Hypertension is one of the most common diseases of the cardiovascular system. It affects more than 40% of the population of our planet. Moreover, if earlier this pathology affected mainly only older people, now it increasingly affects young people and even children. As pressure increases, the blood thickens and the blood vessels narrow. Because of this, oxygen begins to flow worse to the cells, which negatively affects the condition of internal organs and leads to various serious complications. Therefore, hypertension is a situation that cannot be ignored.
In most cases, starting medications such as beta blockers are enough to lower blood pressure. However, sometimes it happens that with their help it is not possible to normalize the condition. In this case, inhibitors can act as the second stage of treatment. One of the most famous of them is Zokardis.
General information about Zokardis
Zocardis is an ACE blocking drug. It has pronounced hypotensive properties.
This remedy is actively used for mild and moderate hypertension. It allows you to quickly lower blood pressure and eliminate rapid heartbeat.
The product is produced in the form of oval tablets coated with a film of titanium dioxide, as well as macrogol 400 and 600. One serving contains 30 mg of the active substance - zofenopril calcium. There is a notch on it that allows you to divide the medicine into two equal doses. Corn starch, MCC, silicon dioxide, magnesium stearate, and lactose monohydrate are used as auxiliary ingredients.
Zocardis does not have a rapid antihypertensive effect. But its effect lasts throughout the day. This allows you to take the drug once a day.
It has a fairly large list of side effects and contraindications, which makes it impossible to take it on an ongoing basis. At the same time, it continues to act even when the dose is reduced.
It is not easy to purchase the product yourself, since it is sold only with a doctor’s prescription.
It should be stored in a dry place, inaccessible to animals and children, at a temperature not exceeding 25 degrees. The shelf life of Zocardis is three years.
The drug has been studied in humans and rodents. Therefore, it is classified as a medicine with proven effectiveness.
The price of Zokardis is quite affordable. It costs less than many of its analogues.
How to take and at what pressure: Zocardis dosage
Many patients ask at what blood pressure to take Zocardis. Zofenopril is sold in 30 and 60 mg tablets. 7.5 mg tablets are also available and should preferably be taken in the first 4 days after a heart attack. For hypertension, it is recommended to take 30 mg once daily.
In case of impaired renal function (creatinine clearance just below 30 ml/min) and mild to moderate liver failure, the dose should be halved. The dosage for acute heart attack is 2 times 7.5 mg in the first two days, 2 times 15 mg for the next 2 days, and then twice 30 mg per day.
If blood pressure drops, the dose should be reduced again. Therapy must be continued for 6 weeks. During pregnancy, ACEIs are contraindicated due to risks to the baby. Treatment with a 30 mg tablet daily requires significant costs. However, the same treatment is available at half the price if half a 60 mg tablet is used.
Pharmacokinetics and pharmacodynamics
This drug lowers blood pressure by blocking ACE. During its influence, several processes occur in the body at once.
Zocardis reduces the rate of synthesis of angiotensin I and II. This leads to inhibition of aldosterone production, as well as a decrease in the breakdown of bradykinin and an increase in prostaglandin production.
During the described processes, veins and arteries expand. Moreover, the latter - to a greater extent. Blood pressure and OPPS also decrease. Afterload and preload are reduced.
The antihypertensive property of the drug is more noticeable when there is a large amount of renin in the blood. At the same time, with a decrease in pressure, blood flow in the parts of the brain will circulate at an optimal level, and coronary and renal circulation becomes more intense.
Long-term use of Zocardis provides additional results in the form of a decrease in myocardial hypertrophy, as well as resistive arterial walls. This helps slow the development of cardiac pathologies, including ventricular failure and dilatation.
There is also a decrease in platelet aggregation, as well as an improvement in the acceleration of blood circulation in the myocardium, with ischemia.
The described remedy belongs to prodrugs. Because when treated with thioester hydrolysis in the body, it turns into the active compound – zofenoprilate.
The antihypertensive effect is observed an hour after taking the drug. In this case, the best performance is achieved over the next six hours. The hypotensive effect of Zocardis persists for 24 hours after taking it.
To completely normalize the condition in terms of lowering blood pressure, it is necessary to take a course of treatment with this drug. It usually lasts only a few weeks. In case of cardiac failure, to achieve a positive effect, it is necessary to undergo long-term treatment, which can last from six months or more.
