Instructions for use of "Corinfar", analogues in composition, prices and patient reviews

Brief information about the drug

Blood pressure medicine Corinfar is an antihypertensive drug that also has antianginal properties. It is effective not only for hypertension, but also for the treatment of certain cardiac diseases, such as angina.

Release form

On the modern pharmaceutical market, the blood pressure drug Corinfar is presented in tablet form. Capsules intended for oral use have a yellowish tint. This release form facilitates the process of dosing the drug and its use.

Composition of tablets

The main active ingredient of the drug Corinfar is nifedipine in a dosage of 10 mg.

In pharmacies you can also buy Corinfar Retard - with a dosage of the main active ingredient - 20 mg and Corinfar UNO, containing 40 mg of nifedipine.

The tablets contain auxiliary components such as dyes, lactose monohydrate, talc, magnesium stearate, silicon dioxide, povidone, talc, hypromellose and macrogol. All ingredients complement each other well, enhance the effect of the main component, providing a pronounced synergistic effect.

Packaging of Corinfar tablets

Terms of sale and price

You can purchase the drug in pharmacy chains only by presenting an appropriate prescription from a doctor. The cost of the medicine depends on the dosage and the number of tablets in the package. On average, the price for Corinfar varies from 69 rubles to 170 rubles. In many ways, it is the affordable cost that explains the popularity of the drug.

Storage conditions

It is recommended to store the drug in a place protected from exposure to ultraviolet radiation, inaccessible to children and pets. Tablets can be stored at room temperature not exceeding +30°C.

Release form and composition

The dosage form of Corinfar is long-acting tablets: round, biconvex, with beveled edges, yellow film-coated (10 pcs. in blisters, 3 blisters in a cardboard pack; 50 or 100 pcs. in brown glass bottles, in a cardboard pack 1 bottle).

Composition of 1 tablet:

• Active ingredient: nifedipine – 10 mg;
• Auxiliary components: potato starch, lactose monohydrate, microcrystalline cellulose, magnesium stearate, povidone K25;
• Shell composition: macrogol 35000, macrogol 6000, hypromellose, talc, titanium dioxide (E171), quinoline yellow dye (E104).

Pharmacodynamic characteristics

Corinfar for high blood pressure is a calcium channel inhibitor. The therapeutic effect is achieved due to the ability of the main active component of the tablets, nifedipine, to suppress the processes of calcium penetration into the cellular structures of the heart and circulatory system of the patient, as well as into the area of ​​cardiomycins.

Corinfar for hypertension helps to dilate blood vessels, activate circulatory processes and microcirculation. Improves blood supply to areas of the myocardium affected by ischemia.

• By gently expanding large arteries, the tablets reduce the myocardium’s need for oxygen and also significantly reduce the load on the heart.
• It has a moderate diuretic effect, helping to eliminate swelling characteristic of hypertension.
• It has a beneficial effect on cardiac functions, eliminates vascular spasms and activates glomerular filtration processes.
• Prevents atherosclerosis and slows down the development of the pathological process in the presence of this pathology.

How calcium channel blockers work

Mechanism of action

The mechanism of action of the drug Corinfar at high blood pressure is due to its following therapeutic properties:

• Diuretic effect, reducing the quantitative indicators of sodium ions in the patient’s body, reducing the level of peripheral resistance from the circulatory system;
• Hypotensive effect, normalizing blood pressure;
• Reducing the load on the cardiovascular system due to the vasodilating properties of the drug;
• Improving blood supply, nutrition and functioning of the myocardium;
• Suppression of the processes of calcium entering the arteries, heart and blood vessels, contributing to a decrease in the contractile capabilities of the elements of the circulatory system;
• Positive effect on the condition and functioning of the renal apparatus, improvement of blood circulation and microcirculation in the kidney area;
• Normalization of the processes of transmembrane current of calcium ions.

Thanks to these qualities, Corinfar not only stabilizes blood pressure, but also eliminates a number of painful symptoms characteristic of arterial hypertension, providing a positive complex effect.

