Rfmk during pregnancy norm by week table

What it is?

SFMC (soluble fibrin monomer complex) is an indicator of the level of fibrin breakdown in the blood, which is responsible for the process of thrombus formation inside blood vessels. The test allows you to monitor markers responsible for blood clotting. During pregnancy, a slightly increased analysis rate is the norm, but when there are significant deviations that are several times higher than the norm, the expectant mother requires emergency treatment under the supervision of a doctor.

The hemostasis system during pregnancy combines a number of biological processes, which together make it possible to ensure the “normal” state of the blood and blood vessels. A blood test for RFMK evaluates the rheological properties of blood, which may be too thin or thick, viscous, which threatens the development of complex pathologies, including fetal death.

RFMKs are particles of blood clots, therefore, with an increased level of indicators, we can talk about the presence of thrombosis, increased blood clotting, as well as impaired blood circulation, which will negatively affect the course of pregnancy and fetal development. If the presence of pathologies of the hematopoietic system is suspected, the doctor may prescribe a detailed coagulogram, but most often pathological processes can be determined using the RFMC test and the D-dimer level, which determine physiological and pathological changes in the hematopoietic system.

During pregnancy, another circle of blood circulation appears - the uteroplacental, which allows you to provide the placenta and fetus with a sufficient amount of oxygen, nutrients and useful substances. The hemocoagulation system reacts to the emergence of a new blood circulation, which from the moment the baby is conceived is forced to work in new conditions.

It is during this period that a woman’s blood begins to change indicators that may exceed the permissible norm, but at the same time not harm the health of the mother and the unborn child. The increase in RFMC during pregnancy is explained by the fact that the expectant mother’s body is preparing for childbirth and possible blood loss. A pregnant woman takes a test for the RFMC level several times, and its indicators may change each time.

RMFC during pregnancy. Norms

Pregnancy changes the structural basis of a woman’s blood, its volume increases, and the processes of blood clots accelerate. Thus, the body prepares for possible blood loss during childbirth. The content of RMFC (soluble fibrin-monomer complex) increases.

Roughly speaking, RMFC are blood clots that occur in the human body during massive thrombosis or thromboembolism. This parameter is the main indicator by which the general condition of the blood vessels and blood components of a pregnant woman is determined.

Any deviation from the accepted parameters threatens to disrupt the functioning of the circulatory system. This could be either increased bleeding of blood vessels or their blockage. The norm is considered to be an indicator determined by trimester, but do not forget about the characteristics of the body. Often the figure of 8 and 9 mg/100 ml in the third trimester was an indicator of the individual characteristics of the body, and not a pathology.

What is hemostasis

One of the main tests for pregnant women is a hemostasiogram. The data from this study shows the state of the entire human blood system. Thanks to this study, the risk of miscarriage, fetal fading in the early stages, the likelihood of blood clots, etc. is determined.

Scientific terminology defines hemostasis as a biological system of the body that preserves the liquid properties of blood, and at the same time is responsible for the timely clotting of blood in case of possible blood loss. By balancing these two parameters, the hemostasis system in pregnant women is also responsible for the high-quality and timely supply of oxygen to the fetus, saturating it with the mineral components and vitamins necessary for full development. If there is an imbalance, when the RMFC during pregnancy exceeds the permissible norms, the developing fetus does not receive nutrients, which threatens its death or death.

In case of RMFC with low indicators that go beyond the norm, there is a threat to the mother; this can be bleeding, which leads to miscarriage in the early stages.

Violation of the norm occurs in women genetically predisposed to thrombosis, strength athletes, if maternal relatives have suffered a stroke or heart attack.

Normal indicators

At different stages of pregnancy, RMFC studies differ in their parameters. The norm for the first trimester is a maximum of 5 mg/100 ml, which corresponds to the blood test parameters of a non-pregnant woman. This is due to the fact that the placental-uterine circulation has not yet been created.

The second trimester determines the norm to 6.4 mg/100 ml. During this period, the blood vessels of the third circle of blood circulation are active, and blood viscosity increases.

By the middle of the third trimester, the development of the placenta stops, its aging processes begin, and the body prepares for labor. RMFC during pregnancy in the last months reaches the norm of 7 mg/100 ml.

Consequences of high analysis parameters

If the analysis reveals an excess from the norm above the critical one, this indicates that the processes of thrombosis and vein blockage have begun.

