10 best drugs for lowering cholesterol with iHerb

“Cholesterol pills”: precautions!

First of all, it is definitely worth noting that virtually any “cholesterol pills” are not at all medications that you can “treat” yourself! Remember, the main purpose of this article is to simply (briefly) introduce you to all the main drugs (indirectly or purposefully) that reduce high cholesterol in the blood.

We (in no case) recommend that you use any specific types of cholesterol/lowering medications! The best SOURCE of competent and useful information (specifically for your health) is a TREATING SPECIALIST! Consult with him in detail about the medications you are taking and discuss all the side effects.

Never change the dosage (and frequency of taking) of the “cholesterol pills” prescribed to you! Never stop taking them without consulting your doctor! Also, be sure to remember that some LDL cholesterol-lowering medications may interact negatively—either with grapefruit or pomegranate juice!

DO NOT HURT TO CHECK OUT:

• High cholesterol – which doctor should I consult?
• Lipidogram - a special biochemical blood test
• Medicines that increase blood cholesterol

Nicotinic acid preparations for lowering cholesterol levels

Nicotinic acid preparations for lowering cholesterol contain B-complex vitamins. Nicotinic acid, or niacin, is found in food, but to achieve faster results, it is better to take it in the form of medications prescribed by a specialist.

Taking niacin helps lower LDL levels and increase HDL. When treated with nicotinic acid preparations, adverse reactions on the part of the patient's body such as hyperemia, itching of the skin, and headaches become possible.

The best drugs for lowering blood cholesterol based on niacin are Nicolar and Niaslan.

Statins (HMG-CoA reductase inhibitors)

Naturally, our list begins with statins, the best and most effective “cholesterol pills.” That is, special medications to reduce high cholesterol in the blood (up to 65% / depending on the dosage). Their mechanism of operation is based on REVERSIBLE “inhibition” of the activity of the key enzyme (HMG-CoA reductase), which is responsible for the biosynthesis of cholesterol in the human liver. According to numerous studies, statins not only have excellent “cholesterol/lowering” properties, but also many other so-called “non/lipid” positive effects. Since they have a good effect on solving other “problems” not related to cholesterol (even cancer).

Despite many myths (and there are about a dozen of them), “horror stories” and all sorts of misconceptions, statins are one of the MOST STUDYED groups of drugs that have been PROVEN to reduce both cardiovascular and overall mortality. In addition, they really improve the quality of life and prognosis of patients suffering from IHD (Coronary Heart Disease) and Atherosclerosis

.
Modern tablets (for example, such as Atorvastatin
and
Rosuvastatin
) even reduce cholesterol/atherosclerotic plaques (in the walls of the coronary arteries). Moreover, virtually all drugs (new generation) are very effective and completely safe for people suffering from arterial hypertension and type 2 diabetes.

NO matter what anyone says, the best and most effective “cholesterol pills” are modern statins, which REALLY prolong people’s lives!
In general, the best advice (regarding the use of these tablets) is to believe the competent recommendations of qualified treating specialists, and not the articles of “dubious journalists”! Which (perhaps for mercantile reasons) either “justify” something or “throw mud at it”! Of course, there are side effects, but they often arise (as American researchers “calculated” this) due to the “placebo” effect. That is, after SELF-SUGGESTION about any possible muscle pain, nausea and other “unpleasant sensations”.

List of the most famous drugs:

• "LOVASTATIN"
  (Choletar, Apekstatin, Cardiostatin, Lovacor, Mevacor, Medostatin, Rovacor / tablets);
• "SIMVASTATIN"
  (Zocor, Actalipid, Atherostat, Vasilip, Zovatin, Zorstat, Levomir, Simvahexal, Simvacard, Simvacol, Simvalimit, Simvastol, Simvor, Simgal, Simlo / tablets);
• "PRAVASTATIN"
  (Lipostat, Pravachol / tablets);
• "FLUVASTATIN"
  (Lescol, Lescol XL / tablets);
• "ATORVASTATIN"
  (Liprimar, Lipitor, Atoris, Atomax, Liptonorm, Torvacard, Lipona, Tulip / tablets);
• "ROSUVASTATIN"
  (Mertenil, Crestor / tablets).

Side effects (actions):

• Common side effects of statins include arthralgia (i.e., intermittent joint pain), dyspepsia (i.e., stomach upset; difficult/painful digestion), constipation, heaviness, and abdominal pain (most commonly in the epigastric region);
• the next common problem is the symptoms of myositis (i.e., inflammatory damage to the skeletal muscles), but very rarely they develop directly into a “real” disease (1 case in (!) 2000 patients);
• EXTREMELY RARE cases of the development of severe myopathy, rhabdomyolysis (which are accompanied by quite severe muscle pain), as well as serious liver damage and an “abnormal” increase in sugar levels have been observed;
• and, finally, in the RAREEST cases - these pills (medicines) can cause short-term “memory lapses” (although complaints were received ONLY from patients from the USA), but they disappear - in fact immediately after stopping taking the drugs (a very strange phenomenon, but the Americans “fixed” it).

Contraindications and restrictions:

• statins are strictly contraindicated during pregnancy (or during breastfeeding), as well as for people with severe (chronic) liver diseases;
• for elderly men and women, it is recommended that very careful treatment be started, starting with minimal doses of statins (since it is quite possible that there is increased sensitivity to them);
• some statin medications may interact poorly with other medications (BE SURE to tell your doctor which specific pills you are already taking);
• DO NOT FORGET that grapefruit juice or grapefruit itself can significantly increase the effect of Lovastatin, Simvastatin and Atorvastatin!

1. MORE ABOUT STATINS
2. NATURAL STATINS: IS THERE AN ALTERNATIVE TO “SYNTHETICS”?

Statins for every day

Read more…

Are there natural analogues of chemical statins? Is it possible to prevent the development of atherosclerosis or defeat it at an early stage with the help of natural medicines, for example, medicinal plants, fruits, berries and their processed products?

So-called natural statins contain substances that lower cholesterol levels in the blood, prevent the development of atherosclerosis, improve the condition of blood vessels and normalize metabolism, including lipid metabolism.

For diagnosed atherosclerosis, natural analogues of statins can be a good additional treatment.

Let's consider the most effective alternative remedies - analogues of medications.

Read more…

1. Citrus fruits, black currants, white cabbage, rose hips - are characterized by a high content of ascorbic acid, which reduces tissue permeability and prevents the penetration of cholesterol into the vascular walls. The effect is enhanced by combining ascorbic acid with rutoside (rutin, vitamin P). It is an antioxidant, slows down the oxidation of vitamin C in tissues and, by reducing their permeability, reduces the rate of excretion of vitamin C from the body.