At what pressure does it help?

Corinfar lowers blood pressure due to its pronounced antihypertensive properties. Quickly normalizes blood pressure monitor readings. Used for high blood pressure (BP).

Injections for high blood pressure

Often, first aid for hypertension is provided by intramuscular and intravenous injections. Nobody gives injections for high blood pressure on their own. The procedure is carried out either in a hospital or by emergency doctors at home. The choice and dosage of the drug is made based on the patient’s symptoms. First aid for high blood pressure at home is done with the following medications:

• triad: Papaverine, Analgin, Diphenhydramine;
• Enalapril;
• Papaverine with Dibazol;
• Clonidine;
• Furosemide;
• Magnesium sulfate.

The following injections may be prescribed in the hospital:

• Nitroglycerine;
• Sodium nitroprusside;
• Metoprolol;
• Pentamin.

In case of hypertensive crisis, hot injections can be given:

• calcium chloride solution;
• Magnesia.

Pharmacokinetic properties

Corinfar reduces blood pressure within 1-1.5 hours from the moment of taking the tablets. The hypotensive effect of the drug lasts for 6 hours.

The maximum concentration of the active components of the medication in the body is observed 2.5 hours after taking the medication. The therapeutic effect of the drug lasts throughout the day.

In the liver it is transformed into inactive metabolites. It is excreted from the body mainly through the renal apparatus, along with urine. Only about 30% of the drug is excreted through the gastrointestinal tract in the feces.

The half-life of the drug is about 11 hours. However, in patients with pathologies of the renal apparatus, this process takes longer, which is why they require individual dosage adjustment.

Corinfar quickly reduces blood pressure

Analogues and synonyms

If necessary, it is possible to use substitutes for Corinfar - synonyms or analogues. Synonyms include drugs that have the same active ingredient. Analogues are drugs with the same therapeutic effect, but with different active ingredients.

Substitute table

Before replacing the drug, you must consult your doctor and carefully read the instructions for using the substitute.

When is the medicine prescribed?

Doctors recommend that users use Corinfar for blood pressure if they have the following clinical indications:

• Arterial hypertension;
• Ischemic disease;
• Angina pectoris (vasospastic, occurring in a chronic form);
• Hypertonic disease.

It can be prescribed for the treatment of diseases and for preventive purposes. Corinfar is used as an independent medication, but can also act as one of the constituent elements of complex therapy for cardiac pathologies.

Indications

Corinfar tablets are prescribed for:

1. angina pectoris;
2. Prinzmetal's angina;
3. arterial hypertension.

Localization of pain during angina pectoris

• The first pathology manifests itself in the form of periodic pain attacks behind the sternum. They are a reaction to physical or emotional stress.

There are several classes of such angina. Classification is made according to the level of physical activity that leads to an attack. The most prosperous is first class. In this case, a person can easily tolerate normal loads. To provoke an attack, you need a long and intense load. The most disadvantaged is the fourth grade. Here a person sometimes cannot figure out what caused the attack - it seems that he walked quietly for several tens of meters and that’s all.

During an attack, the person stops, the hand is automatically pressed to the left side of the chest, the face is distorted by a suffering grimace.

• Variant or Prinzmetal's angina occurs at rest due to spasm of the coronary vessels. The attack is long and severe. The usual time of attacks is at night or in the early morning hours. Blood pressure drops, the heart rhythm is disturbed, the person begins to sweat profusely, and fainting is possible.

Organs that are targets of hypertension

• Arterial hypertension is said to occur when there is long-term elevated blood pressure above 140/90 mmHg. Art. Moreover, to normalize it, it is necessary to use medications that can reduce blood pressure.

A temporary increase in pressure under the influence of some physical or emotional factors with a return of blood pressure to the original level after some time is not considered hypertension. Symptoms depend on blood pressure and the degree of target organ damage.