The consequences can be the most depressing:

• The heart muscle is under excessive stress. There may be disturbances in the functioning of the heart. Symptoms of the disorder may include frequent loss of consciousness, shortness of breath, dizziness, and heaviness in the chest area.
• The cardiovascular system ages rapidly. Swelling of the legs, swelling and puffiness of the face, and disturbances in kidney function are possible.
• For the future baby, any deviations from the norm are fraught with death or congenital pathology.

It is recommended to undergo appropriate tests before conception; when planning the birth of a new person, a woman should undergo a comprehensive examination, including with a geneticist who can identify genetic pathologies, for example, thrombophilia, which is one of the main causes of hemostasis disorders in pregnant women.

Source: sosudask.ru

Norm by trimester

Analysis of the level of RFMC during pregnancy consists of a whole set of blood parameters, each of which indicates the presence or absence of intrauterine abnormalities. This process is due to the fact that the activity of fibrin monomers increases along with platelets, which can cause increased blood clotting. Sometimes test results are lower than normal, but such conditions are much less common and are associated with taking certain drugs that affect the hematopoietic system.

Despite the fact that during pregnancy, increased RFMC is a normal and even necessary physiological process, there are still standards for thrombinemia markers, which should not exceed acceptable values.

First trimester - at this stage of pregnancy, the placenta has not yet formed, so blood counts are practically no different from blood counts in non-pregnant women. At this stage, a result from 3.38 to 5 mg/100 ml is considered normal. Sometimes the readings can be 5.5 mg/100 ml, which is also considered normal.

II trimester - the analysis values ​​slowly increase and amount to 6.5 mg/100 ml. An increased level indicates that the formation of the placenta is taking place, which by 16–20 weeks of pregnancy is formed and begins to function fully. At the same time, during this period, the uteroplacental and fetal placental blood flows begin to function, which increases blood viscosity.

III trimester - the level of RFMC reaches 7.5 mg/100 ml, and the closer to childbirth, the more it increases. The analysis is carried out at 28–34 weeks of pregnancy. An increase in indicators may be associated with aging of the placenta and increased blood viscosity.

The norm and deviation parameters may vary depending on the laboratory, because some of them use their own units of measurement for a given marker. That is why, having the test results in hand, you need to go to a doctor who can decipher them, determine the norm or pathology, and give useful recommendations.

In practice, a table of digital values ​​for the concentration of soluble fibrin-monomer complexes is often used, but only a specialist in the field of obstetrics, gynecology or a laboratory technician who conducts the study can decipher it.

If fibrin is elevated in the blood, a woman must undergo a repeat test and a number of other laboratory tests, and only when the picture is similar to the first results should treatment be carried out under the close supervision of a doctor.

What is RFMK

Participants in thrombosis - fibrin complexes

Soluble fibrin-monomer complexes (SFMCs) are components of blood plasma that are formed in the early stages of the process of thrombus formation. Thrombosis is a normal protective process that is activated in the human body when organs, blood vessels and soft tissues are damaged. Blood clots serve to block the lumen of a damaged vessel and quickly stop blood loss, which can be life-threatening.

But sometimes the process of blood clot formation starts in the body by mistake, often due to severe infectious diseases, when many breakdown products of tissues damaged by the disease appear in the blood. The body takes them as a consequence of an injury and begins the process of pathological (unnecessary in this case) thrombus formation.

At the very beginning of this process, fibrinogen (a protein constantly present in the blood) is activated and converted into two molecules of fibrin monomer. The appearance of these molecules in the presence of fibrinogen triggers a cascading process: the fibrin monomer “crosslinks” two molecules of its parent, fibrinogen, together. This is how FMCs are formed - fibrin-monomer complexes, which then combine with each other, beginning to create the framework of the future blood clot. It is a network into which special building cells for a blood clot - platelets - fall.

Normally, a blood clot forms at the site of injury and is immediately attached to the wall of the desired vessel. In the event of an erroneous start of blood coagulation, multiple unattached and very small blood clots, constantly formed from RFMK, begin to circulate through the vessels. They can easily block the lumen of small veins, arterioles and capillaries, damaging healthy organs.

Increased performance

A high level of RFMC in the blood plasma indicates the activity of the fibrinolytic system, which is responsible for the breakdown of clots in the blood. Sometimes the level of fibrin can increase due to a disruption of the cycle in the placenta, various malfunctions in its functioning, which entail a deficiency in the supply of nutrients to the fetus, and hypoxia. It is these pathological changes that can cause miscarriage, intrauterine fetal death and other serious conditions.