Most rutoside is found in chokeberry, black currant, rose hips, oranges and lemons.

We must not forget that citrus fruits, rose hips and black currants are contraindicated for gastritis, stomach and duodenal ulcers with high acidity. It is not recommended to use these products if you have increased blood clotting or allergies. White cabbage will have to be abandoned in case of diarrhea, myocardial infarction, acute phase of colitis and gastritis, as well as flatulence.

It should be remembered that ascorbic acid serves only as a prophylactic against atherosclerosis. If there are already plaques in the vessels, ascorbic acid alone will not get rid of them.

2. Peanuts, potatoes, tomatoes, mushrooms, avocados, wild (black) rice, beans are sources of nicotinic acid, which is involved in many processes in the body, in particular, it suppresses the synthesis of cholesterol in the liver. Regular consumption of the listed Products should be discussed with your doctor or nutritionist. The fact is that, for example, in treatment table No. 10, legumes and mushrooms are limited, since these products may be poorly absorbed by some people.

Read more…

Potatoes are high in starch, and their presence in the diet of overweight people is undesirable. Tomatoes are contraindicated for gastritis and stomach ulcers with high acidity, as well as for hemorrhoids. Only wild rice has no contraindications.

3. Sea kale contains beta-glucans - polysaccharides that reduce total and “bad” cholesterol. These substances also enhance immunity and have cell rejuvenation properties. If there are contraindications to the use of kelp, for example, with kidney disease, it is recommended to use oats as a source of beta-glucans, which also contains a number of other substances that help prevent and treat atherosclerosis (we wrote about this in the previous section).

4. Unrefined vegetable oil and soybeans are sources of polyunsaturated fatty acids, which reduce cholesterol and triglycerides and strengthen the cardiovascular system.

Read more…

By the way, soybeans also contain substances that lower cholesterol levels. These are essential phospholipids that “extract” cholesterol from atherosclerotic plaques and cell membranes, dissolve it and remove it from the body. In addition to soy, chicken eggs, meat products (liver, chicken, beef), sour cream, cheese, fish (especially trout), sunflower seeds, flaxseed and hemp seed are high in phospholipids. There are many phospholipids in unrefined vegetable oils.

If you have urolithiasis and gout, the consumption of soy products should be approached with caution. The fact is that soybeans are characterized by a relatively high content of purine bases. They also contain oxalic acid. Therefore, it is advisable for people suffering from these diseases to consult their doctor before including soy products in their menu.

Vegetable oil can be consumed by everyone in reasonable quantities.

5. Grain bran is a source of plant fiber, which has a pronounced ability to lower cholesterol levels. It binds bile acids and removes low-density lipoproteins containing “bad” cholesterol from the body. Oat bran is considered the most useful.

It is not recommended to use bran for acute diseases of the gastrointestinal tract.

Read more…

6. Turmeric is an affordable and effective means of preventing atherosclerosis. Regular addition of this spice to food can reduce cholesterol levels by approximately 5%, which is facilitated by curcumin. This substance removes “bad” cholesterol from the body and speeds up metabolism.

Turmeric should not be consumed during exacerbation of cholelithiasis. This spice is also incompatible with drugs that lower blood sugar.

7. Ginger is an excellent remedy for the treatment and prevention of atherosclerosis. Contains gingerol, which increases the metabolic rate, actively participates in fat metabolism, and removes “bad” cholesterol from the body. Shogaol, a substance formed in the ginger root during drying or heat treatment, also has the same properties.

Contraindications to the use of ginger are pancreatitis, stomach and duodenal ulcers, individual intolerance.

8. Dioscorea Caucasica is the most powerful herbal remedy that lowers blood cholesterol levels. The medicinal effect of the plant is manifested due to the content of steroid saponins. These substances remove cholesterol from the body and destroy complex lipid complexes that form in the liver. In addition, the substances in Dioscorea have a vasodilating effect, reduce blood pressure, improve coronary blood flow, relieve angina attacks, and reduce tachycardia.

Dioscorea preparations should not be taken for bradycardia, hypotension, exacerbation of gastritis and gastric and duodenal ulcers. It is recommended to drink infusions and decoctions of the plant after meals, since the substances contained in Dioscorea can irritate the gastric mucosa.

To prepare a healing infusion, pour 1 teaspoon of dioscorea root powder into 250 ml of boiling water, leave for 20 minutes, strain, mix with 1 teaspoon of honey. Take 1/3 cup 3 times a day after meals. The course of prevention is 7 days. If you need to reduce high cholesterol levels, the drug should be taken for at least a month.

Bile acid sequestrants (BAS)

Bile acid sequestrants (“binders”) (or “ion exchange resins”) are a group of drugs that for several decades (before the advent of statins) WAS one of the most popular drugs for reducing the level of “bad” LDL cholesterol in the blood (by 15 -thirty%). Which, of course, reduced the risks of developing IHD (Coronary Heart Disease), as well as other cardiovascular diseases. However, they had no effect on the amount of beneficial HDL cholesterol in the blood and INCREASED (!) the concentration of triglycerides.

In addition, bile acid sequestrants (BAS) had a high frequency of side effects (in particular, constipation in (!) 50% of cases). And also (according to “Soviet” statistics) many patients “flatly” refused to use these medications due to fairly/unpleasant taste sensations. And finally, the biggest problem was that these drugs seriously interfered with the absorption of most other life-saving/essential medications (diuretics, beta blockers, etc.). Perhaps this is why this group of drugs is NOT (!) ALLOWED for use in the Russian Federation.

Bile acid sequestrants are now used only abroad and only in the most extreme cases...

At the moment (when many more advanced lipid-lowering drugs have appeared, with a minimal list of side effects), FFAs (in particular, Colesevelam / Welchol) are prescribed (only!) in combination therapy with statins (and only abroad!) for obtaining an additional effect when reducing dangerously/high levels of LDL cholesterol in the blood in patients suffering from heterozygous hereditary (familial) hypercholesterolemia.

List of names of foreign bile acid sequestrants:

• "CHOLESTYRAMINE"
  /
  "KOLESTYRAMINE"
  (Cholestyramine Light, Prevalite, Prevalite Packets, Questran, Questran Light, Questran Light Packets, Questran Packets, Locholest, Locholest Light);
• "COLESTIPOL"
  (Colestid, Colestid Flavored);
• “KOLESEVELAM”
  (Welchol /
  note
  by the way, this is the most popular drug abroad);
• "COLEXTRAN"
  (Dexide / Spain, Pulsar / Italy).