After taking the drug, the active substance is very quickly absorbed from the gastrointestinal tract into the bloodstream, turning into zofenoprilat. Moreover, after an hour and a half, its highest concentration in the blood is observed. It combines 88% with blood proteins.
The described medication is processed fairly quickly in the liver. In this case, active metabolites are formed. The half-life of Zocardis is 5.5 hours. 69% of the drug is excreted through the urinary tract, and 26% through the intestines.
Description of the mechanism of action of the drug
As with other ACE inhibitors, zofenopril is an inactive precursor (prodrug) to the pharmacologically active drug zofenoprilate. In its structure, zofenoprilat is related to captopril. Like captopril, it has a free sulfhydryl group. The mode of action of zofenopril is similar to the pharmacodynamics of ACE inhibitors: the active substance blocks angiotensin-converting enzyme. This results in inhibition of the conversion of angiotensin I to angiotensin II.
Zofenopril – angiotensin-converting protein blocker
After oral administration, zofenopril is rapidly and well absorbed and is almost completely converted to zofenoprilat. The active ingredient reaches maximum plasma levels in just 1.5 hours. The bioavailability of zofenopril is about 70%. The drug is metabolized in various ways. The plasma half-life is 5.5 hours, which is less than most other ACEIs. According to the manufacturer, plasma ACE activity is still approximately halved 24 hours after the usual dose of zofenopril (30 mg).
Most of the active ingredient is excreted in the urine (76%). Stool contains 16% of the dose. In moderate to severe renal failure (creatinine clearance below 45 ml/min), excretion slows down significantly.
Properties of the product
Zocardis is a fairly effective remedy. It has several distinct actions that help in the treatment of certain diseases.
Properties of Zokardis:
- The drug lowers blood pressure. At the same time, it affects both systolic and diastolic pressure;
- Zocardis also helps increase blood circulation by dilating veins and blood vessels;
- Reduces hypertrophy of the left ventricle and arterial walls;
- The drug reduces platelet aggregation.
These properties help the drug quickly and effectively reduce blood pressure. At the same time, the negative consequences of hypertension are eliminated.
Drug interactions
Zocardis 7.5 can be taken together with other medications. However, sometimes such treatment has negative consequences for human health. Therefore, patients should take into account the following nuances that relate to the simultaneous use of several medications:
- If Zocardis is taken together with analgesics, diuretics, anesthetics, antipyretics or antihypertensive drugs, a strong hypotensive effect may be observed. Reviews from doctors about this medicine confirm this information;
- When taking the drug simultaneously with potassium-sparing diuretics or medications that belong to the NSAID group, the hypotensive effect decreases;
- In the case of interaction of the active substance of the drug with lithium salts, a release line is observed, which is significantly slowed down;
- Hematotoxicity results from the combined use of this drug in therapy with immunosuppressants, alloprinol and cytostatics.
When drawing up an optimal treatment regimen, the specialist must take into account the need for the patient to take several medications at once. He must select medications that will complement the action of Zocardis without causing negative reactions.
Application of Zocardis
This product can only be used after consultation with a specialist. It is very important that it is used for its intended purpose. There are three cases when Zocardis is indicated for use.
Indications for use of Zocardis:
- The main indication for the use of Zocardis is hypertension. This remedy is actively used for hypertension of the first and second degrees. At the same time, to reduce blood pressure to an optimal level, it is enough to take a short course of several weeks.
- This remedy is also indicated for myocardial infarction. In this case, you need to start taking the drug on the first day. However, the use of the drug is possible only if the patient has not undergone thrombolytic therapy.
- If the functionality of the heart is insufficient, the described medication can also be used. It is most often used for heart attacks with signs of disturbances in the functioning of the heart muscle.
This remedy cannot be used for a long time, which exceeds the course. Once optimal pressure is achieved, its use should be discontinued.
Zocardis plus
Zocardis Plus is available in the form of white tablets. They are covered with a shell, fourteen pieces per coin.
Features of composition and action
Zocardis plus according to the instructions for use is an antihypertensive combination drug consisting of:
- 30 milligrams of zofenopril calcium;
- 12.5 milligrams of hydrochlorothiazide.
The presence of a diuretic component allows you to stabilize blood pressure more effectively.
In what cases is the medicine indicated?
Indicated for use in the following cases:
- hypertension (any degree);
- acute period of cardiac muscle necrosis;
- serious cardiac dysfunction.