In addition, with increased RFMC during pregnancy, increased blood thickening occurs - thrombus formation. Blockage can form in large or small vessels, but regardless of its location, the blood circulation process will be disrupted, which will result in quite serious consequences.

Reasons for elevated levels

If RFMC levels in pregnant women exceed the established limit, then this becomes a serious cause for concern. This is especially true for women who have bleeding disorders or vascular problems.

Analysis of RFMC during pregnancy is no longer perceived as an additional or preventive measure, but is a mandatory examination to exclude possible complications.

If RFMK is increased to a significant level during pregnancy, then this may be caused by far from harmless factors. Let's take a closer look at why changes occur and what exactly causes deviations.

The main reasons for increasing the RFMK:

• pathological disorders of blood coagulation functions;
• the presence of thrombosis, especially if the vessels are in a state of narrowing;
• increased cholesterol levels, thyroid disease;
• hemorrhagic vasculitis - the disease is characterized by a high degree of bleeding resulting from inflammation of the blood vessels;
• injuries, damage to organs and tissues of a physical nature, causing increased production of platelets and RFMC high levels of indicators;
• before preparing for surgery;
• when planning conception using IVF, conducts a full range of tests, including examination to check normal values ​​and increased RFMC;
• in the presence of thrombophilia, this is a particularly aggressive pathology that creates a high risk of miscarriage.

Separately, it is worth highlighting DIC syndrome (disseminated intravascular coagulation syndrome).

This dangerous pathology can provoke many reasons for a significant increase in RFMC levels during pregnancy:

• injuries, infections, shock;
• neoplasms;
• prenatal toxicosis;
• purulent-inflammatory processes;
• cardiovascular and other chronic diseases, pathologies of autoimmune diseases.

During childbirth, all processes provoked by DIC can become uncontrollable, which can end very badly.

The risk of developing internal combustion engine requires constant monitoring and very frequent regular tests of indicators, especially if the RFMK is significantly increased. In the presence of pathology (or its signs), the RFMC indicator usually increases several times (3 times or more) and can reach a critical level. For example, in DIC syndrome, the RFMC value is 28 mg for every 100 ml, which means during pregnancy - this figure is 7 times higher than normal.

Only strict adherence to all doctor’s recommendations will help save the life of mother and baby. Ignoring this rule means causing harm with your own hands, first of all, to your own child.

How dangerous are deviations from the norm?

A blood test - coagulogram - is carried out for all pregnant women, without exception, since the results of the study can reveal the slightest deviations and pathologies in the development of the fetus and the course of pregnancy itself.

When RFMC levels during pregnancy are higher than the permissible norm, this may be a sign of quite serious conditions, including:

• Blood clot in the umbilical cord. This condition is a “sentence” for the fetus, which causes its death at any stage of pregnancy.
• Miscarriage.
• Early aging of the placenta.
• Placental dysfunction.
• Fetal hypoxia.
• Pathological birth.
• Intrauterine fetal defects.

As a rule, children who were born with elevated fibrin in the blood are very weak, weigh little, may have congenital pathologies, extensive damage to the central nervous system, heart defects and other serious conditions that threaten the child’s life. In order to reduce the risk of developing such pathologies, pregnant women need to regularly undergo laboratory tests, follow and listen to all doctor’s recommendations.

RFMK norms

Often patients who have received a referral for RFMC wonder what kind of analysis this is and what is the interpretation of the results obtained. In medical practice, there are universal standards that allow assessing blood clotting in patients.

According to experts, a negative result is the ideal value for an adult. Thus, with an ideal diagnostic result, fibrin should not be present in the blood.

The result is considered positive when fibrin appears in the patient’s plasma within 2.5 minutes. Using a specialized formula, doctors convert the specified time into a numerical analysis value.

The normal level of RFMC varies between 3.38 +0.02 mg per 100 ml. The limit value is 4 mg.

Note. When conducting a study, you need to take into account the reference indicators of a specific laboratory. Often the norm in individual medical institutions varies within the range of up to 5.0 mg/100 ml, causing unnecessary concern in the patient.

Violation of the norm during diagnosis indicates a violation of the hemostatic system, which is a clear sign of a blood clotting disorder. A patient with this result runs the risk of serious illness.

Which doctor should I contact to take the RFMC during pregnancy?

The RFMK blood test during pregnancy is routine and is prescribed by the gynecologist who is managing the pregnancy. In cases where the results exceed the norm, the doctor must prescribe additional homeostasis studies that will help confirm or refute the initial results of the examination.