When use is contraindicated

Taking Corinfar for high blood pressure is not recommended for patients with the following clinical contraindications:

• Ileostomy;
• Hypotonic disease (low blood pressure);
• Shock state of cardiogenic nature;
• Myocardial infarction;
• Individual intolerance and hypersensitivity to the components contained in the tablets;
• Unstable angina;
• Colostomy;
• Aortic stenosis.

It is strictly forbidden to take the drug Corinfar during the first trimester of pregnancy, since, penetrating the placental barriers, its active substances negatively affect the formation of the fetus and can even cause dangerous mutations.

At later stages, tablets can be prescribed to expectant mothers only in exceptional cases and in minimal dosages. In this case, therapy should be carried out under strict medical supervision, preferably in a hospital setting, since there is a possibility of stopping the birth process and pulmonary edema.

Corinfar is also contraindicated for mothers during breastfeeding. If treatment with this drug is necessary during lactation, it is recommended that the baby be switched to artificial formula.

Pregnant women and nursing mothers should not take Corinfar

Compatibility of Corinfar and alcohol

The product is available in tablet form. It is consumed orally, so interaction with ethanol begins at the gastrointestinal tract stage. When substances are combined, dyspeptic disorders, increased gas formation in the intestines, and a large load on the liver appear. If the patient has a predisposition to pathologies of this organ, the disease worsens and may progress to the stage of fibrosis.

Absorbed into the bloodstream, the substances spread throughout the tissues. The main action occurs in the blood vessels, the heart. Since ethanol reverses the effect of the medication, angina becomes worse. Myocardial infarction may occur. Severe hypotension leads to loss of strength and fainting.

The drug and ethanol penetrate the blood-brain barrier into the brain. Alcohol damages neurons, the drug leads to extrapyramidal disorders, sleep disturbances and other neurological pathologies. Under the influence of alcohol, the side effects of the drug on the central nervous system are enhanced.

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Pros and cons of the drug

The drug Corinfar has earned numerous positive reviews from patients and medical specialists due to its following indisputable advantages, which distinguish it favorably from its analogues:

1. High efficiency indicators;
2. Affordable price for every buyer;
3. Prolonged action, allowing you to avoid frequent pill taking;
4. A wide spectrum of action, making it possible not only to lower blood pressure, but also to get rid of other symptoms of arterial hypertension;
5. The presence of an additional diuretic effect;
6. Beneficial effects on the renal apparatus, extremely rare for antihypertensive drugs;
7. The ability to regulate the strength of the therapeutic effect and effectiveness of the tablets by adjusting the dosage of the tablets.

However, despite the obvious advantages of Corinfar for blood pressure, it also has a number of disadvantages that you need to be aware of before starting treatment:

1. The ability of the drug components to penetrate the placental barrier and into breast milk;
2. A wide range of absolute contraindications and restrictions on taking pills;
3. The impossibility of dividing capsules, requiring the purchase of the drug strictly in a specific, optimal dosage for a specific clinical case;
4. Extensive list of possible adverse reactions.

It is obvious that the number of advantages of the drug significantly exceeds its disadvantages, which explains its demand and popularity in the pharmaceutical market.

Dispensing from pharmacies and approximate cost

Due to the danger that the drug poses and the presence of a wide list of side effects and contraindications, it is sold in pharmacies only with a doctor's prescription. Its cost is clearly displayed in the table.

The drug can be stored for 5 years if it is kept in a dry and dark place, protected from children, at a temperature not exceeding 23-25°C.

How to take for arterial hypertension

The instructions for use of Corinfar recommend taking the drug regularly, preferably at the same time of day.

Corinfar tablets should be taken whole, without chewing or crushing, with clean water. It is best to take the medicine before meals. The optimal dosage for blood pressure and hypertension is 10 mg 2-3 times a day.

It is recommended to drink Corinfar Uno in the morning before breakfast once a day.

Corinfar Retard is taken after a meal with plenty of water. The recommended dose of the drug is 20 mg 1-2 times a day.

The duration of the therapeutic course is determined by a medical specialist individually, taking into account the exact diagnosis, present symptoms, the stage of development of the pathological process, the general condition of the patient and the reaction of his body to the proposed treatment.

