Hepatrombin - effective treatment and prevention of hemorrhoids

Release forms

When released, Gepatrombin ointment and gel are packaged in 40 g quantities in aluminum tubes, the hole in which is closed with thin metal foil. The tube is equipped with a screw-on plastic cap with a device for piercing the protective membrane and is placed in a rectangular cardboard package with instructions.

Hepatrombin ointment and gel for hemorrhoids are produced with concentrations of 300 IU and 500 IU of heparin sodium salt per gram of ointment.

REFERENCE! 1 IU is an international unit (otherwise known as a unit of action) of the anticoagulant activity of heparin sodium salt, corresponding to 7.7 μg of substance II of the International Standard of Heparin (WHO).

Hepatrombin G ointment is produced in quantities of 20 g containing 65 IU of heparin sodium salt per gram of ointment. The drug is packaged in aluminum tubes similar to Gepatrombin ointment, only in a smaller size.

pharmachologic effect

Proctologists recommend using Gepatrombin for hemorrhoids as an antithrombotic, venosclerosing, decongestant, regenerative drug for hemorrhoids.

Gepatrombin G is a combination medicine with a medicinal composition:

Coloproctologist

• Heparin is an anticoagulant component that helps prevent plasma clotting in hemorrhoids. When treating external nodes, the ointment composition is aimed at preventing thrombus formation and resolving existing blood clots. The drug has anti-exudative and anti-inflammatory effects. The anti-exudative effect of the drug helps eliminate swelling of the mucous and perianal tissues.
• Prednisolone is a glucocorticosteroid component with the same effect as heparin. The substance helps relieve inflammatory processes, has an anti-exudative effect, alleviates general well-being, relieves itchy symptoms with burning, pain in the anorectal canal and perineum. Prednisolone prevents the occurrence of allergic reactions.
• Lauromacrogol - relieves disturbing symptoms, has a local anesthetic effect, scleroses hemorrhoids.

Compound

Gepatrombin ointment and gel have an active pharmacological effect due to the following contained in it:

• heparin sodium salt;
• allantoin;
• dexpanthenol.

Ballast substances included in the ointment:

• bronopol is used as a preservative;
• carbomer - as a thickener;
• mountain wax - gives the ointment plasticity;
• distilled water and other substances to create the required consistency of the drug.

Excipients included in the gel:

• carbomer is used as a gelling agent;
• levomenthol - creates a cooling effect;
• aromatic oil of mountain pine needles - a natural antimicrobial agent;
• aromatic oil of Scots pine needles – antiseptic;
• lemon aromatic oil – flavoring;
• distilled water.

The excipients of Hepatrombin Gel for Hemorrhoids 500 also include aromatic cedar oil.

Active ingredients of hepatrombin ointment for hemorrhoids:

• heparin sodium salt;
• prednisolone salt of acetic acid;
• lauromacrogol 600.

Auxiliary components:

• solid and liquid paraffins for the plasticity of the drug;
• lanolin - has a softening effect;
• silicon oxide in colloidal form - used as a filler.

Ointment analogues

There are no drugs similar in composition to Gepatrombin G ointment for hemorrhoids. But there are ointments and gels that contain the same active ingredients, for example:

• Hepatrombin. The active ingredient in it is heparin, as well as dexpanthenol, allantoin. Medicine is prescribed to prevent thrombosis;
• Venitan forte. The active substance is heparin, as well as horse chestnut seed extract. Used only for external hemorrhoids;
• heparin ointment. Also used for external hemorrhoids. Reduces pain and inflammation, but does not glue damaged vessels;
• Gepasolone. Suppositories are used for internal hemorrhoids. The composition contains heparin, lidocaine, prednisolone.

Hepatrombin G is the only drug of its kind that has a complex effect. There are many substitutes for this drug, but their composition is different. For example, Hemoral suppositories, Procto-Glivenol cream, etc.

The cost of Gepatrombin G ointment in Russia averages 250 rubles per tube weighing 40 grams. At the same time, Procto-Glivenol ointment costs 450 rubles per 30 grams, which is almost 2 times more expensive. The cost of Gepatrombin gel is slightly lower - 180 rubles, however, the effectiveness of this drug is lower, judging by patient reviews.

Scope of application and therapeutic effects

All medications discussed here should be used only externally , applied directly to the skin.

Gepatrombin G ointment can be used rectally, according to the instructions.

ATTENTION! Hepatrombin in any form is not suitable for oral administration, that is, orally.