In cases where a woman’s history includes diseases of the hematopoietic system, the doctor gives a referral to a hematologist who can identify the slightest changes and prescribe treatment.

RFMK norm

Before conceiving a child, the RFMC level is 3.5-4 mg/100 ml. The lower limit is arbitrary: a drop in the indicator occurs when taking certain medications (antiplatelet agents, anticoagulants). When reducing the RFMK, it is necessary to take into account the initial data, and not focus on the conditional norm.

In obstetric practice, the growth of complexes is important. The upper limit of normal is 4 mg/100 ml. This parameter is taken into account when planning pregnancy. An increase in RFMC is a reason for a targeted examination and consultation with a hemostasiologist. You need to visit a specialized specialist before conception.

During pregnancy, there is a physiological increase in fibrin-monomeric complexes. Their level depends on the gestational age:

• I trimester – up to 5 mg/100 ml;
• II trimester – up to 6 mg/100 ml;
• III trimester – up to 7 mg/100 ml.

When assessing the parameters of a hemostasiogram, it is worth taking into account the laboratory standards given on the form. Different approaches to studying the material lead to different interpretations of the results.

What to do?

If the level of RFMC is increased during pregnancy, the treatment tactics are determined by the doctor individually for each woman, based on the indicators and characteristics of her body. The main thing in treatment is the normalization of blood microcirculation in the uteroplacental system. Treatment mainly consists of taking medications to improve the process of blood clotting, thereby eliminating the risk of thrombus formation in the lumen of blood vessels.

In practice, the following medications are most often used:

• Heparin is one of the effective drugs that can reduce the level of RFMC. Doses and treatment course are determined by the doctor. As dynamics improve, the dose is slowly reduced until the drug is completely discontinued.
• Curantil is a safe drug for stabilizing blood clotting. Available in tablet form. The treatment course can take up to 3 months.
• Actovegin - if the marker is elevated, injections may be prescribed, which are administered intravenously or intramuscularly for 2 weeks. Afterwards you can switch to tablets.
• Folic acid is a therapeutic and prophylactic drug for normalizing the process of hematopoiesis. Taking the drug helps prevent the formation of blood clots and keep marker levels within acceptable limits. You can take folic acid throughout your pregnancy.

Any of the drugs used for elevated RFMC levels can only be prescribed by the attending physician and only after the results of additional studies. Therapy is determined individually and can take from several weeks to several months. Treatment is carried out both on an outpatient basis, for minor deviations, and inpatiently.

What determines the analysis of RFMC in pregnant women - the essence and methods of examination

During pregnancy, every woman's body is forced to work for two.
A number of significant changes occur in it: almost all systems and organs are rebuilt and adapted to the new physiological state. Also, the expectant mother has an additional, uteroplacental circulation. Because of this, the amount of circulating blood in the body increases, which, in turn, activates hemostasis processes.

Hemostasis is the body's reactions responsible for the state of the blood. They keep it in a liquid state, stop bleeding and prevent the formation of blood clots. During pregnancy, it is by the indicators of hemostasis that specialists learn how the fetus feels and whether the placenta is functioning normally.

Why is RFMC analysis needed during pregnancy?

Changes in hemostasis during pregnancy contribute to an increase in the level of soluble fibrin-monomer complex (SFMC - small particles of blood clots that form as a result of extensive thrombosis) in a woman’s body.

This is a normal phenomenon during pregnancy, but an excess or lack of fibrin can cause circulatory problems in the body. If the problem is not detected in time and you do not undergo blood-thinning therapy, the risk of premature birth or death of the child increases significantly.

In addition, this can lead to other negative consequences:

• dysfunction of the placenta or its early aging;
• abortion;
• fetal hypoxia;
• developmental defects;
• pathological childbirth;
• the formation of a blood clot in the umbilical cord - this, unfortunately, always leads to the death of the fetus.

That is why at this time it is so important to monitor the level of RFMC and, if any deviations are detected, to immediately take the necessary measures. The test for the RFMC norm must be taken several times during pregnancy. It is prescribed at different periods - 10, 11, 12, 13, 14, 15, 17-19, 22-28, 32-36 weeks and sometimes even later.

RFMC norms for pregnant women by trimester

There are certain norms for RFMC indicators in pregnant women. In cases where the analysis shows their increase or decrease, surgical medical intervention and correction with special drugs, which are prescribed exclusively by the doctor, are required.

