Aprovel: instructions for use, indications, side effects

pharmachologic effect

Aprovel 150 mg or 300 mg helps lower high blood pressure.
It does not have a significant effect on heart rate. The maximum decrease in blood pressure is observed approximately 3-6 hours after a person takes the tablet in the prescribed dosage. The effect of the drug will be observed throughout the whole day. If one person takes 150 mg of the drug at once, and the other divides this dose into 2 doses of 75 mg, then they will both achieve the same therapeutic effect. Due to this treatment, the hypotensive effect will gradually develop over a period of 4 to 6 weeks from the moment of taking the first tablet.

If for some reason the patient is forced to stop taking the medication further, the effect achieved during therapy will continue to be observed for some time.

It is worth noting that this drug is not characterized by withdrawal symptoms.

The drug, along with its metabolites, is excreted from the body through urine and bile. "Aprovel" is used to treat those who have problems with the kidneys. With such violations, the pharmacokinetics of the drug does not change at all.

The peculiarity of the drug is the absence of a serious effect on heart rate

Use during pregnancy and lactation

There is no sufficient experience with the use of Aprovel during pregnancy. However, it has been established that in the second and third trimesters, ACE inhibitors can cause damage and intrauterine death of the fetus. In this regard, irbesartan, which directly affects the RAAS, is contraindicated for use in pregnant women of all trimesters. If pregnancy is diagnosed while taking the drug, treatment should be interrupted as soon as possible.

It has not been established whether irbesartan and/or its metabolites are excreted into breast milk, therefore Aprovel is also prohibited for breastfeeding women. If its use is clinically justified, breastfeeding should be discontinued.

Contraindications

The drug is prohibited from use:

People who have hypersensitivity to the drug and its components.
Pregnant and breastfeeding women.
For minors.
With hereditary galactose intolerance, lactose deficiency or impaired absorption of glucose and galactose.

In addition, under strict control, Aprovel is used for such pathologies and pathological conditions as:

Hypertrophic obstructive cardiomyopathy.
Dehydration.
Hyponatremia.
Hyperkalemia.
Dyspepsia.
Bilateral renal artery stenosis.
Unilateral stenosis of the only functioning kidney.
Chronic heart failure.
Cardiac ischemia.
Atherosclerotic lesion of the arterial vessels of the brain.
Kidney failure.
Hemodialysis.
Liver failure.

In addition, due to the lack of clinical experiments, the drug is used with caution in recent kidney or kidney transplants. A negative effect of the drug was also noted when used in conjunction with a diet that included limited consumption of table salt.

Indications for use

Doctors suggest that patients who show signs of hypertension take Aprovel, since this drug is highly effective compared to other similar medications. It improves the condition of patients suffering from the following diseases:

Nephropathy, which is accompanied by diabetes;
Essential type hypertension;
Arterial hypertension.

For arterial hypertension, the drug is used as one of the components of complex therapy, the effect of which is aimed at reducing high blood pressure. The medicine is recommended for nephropathy, as it has a positive effect on the condition of the kidneys, which suffer greatly in diabetes mellitus.

Instructions for use

The tablets are intended for oral administration. Aprovel does not need to be chewed. It should be taken with enough water. At the very beginning of treatment, it is recommended to limit the dose to 150 mg. It should be taken once a day before or after meals.

By adhering to the optimal dosage of the drug, you can control the daily level of blood pressure. In some cases, doctors recommend limiting the medication to 75 mg. Most often, this treatment regimen is offered to patients who are over 65 years of age or undergoing hemodialysis. Then their body will respond better to the medicine, since it will not be able to cause an aggressive reaction in them.

If it is not possible to achieve the desired treatment results with the help of a pharmaceutical product, the dosage of Aprovel will need to be adjusted. The daily dose will be increased to 300 mg. To enhance the effect of the drug, you may also need to take additional medication "Hydrochlorothiazide", which belongs to the group of diuretics.

150 mg per day is the optimal dosage of the drug for patients diagnosed with type 2 diabetes. You can gradually increase it to 300 mg. The last dose is the most preferred for patients with nephropathy.

The doctor will not be able to prescribe this drug to patients who have severe water-electrolyte imbalance. Before starting therapy, they will have to bring their blood volume back to normal. In some cases, measures are required that help eliminate obvious signs of hyponatremia.

If a person has impaired renal function, then changing the dosage regimen of the drug "Aprovel" is not necessary. He should stop at 75 mg per day. The same applies to patients in whom, during diagnosis, problems in the functioning of the liver were identified.