According to the instructions for use, Zocardis plus is prescribed if Zocardis 7, 5 and 30 do not have the expected hypotensive effect, since due to the diuretic component in the drug, it has a stronger effect.
Directions for use and doses
According to the instructions for use, Zocardis Plus is prescribed once a day, regardless of food.
Dosages and method of administration:
- hypertension with normal kidneys and liver - 1 tablet 1 time per day. If necessary, increase the dose;
- if the patient is over 65 years old, when prescribing, all the pros and cons are weighed;
- during pregnancy and breastfeeding, as well as if the patient is under 18 years of age, it is not recommended to take the drug;
- Doses according to the instructions for use are prescribed individually, taking into account many factors: age, clinical picture of the disease, patient complaints, concomitant diseases.
Advantages and disadvantages of the drug
Zokardis received positive reviews from cardiologists. After all, this drug has a number of advantages over other drugs for blood pressure.
Advantages of the product:
- Greater efficiency. The drug is excellent at lowering blood pressure.
- Long validity period. A single dose will keep your blood pressure at normal levels all day long.
- Short course duration for blood pressure. For optimal normalization of blood pressure, several weeks of taking the drug are sufficient.
Unfortunately, this tool also has some disadvantages, which are also of great importance. And they must be taken into account.
Disadvantages of Zocardis:
- The main disadvantage of the drug is the large number of side effects. Moreover, the probability of some of them occurring is quite high.
- The drug also has many contraindications.
- This drug, when taken in excess of the maximum permissible dose, causes extremely dangerous overdose symptoms. Moreover, the consequences of such an error have a detrimental effect on the body and can lead to death.
- For the drug to lower blood pressure, you must wait at least an hour after taking it.
Side effects of the drug
Zocardis has a fairly large number of side effects. Some of them are dangerous to the body. And, despite the fact that such problems arise quite rarely, everyone who uses this product should be aware of them.
Side effects of Zocardis:
| Systems and organs | Side effect |
| Central and peripheral nervous systems | Insomnia, depression, feeling of disorientation, dysgeusia, impaired consciousness, paresthesia, headache and dizziness, fatigue, imbalance. |
| Circulatory and lymphatic system | Hemolytic anemia, pancytopenia, agranulocytosis. |
| Sense organs | Decreased quality of vision, tinnitus. |
| The cardiovascular system | Angina pectoris, myocardial infarction, arrhythmia, palpitation, fainting, tachycardia, chest pain, hypotension. |
| Stomach, intestines and liver | Liver dysfunction, hepatitis, and drug-induced jaundice. Vomiting, dry mouth, diarrhea, abdominal pain, intestinal obstruction, pancreatitis. |
| Airways | Pharyngitis, bronchospasm, sinusitis, shortness of breath, rhinitis, obstruction, dry cough, as well as swelling of the mucous membranes and lungs. |
| Allergic reaction | Urticaria, itching, Quincke's edema, skin rash, erythema multiforme, various manifestations of psoriasis, toxic cutaneous necrolysis, fever, myalgia, arthralgia, increased titer of antinuclear antibodies. |
| Skin reactions | Hypersweating, hyperthermia, swelling and redness of the skin. |
| Muscular system | Muscle weakness |
| Kidneys and urinary tract | Kidney failure, urinary problems |
| Sexual functions | Erection problems, breast pain and swelling in women. |
| Metabolism | Hypokalemia, increased levels of creatinine and urea, decreased levels of hemoglobin, white blood cells, hematocrit. Increased levels of bilirubin and liver enzymes. |
Such side effects occur quite rarely. However, if they appear, you should immediately consult a doctor. The specialist will find out the cause of the problem, prescribe symptomatic treatment, and also select a more suitable antihypertensive drug.
Side effects
Patients with cardiovascular diseases should use this drug with caution. This is because this medicine has a number of side effects. They appear if the patient does not adhere to the dosage regimen suggested by the doctor. In addition, Zocardis has contraindications, in which it is almost impossible to avoid negative reactions.