What are the acceptable levels of fibrin in each trimester of pregnancy:

1. In the first trimester, the placenta is not yet fully formed, so the indicators are practically no different from the norms that occur in non-pregnant women. In the absence of pathologies, thrombinemia markers should not exceed 5.5 mg/100 ml of blood (in non-pregnant women - 5 mg/100 ml of blood).
2. In the second trimester, the levels increase slightly, normally up to 6.5 mg/100 ml of blood. This is explained by the fact that before 16 weeks of gestation, the placenta matures and begins to fully function. The work of the uteroplacental and fetal-placental blood flow also begins, which causes an increase in blood viscosity.
3. In the last trimester, levels can reach 7.5 mg/100 ml of blood. At this time, the placenta is already beginning to age and homeostasis, as if “anticipating” blood loss in the near future, begins to work in an enhanced mode.

In addition to the level of the soluble complex in plasma, other factors are also of great importance, including the so-called D-dimer. This is a protein that is formed during the breakdown of fibrins.

The level of D-dimer indicates the activity of the system that is responsible for blood clotting and the destruction of blood clots that form in it. The higher the indicator, the faster they appear.

Therefore, in most cases, doctors evaluate tests for RFMK and D-dimer in combination.

A doctor should decipher the tests, since different laboratories may use different units of measurement for these markers.

Possible reasons for changes in the level of RFMK

The level of soluble fibrin in the blood increases in cases where a person’s blood coagulation system is activated. The higher the value, the higher the risk of blood clots and blood flow problems.

It is very difficult to completely determine the reasons for changes in levels, but there are a number of diseases that are characterized by an increase in its levels.

These include:

• DIC syndrome;
• thrombosis;
• thrombophilia;
• liver pathologies;
• hypercoagulability syndrome;
• hemorrhagic vasculitis and others;

The following factors can also lead to blood flow disorders:

• heredity;
• burns;
• injuries;
• unauthorized taking of medications;
• bad habits;
• excessive physical activity;

How is biological material collected for analysis?

The collection of material for analysis occurs quite quickly: blood is drawn from a vein at the elbow joint. Research results, depending on the laboratory, can be obtained in 1-3 days.

In order for the analysis to show the most reliable results, the following recommendations should be followed:

1. Blood is donated on an empty stomach. The last intake of food and various liquids (juices, tea, coffee, etc.), except for purified still water, is allowed 8-9 hours before the test.
2. You should stop taking blood thinners and other medications 24 hours before the test.
3. Smoking and alcohol are prohibited (as at any other time and especially during pregnancy).
4. It is important to be rested and calm. Don't overwork yourself physically, avoid stress.

Violation of even one of these points can distort the data, which is why the doctor will not be able to make an adequate diagnosis and prescribe treatment.

What to do in case of deviations from the norm - doctor’s recommendations

What should be done if the indicators deviate from the norm?

First of all, treatment and prevention tactics depend on how high or low the indicators are. Sometimes, in cases where the condition of the expectant mother and child is not in danger, the doctor can simply monitor and, if necessary, prescribe treatment.

If RFMK is increased

If the level exceeds the norm, the blood plasma becomes very thick, which causes blood clots. Narrowing and blockage of blood vessels prevent the supply of oxygen and nutrients to the fetus, and this causes hypoxia, premature placental abruption, and uterine bleeding. The risk of miscarriage and antenatal fetal death also increases significantly.

Treatment in this situation is aimed at stabilizing blood flow in the uteroplacental circle and preventing the threat of miscarriage.

If the therapy prescribed by the gynecologist does not produce results and the level of fibrin monomer remains high, the woman is referred for consultation to a hematologist and geneticist.

In cases of a sharp increase in plasma viscosity several times, the patient is placed in a hospital, since there is a threat of interruption of the life of not only the fetus, but also the expectant mother.

If RFMK is lowered

Those cases when a pregnant woman's readings are below normal should also alert doctors, since this impairs the blood's ability to clot, which can cause bleeding and loss of a large amount of blood during childbirth.

Also, too low a level is fraught with premature placental abruption and the entry of amniotic fluid into the mother’s bloodstream, which leads to respiratory failure in the child.

In practice, low fibrin is quite rare: this happens when taking certain medications to treat varicose veins. They are eliminated from the body quite quickly, but if you take an analysis for RFMC during this period, the result may be underestimated.

To normalize the indicators, the doctor prescribes the use of appropriate medications aimed at stabilizing blood circulation.