The drug should be taken 2-3 times a day at a dosage of 10 mg

Review of the drug Corinfar

The drug "Corinfar" is a calcium channel blocker, which determines the indications for use.
That is, it prevents the passage of Ca2 (calcium ions) through channels in cell membranes. As a result, the tone of the vascular walls decreases, which is necessary for high blood pressure to reduce it. Corinfar has an antianginal effect, that is, it prevents or relieves attacks of angina pectoris, treats coronary insufficiency in coronary artery disease. The main indications for the use of the drug "Corinfar" are arterial hypertension (primary and secondary), angina pectoris. variant angina. Thus, Corinfar is prescribed for blood pressure and heart diseases. These are the main indications for taking Corinfar.

The active ingredient of Corinfar is nifedipine. Among the auxiliary components: potato starch, lactose monohydrate, povidone and magnesium stearate.

The release form of the medicine is film-coated tablets. You can purchase the product in blisters (10 pcs.) or in dark glass bottles (50 pcs. or 100 pcs.).

The pharmaceutical actions of the active substance determine the indications for use of the drug. Corinfar improves coronary blood flow and circulation in the myocardial area subject to ischemia. In addition, it dilates peripheral arteries, as a result of which the myocardial tone decreases and its oxygen demand decreases. The effect of the medicine begins within 20 minutes and lasts for 4 to 6 hours.

Corinfar has a high degree of absorption - up to 90%, the ability to assimilate ranges from 50 to 70%. Eating increases bioavailability.

The drug penetrates the placental and blood-brain barrier and enters breast milk. Subject to complete metabolism in the liver.

From 60 to 80% of the active substance is excreted by the kidneys, about 20% with bile. The half-life is 2-5 hours.

Long-term use of Corinfar (2-3 months) leads to the development of tolerance to the drug.

Contraindications

1. Arterial hypotension (decrease in upper pressure to 90 mm Hg).
2. Decompensated CHF (chronic heart failure).
3. Severe narrowing of the aortic valve (stenosis).
4. Unstable angina.
5. Acute severe left ventricular failure.
6. Acute vascular insufficiency (collapse).
7. The first four weeks after acute myocardial infarction.
8. First trimester of pregnancy.
9. Breastfeeding period.
10. Individual intolerance to nifedipine or other components.
11. Taking rifampicin.

The drug "Corinfar" is used with caution in the following conditions:

• hypertrophic obstructive cardiomyopathy;
• mitral valve stenosis;
• severe tachycardia (fast pulse) or bradycardia (slow pulse);
• malignant arterial hypertension (persistent and significant increase in pressure);
• liver and kidney failure;
• severe cerebrovascular accidents;
• heart attack with left ventricular heart failure;
• decrease in blood circulation volume (hypovolemia);
• gastrointestinal obstruction;
• during pregnancy (second and third trimesters);
• under the age of 18.

Side effects

The drug "Corinfar" has quite a lot of side effects from various body systems.

Central nervous system. Fatigue, weakness, dizziness, headache, drowsiness. Long-term use of the drug "Corinfar" can cause parasthesia (numbness) of the limbs, tremor (shaking), parkinsonian disorders (shuffling gait, poor coordination of movements, mask-like face, trembling of the hands and fingers), depression.

The cardiovascular system. Arrhythmias, tachycardia, rapid heartbeat, swelling (of the legs, ankles, feet), development of heart failure, decreased blood pressure, flushing of the face, feeling of heat. Attacks of angina pectoris and the development of a heart attack are possible (rare), in which case the use of the drug should be stopped.

Gastrointestinal tract. Dry mouth, nausea, diarrhea or constipation, flatulence, increased appetite. Long-term use of Corinfar tablets can lead to disruption of the liver.

Musculoskeletal system. Swelling of the joints, arthritis, myalgia, cramps of the arms and legs.

Hematopoietic organs. Leukopenia, anemia, thrombocytopenia, agranulocytosis, thrombocytopenic purpura.