For elderly patients, the dosage is reduced

special instructions

After the first use of Aprovel, arterial hypotension may develop in patients with hyponatremia, dehydration or on hemodialysis.

When prescribing the drug to patients with renal failure, it is recommended to periodically monitor the level of creatinine and potassium in the blood serum.

Doctors do not prescribe the drug "Aprovel" to patients, among other things, if there is a violation of the water-electrolyte balance. Before starting to use the medicine, all such problems must be corrected with the use of other medicines.

If the drug is prescribed to a patient with renal failure, the physician should periodically monitor serum creatine and potassium levels in his blood. The same applies to individuals with hyperkalemia.

Treatment of patients suffering from coronary heart disease or atherosclerosis using this drug or its analogues should be carried out under strict blood pressure control.

Patients with improper functioning of the cardiovascular system or with severe renal dysfunction have an increased risk of developing acute hypotension, oliguria and increased nitrogen in the blood. With a strong decrease in blood pressure against the background of ischemia, myocardial infarction or cerebral vascular stroke may occur.

The drug is prohibited for use during pregnancy. Like other drugs that affect the renin-angiotensin-aldosterone system, irbesartan freely penetrates the placental barrier. The active component can affect intrauterine development at any stage of pregnancy. In this case, irbesartan is excreted in breast milk, and therefore it is necessary to stop lactation.

Use is not recommended for patients under 18 years of age, because there is no data on the effect of the drug on development in childhood and adolescence.

People over 50 years of age do not require additional correction of the daily intake.

Only 2% of the drug leaves the body through the kidneys, so people with kidney pathologies do not need to reduce the dosage.

In case of severe disruption of hepatocyte function, taking the drug is not recommended.

Interaction with other drugs

Treatment of patients with the active substance "Aprovel" irbesartan should be carried out under the supervision of a physician. Do not forget to inform the specialist about what medications the patient is already taking. The interaction of a drug with other medications does not always bring good results. Therefore, it is necessary to select for complex therapy exactly those means that are well suited to each other.

The interaction of Aprovel with other medications may be as follows:

Due to the fact that the drug is taken with other drugs with antihypertensive effects, its effectiveness is significantly increased;
If “Hydrochlorothiazide” is additionally introduced into the body in a minimal dosage, then the therapeutic effect of drug therapy becomes more pronounced;
The patient will experience severe dehydration if, before starting treatment with Aprovel, he underwent therapy that included taking diuretic medications. Against this background, the likelihood of developing arterial hypotension at the very beginning of the treatment course also increases;
The level of potassium in the blood will increase after taking the drug if the patient has to simultaneously take solutions containing this substance, as well as potassium-sparing diuretics;
An increased amount of lithium will appear in the blood if the patient is undergoing treatment in which the drug is used together with ACE inhibitors. This also includes products that contain this microelement;
There will be a sharp weakening of the effect of the antihypertensive drug and an increased risk of impaired renal function when taking Aprovel and angiotensin II antagonists simultaneously. NSAIDs also fall into this category. Adhering to such a treatment regimen, the patient runs the risk of acute renal failure;
It is allowed to take Digoxin during treatment with Aprovel, since the latter drug does not at all affect the pharmacokinetics of the first drug.

The patient should not take medications without agreeing on their inclusion in the therapeutic course with the doctor, as they can negatively affect the action of Aprovel and its effect on the body of a hypertensive patient.

Compatibility with other drugs and alcohol

Let's consider the interaction of Aprovel with other drugs:

Diuretics and other antihypertensive drugs. When antihypertensive drugs are used together, their action is potentiated. Despite this, Aprovel is used with beta-blockers, long-acting calcium channel blockers and thiazides. If we talk about the drugs of the above groups, then we cannot do without Hydrochlorothiazide, Amlodipine, Nifedipine, Verapamil, Diltiazem, Anaprilin.
Potassium supplements and potassium-sparing diuretics. The use of drugs of these groups, as well as drugs that increase the level of potassium in the blood serum together with Aprovel and other drugs that affect the renin-angiotensin-aldosterone system, can cause an excessive increase in the level of potassium ions in the serum. Among these drugs, the most widely used are: Spironolactone, Heparin, and its low-molecular derivatives.
Non-steroidal anti-inflammatory drugs. When Aprovel is used with drugs of this group, a decrease in the antihypertensive effect is observed. The most famous NSAIDs: Lornoxicam, Meloxicam, Nimesulide, Celecoxib.
Lithium preparations. When drugs of this group were used together with angiotensin-converting enzyme inhibitors, an increase in the toxicity of metal-based drugs was noted. Occasionally, an increase in side effects is observed when using lithium preparations together with Aprovel, which is why this combination is used only in rare cases and under strict control of the level of metal ions in the blood serum.