The biologically active substances included in Gepatrombin ointment and gel have the following pharmacological properties:

• Heparin sodium salt, coming into contact with the skin, under the influence of moisture contained in it, breaks down into a positively charged heparin ion and a negatively charged sodium ion. Dissociation of the substance is slow, since the skin contains a limited amount of water. Active heparin has a powerful absorbable and anticoagulant effect.
• Allantoin is known for its anti-inflammatory and skin soothing properties.
• Dexpanthenol promotes tissue regeneration and also enhances the effect of heparin.

Aromatic oils of natural origin included in the gel have a mild analgesic and antimicrobial effect.

In addition to heparin sodium salt, the composition of Heparin G ointment also includes:

• prednisolone salt of acetic acid (acetate), which has a powerful anti-inflammatory, anti-edematous and antipruritic effect. The mechanism of its pharmacological action is similar to heparin. Only this remedy refers to hormonal drugs.
• Lauromacrogol 600 is the technocratic name for the extract of chamomile flowers, which is a natural antiseptic and promotes rapid tissue healing.

Contraindications for the use of Gepatrombin and Gepatrombin G

The drugs have general contraindications. Thus, neither one nor the other drug is prescribed if the patient’s body is intolerant of the active or additional components included in the medications.

It is not recommended to use both medications if you have skin infections at the application site.

Hepatrombin should not be used for:

• trophic ulcers, if bleeding from them is observed;
• violation of the integrity of the cover.

Contraindications to the use of Gepatrombin G:

• syphilis, tuberculosis;
• skin tumors, including benign ones;
• pregnancy period up to 12 weeks.

It is not recommended to use the drug during lactation. If treatment is necessary, you should stop breastfeeding and transfer the child to artificial nutrition.

Indications for use

Gepatrombin ointment is used for the prevention and treatment of inflammatory processes in tissues and blood vessels in the following cases:

• with venous thrombosis;
• as one of the means for the prevention and treatment of thrombophlebitis;
• varicose veins;
• in the treatment of leg ulcers resulting from impaired blood supply;
• sports injuries;
• for inflammatory processes of ligaments, skin and muscles;
• mastitis;
• boils and carbuncles.

Gepatrombin gel is not used for hemorrhoids; it is used in the treatment and prevention of the following diseases:

• tendovaginitis;
• for the prevention of vein thrombosis;
• joint inflammation, bursitis;
• sprains of ligaments and tendons as a result of sports injuries;
• varicose veins

How Hepatrombin G helps in the treatment and relief of symptoms

Heparin is a direct anticoagulant that does an excellent job of vascular thrombosis. It will help prevent thrombosis of the hemorrhoidal sinuses. If thrombosis has already occurred, it will help dissolve the clot without the risk of thromboembolism and node necrosis. This component is simply necessary to use, since the nodes are cavernous sinuses of hemorrhoidal veins.

After the formation of a protrusion, the blood in this place loses its direction and cannot pass at the same speed as in other parts. Blood clots and red blood cells that have lost their flow rate attach to the inflamed vessel wall.

Subsequently, they layer on top of each other and form a thrombus, which can block blood access to the tissues (this will cause acute ischemia of the node and further necrosis) or break off and cause blockage of the vessel in another place (this can lead to all sorts of complications, depending on the location of the thromboembolism) .

Heparin improves the rheological properties of blood and increases its fluidity. It also reduces the synthesis of platelets and prothrombin. Hyaluronidase controls the anticoagulant system.

Prednisolone is a representative of glucocorticosteroids - adrenal hormones. It is very effective in treating the problems caused by hemorrhoids. Thanks to it, itching and burning are reduced, pain subsides. The node is reduced due to the fact that it becomes smaller in size. Prednisolone ensures this, as it relieves inflammation of the vessel wall and surrounding tissues.

Reflex swelling to pain and inflammation also goes away. This occurs due to the effect of prednisolone on the walls of blood vessels and cells. They become less permeable, so plasma cannot diffuse into the intercellular space. It also has an antihistamine (anti-allergic) effect.

Lauromacrogol - provides rapid pain relief to nodes and weakens reflex spasm of the rectal sphincter. This substance provides a good therapeutic effect, since lauromacrogol scleroses the node (the protrusion becomes empty and is replaced by connective tissue. This action becomes possible, since the substance causes the walls of the node to stick together and further reduce it. Such an empty node is easily reduced and the muscle tone of the rectal ampulla supports it being inside.