What are the side effects (actions) of FFA:

• constipation, flatulence and dyspepsia (in 50% of cases);
• exacerbation of peptic ulcer of the stomach and duodenum;
• formation of gallstones;
• less commonly, diarrhea, belching, dizziness, nausea, abdominal pain and vomiting.

Contraindications and restrictions:

• increased level of triglycerides in the blood (hypertriglyceridemia - more than 6 mmol/l);
• familial dysbetalipoproteinemia / HLP type III (increased concentration of DILI / Intermediate Density Lipoproteins and residual chylomicron components);
• stomach and duodenal ulcers;
• disorders of coagulation and fibrinolysis;
• malabsorption syndrome;
• biliary cirrhosis of the liver;
• problems with constipation (and hemorrhoids).

Fibrates to lower blood cholesterol

These cholesterol-lowering drugs affect lipid metabolism. If we compare medications from this group with statins, they act on sterols of different densities. Fibrates effectively affect high-density cholesterol, statins – low-density cholesterol. In terms of popularity in medicine, fibrates are significantly inferior to statins; they are used less frequently in solving this problem.

Indications for the use of fibrates are:

• triglyceride level from 4.5 mmol/l;
• isolated hypoalphacholesterolemia in people suffering from coronary heart disease;
• decrease in HDL cholesterol levels.

The use of fibrates to reduce the level of sterol in the blood allows patients to avoid the development of pancreatitis and reduce the risks of cardiovascular complications. They also activate the process of producing beneficial sterol.

However, improper use of medications to lower blood cholesterol, which are fibrates, can cause a number of side effects. Treatment may be accompanied by nausea, vomiting, pain in the abdominal area, diarrhea, and flatulence.

Fibrates include the following medications:

• Clofibrate;
• Bezafibrate;
• Fenofibrate;
• Gemfibrozil;
• Ciprofibrate.

It is strictly forbidden to take fibrates and statins at the same time, since this combination can lead to quite dangerous consequences.

Cholesterol absorption inhibitors (ezetimibe, ezetrol, zetia)

Cholesterol absorption inhibitors are lipid-lowering drugs (“EZETIMIB” / “EZETROL” tablets) that “inhibit the absorption” (i.e., “prevent the absorption”) of cholesterol in the human intestine (small intestine). Which significantly reduces its supply to the liver, and therefore significantly reduces (in it) its “excess reserves”. As a rule, prescribed (with STRICT adherence to a diet to lower cholesterol

) together with statins for the treatment of primary hypercholesterolemia.

Cholesterol absorption inhibitors are quite effective in reducing elevated levels of Total Cholesterol in the blood, LDL cholesterol, apolipoprotein B, triglycerides, and also increase the amount of useful HDL cholesterol. However, in the treatment of homozygous hereditary hypercholesterolemia, it may be necessary to use other (additional) agents, for example, such as LDL apheresis.

The cholesterol absorption inhibitor “Ezetimibe” (in tablets) is registered in the Russian Federation under the trademark “Ezetrol”...

This medicine is available in tablets. Successfully approved by the FDA (Food and Drug Administration/USA) in October 2002. After a short time, it became one of the best-selling cardiological drugs on the international pharmaceutical market, which “pushed” its “creator” () to begin developing (together with) more advanced (combined) drugs, which will be discussed below.

Trademark names (ours and foreign ones):

• "EZETIMIBE"
  (Ezetrol, Zetia).

EZETIMIBE – side effects (actions):

The most common side effects with monotherapy (ezitimibe or other cholesterol absorption inhibitors) are headaches, abdominal pain and diarrhea. In combination treatment with statins: headaches, fatigue, abdominal pain, constipation, diarrhea, bloating, nausea, increased AST and ALT activity, myalgia. Extremely rare side effects are myopathy and rhabdomyolysis.

Contraindications and restrictions:

• This medicine is not prescribed to patients with moderate (or severe) liver failure, because in this case, its concentration in the blood plasma increases significantly;
• Ezetimibe tablets (at least for now) are NEVER (!) prescribed together with fibrates (medicines to reduce elevated triglyceride levels in the blood);
• "Ezetimibe" is contraindicated for people with hypersensitivity to any of the components of this drug, children and adolescents under 18 years of age, as well as for pregnant (or lactating) women;
• is prescribed with extreme caution (by doctors) for patients taking Cyclosporine (when using this combination, blood serum levels should be monitored).

The effect of dietary supplements on cholesterol levels

All supplements have almost the same effect on the body. The main component of each dietary supplement is plant raw materials. Such cholesterol-lowering pills will have to be taken for quite a long time, but they have significantly fewer unwanted effects, and some have none at all.

The effect of dietary supplements:

• strengthening cell membranes;
• cleansing the inner surface of the vascular walls;
• help natural regulation of cholesterol concentrations;
• reduce LDL levels by inhibiting its absorption from food;
• strengthen the immune system and the body as a whole.

Chitosan

Chitosan should be taken three times a day, 3 tablets each.

This product is manufactured by Evalar. Chitosan is an aminosaccharide obtained from natural raw materials. Helps reduce fat and uric acid in the body, improves digestive processes. Regular use of the product helps remove heavy metals from the body and provide a worthy rebuff to pathogens of fungal diseases.

The main active component is chitosan, obtained by processing the shells of various types of crustaceans. When it enters the human intestine, chitosan binds to fat molecules. Intestinal function improves, microflora is restored, and the feeling of fullness lasts much longer.

Evalar produces Chitosan in tablets, 100 pieces per pack. The composition of the product is complemented by other components: vitamin C, silicon oxide, citric acid, calcium stearate.

The product is prohibited when:

• allergies to components;
• pregnancy and breastfeeding;
• children under 12 years old.

Correctly following dosage recommendations will help prevent the development of unwanted effects. Chitosan should be taken three times a day, 3 tablets. Duration of use is 4 weeks. It can be repeated after 4 months if necessary.

Lecithin Granules

This dietary supplement is rich in lecithin, which is obtained from soy. It has a positive effect on the nervous system, helps restore phospholipid metabolism, helps prevent the development of multiple sclerosis and vascular pathologies, and reduces the concentration of fatty acids and cholesterol.

It is used to lower cholesterol, in the treatment of atherosclerosis, diseases of the nervous system, liver failure, physical activity and as a general tonic.

Use is prohibited if you are allergic to the components of the supplement, for children, during pregnancy and while breastfeeding.

Lecithin Granules is produced in granular form. Sold in jars, each containing 227 grams of granules. You need to drink a teaspoon twice a day with food. The granules can be mixed with food or added to juices.

In some cases, the use of dietary supplements may cause the development of an allergic reaction or disruption of the digestive process. Careful adherence to the dosage regimen will help avoid this.