The combined use of Aprovel and alcohol, narcotic and other harmful substances is prohibited. This is due to the fact that the drug has an antihypertensive effect, while alcoholic drinks and the above drugs act in the opposite way and lead to an increase in blood pressure.

There have been cases where such a combination of substances led to a stroke.

Side effects

According to numerous clinical studies, the following possible disorders have been identified:

Heart rhythm disturbances;
Redness of the skin of the face;
Swelling of the limbs or throughout the body;
Dizziness and nausea;
Headaches of various types;
Attacks of nausea, often turning into vomiting;
Digestive and stool disorders;
Paroxysmal dry cough.

In some cases, men experienced erectile dysfunction, and women experienced decreased libido.

While taking Aprovel tablets, there may be side effects; you should inform your doctor if they occur.

Release form and composition

The dosage form of Aprovel is film-coated tablets: oval, biconvex, white or almost white, with an engraving of a heart on one side and the numbers 2872 (150 mg tablets) or 2873 (300 mg tablets) on the other.

Composition of tablets:

active substance: irbesartan – 150 or 300 mg;
auxiliary components: microcrystalline cellulose, lactose monohydrate, hypromellose, colloidal silicon dioxide, magnesium stearate, croscarmellose sodium;
film shell: carnauba wax, Opadry white (macrogol-3000, hypromellose, lactose monohydrate, titanium dioxide E 171).

Aprovel price, where to buy

You can buy it in many pharmacies in Moscow. The price of Aprovel in tablets of 150 mg No. 28 ranges from 599 rubles. up to 1409 rubles, and 300 mg tablets No. 28 - from 807 rubles. up to 1607 rub. In pharmacies you can also buy Coaprovel tablets 300 mg / 12.5 mg No. 28 at a price of 1557-2110 rubles.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine

ZdravCity

Aprovel tablets p.p.o.
150 mg 28 pcs. Sanofi-Winthrop Industrie RUR 555 order
Coaprovel tablets 300mg+12.5mg 28 pcs.Sanofi-Winthrop Industrie
RUB 813 order
Coaprovel tablets 150mg+12.5mg 28 pcs.Sanofi-Winthrop Industrie
RUR 621 order
Aprovel tablets p.p.o. 300mg 28 pcs.Sanofi-Winthrop Industrie
760 rub. order
Coaprovel film-coated tablets 300mg+25mg 28 pcs. Sanofi Winthrop Industry
RUB 815 order

Pharmacy Dialogue

Aprovel tablets 300 mg No. 14Sanofi-Winthrop Industrie
436 rub. order
Aprovel tablets 150 mg No. 14Sanofi-Winthrop Industrie
RUB 315 order
Coaprovel tablets 150/12.5 mg No. 28Sanofi-Winthrop Industrie
675 rub. order
Aprovel tablets 150 mg No. 28Sanofi-Winthrop Industrie
RUR 615 order
Coaprovel tablets 300/25 mg No. 28Sanofi-Winthrop Industrie
903 rub. order

Side effects

Side effects according to the frequency of development are classified as follows: very often - ≥ 1/10, often - from ≥ 1/100 to

The safety of Aprovel was studied in clinical studies that involved 5,000 people, including 1,300 patients with hypertension who received the drug for a period of more than 6 months, and 400 patients who received the drug for 1 year or more. Negative reactions were usually transient and moderate in nature. Their frequency did not depend on the age, gender and race of the patient, as well as on the dose of irbesartan.

In placebo-controlled studies, 1965 patients took irbesartan (for an average of 1-3 months). Discontinuation of therapy due to the development of adverse reactions was required in 3.3% of patients receiving Aprovel and 4.5% of patients receiving placebo.

Side effects reported in placebo-controlled studies in patients with hypertension treated with Aprovel that may be related to the drug, and those reactions that have not been proven to be related (frequency approximately comparable to that with placebo):

Adverse effects reported in controlled clinical trials (IDNT and IRMA 2) in patients with nephropathy, hypertension and type 2 diabetes mellitus treated with Aprovel (adverse reactions similar to those in patients with hypertension, with the exception of orthostatic symptoms):

The rate of discontinuation of Aprovel due to orthostatic symptoms was:

for dizziness – 0.3% (placebo – 0.5%);
for orthostatic dizziness – 0.2% (placebo – 0%);
for orthostatic hypotension – 0% (placebo – 0%).