Incorrect use of Zocardis for medicinal purposes leads to the following negative reactions:
- From the cardiovascular system. Some patients begin to complain of pain in the chest area. They notice a clear decrease in blood pressure. Most often, tachycardia, angina, arrhythmia and fainting are considered as side effects;
- From the central nervous system. Side effects manifest themselves in the form of weakness, headaches, increased fatigue, sleep disturbances and anxiety;
- From the senses. Patients may experience vestibular dysfunction and may also hear tinnitus;
- From the gastrointestinal tract. After taking the medicine, dry mouth, diarrhea, constipation, stomach pain, nausea and vomiting may occur;
- From the respiratory system. Side effects are extremely rare. They are limited to dry cough, bronchospasm and pharyngitis.
"Zocardis 7.5" can lead to an allergic reaction. In this case, the patient will notice unnatural rashes and signs of myosin on his skin. Cases of Steven-Jones syndrome occurring due to allergies have been reported.
Contraindications for use
When choosing a drug to lower blood pressure, you need to take into account contraindications to them. Zocardis has several limitations.
Contraindications to the use of the drug:
- Children under the age of majority;
- Severe liver pathologies;
- Severe renal failure;
- People who have reached the age of 70;
- Sensitivity to the components of the drug;
- A history of edema associated with the use of antihypertensive drugs of the same effect;
- The period of bearing a child;
- Porphyria;
- Lactation period.
In addition to absolute contraindications, this remedy also has relative prohibitions. In this case, the drug must be taken with extreme caution and only in cases where the potential harm is less significant than the benefits of using the drug.
Relative contraindications:
- Narrowing of the arteries in the kidneys and liver and other types of stenosis;
- Primary type aldosteronism;
- Hyperkalemia;
- Connective tissue diseases;
- Pathologies of cerebrovascular type;
- Diabetes;
- Mild forms of renal and liver failure;
- Patients on a salt-free diet and using hemodialysis;
- Psoriasis;
- Decrease in the level of bcc.
This drug has not been studied in pregnant women. However, animal tests have shown that the use of Zocardis during pregnancy can cause impaired fetal development, renal and liver failure in the child, pulmonary edema and other pathologies.
In the first days after birth, children whose mothers took this drug should be under medical supervision. You need to monitor your blood pressure especially carefully.
The active substance of Zocardis can pass into breast milk. Therefore, it is not recommended to use it during breastfeeding.
This drug should also not be used when planning pregnancy. It is not recommended for use by women capable of reproduction who do not use effective methods of contraception. So this drug is capable of causing various mutations.
The drug has a negative effect on the kidneys and liver. Therefore, patients using Zocardis and suffering from diseases of these organs should take examinations especially seriously.
Overdose symptoms
The described drug must be taken strictly in the dosages prescribed by the doctor. If the maximum permissible volume is exceeded, the most unpleasant consequences may occur. And in order to cope with them in time, you need to know the symptoms of this condition.
Overdose symptoms:
- First of all, there is a significant decrease in pressure;
- Vomiting and nausea also occur in the first stages. A feeling of anxiety appears, as well as fainting and fainting;
- Seizures are another common symptom of overdose;
- A state of shock, blurred vision and confusion of thoughts are also characteristic of this condition;
- Heart problems are also observed. Starting from angina and bradycardia and ending with its arrest;
- Kidney failure is also possible.
Such symptoms are very life-threatening. If the patient’s condition is not normalized in time, then death is quite possible. Therefore, if signs of overdose occur, you should call an ambulance and provide first aid techniques.
What to do if you overdose with Zocardis
An overdose of Zocardis is life-threatening. Therefore, if such a problem arises, it is not worth solving it at home. It is necessary to seek help from qualified specialists who can assess the victim’s condition and prescribe the correct treatment.
However, in order to reduce the risk of unpleasant consequences for the body, you need to start providing first aid even before the ambulance arrives. To do this, you need to use several methods.
First aid rules:
- First of all, it is necessary to ensure free access of oxygen to the lungs. To do this, you need to open the windows in the room and remove or unfasten tight clothing.
- Then you need to cleanse the stomach. To do this, the patient is asked to drink a large amount of water, which then needs to be thrown out. A cleansing enema is done to empty the intestines. These methods will give the desired effect only if they are taken literally immediately after taking an excessively large dose.
- It is also necessary to take an absorbent. You can use activated carbon, Atoxil-gel or Smecta. You also need to take sodium sulfate.
- To normalize the pressure, the patient must be transferred to a horizontal position. Then it is “dropped” with saline solution.
Even after providing competent medical care, it is advisable to hospitalize the patient. In a hospital setting, he will be prescribed the correct symptomatic treatment.