Vita Taurine

Vita Taurine helps fight the manifestations of atherosclerosis

A supplement in which the main active ingredient is taurine, a plant amino acid that is the main component of bile. It is required to maintain the digestive process, absorb fat-soluble vitamins and lower cholesterol concentrations. It has a diuretic effect, which helps remove excess fluid from the body.

Vita Taurine helps fight the manifestations of atherosclerosis, prevents the formation of blood clots, the development of heart pathologies, and helps strengthen the immune system.

The supplement is available in capsule form. They are taken 2 times a day, one at a time, 30 minutes before meals. The duration of therapy is 4-8 weeks. The duration of the course is determined by the attending physician.

It is not recommended to take it for patients with stomach diseases, during pregnancy and for patients with allergies to the components present in the product.

Sitoprene

The additive slows down the absorption of fat inside the intestines. Helps reduce the risk of developing hypertension and coronary artery disease, increases vascular protection from damage, and increases the strength of cell membranes. The main active ingredient of the dietary supplement is Siberian fir extract. It is also supplemented with calcium stearate and sorbitol.

It is produced in the form of tablets, 60 pieces per package. This supplement should not be used if you are allergic to any of the components, or if you are pregnant or breastfeeding.

You need to take two tablets daily with food. The course of treatment is 30 days. You can repeat it after a second examination and visit to a specialist.

Anticholesterol Alfalfa

Anticholesterol Alfalfa is completely harmless

The product reduces cholesterol and normalizes the concentration of glucose in the blood. An excellent source of vitamins and microelements. The main active ingredient is alfalfa extract. Has a positive effect on the entire body.

Anticholesterol Alfalfa prevents the formation of cholesterol clots, increases blood clotting, has an anti-inflammatory effect, and helps eliminate uric acid salts. The product is recommended for the prevention of cancer pathologies and hypertension.

Produced in capsules. Packed in 50 capsules. The daily dose is 2 capsules 2 times a day with meals. Duration of admission is 30 days. If necessary, the course can be repeated no earlier than 4 weeks after visiting the doctor.

The additive is completely harmless. It should not be used only by patients who are allergic to the components present in the supplement.

Vitamnorma-geronto

This dietary supplement contains extracts of medicinal plants that help lower cholesterol and have a general strengthening effect. It helps strengthen vascular walls, prevents the formation of cholesterol clots, normalizes blood circulation in the brain, and restores gastrointestinal functions.

1. Hawthorn – normalizes heart function, lowers blood pressure, eliminates arrhythmia and tachycardia.
2. Ficus is a source of iodine. Restores the functioning of the thyroid gland, metabolic processes, and prevents the development of atherosclerosis.
3. Ginko biloba - helps restore blood circulation in the brain, effective in rehabilitation after a stroke.
4. Vitamins B, C, E - have a positive effect on blood vessels and the heart, and are necessary to maintain immunity.

Produced in the form of capsules, packaged in 60 pieces per package. You need to take it for three weeks. The course can be repeated after a month if necessary. Before use, you should consult your doctor. You need to drink one capsule daily three times during the day.

Contraindicated in case of allergy to the components of the product, pregnancy and lactation.

Lemon prune. Fibropect

The treatment course lasts 30 days

This supplement helps maintain the required cholesterol level, normalize the gastrointestinal tract, restore intestinal microflora, remove toxins from the body, and reduce the risk of oncological pathologies.

Ingredients: prunes, apple pectin, wheat fiber, red rice, maltodextrin, lactulose, gaur gum, lemon juice, fructose, chokeberry powder.

Release form: powders. The cardboard package contains 10 fifteen gram sachets. To prepare a healing drink, you need to pour the contents of the sachet into a glass of hot water. Then mix thoroughly and leave for a quarter of an hour. After the time has elapsed, the drink is ready for consumption. You need to drink it 2 times a day, half an hour before meals. If the acidity of gastric juice is increased, the drink can be consumed with food.

This dietary supplement is completely harmless. It should not be taken by people with allergies to the ingredients of the product. The treatment course lasts 30 days. To extend it, consultation with a specialist is required.

Mega plus

The basis of the product is docosahexaenoic and eicosapentaenoic acids. They are present in purified fish oil. The supplement effectively helps reduce cholesterol in the blood plasma, promotes the absorption of magnesium and calcium, and reduces the possibility of developing atherosclerosis and thrombosis. Can be used as a source of Omega-3.

Produced in capsule form. The recommended dose is 1 capsule three times a day with food. Treatment lasts 1 month.

The supplement is prohibited for use if you are allergic to the components of the product, pregnant or lactation. Before starting use, you should consult a specialist.

Optima seaweed

Capsules should be taken one three times a day

This supplement uses sugar kelp and common kelp as a base. This composition allows it to be a unique source of iodine. Its use will help reduce cholesterol levels, normalize the functioning of the gastrointestinal tract, strengthen vascular walls, and minimize the risk of thrombosis. It is recommended to take dietary supplements to improve the health of the body, restore thyroid function, and cleanse the intestines. The supplement contains more than 40 elements necessary for the body. These include vitamins belonging to group B, polysaccharides, and ascorbic acid.

Capsules should be taken one three times a day. Therapy is carried out for 30 days. Its duration is determined by the attending physician.

The supplement should not be taken if you are allergic to its components.

Artemisin

The additive has a wide spectrum of action. It regulates cholesterol levels in the blood, stimulates intestinal function, has a fungicidal effect, helps restore metabolic processes, and relieves vascular spasms. It is often recommended for use in diabetes mellitus, parasitic infections, respiratory pathologies, and skin problems.

Artemisin contains:

• tansy flowers - having antispasmodic and anti-inflammatory effects, effective in the fight against parasites;
• wormwood – helps restore microflora in the intestines;
• allspice clove – has an antimicrobial effect;
• knotweed herb - helps restore the gastrointestinal tract;
• peppermint – removes harmful substances from the body, has antispasmodic and antiseptic effects;
• St. John's wort - has choleretic properties, relieves spasms, has a slight laxative effect;
• buckthorn bark – contains alkaloids and ascorbic acid;
• hops – has an anti-inflammatory effect, helps stimulate the digestive process;
• thyme herb – has an analgesic and disinfectant effect.

Tablets should be taken three times a day, 2 pieces. To achieve maximum effect, they need to be used for at least one and a half weeks. In this case, you need to adhere to a low-carbohydrate diet.

Sometimes the use of the product leads to allergies in people with hypersensitivity to the components of the dietary supplement. Otherwise it is completely harmless. It can be used during the treatment of children.