Hyperkalemia in patients with arterial hypertension and diabetes mellitus occurred more often when taking irbesartan than when taking placebo. In the IDNT clinical trial, the rate of discontinuation of therapy due to hyperkalemia was 2.1% when taking Aprovel, 0.36% when taking placebo. In the IRMA clinical trial, this figure was 0.5 and 0%, respectively, for Aprovel and placebo.

Side effects noted during post-marketing use of Aprovel:

APROVEL (tablets)

pharmachologic effect

Selective antagonist of angiotensin II receptors (AT1 type).
Irbesartan does not require metabolic activation to acquire pharmacological activity. Angiotensin II is an important component of the RAAS and is involved in the pathogenesis of arterial hypertension, as well as sodium homeostasis. Irbesartan blocks all physiologically significant effects of angiotensin II, regardless of the source or route of its synthesis, incl. a pronounced vasoconstrictor effect and increased secretion of aldosterone, realized through AT1 type receptors located on the surface of vascular smooth muscle cells and in the adrenal cortex. Irbesartan does not have agonistic activity against AT1 receptors and has a much greater (more than 8500 times) affinity for AT1 receptors than for AT2 receptors (receptors not associated with the regulation of the cardiovascular system).

Irbesartan does not inhibit RAAS enzymes (such as renin, ACE) and does not affect other hormone receptors or ion channels involved in the regulation of blood pressure and sodium homeostasis. Blocking AT1 receptors with irbesartan interrupts the feedback chain in the renin-angiotensin system, which leads to an increase in plasma concentrations of renin and angiotensin II. After taking irbesartan in recommended doses, the plasma concentration of aldosterone decreases, without having a significant effect on the content of potassium in the blood serum (the average increase is <0.1 mEq/L).

Irbesartan has no significant effect on serum concentrations of triglycerides, cholesterol and glucose. Irbesartan does not affect the concentration of uric acid in the blood serum or the rate of excretion of uric acid by the kidneys.

The antihypertensive effect of irbesartan appears after taking its first dose and becomes significant within 1-2 weeks of administration, its maximum antihypertensive effect is achieved by 4-6 weeks of treatment. In long-term clinical studies, the antihypertensive effect of irbesartan was observed to persist for more than one year.

The antihypertensive effect with a single daily dose of irbesartan in doses up to 900 mg is dose-dependent. Irbesartan, when taken once a day in doses of 150-300 mg, reduces blood pressure, measured in a lying or sitting position at the end of the interdose interval (24 hours after taking a dose of irbesartan, i.e. before taking the next dose of irbesartan), by an average of 8 -13/5-8 mm Hg. Art. (systolic/diastolic blood pressure) compared with placebo. The antihypertensive effect of irbesartan before taking the next dose is 60-70% of the maximum values for reducing diastolic and systolic blood pressure. The optimal reduction in blood pressure within 24 hours is achieved by taking irbesartan once a day.

Irbesartan reduces blood pressure to approximately the same extent in a standing and lying position. Orthostatic effects are rare, however, as with ACE inhibitors, in patients with hyponatremia and/or hypovolemia, an excessive decrease in blood pressure with clinical manifestations is possible.

The antihypertensive effect of irbesartan and thiazide diuretics is additive. In patients with insufficient reduction in blood pressure during monotherapy with irbesartan, the addition of hydrochlorothiazide in low doses (12.5 mg) once a day to its intake leads to an additional decrease in blood pressure by 7-10/3-6 mm Hg. (systolic/diastolic) versus adding placebo.

The effectiveness of irbesartan does not depend on age or gender. As with the use of other drugs that affect the RASS, the antihypertensive effect of irbesartan in black patients is noticeably less pronounced, however, when irbesartan is used simultaneously with hydrochlorothiazide in low doses (for example, 12.5 mg / day), the antihypertensive response in black patients approaches effectiveness to that in Caucasian patients.

After discontinuation of irbesartan, blood pressure returns to its original level gradually. There is no withdrawal syndrome observed.