Instructions for use

Gepatrombin ointment is applied only to dry skin. The amount of the drug should be approximately 6 cm per 400 square meters. cm skin.

• For thrombophlebitis, apply ointment to the affected area without rubbing. Cover the top with a sterile napkin. Bandage it and leave it overnight.
• To treat ulcers, the drug is squeezed out around them, covered with gauze and bandaged. The dressing is changed every six hours.
• Apply a thin layer of ointment to boils and carbuncles.
• To treat sports injuries, the ointment is lightly rubbed on the sore areas after a therapeutic massage.
• When treating or preventing venous thrombosis, treat the affected area with ointment twice a day.
• Treatment of mastitis is a very complex process, so in this case the drug should be used only on the recommendation of the attending physician.

REFERENCE! The course of treatment should not exceed two weeks. After this period, you should take a break for a month or change the drug to another.

Gepatrombin gel is used only for intact areas of the skin. Otherwise, the use of the drug is similar to the ointment.

The gel is absorbed very quickly, so do not forget that the drug should be applied only to dry skin.

Sale of the drug and its analogues

"Gepatrombin" and "Gepatrombin G" are dispensed without a doctor's prescription.

Cost of drugs (average):

• ointment "Gepatrombin G" - from 180 to 200 rubles;
• “Gepatrombin G” candles – from 190 to 220 rubles;
• gel “Gepatrombin” (300 IU) – from 155 rubles;
• gel “Gepatrombin” (500 IU) – from 260 rubles.

Analogues of these drugs are mainly drugs containing heparin and serving as anticoagulants:

• "Heparil";
• "Heparin ointment";
• "Heparin combi" and others.

“Hepatrombin G” is also being replaced by other antihemorrhoidal drugs – “Relief”, “Natalsid”, “Aurobin”, etc. But the prescription must be carried out by the attending physician.

Gepatrombin ointment for hemorrhoids

The drug is squeezed out of the tube and applied to sore spots in the anus area. During an exacerbation, the ointment should be used up to four times a day. After stabilization of the condition - twice a day, morning and evening for one week.

If it is necessary to administer the ointment into the rectum, you need to put the tip included with the medicine on the tube. Only a doctor can prescribe the dosage of the drug and the duration of use of this procedure.

Before using the ointment, you need to thoroughly wash the anus with baby soap and pat dry with a towel.

Candles Gepatrombin G

Gepatrombin G suppositories (rectal suppositories) are a convenient dosage form that allows you to deliver active substances directly to the site of injury for internal hemorrhoids. Many patients who underwent conservative treatment of hemorrhoids, in reviews of Gepatrombin G suppositories, noted that this dosage form provides a more noticeable therapeutic effect than ointment or gel.

Lauromacrogol is a venosclerosing drug. This substance causes destruction of protein structures, damage to the inner lining of blood vessels, due to which it is used for sclerosis of varicose veins of hemorrhoids.

The candles have a conical shape, white color with a yellowish tint and a homogeneous consistency. One suppository contains 120 IU of heparin, 1675 mg of prednisolone and 30 mg of lauromacrogol, although the composition may vary slightly in suppositories from different manufacturers. The excipients in the suppositories include triglycerides, silicon dioxide, solid fat and glyceryl.

Indications for the use of Gepatrombin G suppositories:

• mixed and internal hemorrhoids;
• itching and burning in the anus;
• thrombophlebitis of the anal veins;
• fistulas, eczema;
• anal fissures.

Gepatrombin G rectal suppositories should be stored in the refrigerator

Suppositories for hemorrhoids with Gepatrombin G should be stored in the refrigerator at a temperature of 2 to 8 ° C, this helps prevent premature softening. Candles should be removed immediately before use. The suppository should be inserted into the rectum after bowel movements and hygiene procedures, the same as before applying the ointment or gel. The suppository is administered by lying on your left side and slightly tucking your knees to your chest. To avoid damaging the inflamed tissue with your nail, it is recommended to use a rubber fingertip or a medical glove. After inserting the suppository, you need to turn over on your stomach and remain in this position for at least half an hour, allowing the drug to completely dissolve.

Use during pregnancy

In addition to heparin, which is not recommended for use during pregnancy and breastfeeding, this product also contains prednisolone, which belongs to the group of hormonal drugs. For this reason:

• hepatrombin for hemorrhoids during pregnancy cannot be used for the first three months;
• the second two trimesters and during feeding of the child can be used only in case of emergency.