In this case, in case of manifestations of bradycardia and other severe consequences from the heart, the patient is prescribed atropine or a pacemaker is used. Hemodialysis is used to remove remaining drug from the blood.
During the treatment of overdose, it is imperative to monitor the amount of keratinin and electrolytes in the blood serum. It is also necessary to monitor the condition of the kidneys and liver.
Compatibility with other substances
Zocardis is not compatible with all active ingredients. Some drugs can change its properties for the worse. Therefore, before using other drugs together with Zocardis, you should consult your doctor.
Compatibility of Zocardis with other drugs:
| Groups of medications | The effects that their combination with Zocardis gives |
| Antipyretic drugs | Increased hypotensive effect. Hypotension may occur. |
| Nonsteroidal anti-inflammatory drugs | Reduced effectiveness of the drug in terms of pressure position. |
| Painkillers | Increased hypotensive effect. Hypotension may occur. |
| Preparations with lithium components | Increased lithium concentration in the blood. Intoxication with lithium salts is possible. |
| Diuretics | Increased hypotensive effect. There may also be a significant increase in potassium levels in the blood. |
| Immunosuppressants | Increased hematotoxicity. |
| Antihypertensive drugs | Increased hypotensive effect. Hypotension may occur. Increased likelihood of side effects. |
| Anesthetic drugs and narcotic substances | Increased hypotensive effect. Hypotension may occur. |
| Cytostatics | Increased hematotoxicity |
| Gold | In this case, the likelihood of developing such effects increases. Nausea, vomiting and dizziness are especially common. |
| Cyclosporine | The likelihood of a negative reaction from the kidneys increases |
When the drug is taken simultaneously with food, the absorption of Zocardis is reduced. You will have to wait longer for its effect.
When drinking alcohol, the antihypertensive abilities of the drug are reduced. This increases the risk of side effects. Therefore, combining alcoholic beverages and Zocardis is unacceptable.
It is advisable not to use Zocardis with these drugs. However, if it is necessary to include them in the therapeutic complex, it is necessary to especially carefully monitor the patient’s indicators.
Indications and restrictions for use
The medicine is used in the treatment of acute myocardial infarction.
"Zocardis" is prescribed to patients who have been diagnosed with the following pathologies:
- acute myocardial infarction;
- arterial hypertension;
- decompensated myocardial dysfunction.
The blood pressure drug in question is contraindicated if pathological conditions such as:
- impaired liver/kidney function;
- hypersensitivity to the components of the medication;
- angioedema caused by treatment with ACE inhibitors;
- aortic, mitral stenosis;
- increased level of potassium in the blood.
In addition, patients who have undergone kidney transplantation should avoid Zocardis, and it is also not recommended to use it for the treatment of high blood pressure in childhood. Women carrying a child and nursing mothers should take the tablets with extreme caution.
Rules of application
Only a doctor can prescribe the dosage of Zocardis, because this serious drug must be used taking into account all the characteristics of the body. However, you can find general rules for the use of such medications in the instructions for use.
Patients with normal indicators begin treatment with Zocardis with small doses, gradually increasing them. The first dose of the drug will be 15 mg or half a tablet once a day. After a month, the volume of the drug can be doubled to one tablet. If the desired result is not achieved after this, then you can gradually double this volume, dividing it into two doses per day.
If the patient has electrolyte deficiency and dehydration, then these indicators are first restored by stopping diuretics. In this case, the starting dose will be 7.5 mg, or a quarter of a Zocardis 30 tablet. Gradually you need to increase the dosage, bringing it to the one that will lower the pressure to the optimal level. Moreover, during the period of drug administration and dosage increase in the therapeutic complex, the patient should be under constant supervision of specialists.
For mild renal pathologies, the instructions for using Zocardis 30 will not differ from the method of taking this drug by a healthy patient. In severe stages of the disease, the maximum allowable dose will be one tablet per day. In this case, the initial dose will be equal to a quarter of a tablet. You can increase the volume of the drug once every four weeks by a quarter of a tablet.
Patients over sixty years of age with normal clearance levels are prescribed a standard dosage. Pensioners with low clearance are prescribed half the maximum dosage, with a gradual increase.
In case of serious liver pathologies, the drug is contraindicated. For mild liver diseases, half the dosage of the drug is allowed.