In the multicenter, randomized, active substance (amlodipine) and placebo, double-blind clinical trial IDNT, conducted in 1715 patients with hypertension and type 2 diabetes mellitus (proteinuria ≥900 mg/day and serum creatinine concentration in the range of 1.0-3.0 mg /dl) showed a 20% reduction (compared with placebo) (p=0.024) and a 23% reduction (compared with amlodipine) (p=0.006) in the relative risk of the first occurrence of any of the following conditions: doubling of serum creatinine concentration, development of end-stage renal failure or death from any cause (with a comparable reduction in blood pressure achieved when using irbesartan and amlodipine).

In a multicenter, randomized, placebo-controlled, double-blind clinical trial examining the effects of irbesartan on microalbuminuria in patients with hypertension and type 2 diabetes mellitus (IRMA 2), conducted in 590 patients with arterial hypertension and type 2 diabetes mellitus with microalbuminuria ( 20-200 mcg/min, 30-300 mg/day and normal renal function (serum creatinine concentration <1.5 mg/dl in men and <1.1 mg/dl in women), the effect of long-term treatment (for 2 years) with Aprovel was assessed ® on the progression of clinically significant proteinuria. When taking the drug at a dose of 300 mg / day, a reduction in the relative risk of developing clinically significant proteinuria (compared with placebo, p = 0.0004) was demonstrated by 70%, and at a dose of 150 mg - a reduction in the relative risk of developing clinically significant proteinuria significant proteinuria (compared with placebo, p=0.085) by 39%. A slowdown in the progression of clinically significant proteinuria was noted after 3 months and continued throughout the entire 2-year clinical study period. The decrease in creatinine clearance within 24 hours did not differ significantly between treatment groups. Regression of microalbuminuria to normal albuminuria levels (<20 mcg/min; <30 mg/day) was more often observed in the Aprovel® drug group at a dose of 300 mg (34%), compared with the placebo group (21%).

Drug interactions

The combination of Aprovel with aliskiren or ACE inhibitors leads to double blockade of the RAAS. The use of such combinations is not recommended, since the risk of a sharp decrease in blood pressure, impaired renal function and the development of hyperkalemia increases. The use of Aprovel simultaneously with aliskiren is contraindicated in patients with diabetes mellitus and renal failure (glomerular filtration rate 2 body surface). The use of Aprovel in combination with ACE inhibitors is strictly contraindicated in patients with diabetic nephropathy and is not recommended for all other patients.

Irbesartan may increase serum lithium concentrations and increase its toxicity.

In patients who received high doses of diuretics before Aprovel, hypovolemia may develop, and the risk of an excessive decrease in blood pressure when starting to take irbesartan increases.

Nonsteroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors, may weaken the hypotensive effect of angiotensin II receptor antagonists, which include irbesartan. In elderly people, patients with hypovolemia and patients with impaired renal function, NSAIDs can cause deterioration of renal function, including the development of acute renal failure. Usually these phenomena are reversible. In this regard, when using such a combination, careful monitoring of renal function is required.

There is experience with the use of other drugs that affect the RAAS, simultaneously with potassium-sparing diuretics, potassium-containing salt substitutes, potassium supplements and other drugs that can increase plasma potassium levels (for example, heparin). There are isolated reports of increased serum potassium concentrations. Taking into account the effect of irbesartan on the RAAS, when using Aprovel, it is recommended to monitor potassium levels in the blood serum.

With simultaneous use of other antihypertensive drugs, the hypotensive effect may be enhanced. Irbesartan was used in combination with thiazide diuretics, beta-blockers and long-acting calcium channel blockers without any undesirable effects.

Indications

hypertonic disease;
damage to the glomerular apparatus due to hypertension and problems with glucose absorption.
severe liver problems;
when taking the medication together with other antihypertensive medications for diabetes or severe kidney problems;
when using Aprovel with substances that slow down the enzymatic reaction in case of damage to arteries and arterioles due to diabetes;
when carrying a child;
during the period of breastfeeding;
patients under 18 years of age;
galactohexose intolerance;
insufficient amount of lactase;
with dextrose malabsorption syndrome;
increased susceptibility to the components present in Aprovel.
aortic stenosis;
hypertrophy of the wall of the left or right ventricle;
decrease in circulating blood volume;
a drop in the amount of sodium ions in the blood below normal;
impaired renal function together with severe hypertension;
chronic cardiac dysfunction;
a disease caused by the formation of atherosclerotic plaques in the vessels of the brain;
after a kidney transplant.

In accordance with the instructions, Aprovel is prescribed for the treatment of essential hypertension, as well as nephropathy due to type 2 diabetes mellitus and arterial hypertension.