Argillavit "Antioxidant"

Argillavit “Antioxidant” is produced in tablet form

This dietary supplement is based on blue Cambrian clay, purified using a multi-stage method. It is an excellent sorbent and removes harmful substances from the body. The supplement contains almost 40 microelements that are beneficial to the body.

It contains grape seed extract, rose hips, linden blossom, ficus, echinacea, and green tea. Thanks to these plants, cholesterol levels are reduced. In addition, the risk of developing thrombosis is reduced, the immune system is strengthened, and blood circulation is restored.

The product is produced in tablet form. This allows you to correctly dose the dietary supplement when used. Take two tablets three times a day, half an hour before meals.

You should not take tablets if you are allergic to their components. Before you start taking these pills, you should definitely consult your doctor.

Atheroclephitis Bio

Another supplement produced by Evalar, aimed at reducing cholesterol levels and normalizing the functioning of the cardiovascular system. It is not toxic to the liver, which makes it completely harmless. Its use stops the formation of cholesterol clots in blood vessels and restores blood viscosity. Its use is recommended for excess weight, high blood pressure, diabetes, overexertion, and prolonged stress.

The product consists of hawthorn flowers, red clover extract, proteins, rutin, panthenoic acid, vitamins and minerals. Produced in capsules. Packed in 30 or 60 pieces per box with instructions for use.

You need to take capsules twice a day, one with food.

Even long-term use does not lead to the development of side effects and addiction. The drug should not be taken in case of individual intolerance, children under 18 years of age, after head injuries, with a tendency to alcoholism and kidney pathologies.

Antioxidant biocomplex

Antioxidant biocomplex should be taken 1 capsule twice a day

The product contains vitamins C, A, E, dihydroquercetin, copper, selenium, zinc, green tea extract. It helps protect cells from free radicals, helps remove cholesterol, improve immunity, remove toxins, and prevent premature aging.

Available in capsule form. You need to drink 1 capsule twice a day. Therapy lasts 60 days. Three courses can be taken in 12 months.

Gepar Code of Life

The dietary supplement is made from medicinal herbs growing in Russia. It contains: wormwood, chamomile, blueberry, yarrow, mint, coriander, motherwort, lingonberry, milk thistle, dill, rose hips, eucalyptus, calendula.

This composition helps reduce the concentration of cholesterol, restore liver function, normalize hormonal levels, improve the functioning of the kidneys and thyroid gland, helps cleanse blood vessels from cholesterol clots, improves blood flow, and increases performance.

Produced in filter bags. It must be brewed like tea and drunk three times a day for 14 days. Before starting therapy, you need to check for allergies to the components of the product and consult a specialist.

Tykveol

The supplement is produced in the form of capsules and oily liquid. The main active ingredient is pumpkin seed extract. The dietary supplement contains: tocopherol, sterols, phospholipids, carotenoids.

Tykveol regulates cholesterol levels, prevents the formation of atherosclerotic clots, has an anoxidant effect, improves the efficiency of the biliary tract, and improves blood circulation. Dietary supplements are used during the treatment of atherosclerosis, gastritis, hepatitis, and skin diseases.

This supplement should not be prescribed to children under 12 years of age or to people with allergic reactions to the components present in the dietary supplement. Sometimes the use of Tykveol can cause gastrointestinal upset.

Drink a teaspoon of the oil-based product 30 minutes before meals three times a day. The therapeutic course is 3 weeks. In 12 months you can conduct 4 courses. The capsule form of the drug is drunk one three times a day. The duration of treatment can be up to 4 months.

Policosanol

Policosanol is best taken with dinner because cholesterol synthesis accelerates at night

The dietary supplement is produced in tablets that may contain 10 or 20 milligrams of polycasanol. The main active substance is obtained from sugar cane. It helps to enhance lipid metabolism and cholesterol metabolism. The use of the product helps improve the delivery of LDL to liver tissue and helps accelerate the processes of their breakdown.

The initial recommended dosage is 10 mg of the drug. It is best taken with dinner because cholesterol synthesis accelerates at night. This way the product will be more effective. After 4 weeks, the dose can be doubled.

Contraindications: childhood, intolerance to components, pregnancy and lactation.

Lipoic acid

It has antioxidant properties, promotes the removal of toxins, helps with glucose utilization, and accelerates cholesterol metabolism. Often used during the treatment of hepatitis, pathologies of the liver and nervous system, and poisoning.

It is prohibited for use by people prone to allergies, during pregnancy and breastfeeding. In case of overdose, side effects appear in the form of nausea, itching, vomiting, and convulsions.

You need to take one tablet daily for 4 weeks. Patients with insufficient liver function can take 4 tablets per day for 30 days. When starting treatment, you need to consult with your treating specialist.

Important! You can start using any of the above described remedies only after visiting a treating specialist. It is he who should give a recommendation for the use of a particular supplement.

Cholesterol absorption inhibitor and statin combinations (Ineji)

So, after the success of the drug, EZETIMIB (together with) is developing more effective drugs that are a combination of two inhibitors at once: cholesterol absorption (in the intestines) and HMG-CoA reductase (in the liver). That is, a certain “pharmacological duet”: “ezitimibe + statin”. Thus, exactly 4 years later (in October 2006), the FDA approved for use their first “brainchild” called “VITORIN” / “Vitorin” (known in our country under the brand name “Ineji”), which is a combination of “ezetimibe + simvastatin” . And in May 2013 - a second (of the same kind) medicine called “Liptruzet” / “Liptruzet”. Only this time in combination with a more recent (THIRD) generation statin: ezetimibe + atorvastatin.

The main advantages of the first medicine (in particular, Vytorina) are the highly/effective reduction of high levels of LDL cholesterol in the blood plasma (up to 61%/depending on the dosage). According to the results of the very first studies, it turned out that this drug was able to “overtake” (at least in terms of a very effective reduction in the level of “bad” cholesterol in the blood) even the newest generation statin - Crestor (Rosuvastatin), produced by Astra Zeneca." The second drug (Liptruzet) was also an excellent tool for reducing elevated levels of LDL cholesterol in the blood in patients with primary or mixed hyperlipidemia (as an additional therapy to diet). When therapy (the most popular in the USA and Canada) with Atorvastatin alone did not help. However, in January 2014, these tablets were urgently completely recalled due to defects in the packaging (the foil allowed air and moisture to pass through).

Cool duet: “ezitimibe + statin / simvastatin”, registered in the Russian Federation under the trademark “INEGI”...

Effective inhibitor drugs for lowering blood cholesterol

Cholesterol absorption inhibitors (CAIs) are quite effective drugs for lowering blood cholesterol, but there are very few medications available worldwide. In Russia today, among the registered medications from this group, there is only one drug - Ezetrol.