Urinary system. Increased daily urine volume, deterioration of kidney function in renal failure.

Allergies. Urticaria, skin itching, dermatitis, skin rashes.

How to use?

The drug "Corinfar" is taken orally, without chewing and with a sufficient amount of water. It is recommended to take the tablets after meals. When taking the medicine with food, the absorption time of the drug from the gastrointestinal tract increases, but its amount does not decrease.

The regimen for taking Corinfar, dosage, and duration of treatment depend on the diagnosis, severity of the disease, the patient’s response to the action of the active substance and are determined only by the attending physician individually.

Overdose

In case of overdose, headache, tachycardia or bradycardia occurs, pressure decreases, the face turns red, and bradyarrhythmia develops. In severe cases, loss of consciousness or coma may occur. In case of poisoning with the drug "Corinfar", gastric lavage and, in some cases, small intestinal lavage are prescribed.

Special Recommendations

While taking Corinfar, you should not drink alcoholic beverages. The withdrawal of the drug occurs gradually. While taking pills, you need to be careful when working with machinery, while driving, and during any actions that require increased concentration.

Analogs

The most well-known analogues of the drug: Cordafen, Adalat, Cordaflex, Cordipine, Phenigidine, Nifecard, Nifedipine, Sanfidipine. They all contain the same active ingredient – ​​nifedipine.

Special instructions and recommendations

In order for therapy with the blood pressure drug Corinfar to be as effective and safe as possible, you need to pay attention to the following recommendations from specialists:

• Drink the tablets whole, since when they separate and destroy the protective shell, they lose their effectiveness and have an improper effect on the patient’s body;
• To achieve a stable hypotensive effect, maintain equal time intervals between doses of the drug;
• During the therapeutic course, refrain from driving or other activities that require composure, concentration, attention and speed of reactions due to the suppressive effect of Corinfar tablets on the central nervous system;
• Exclude grapefruit juice from the diet, as it helps to increase the antihypertensive properties of the drug, increases the concentration of the active ingredients of Corinfar in the blood and slows down the process of removing the drug from the body, which threatens overdose, side effects, and excessive decrease in blood pressure.

By following these simple rules, you can get the maximum benefit from the drug Corinfar, avoiding undesirable consequences and complications!

Reviews

Matvey Ivanovich, 62 years old

The medicine is not bad. But it is more suitable for a one-time dose to relieve an attack. To treat hypertension, I think other medications should be taken.

Vera Vasilievna, 76 years old

I'm suffering from blood pressure. I must say that Corinfar helps. I've been drinking it for about two weeks. I take the dose in the morning and feel fine all day. I repeat the procedure in the evening.

Corinfar can often be purchased in pharmacies without a prescription, although it should only be sold with a prescription. However, this circumstance does not mean that you can self-medicate. The drug has complex side effects and interacts with many medications, so it cannot be treated without a doctor’s prescription.

For more information about angina and its treatment, watch the video.

You can learn more about hypertension from the video.

Possible side effects

Treatment of hypertension with Corinfar blood pressure tablets can cause the following side effects:

• Hyperglycemia;
• A sharp and too strong decrease in blood pressure, up to a hypotensive crisis;
• Anemia;
• lacrimation,
• Painful sensations localized in the area of ​​the visual organs;
• Thrombocytopenia (decreased blood clotting rates);
• Feeling of ringing and noise in the ears;
• Skin itching;
• Swelling;
• Headache;
• Vertigo;
• Rash on the skin like urticaria;
• Chronic fatigue syndrome;
• Migraine attacks;
• Fainting conditions;
• Paresthesia;
• Dizziness;
• Visual impairment;
• Hypesthesia;
• Psycho-emotional instability, sudden mood swings;
• Depressive states;
• Sleep disorders (insomnia at night and increased sleepiness during the day);
• Erythromegaly;
• Rapid heartbeat (tachycardia);
• Painful sensations localized in the chest area;
• Erythema:
• Dermatitis;
• Nosebleeds;
• Hyperhidrosis;
• Mastopathy in female patients;
• Myalgia;
• Convulsive syndrome;
• Muscle pain;
• Erectile dysfunction in representatives of the stronger sex;
• Arthralgia;
• Swelling of the joints;
• Feverish state;
• Lethargy, weakness, apathy, decreased performance, general malaise.