The use of Aprovel is contraindicated in case of hypersensitivity to the components of the drug, pregnancy, hereditary galactose intolerance, impaired absorption of glucose and galactose, lactase intolerance, as well as during breastfeeding. The drug is not prescribed to children under 18 years of age.

The medication is prescribed with caution in the following cases:

IHD, hyperkalemia and renal failure;
Mitral and aortic valve stenosis;
Unilateral stenosis of the artery of the only functioning kidney;
Dehydration, hyponatremia and hypertrophic obstructive cardiomyopathy;
Following a diet with limited salt intake;
Vomiting, diarrhea and bilateral renal artery stenosis;
Stage III–IV CHF;
Atherosclerotic lesions of cerebral vessels;
Carrying out hemodialysis.

Aprovel is also prescribed with caution during previous treatment with diuretics in high doses, since the medication can increase the risk of arterial hypotension and lead to dehydration at the beginning of therapy.

The drug is intended for the treatment and prevention of high blood pressure as monotherapy or in combination with other antihypertensive medications (beta-adrenergic blockers, thiazide diuretics). Medical specialists prescribe Aprovel for nephropathy against the background of type 2 diabetes mellitus, accompanied by arterial hypertension. In such a situation, monotherapy is not carried out, but complex treatment to lower blood pressure is prescribed.

The drug is not recommended or prohibited for use in the following cases:

increased sensitivity of tissues to the structural components of the drug;
lactose intolerance, lactase;
malabsorption of monosaccharides - galactose and glucose;
severe liver dysfunction.

Due to the lack of adequate clinical studies, the medication is prohibited for persons under 18 years of age.

Due to the lack of adequate clinical studies, the medication is prohibited for persons under 18 years of age.

The drug is used with caution for aortic stenosis.

Aprovel is used with caution for coronary heart disease.

Carefully

Caution is recommended in the following cases:

stenosis of the aorta or mitral valve, renal arteries;
kidney transplantation;
IHD (coronary heart disease);
in case of renal failure, it is necessary to monitor the level of potassium and creatinine in the blood;
atherosclerosis of cerebral vessels;
salt-free diet accompanied by diarrhea and vomiting;
obstructive cardiomyopathy;
hypovolemia, sodium deficiency due to drug therapy with diuretics.

https://www.youtube.com/watch?v=vtgrQB789lU

Since this medicine is effective, doctors quite often prescribe the drug “Aprovel” to their patients. Its use is indicated for diseases such as:

essential hypertension;
nephropathy in type 2 diabetes mellitus and arterial hypertension.

In the latter case, Aprovel is usually prescribed by doctors as part of complex antihypertensive therapy. Doctors have noticed that this medicine can have a beneficial effect on the renal activity of patients with diabetes.

These tablets are also contraindicated for children and adolescents under 18 years of age. Of course, under no circumstances should you take the drug if you are hypersensitive to any of its components.

In addition, Aprovel is contraindicated for women who are pregnant or breastfeeding. You should stop taking it when planning a pregnancy. The analogues of the drug discussed above have the same contraindication. But there is also one on sale today, which is an exception to this rule, the substitute “Aprovel”.

essential hypertension; nephropathy in type 2 diabetes mellitus and arterial hypertension.

renal artery stenosis; low-salt diet; severe vomiting or diarrhea.

pharmachologic effect

In therapeutic doses, the drug helps to lower the concentration of the hormone aldosterone produced by the adrenal cortex. Having a comprehensive effect on the body, the drug does not affect the levels of potassium ions in the blood. In addition, the components regulate the functions of other hormone receptors and ion channels, which prevents surges in blood pressure.

After using the medicine, the level of cholesterol in the blood, as well as glucose, triglycerides and uric acid, is normalized. All these effects help control the activity of the heart muscle and normalize blood pressure to an acceptable level.

The effect of the drug lasts throughout the day. In order to control blood pressure on an ongoing basis, the drug must be taken daily, and the maximum therapeutic effect can be achieved after 4-6 weeks from the start of treatment. No cases of drug withdrawal syndrome were recorded.

Note. Along with analogue drugs, Aprovel tablets are considered quite fast-acting, since the maximum therapeutic effect is achieved 2-3 hours after consuming the recommended dosage.

Analogs

There are analogues of the drug "Aprovel", which in some situations can replace it. This happens when the prescribed drug is simply not suitable for a particular patient in terms of its composition or cost. It is not advisable to select a similar medication for yourself. This issue also needs to be discussed with a specialist. Only he can select the most successful drug, which will become a full-fledged replacement for Aprovel.