This drug is practically safe to take for the purpose of lowering cholesterol levels. The safety of the drug is due to the fact that it is almost not absorbed into the blood. In addition, it can be taken even by patients with serious liver problems, as well as people who cannot tolerate statins.

Drugs from this group can be taken simultaneously with statins, unlike fibrates. This combination will only increase the effectiveness of treatment, but statins are still significantly superior to IAC in this regard.

Combination of a statin and a calcium channel blocker (Caduet)

Just like the previous tablets, this drug (in particular, “Caduet” / “Caduet”) is also a combination drug. Only this time, it has hypolipidemic, antihypertensive, and antianginal pharmacological actions. Due to the content in its composition - both a statin and a calcium channel blocker / or calcium antagonist, that is, Atorvastatin and Amlodipine.

That is why, "Caduet" / "Caduet" is used as a prevention of cardiovascular diseases in people with high blood pressure, in the presence of 3 (or more) associated risk factors, including either normal or moderately/elevated cholesterol levels in blood plasma. Most often, it is prescribed in cases where ischemic heart disease is not yet clinically expressed, but treatment is already recommended - with minimal doses of Atorvastatin in combination with Amlodipine.

Benefit and effectiveness

Cholesterol dietary supplements are an excellent addition to pharmaceutical medications, but not a replacement for them. Dietary supplements do not have the power and speed of action on the body and intracellular processes in the same way as drugs from the chemical medical industry. That is why they are practiced as auxiliary medicines for progressive ailments and as a means of prevention when the disease has not been identified, but there is a tendency to it.

Spirulina, alfalfa, and taurine included in the dietary supplements help not only prevent atherosclerosis and treat the disease at the initial stage, but also strengthen the immune system, normalize blood pressure and gastrointestinal functions.

Newest Cholesterol Drugs: PCSK9 Inhibitors

Inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9 / Proprotein Convertase Subtilisin/Kexin type 9) are the newest class of lipid-lowering drugs (injections) intended for the most problematic cases. For example, doctors prescribe it when statin therapy (even in maximum/tolerable doses, in combination with ezetimibe) does not help! Which most often occurs in patients suffering from heterozygous hereditary (familial) hypercholesterolemia or rapidly/progressive atherosclerosis.

According to research results, the “PCSK9 inhibitor” is able to (record) reduce the level of “bad” LDL cholesterol in the blood by 50-60%! Injections are given once every 2 weeks (the injection is administered subcutaneously). The medicine has received a lot of grateful reviews, but it has a simply “cosmic” cost: from 200 euros per package (with one filled “syringe/pen”)!

The most famous drugs:

• "ALIROKUMAB"
  / "Alirocumab" ("PRALUENT" / "Praluent");
• "EVOLOCUMAB"
  / "Evolocumab" ("REPATA" / "Repatha").

Side effects (actions):

The most common undesirable effects after using Alirocumab/Praluent are allergic reactions in the form of itching, swelling of the tissues of the face and neck, redness and swelling at the injection site, rhinitis, sneezing, and sore throat. After injections with the drug "Evolocumab/Repata" there are flu-like symptoms, nausea, urticaria, rash on the skin, back pain, bruise (hematoma) at the injection site.

Review of popular dietary supplements and herbal preparations for cholesterol

Dietary supplements (BAA) are preparations that contain particles of natural origin. Often these are extracts of medicinal plant species, minerals, concentrates or extracts of animal origin. In addition, dietary supplements include vitamins, macro-/micro-elements, and other health-promoting compounds.

These medications are produced in tablet, capsule and powder forms. They are easy to use - just drink them with a glass of distilled water. Not all dietary supplements have a sufficient clinical research base to confirm or refute their effectiveness. Dietary supplements are not drugs and are not part of traditional medicine. Despite this, the available scientific data indicate the advisability of using some of them for high cholesterol.

Dietary supplements for lowering cholesterol levels can be divided into three large groups :

1. Accelerating and activating fat metabolism . These drugs are aimed at increasing the excretion (removal) of bad cholesterol from the bloodstream. Most often they are made from plant materials - for example, based on garlic.
2. Reducing the absorption of fats in the gastrointestinal tract . The mechanism of action of this group of dietary supplements is to reduce the amount of digestible substrate for cholesterol synthesis. Thus, it is possible to influence not only the exogenous part of fats, but also the endogenous part, which is produced by the body itself. Extracts from arthropod crustaceans serve as a common basis.
3. Reducing the content of harmful cholesterol in the bloodstream. They act on LDL and VLDL, reducing the risk of developing atherosclerosis and other vascular complications.

Before choosing a specific drug from the group of dietary supplements, you must undergo a full medical examination and consult with a specialized specialist. If cholesterol levels are high in the lipid profile, monotherapy with dietary supplements is not indicated - dietary supplements should only be an addition to the main drug treatment.

Policosanol (from cane sugar)

Policosanol is a popular dietary supplement that a doctor can prescribe as an addition to the main therapy of atherosclerosis. The main active ingredient of the drug is a compound obtained from cane sugar. It affects fat metabolism and metabolism, accelerating and stabilizing them. Thanks to the action of the drug, the metabolic cycle of LDL (bad cholesterol) is reduced and they are broken down faster in the liver. This is how there is a gradual reduction in “bad” cholesterol.

Policosanol is produced in tablet form with two dosage options - 10 and 20 mg, respectively. According to the instructions for use, a minimum dose of 10 mg is recommended as initial therapy. Taken once a day, preferably in the evening with dinner. After four weeks, with the doctor’s permission, the dosage of the dietary supplement can be increased to 20 mg.

Reviews of policosanol group drugs are positive from both patients and doctors. Cost from 200 UAH in Ukraine and from 500 rubles in Russia. It is recommended to buy the supplement only in pharmacies or on iHerb (Solgar, Now Foods, Source Naturals).

Sitoprene (from Siberian fir needles)

Sitoprene belongs to the second group of dietary supplements - drugs that reduce absorption processes in the gastrointestinal tract. This dietary supplement is produced on the basis of Siberian fir needle extract. The healing effect is achieved due to beta-sitosterol and polyprenols. These compounds reduce the progression of hypertension, reduce the frequency of ischemic cardiac crises, have a protective effect on vascular walls and strengthen cell membranes.

Produced in tablet form. According to the instructions for use, take 2 tablets per day directly with meals. The course of such treatment is up to 4 weeks. Therapy is prescribed at the discretion of the treating doctor, who will recommend the most rational instructions for the daily use of Sitoprene. The price of the drug is 450–550 rubles (200–280 UAH).