During pregnancy, the following ointments are also allowed: Levomekol, Vishnevsky, Ichthyol ointment, Troxerutin gel, Fleming's ointment.

Composition of the drug Gepatrombin G

Hepatrombin G contains 3 active substances: heparin, lauromacrogol and prednisolone. Thanks to their combination, the drug is effective for hemorrhoids, especially in the initial stages.

Heparin is an anticoagulant, a substance that prevents blood clotting. This is a natural anticoagulant factor, which, together with the protein fibrinolysin, is part of the physiological anticoagulation system of the blood. Heparin belongs to the group of direct-acting anticoagulants, since its effect is due to its direct influence on coagulation factors found in the blood. In addition, heparin inhibits the formation of the main blood clotting protein, thrombin, and reduces platelet aggregation (sticking together), thereby preventing the formation of blood clots. The substance stimulates tissue regeneration and healing, reduces swelling, inhibits inflammatory processes, prevents the development of stagnation and promotes the removal of decay products from the body.

Gepatrombin G ointment is sold complete with a special tip that facilitates its use for internal hemorrhoids

When applied to the skin or mucous membrane, heparin is quickly absorbed and concentrated in the subcutaneous tissue, from where it penetrates into the surrounding tissues through the capillary network, improving their blood circulation by stimulating blood circulation in small vessels. Heparin is biotransformed in the liver and excreted from the body in the urine.

Contraindications to the use of heparin:

• increased sensitivity;
• heparin-induced thrombocytopenia;
• bleeding;
• pregnancy and lactation - with caution.

Prednisolone is a synthetic analogue of the steroid hormone hydrocortisone, which performs functions identical to natural ones.

When the inflammatory process worsens, the ointment is applied to a gauze swab and then applied to the affected area.

In the body, prednisolone provides many effects related to the regulation of metabolism and relief of inflammatory reactions:

• controls the metabolism of carbohydrates, proteins and lipids;
• responsible for the formation of carbohydrate reserves in the liver;
• maintains vascular tone;
• regulates the balance of sodium and water;
• increases diuresis;
• stimulates the activity of the heart muscle, accelerates the heart rate;
• improves the functioning of the central nervous system;
• suppresses cellular and humoral immunity, due to which it has an anti-inflammatory and hyposensitizing effect.

Prednisolone, applied topically, helps relieve swelling, eliminates burning and itching, and has anti-allergic and anti-inflammatory effects. However, this is one of those drugs that must be used with caution, only as prescribed by a doctor and strictly in the prescribed dose. There are quite a few contraindications to the use of prednisolone:

• viral infections;
• systemic fungal diseases;
• parasitic diseases;
• ulcers of the stomach and duodenum;
• tendency to thromboembolism;
• osteoporosis;
• acute renal failure;
• Itsenko-Cushing's disease;
• arterial hypertension;
• thrombophlebitis;
• tuberculosis;
• glaucoma;
• polio;
• increased sensitivity.

Lauromacrogol is a venosclerosing drug. This substance causes destruction of protein structures, damage to the inner lining of blood vessels, due to which it is used for sclerosis of varicose veins of hemorrhoids. In addition, lauromacrogol has an anesthetic effect.

Heparin is an anticoagulant, a substance that prevents blood clotting. This is a natural anticoagulant factor, which, together with the protein fibrinolysin, is part of the physiological anticoagulation system of the blood.

Contraindications to the use of lauromacrogol:

• arterial hypertension;
• atherosclerosis;
• pregnancy (first trimester);
• obesity;
• swelling of the limbs;
• lactation period;
• violation of arterial peripheral circulation;
• endocarditis, myocarditis;
• thrombophlebitis of superficial and deep veins in acute form;
• acute infectious and inflammatory diseases;
• bronchial asthma;
• pneumonia, bronchitis (in the acute phase);
• diabetes;
• diabetic microangiopathy;
• hypersensitivity;
• old age.

Side effects and contraindications for use

When using drugs, allergic reactions of various kinds are possible - hives, rash, swelling, etc.

Before using the medicine, you must perform an allergy test on the inside of your elbow or wrist.

• first trimester of pregnancy;
• individual intolerance;
• poor blood clotting;
• violation of the integrity of the skin (for Gepatrombin gel)
• the presence of skin infections.

IMPORTANT! Patients with diabetes mellitus should consult their doctor before using the drug.