Most analogues of the drug are identical in their active substance. Therefore, they have a similar effect on the body of a hypertensive patient. Similar drugs include:

"Firmasta";
"Ibertan";
"Irsar";
"Converium";
"Walz"
"Irbesartan";
"Lozap";
"Irbesan."

Sometimes similar drugs, which differ from Aprovel in the active substance, are recommended to be taken together with it in one course. This applies to drugs such as Valz and Lozap. The first medication contains valsartan, and the other contains potassium losartan. Despite the difference, these drugs are no worse at reducing high blood pressure.

"Ibertan" is one of the most popular analogues of "Aprovel". They have the same active substance and the same pharmacological effect. The drug is marketed in the form of tablets of 75 mg, 150 mg and 300 mg. The main difference between medications is their auxiliary components.

Ibertan contains the same active ingredient as Aprovel

Another good analogue of the drug for the active substance is Irsar. It is sold in tablet form. When treating with this remedy, you must follow a special diet, which is based on limiting the consumption of salty foods and dishes. When used correctly, Irsar copes well with high blood pressure.

Analogues of Aprovel

Synonyms for the drug are the drugs Ibertan, Firmasta, Irbesartan and Irsar.

Analogs of Aprovel are such drugs as:

Atakand;
Blocktran;
Vasotens;
Diovan;
Zisakar;
Cardosten;
Losartan;
Micardis;
Nortivan;
Presartan;
Renicard;
Tareg;
Edarby.

Another item that needs to be looked at is Aprovel analogues. In some cases, the drug may either not be suitable for one reason or another, or may be too expensive. Therefore, we suggest looking at analogues of the drug Aprovel and discussing alternatives with your doctor.

The main active ingredient of Aprovel is irbesartan. Based on it, we will form analogues of Aprovel, including Russian variants. Among the analogues are:

Irbesartan;
Irsar;
Firmasta;
Irbesan;
Ibertan.

As you can see, manufacturers have given names that are consonant with the main component, which help determine the drug. The cost of each individual drug is different, as is the effectiveness, and therefore we recommend that before you start taking it, consult a doctor for advice on analogues of Aprovel, who will help you find any dosage - from 150 mg to 300 mg.

Ibertan;

Irbesartanum;

Firmasta;

Irsar.

Before deciding to replace the drug, you should consult with your doctor about the feasibility and effectiveness.

The drug "Aprovel" has received quite good reviews from patients. Many believe that today it is the best remedy in its group. But unfortunately, it is not always possible to find it in a pharmacy. If this drug is not available for sale, of course, you have to use its substitutes. If necessary, you can take an analogue instead of Aprovel:

"Ibertan."
"Irsar".
"Converium".
"Firmasta".

Sometimes, instead of this medication, patients are also prescribed Lozap or Valz. A generic version of this drug, “Irbesartan” (with the same composition, but not a brand name), is also available for sale today.

Among the structural analogues, the action of which is based on the active component irbesartan, there are drugs of both Russian and foreign origin. You can replace Aprovel tablets with the following medications:

Irbesartan;
Ibertan;
Firmasta;
Irsar;
Irbesan.

It is important to remember that before switching to a new drug, you must consult with your doctor. Self-replacement is prohibited.

The antihypertensive drug must not be taken simultaneously with alcoholic beverages.

You can replace Aprovel tablets with Irbesartan.

The drug is sold by prescription.

“Ibertan.” “Irsar.” “Converium.” “Firmasta.”

Instructions for use

The medication is taken exclusively orally (by mouth). The rules of administration and dosage are selected individually for each patient. The most common standards are:

The minimum therapeutic dosage at the initial stage of treatment is 150 mg 1 time per day.
In situations where no positive result from treatment is observed, the dosage is increased to 300 mg per day. You can take the medicine at one time or divide it into two doses of 150 mg. Taking additional medications, for example, a group of diuretics, significantly increases the effect of the drug Aprovel.
For patients with diagnosed diabetic nephropathy and high blood pressure, a gradual increase in dosage from 150 mg to 300 mg/day is a mandatory regimen that must be strictly adhered to.
In the case of kidney failure, the therapeutic dose, as a rule, does not require adjustment. However, if the patient is on hemodialysis, the rate of the active element is reduced to 75 mg/day.
Elderly people are initially prescribed 75 mg, and then the amount of the active substance is gradually increased.