Prevention measures

A pregnant woman must be aware of the seriousness of the situation and bear responsibility on her part so that the treatment brings positive results and the baby is born without complications.

Prevention of the problem lies in maintaining a healthy lifestyle. A pregnant woman should not smoke or drink alcohol. Sometimes, once every 2-3 months, the doctor may allow you to drink a glass of unfortified red wine to thin the blood.

The diet should contain fresh vegetables and fruits, but you should not get carried away with fatty, floury and high-calorie foods. If there is no swelling and a heavy load on the kidneys, you should drink more clean water.

To prevent complications, you need to regularly visit your doctor at the antenatal clinic, and always undergo all the necessary checks and tests.

Particular attention to monitoring the level of RFMC is paid if the pregnant woman has:

• phlebeurysm;
• purulent inflammation;
• diabetes;
• autoimmune pathologies;
• diseases of the cardiovascular system;
• neoplasms;
• gestosis;
• pathologies of the lungs, liver, kidneys;
• a significant increase in the level of RFMC in the early stages;
• recurrent miscarriage;
• placental dysfunction;
• bad habits.

Cases of multiple pregnancies and in vitro fertilization are also monitored with special care.

There is a lot of useful information about blood clotting in this video:

Conclusion

If your RFMC analysis shows a deviation from the norm, do not panic, but still be sure to consult your doctor and follow all his recommendations.

Source: https://AzbukaRodov.ru/analizy-i-obsledovaniya/rfmk-pri-beremennosti

Prevention

Prevention of elevated levels of fibrin-monomer complexes should be carried out long before the child is conceived. It consists of a correct lifestyle, maintaining a healthy diet, as well as timely treatment of all concomitant diseases that can provoke a violation of homeostasis.

During pregnancy, you also need to be careful about your health. Avoid taking medications, alcohol, and junk food. It is recommended to spend as much time as possible in the fresh air, avoid stressful situations, physical and psychological stress, and listen to all doctor’s recommendations.

The RFMC test is one of the few indicators of the internal health of the fetus and the course of pregnancy, so it must be taken several times throughout pregnancy. This will help significantly reduce the risk of all kinds of complications and help you carry and give birth to a healthy baby.

Author: Maryana Zyatik, doctor, especially for Mama66.ru

Analysis of RFMC: features of the procedure

When passing the RFMC test, the collection is carried out from the ulnar vein.

To obtain an accurate result of the RFMC level, patients are recommended to follow simple rules when preparing for the examination. Among them are the following:

Patients must refrain from eating 8 hours before the examination; a RFMC coagulogram must be scheduled in the morning on an empty stomach. Doctors also recommend limiting the intake of any drinks other than still water.

A few days before donating blood, the patient should refrain from physical activity and minimize stressful situations.

If the patient is taking medications that promote blood clotting, for example, anticoagulants, it is necessary to stop taking the drug one day before the test, as it affects the test result.

Reasons for changes in the level of RFMK

Soluble fibrin - a monomer complex in a blood test increases when the patient has activation of the blood coagulation system. The higher the value deviates from the norm, the more likely the occurrence of blood clots and intravascular coagulation.

Increased RFMK is a characteristic sign of a number of diseases. Among them are the following:

Thrombosis, or blockage of blood vessels by a blood clot - a person’s condition worsens significantly if the examination reveals a high cholesterol level. Fatty deposits in the area of ​​blood vessels impair blood flow.

Disseminated intravascular coagulation (DIC) syndrome (disseminated intravascular coagulation, or consumption coagulopathy) is a syndrome that causes the formation of microthrombi in the vascular area, complicating the movement of blood. Then the blood clots dissolve, but with an “inflection” towards hypocoagulation. After this, the body restarts the process of thrombosis. This “swing” cannot stop, and as a result, the plasma’s ability to clot is completely depleted. A serious defibrinolytic bleeding occurs that cannot stop.

Hemorrhagic vasculitis - the disease is accompanied by increased bleeding, which occurs through inflammation in the vessels.

Severe injuries - damage to organs and adjacent tissues causes excessive platelet production and an increase in monomers.

Often, the RFMC is increased not because of diseases, but because of the characteristics of the patient’s physiological state. What does this mean?

RFMK norms are affected by excessive physical activity and stress. The normal indicator “returns” when the psychological and physical state of the body is restored.

There are also patients whose analysis is higher than normal due to hereditary factors. In this case, specialists do not prescribe treatment.