlebitis is ensured.

Detralex normalizes the activity of the vascular system and promotes the elimination of toxins. Taking the drug provides protection against free radicals that reduce the tone of the vascular walls. In addition, the tablets have an anti-inflammatory effect, which is achieved by blocking the formation of prostaglandins.

Detralex is prescribed to eliminate:

pain syndrome;
convulsive attacks;
syndrome of heaviness, fatigue.

It is also used to treat manifestations of hemorrhoids and venous-lymphatic insufficiency, manifested by:

swelling;
changes in the skin of a trophic nature;
ulcerative lesions of veins.

About 80% of the drug's components are excreted from the body in feces, the remaining 20% in urine. It should be noted that during treatment, changes in urine test results are possible, since the drug provokes the appearance of phenolic acid.

Effect on pressure

Detralex has no effect on blood pressure. Taking it is not able to relieve hypertension or hypotension.

However, Detralex has a positive effect on the circulatory system, so it can be used additionally during therapy when surges in blood pressure occur against the background of impaired blood flow, edema, and blood clots.

The drug is prescribed to patients for the treatment of venous insufficiency and disorders of the lymphatic system. The components contained help eliminate pain in the limbs and eliminate the feeling of heaviness. The result of taking Detralex is an improvement in blood flow tone and a reduction in the distensibility of veins.

For hypertension and hypotension, the drug is prescribed only to eliminate unpleasant symptoms. It is not used to treat the underlying disease, since it does not help either lower or increase blood pressure.

Mode of application

The tablets are swallowed whole with plain water. If a person has venous-lymphatic insufficiency, 1 tablet of Detralex is prescribed in the morning and evening with meals. The duration of treatment is individual, depending on the severity of the disease. Can reach 12 months.

With the development of acute hemorrhoids, the daily dosage is 6 tablets/day. They are divided into 2 doses, drunk in the morning and evening with meals. This therapy lasts 4 days. Then the daily dosage is reduced to 4 tablets. For chronic hemorrhoids, Detralex is taken 2 times a day, 1 tablet.

Adverse reactions

Taking the drug may be accompanied by adverse reactions. Most often they are noted from:

central nervous system: dizziness, sleep disturbances, headaches;
gastrointestinal tract: stool disorders, dyspepsia, nausea, gag reflexes, intestinal spasms;
skin: rash, itching, hyperemia, angioedema (rare).

If adverse reactions occur, stop taking the medication. The patient needs to immediately consult a doctor and undergo laboratory tests.

Contraindications

Detralex is a herbal drug that has virtually no contraindications. Taking tablets is not recommended only for persons with hypersensitivity to the active or auxiliary substances of the drug, as well as for women during breastfeeding.

Source: //sosudy.info/detraleks-i-davlenie

What kind of drug is this?

"Detralex" is a drug that is part of the group of venotonic and angioprotective medications. The main healing elements of the pharmacological agent are hesperidin (a group of ioflavonoids) and diosmin (bioflavonoid), which are of plant origin.

The medicinal effect of such substances is aimed at eliminating the various etiologies of congestion in the veins and blood vessels. The use of the drug reduces the fragility of capillaries, and with systematic use, blood microcirculation in small vessels increases.

Veins and blood vessels become flexible, and the outflow of lymph in the body improves.

The pharmacological drug "Detralex" is presented in the form of yellow-pink film-coated tablets. More than 80% of the active substances of the drug are excreted by the body in feces, and the remainder is excreted during urination. The half-life is 11-12 hours.

Metabolism of the drug inside the body provokes the appearance of phenolic acid in urine. "Detralex" is an angioprotector that improves the functioning of blood vessels and is characterized by an antioxidant effect.

Taking the medicine prevents the formation of free radicals that damage the integrity of the vascular membranes. The anti-inflammatory effect of the drug is based on preventing the formation of prostaglandins (lipid physiologically active components).

The flavonoids included in the medication prevent the formation of blood clots and reduce the risk of sudden strokes, but do not affect blood pressure.

Indications, contraindications and application features

Features of taking Detralex for certain diseases are presented in the table:

Does Detralex increase or decrease blood pressure?

Taking the drug "Detralex" increases the tone and elasticity of blood vessels and capillaries.

The drug "Detralex" is prescribed to patients in the complex treatment of venous insufficiency and disorders of the functioning of the lymphatic system. The active herbal components of the medicine relieve pain in the limbs and reduce the feeling of heaviness.

Recommended for the treatment of hemorrhoids, and as a prophylactic against thrombosis. The result of taking the pharmaceutical drug is an increase in the tone of blood flow in the veins and a reduction in the distensibility of the veins.

Doctors consider it inappropriate to prescribe the drug “Detralex” for low or high blood pressure, because such a pharmaceutical does not affect blood pressure, it does not increase or decrease it.

Does Detralex increase blood pressure?

Pathologies of the cardiovascular system make up the majority of all diseases that can lead to disability or death. Inflammatory processes in the venous vessels of the lower extremities often occur even in young patients.

To prevent and treat these conditions, drugs from the venotonic group or drugs that have angioprotective properties are used. One of the substances that has the necessary effects and can also influence blood pressure levels is diosmin.

This molecule is contained in the drug “Detralex”; its properties, indications for use, adverse reactions and conditions for dispensing from pharmacies will be discussed in the article.

Detralex® 500 mg tablets

Release form and dosage composition

The presented medicine is produced in the form of specially coated tablets of 30 and 60 pieces in one package. The main therapeutic properties of the drug are due to its main component - diosmin; one tablet contains about 450 milligrams.