If you detect at least some of the possible adverse reactions listed above, you must stop taking the pills and consult a doctor about selecting an analogue or adjusting the dosage of the drug.

Eye pain may be a side effect of taking Corinfar

Medicines with similar effects

If for some reason Corinfar is not prescribed or is contraindicated, the doctor can replace it with a worthy analogue. Nowadays, any medicine is presented in a wide range on the pharmaceutical market. Effective agents that are similar in composition or clinical effects are:

• "Adalat";
• "Cordafen";
• "Nifedipine";
• "Phenigidine";
• "Cordaflex";
• "Sanfidipin";
• "Calcinard Retard";
• "Sponif 10";
• "Nifecard HL".

Substitutes for Corinfar are considered ineffective and useless in case of intolerance to the main active component - nifedipine.

Drug overdose

Exceeding the recommended doses of the drug Corinfar leads to an acute, severe form of intoxication of the body, manifested by the following alarming symptoms:

• Metabolic acidosis;
• A sharp decrease in blood pressure (hypotonic crisis);
• Hypoxia, oxygen starvation;
• Fainting;
• Cardiopalmus;
• Nausea and vomiting;
• Severe dizziness;
• Bradycardia (slow heart rate);
• Hyperglycemia;
• Pulmonary edema;
• Weakness, increased drowsiness;
• Coma.

An overdose of Corinfar poses a direct threat not only to human health, but also to human life! Therefore, if at least some of the above clinical signs appear, it is necessary to call an ambulance. Before the doctors arrive, the patient should be given first aid by performing gastric lavage and giving a portion of sorbents.

Further therapy is usually carried out in hospitalization and is symptomatic.

Consequences of drinking alcohol

When treating heart pathology and systemic hypertension, drinking alcohol is prohibited.

If you combine it with medication, the following consequences will occur:

• pressure changes with a risk of hypertensive crisis;
• angina pectoris, ischemia, heart attack;
• heart failure;
• dyspepsia, if the patient vomits, the taken tablet will be excreted from the gastrointestinal tract without causing any effect;
• inflammation of the kidneys with impaired urine output, which leads to pathology of mineral metabolism and damage to the glomerular apparatus;
• systemic allergic reactions that are dangerous to the life and health of the patient;
• liver inflammation, impaired detoxification function.

Consequences occur even if a person has consumed a small portion of ethanol. If the rule is systematically violated, the state of health deteriorates sharply, and sudden death is possible.

What to replace for hypertension

The following analogues of Corinfar can be purchased in pharmacy chains:

• Osmo-Adult;
• Nifedipine;
• Adalat;
• Nifecard HL;
• Cordipin;
• Nicardia.

Corinfar helps with blood pressure and other symptoms characteristic of hypertension. Despite its high effectiveness, the drug has a wide range of contraindications and possible adverse reactions. To prevent complications, it is important to take the tablets in the correct dosage, recommended by a qualified specialist!

Reduce blood pressure quickly using folk remedies

There are several effective ways. To reduce blood pressure using folk remedies, quickly take the following measures:

1. Soak your feet in hot water for 10 minutes.
2. Soak a cloth in vinegar (apple or table vinegar) and apply to your heels.
3. Place mustard plasters on your calves and shoulders.

Herbs for blood pressure

Remember a few recipes:

1. 1 tbsp. l. motherwort and hawthorn, meadowsweet and dried grass and 1 tsp. Mix valerian root and pour half a liter of vodka. Leave the anti-pressure herbs like this for 2 weeks. Drink 1 tbsp three times a day. l. (before meals).
2. Make a strong mint infusion. Drink it, and also apply lotions to your neck, back of the head, and shoulders.