Meadowsweet oil extract

Meadowsweet is a natural remedy containing active compounds such as flavonoids, catechins, heliotropins, and essential oils. This natural composition has anti-cholesterol properties. In addition, the extract of this plant promotes accelerated lysis of blood clots in blood vessels, stabilization of capillary circulation and cardiac activity.

Meadowsweet oil extract can be purchased at a regular pharmacy. Take 1-2 spoons orally daily. It is not recommended to take breaks between doses, since the accumulation effect will be disrupted. The course of therapy is about one month. The price of the product is about 1000 rubles (500 UAH).

Garlic Cholesterol Tablets

Preparations based on garlic have a very wide spectrum of action:

• I reduce the content of “harmful” cholesterol in the blood - reduce LDL and VLDL;
• reduce triglyceride concentrations;
• have an immunological effect - increase the body’s resistance (immunity) to infectious agents such as viruses and bacteria;
• reduce the likelihood of blood clots;
• increase bile excretion and, as a result, contribute to the rapid removal of excess cholesterol from the body;
• recommended for hypertension, high risk of heart attack;
• influence atherosclerotic plaques - prevent their formation.

Bioadditives such as Alisat, Kyolic, Solgar garlic oil and their other analogues are available in our pharmacy market. They are not medicines, therefore, in case of high cholesterol levels, they are prescribed only as an addition to the main treatment. Drugs in this group are not prescribed to patients diagnosed with cholelithiasis (cholelithiasis), pregnant women, lactating women, and patients with individual hypersensitivity to dietary supplement components. The average price of Alisat in Ukraine is 70 UAH, in Russia – up to 200 rubles.

1. Solgar Perles Garlic Oil (250 capsules).
2. Now Foods Garlic Oil, 1500 mg (250 capsules).
3. Nature's Bounty Garlic Tablets, 2000 mg (120 tablets).
4. Kyolic Aged Garlic Extract (300 Capsules).
5. Mason Natural Garlic Oil, 1000 mg (100 capsules).

Fish oil and Omega-3

The main goal for high blood cholesterol is to reduce the level of low-density lipoproteins and increase the concentration of HDL (high-density lipoprotein). Omega-3 fatty acids have this effect. They are a type of polyunsaturated fat. Our body does not produce them on its own, so we can only get them from food.

High content of Omega-3 and Omega-6 in seafood, and especially in fish oil. It is most often sold in capsules and contains EPA and DHA - eicosapentaenoic and docosahexonic acids. In addition to reducing the level of harmful cholesterol, these active compounds also affect the level of triglycerides, reducing it to physiological norms.

Bempedoic acid (ATP citrate lyase inhibitor)

These are the newest “cholesterol pills 2019-2022”, however (!) at the moment – ​​they are not yet (!) approved by the FDA and EMA. The estimated date of entry into the pharmaceutical market is 2022. Their most important advantage is the significant assistance they provide to those patients (in lowering LDL cholesterol) who CANNOT take statins - either due to some side effects (for example, muscle pain, in almost 90% of cases), or because of “ incompatibility” of the latter with some other drugs.

According to the results of a series of studies (phase 3 of which was completed in 2020), bempedoic acid (or an ATP-citrate lyase inhibitor) when combined with Ezetemibe reduces LDL cholesterol levels by 43%. That is why the company has submitted an application to the FDA and EMA - for now, to produce tablets with bempedoic acid, and to take it exclusively in combination with Ezetemibe.

The medicine will be taken only once a day, but the cost is by no means cheap (at least by our domestic standards). Specialists from the commercial department of Esperion Therapeutics (i.e., the developer of this drug) suggest that treatment with this newest drug will cost Americans NO MORE than $4,000 per year. Probably, for many, this “NO MORE” will not reassure you at all!

Fibrates (fibric acid derivatives)

Fibrates are highly effective medications designed to reduce elevated triglyceride levels in the blood (up to 50%). Typically, they are prescribed (by doctors) for patients suffering from hypertriglyceridemia, familial combined dyslipidemia, and diabetic dyslipidemia. In addition, fibrates slightly lower LDL cholesterol (by 10-20%), but significantly increase the amount of “good” HDL cholesterol (up to 20-25%)! There are many other beneficial properties of these drugs.

Specifically, to slow the development of atherosclerosis in patients with IHD (Coronary Heart Disease), treating specialists prescribe Bezafibrate or Gemfibrozil. And for patients suffering from type 2 diabetes mellitus - Fenofibrate. Together with statins (cautiously, and in minimal dosages), fibrates are prescribed (!) only for the treatment of isolated hypertriglyceridemia (i.e. endogenous type IV HLP / elevated VLDL levels). Since these drugs work great, but paradoxically increase Total Cholesterol. That is why Simvastatin (10 mg per day) or Fluvastatin (20 mg per day) successfully solve this problem.

List of the best fibrates:

• "FENOFIBRATE"
  / "FENOFIBRATE" ("Traykor" / tablets);
• "GEMFIBROZIL"
  / "GEMFIBROZIL" ("Lopid" / tablets);
• BEZAFIBRATE
  (available only in Europe);
• "CIPROFIBRATE"
  / "CIPROFIBRATE" ("Lipanor" / capsules).

Side effects:

By and large, fibrates are tolerated NORMALLY! Although, 5-10% of patients may still experience side effects: abdominal pain, constipation, diarrhea, flatulence, skin rash, insomnia. But it is definitely worth noting that all these phenomena are not severe in nature, therefore, they do not even require immediate cessation of therapy. Perhaps the most unpleasant situation that can happen to men taking these pills (or capsules) is a decrease in potency (to a greater extent during treatment with “ciprofibrates”).

Contraindications (restrictions):

These medications are contraindicated in patients with severe renal and liver dysfunction, children and adolescents (under 18 years of age). Doctors never prescribe them for congenital galactosemia and lactase deficiency. The drugs (the first 2 generations, i.e. clofibrate, bezafibrate and gemfibrozil) are not (!) recommended for patients suffering from cholelithiasis. And finally, fibrates are strictly (!) prohibited for use by women - either during pregnancy or lactation (i.e. breastfeeding).

1. MORE ABOUT FIBRATES
2. DETAILS (FROM “A” TO “Z”) ABOUT REDUCING TRIGLYCERIDES IN THE BLOOD

Fibrates

Code in the telephone exchange: C10AB.

List

List of the main active ingredients of fibrates and drugs developed on their basis:

• Bezafibratum;
• Gemfibrozil: Lopid, Gevilon;
• Clofibrate: Aluminum Clofibrate, Atromidine, Lipomide, Miscleron, Clofibride;
• Ronifibrate;
• Simfibrate;
• Fenofibrate: Lipantil, Traykor, Exlip 200, Trilipix;
• Ciprofibrate: Ciprofibrate Lipanor;
• Etofibrate.