The molecule significantly increases the tone of the muscle layer of the vascular wall. As a result, the drug not only helps to improve hemodynamic parameters in the lower extremities, but also reduces inflammation during phlebitis. In addition to diosmin, the composition includes the following components:

hesperidin – about 50 milligrams;
magnesium stearate;
gelatin;
cellulose;
macrogol;
hypromellose.

These substances enhance the effect of the drug and also form a coating that prevents the tablet from dissolving in the proximal parts of the digestive system.

Contraindications for use

“Detralex” is a potent drug, and therefore, before prescribing it yourself, you should definitely undergo a full range of diagnostic tests with your doctor. Once a final diagnosis has been established, treatment can begin. Indications for use of the drug are the following conditions:

development of insufficiency of the vascular wall or valves of the veins of the lower extremities;

Why should you take Detralex?

complicated course of venous insufficiency, accompanied by the development of trophic ulcers;
prevention of phlebitis;
treatment or prevention of acute hemorrhoids of varying severity.

Use during pregnancy and breastfeeding

The molecules of the drug "Detralex" have a complex branched structure, due to which they do not pass through the placental barrier and cannot harm the developing fetus. The use of the drug in the third trimester is strictly prohibited; in earlier stages, its use is possible only in extreme cases .

Adverse reactions and overdose

Detralex is well tolerated by patients even after long-term use. The only contraindication to its use is the presence of an allergy to one of the components of the product. No cases of overdose have been reported either during clinical trials or after the drug was released onto the public pharmaceutical market.

It is extremely rare to develop adverse reactions, these include:

dyspeptic symptoms;
the occurrence of vegetative-vascular dystonia.

If such conditions are identified, specific therapy is not required; it is enough to reduce the dose of the drug or stop taking it for a while.

Interaction of the drug with other drugs

Clinical and preclinical studies have not revealed cases of possible interaction with various drugs.

Treatment of hemorrhoids with Detralex tablets

Detralex is not the only drug on the market containing diosmin. Cheaper analogues of the presented drug are:

Conditions of release and storage

It must be stored in a dark place, inaccessible to both children and direct sunlight, with a relative humidity not exceeding eighty percent and an air temperature within 15-25 degrees Celsius.

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Analogs

An analogue of Detralex for varicose veins, hemorrhoids and other pathologies is any of the following:

Avenue;
Venosmin;
Venarus is a Russian (domestic) analogue of Detralex;
Dioflan;
Venorin;
Juantal;
Normoven;
Nostalex.

Detralex does not differ from the indicated drugs in composition, but differs only in the manufacturer. Without loss of effectiveness, you can replace Detralex with any of the drugs listed above.

Means that have a difference in composition, but are characterized by an identical effect, are the following:

Antistax;
Anavenol;
Ascorutin;
Venolan;
Venorutinol;
Ginkor;
Hydrosven;
Venosmil;
Venoruton;
Diosven;
Indovazin;
Panthevenol;
Troxegel;
Troxevasin (release form - gel, capsules);
Troxerutin;
Phlebodia;
Phleboton.

Use during pregnancy and breastfeeding

During pregnancy, the drug is prescribed by a doctor based on determining the potential risk for the mother and fetus and the expected effect of use. Today there are no studies regarding the safety of Detralex during pregnancy and lactation. During some experiments, no teratogenic effects were found.

The molecules of the drug "Detralex" have a complex branched structure, due to which they do not pass through the placental barrier and cannot harm the developing fetus. The use of the drug in the third trimester is strictly prohibited; in earlier stages, its use is possible only in extreme cases.

Also, of course, this drug should not be taken by those people who are allergic to any of its constituent substances.

Another contraindication to the use of Detralex tablets, the side effects of which can actually appear in this case, is the lactation period. Whether the substance penetrates into breast milk and whether it can harm the baby - doctors, unfortunately, do not know about this. Research in this regard has also not been conducted.

It is not recommended for pregnant women to take Detralex only in the first trimester. However, during this period, the use of not only this drug, but also most others is prohibited.

special instructions

It is important to understand that this drug cannot replace the use of other drugs in case of acute and serious pathologies. In addition to drug therapy for venous diseases, it is imperative to follow non-drug measures to prevent diseases (rest more often, avoid overheating of the body, drink a limited amount of fluid and other doctor’s recommendations)

In addition to drug therapy for venous diseases, it is imperative to follow non-drug measures to prevent diseases (rest more often, avoid overheating of the body, drink a limited amount of fluid and other doctor’s recommendations).

It has been established that the medicine has no effect on the liver and kidneys. Therefore, in the presence of diseases of these organs, dose adjustment is not required.

The product does not affect the ability to drive vehicles.

Conditions of release and storage

Detralex does not cause severe side effects, and no cases of overdose have been identified. In this regard, the drug is in free circulation and is sold in city pharmacies without a doctor’s prescription. It must be stored in a dark place, inaccessible to both children and direct sunlight, with a relative humidity not exceeding eighty percent and an air temperature within 15-25 degrees Celsius.

The cost of the drug is one of its main strengths. The composition does not include hard-to-find or technically expensive components, making even long-term drug therapy accessible to all segments of the population.

Detralex tablets in packaging

Medicines are dispensed from pharmacies without a prescription.

The drug can be stored for 4 years. The product does not require special conditions for preservation; you just need to protect Detralex from falling into the hands of children. When the expiration date has expired, the use of the drug is prohibited.