The impact of active elements on the body regardless of food consumption. Therefore, the medicine can be taken both before and after meals. It is better to drink plenty of clean drinking water.

Important! If used incorrectly, Aprovel can cause an excessive drop in blood pressure to levels incompatible with life. Self-medication and self-adjustment of doses is strictly prohibited

The appointment should only be made by the attending physician.

Use during pregnancy

The analogues of this medicine, which we discussed above, which are made on the basis of the same substance, have similar instructions for use. But some of them still need to be taken a little differently than Aprovel. An analogue of this medicine, Converium, for example, is recommended to be taken in the morning before meals.

Of course, the substitutes for this drug “Lozap” and “Valz” with a different active ingredient have completely different instructions for use. The average daily dose of the former is 50 mg per day. For patients with chronic heart failure, this medicine is usually prescribed in an amount of no more than 12 mg per day. Valz is most often taken at 80 mg per day.

For chronic heart failure, this dose is reduced to 40 mg per day.

There are no clinical indicators or research results on the effect of Aprovel on a nursing mother and child. You should still stop using the medication during pregnancy, as in the later stages this can cause the death of the fetus or its abnormal development. The components of the drug can have a toxic effect on the unborn child, who has an increased sensitivity to all elements entering the body.

The medication is used regardless of the time of consumption of food, orally, with a small amount of water at a dosage of 150 mg. in a day. If the dose of medication turns out to be insufficient, then you can increase it to 300 mg. per day after consultation with your doctor. The duration of therapy is prescribed by the attending physician after collecting all tests and laboratory indicators, the average duration of therapy is from six to eight weeks.

The analogues of this medicine, which we discussed above, which are made on the basis of the same substance, have similar instructions for use. But some of them still need to be taken a little differently than Aprovel. An analogue of this medicine, Converium, for example, is recommended to be taken in the morning before meals.

Release form

The medication belongs to the group of receptor antagonists of the second group of angiotensin. It can be found on sale in tablet form. On one side they have an engraving. She depicts hearts. On the reverse side are the numbers 2872.

There are 2 types of medicine. They differ from each other in the dosage of the active substance. Some tablets contain 150 mg of this component, while others contain 300 mg. Thanks to this, doctors are able to choose the optimal course of therapy for the patient, which will help him cope with the disease, but will not cause any complications.

The drug is produced in different dosages

Overdose

The cardiologist is obliged to warn the patient about the consequences of an overdose of Aprovel. In such a situation, it is necessary to immediately call an ambulance for the person.

If you overdose on medication, you need to call an ambulance.

Before doctors arrive, you should try to induce vomiting in the victim and perform gastric lavage. These measures will help minimize the harm from an excessive dose of the drug. It is necessary to constantly monitor the patient's condition. If necessary, supportive and symptomatic therapy should be carried out, which will improve his general condition.

Manufacturers of the drug and doctors do not have detailed information about the form in which an overdose of Aprovel manifests itself. Although studies have revealed that the drug is not particularly toxic, even if taken for 2 months at 900 mg per day. So experts call antihypertensive pills relatively safe for the human body. However, they should be taken strictly according to the instructions of the cardiologist. If you read reviews from doctors, you can learn more about the rules for using the medication.

Price

It is difficult to say exactly how much you will have to pay for a package of Aprovel. Its cost varies depending on what factors influence it. The final price is determined based on the composition of the drug, the popularity of its manufacturer, the region where the sale takes place, and the pricing policy of the pharmacy.

On average, you need to pay 320 rubles for a package of 150 mg tablets. The drug 300 mg will cost about 460 rubles.

You can purchase the medicine at any pharmacy. If the cost of the drug does not suit the patient, he can always ask the doctor to find a cheaper analogue with the same effectiveness.

To buy tablets, you must provide the pharmacist with a prescription from your doctor. This measure is necessary to ensure that patients do not try to be treated with this medication without first consulting a cardiologist, as it can cause serious harm to health if used incorrectly.

Interactions with other medications

Complex therapy in combination with diuretics and other medicinal groups enhances the therapeutic effect, however, some features should be taken into account:

The combined use of the drug Aprovel with a group of NSAIDs helps to reduce the antihypertensive effect.
The combination of irbesartan and potassium-sparing medications may cause an increase in potassium levels in the blood.

If you ignore these specific features and use the drug incorrectly, there will be no therapeutic effect. In addition, this can lead to serious consequences that are life-threatening to the patient.

Aprovel can be prescribed with other medications, but has a number of peculiarities