Contraindications

Among the restrictions on the use of the drug are:

• the presence of diseases caused by bacteria, viruses and fungi;
• the formation of tumors, the nature of which is unknown and has not been examined;
• the patient's predisposition to various types of bleeding and poor blood clotting;
• tuberculosis;
• venereal diseases;
• individual intolerance to components;
• gestational age is less than 12 weeks.

If nothing of the kind is observed in the patient, it is still worth starting to use the product after a full medical examination and preliminary consultation with a proctologist.

It is prescribed to pediatric patients with caution and increased attention from the attending physician.

Reviews

We recommend studying reviews of hepatrombin ointment for hemorrhoids.

Maria, 31 years old: Used hepatrombin for hemorrhoids during pregnancy. 2 weeks and completely forgot about hemorrhoids. Now I recommend it to everyone.

Christina, 27 years old : I spent a long time studying reviews of hepatrombin for hemorrhoids. In the end, I decided to try it anyway. To be honest, it didn’t help me at all. It got a little better, but the problem still hasn't gone away.

Maxim, 42 years old: I liked the gel. I use it at the first symptoms of this disease. 3-4 days and that’s it, you can enjoy life to the fullest again.

Ulyana, 22 years old: My friend always recommended Gepatrombin to me. She used both gel and ointment. But I still somehow doubted it. I even read reviews on hepatrombin for hemorrhoids. In the end I bought it and was pleasantly surprised. Now I regret that I delayed treatment for so long.

Mechanism of action

When applied topically, the active substances are absorbed by the rectal mucosa and enter the systemic circulation. Sodium heparin helps improve microcirculation due to the rheological state of the blood. The balance of coagulation and fibrinolysis helps relieve severe tissue swelling, itching and pain, prevents the development of thrombophlebitis (reduces blood viscosity and the occurrence of blood clots in the hemorrhoidal vein system). Heparin accelerates the process of resorption of hematomas caused by bleeding from internal nodes.

Prednisolone, due to its anti-inflammatory and antiallergic effects, reduces tissue swelling, relieves pain and itching in the anus. The dose of corticosteroid used in the drug does not cause side effects (osteoporosis, decreased immunity, etc.) when it enters the systemic circulation.

Suppositories have a more pronounced analgesic effect, help get rid of internal nodes and bumps in hemorrhoids, heal rectal fissures.
Lauromacrogol prevents the occurrence and conduction of pain impulses. The substance has sclerosing properties: when it enters the wall of varicose vessels of the rectum, it promotes increased breakdown of proteins and reduces the inflammatory process. The completion of aseptic inflammation is the development of dense connective tissue - a fibrous scar that fills the lumen of the vessel and prevents the accumulation and stagnation of blood in it.

All components, after entering the general bloodstream, are subject to chemical transformation (bind to proteins and deactivated) in liver cells. The drug is excreted primarily by the kidneys.

Using the product for hemorrhoids

Hemorrhoids are considered one of the most common ailments today. People of any age can experience its symptoms. But still, those who lead a sedentary lifestyle are at risk. Unfortunately, most patients try to delay their visit to the proctologist, which only aggravates the situation. In advanced cases, the disease practically does not respond to conservative methods of therapy.

“Gepatrombin” (gel) is not used for hemorrhoids, because its composition is not intended for use in delicate areas and can cause burns to the mucous membranes. Hepatrombin G ointment and suppositories will help to cope with this problem. The drug will be effective for any type of hemorrhoids, for acute thrombosis at the site of inflammation of the nodes, for burning and eczema in the anus, for anal fissures.

Heparin in the hemorrhoid remedy “Hepatrombin G” can improve blood microcirculation and regulate circulatory processes. The component eliminates congestion and swelling. Prednisolone, found in ointments and suppositories, is a glucocorticoid hormone and has anti-inflammatory, antipruritic and decongestant properties. Lauromacrogol has a moderate analgesic effect. This component also has a sclerosing effect, that is, it reduces the size of veins.

"Gepatrombin" (gel): analogues

The use of local drugs in the treatment of varicose veins is the most important stage of therapy. In pharmacies you can find a huge number of medications whose action is aimed at reducing inflammation and swelling.

A drug such as Hepatrombin belongs to the category of anticoagulants and effectively eliminates the symptoms of varicose veins by thinning the blood, strengthening the walls of blood vessels and stopping the inflammatory process. Analogues of the drug include the following products (gels):

1. "Venolife".
2. "Heparin."
3. "Dolobene."
4. "Troxevasin".
5. "Trombless."
6. "Lyoton."
7. "Troxerutin."