They are derivatives of fibric acid.

Fibrate-based drugs

Action

Pharmachologic effect:

• form inextricable chemical compounds with bile acid, which leads to a decrease in the production of cholesterol by the liver.
• they reduce the level of predominantly triglycerides (increase the destructive effect of cholesterol), in this regard they are more effective than statins;
• reduce the concentration of uric acid;
• eliminate extravascular deposits;
• choleretic;
• weaken postprandial hyperlipidemia, which most often affects diabetics (type II disease);
• reduce the concentration of bad cholesterol by 25%, triglycerides by 50%, increase the amount of healthy lipoproteins by 30%.

Despite the widespread use of fibrates in the treatment of CVD, their effectiveness in influencing cholesterol is significantly inferior to statins.

Side effects

Fibrates have milder and less dangerous side effects than statin drugs. However, you don’t need to think that they don’t exist at all. Most often noted:

• vomiting, increased gas formation, gastric and intestinal dyspepsia, diarrhea, abdominal pain, nausea;
• pancreatitis, hepatitis, cholelithiasis;
• myopathy (up to the development of rhabdomyolysis), myalgia, myositis, paresthesia, lower back pain, arthritis;
• migraine;
• impotence, frigidity, infertility;
• thromboembolism of the pulmonary artery and veins;
• dermatological problems.

To lower blood cholesterol levels, combinations of statins and fibrates are possible. At the same time, the dosage of both is reduced, as is the risk of side effects.

Contraindications include pathologies of the liver, gall bladder, and impaired hematopoiesis.

OMEGA 3 (PUFA / Polyunsaturated Fatty Acids)

Lipid-lowering drugs developed on the basis of a mixture of OMEGA-3 PUFA (polyunsaturated fatty acids) ethyl esters, up to 90%, to a greater extent, are intended to reduce VERY HIGH levels of triglycerides (from 500 mg/dL / over 5.7 mmol/L) , by reducing the concentration of VLDL (Very Low Density Lipoproteins). Slightly, but they increase the level of “good” HDL cholesterol.

In addition, these drugs (in particular, the drug "Omacor") literally save people's lives after myocardial infarction! Excellent for patients suffering from type 2 diabetes (due to a decrease in insulin resistance during combination treatment - together with statins). They also prevent muscle degeneration, dementia (in older people), and have a positive effect on certain depressive conditions.

List of the most effective means:

• "OMACOR"
  / "OMACOR";
• "Vitrum Cardio Omega-3"
  .

The names of the most famous foreign brands: “Epanova”, “Lovaza”, “Omtryg”, “Vascepa”.

OMEGA-3: side effects (actions):

• gastrointestinal disorders (bloating, abdominal pain, constipation, diarrhea, dyspepsia, flatulence, belching, nausea or vomiting);
• halitosis (bad breath);
• dysgeusia (disorders of taste);
• infrequently – dizziness, headaches;
• hypotension (low blood pressure).

Contraindications (cautions):

• individual hypersensitivity to active substances or to any other components of the (above) medications produced in soft capsules;
• hypervitaminosis (excess) of vitamin E (for Vitrum Cardio Omega-3 capsules);
• Not recommended (or prescribed with extreme caution) to pregnant (or breastfeeding) women, as well as children and adolescents under the age of 18 years.

Omega-3 supplements

Omega-3 supplements help reduce bad cholesterol levels. They come in different types and from different manufacturers. To get a good result, these funds must meet several conditions:

• Availability of an international GMP certificate
• Russian Federation Certificates
• Testing in medical institutes and clinics
• Guaranteed amount of useful substance in each capsule

Fish Oil GP fully complies with these standards . It is suitable for both the prevention and reduction of low-density triglycerides.

Mechanism of action

Omega-3 contains polyunsaturated acids, each of which brings specific benefits to the body:

Linolenic acid reacts actively with bad cholesterol, breaks it down and removes it from the circulatory system. Also, the substance gradually reduces already formed cholesterol plaques and restores the damaged vessel, making its walls elastic and strong.

Eicosapentaenoic acid tones arteries and veins, protects them from high pressure and deformation. Such properties not only lower cholesterol levels, but also reduce the symptoms of hypertension, reduce the risk of atherosclerosis and other diseases of the cardiovascular system.

Thanks to docosapentaenoic acid , beneficial substances are better absorbed in the gastrointestinal tract. In addition, the body begins to more actively synthesize endogenous (low molecular weight biologically active) substances that are vital for biochemical and physiological processes.

Docosahexaenoic acid ensures proper functioning of the nervous system and brain. This is especially important for pregnant women and children during periods of active growth.

However, the beneficial properties of omega-3 do not end there. Taking Fish Oil GP will have a positive effect on your overall well-being:

• Your immune system will become stronger
• Reduce the risk of heart attacks, strokes and neoplasms
• Blood viscosity will decrease
• Skin quality will improve

How to use

Fish Oil from Santegra should be taken three capsules once a day with meals.

more about indications for use here .

Where can I buy

It is safest to order Santegra dietary supplement on the official website of Santegra Shop. This will protect you from counterfeits and unreliable sellers.

Niacin (vitamin B3/PP, nicotinic acid, nicotinamide)

In large dosages (much higher than the daily norm), NIACIN reduces the levels of LDL cholesterol (by 20-30%), triglycerides (by 20-50%), and apolipoprotein A (up to 30%). It also increases the concentration of beneficial HDL cholesterol (by 25-50%), which has anti-atherogenic properties (i.e., preventing the formation of cholesterol plaques). In addition, it dilates small blood vessels well and reduces platelet aggregation (thus, “interfering” with the formation of blood clots).

However, it is in LARGE quantities (or during LONG-TERM use) that this medicine has a huge list of side effects that occur in almost (!) 30% of patients. The most common are skin problems (redness, dryness, itching, ichthyosis), a serious increase in sugar levels in diabetics, “tingling” in the abdominal area and headaches.

Thus, most doctors try to prescribe niacin (as a lipid-lowering drug) only in the most extreme cases! For example, when a person (for a variety of reasons) cannot take statins (i.e., classic “cholesterol pills”). In addition, according to recent studies, this drug does not (!) provide any additional benefits (for example, when combined with statins) in terms of reducing the risk of cardiovascular diseases.

• MORE ABOUT NICOTINIC ACID (NIACIN)
• HOW TO LOWER CHOLESTEROL LEVELS WITHOUT MEDICATIONS?