In case of myocardial infarction, treatment with Zocardis can be started on the first day after the attack. In this case, for the first two days, a quarter of a tablet is prescribed once every 12 hours, then for another two days, half a tablet. Then, for six weeks, taking the whole tablet once every twelve hours is recommended.
After six weeks of treatment, if the indicators have returned to normal, treatment should be stopped. If there are signs of heart failure, the course can be extended to six months or more. In this case, monitoring of biochemical blood parameters, as well as liver and kidney functions is mandatory.
Instructions for use Zocardis 7.5 mg
Zocardis 7.5 mg, according to the instructions for use, is a tablet dosage form. The tablets are coated.
The package contains fourteen and twenty-eight pieces. The main active ingredient, of which there is 7.5 mg in one tablet, is zofenopril calcium.
Indications for treatment
According to the instructions for use, Zocardis 7.5 is indicated for:
- moderate hypertension;
- heart attack, if the activity of the heart is disrupted with stable hemodynamics and in those who have not undergone thrombolytic treatment.
Dosages and regimen
The product is taken orally according to the instructions for use, regardless of food, washed down with plenty of plain water. Dosage and take as follows:
- for healthy kidneys and liver - two tablets once a day. If necessary, the dosage is increased after four weeks;
- moderate and severe renal failure - start with 1 tablet;
- for mild liver pathologies - half a dose, for severe ones - not prescribed at all;
- myocardial infarction - start taking it within 24 hours after the first signs, continue taking it for up to one and a half months.
According to the instructions for use, Zocardis 7.5 is carefully prescribed for myocardial infarction after the age of 75 years.
For myocardial infarction, the following scheme is used:
- first and second days - 1 tablet each. in twelve hours;
- the third and fourth days - two tablets every 12 hours;
- from the fifth day - four tablets. in 12 hours
If blood pressure drops too much within three days after a heart attack, do not increase the dose or stop taking it. After six weeks, according to the instructions for use, Zocardis can be discontinued if there are no symptoms of cardiac or left ventricular failure.
The reduction in blood pressure is enhanced according to the instructions for use when Zocardis 7.5 is combined with the same drugs for lowering blood pressure, diuretics, antipyretic and analgesic drugs, and alcohol.
Tips for use
In order for the drug to have the best effect and at the same time not have negative effects on the body, you need to take into account all the rules for its use. There are a lot of such nuances and they must be observed.
Tips for using the product:
- The drug may have a negative effect on concentration, as well as cause convulsions and dizziness. Therefore, when taking it, it is better to avoid driving a car and performing tasks that require increased concentration.
- You should also stop drinking alcohol and smoking while taking the drug. Such habits not only reduce the effectiveness of Zocardis, but also increase the likelihood of side effects.
- It is very important to monitor blood pressure readings when taking the drug for the first time. If signs of severe hypotension occur, use a saline drip and contact your doctor to change your medication.
- In the presence of renal pathologies, during the first weeks of treatment it is necessary to monitor renal function.
- During dialysis and taking Zocardis, a number of unpleasant sensations may occur. For example, swelling of the face, feeling of hot flashes, shortness of breath, etc.
- Insect bites are especially dangerous when taking Zocardis. They can cause life-threatening anaphylactic shock.
Reviews about the medication
Doctors speak well of Zocardis, considering it an effective drug. However, they note the fact that this remedy can have a negative effect on the body. Therefore, its appointment is not justified in all cases.
Ordinary people who use such means speak of its effectiveness. However, many note that when using it, adverse reactions often occur.
Reviews about Zokardis:
The doctor prescribed me Zokardis. I used it for stage 2 hypertension for two weeks. The pressure returned to normal. I was switched to less serious drugs. Until now, blood pressure levels remain within normal limits. I did not observe any side effects from using Zocardis. (Svetlana, Odessa)
I was prescribed the drug after a myocardial infarction, which resulted in heart failure. I drank according to the regimen prescribed by the doctor. The first side effects were stool upset and mild drowsiness. However, then these unpleasant signs disappeared. After six months of treatment, my condition returned to normal. (Sofia, Orel)
I've been taking Zocardis for a week now. The pressure is normal. However, the doctor recommended extending the course for another week. I have a mild form of hypertension, so I hope that after using Zocardis I will get rid of this problem forever. (Irina, Ryazan)
You need to understand that reviews of other patients cannot be a reason for choosing medications. After all, what suits one person may not suit another. Therefore, the decision to prescribe Zocardis can only be made by a doctor.
Drug analogues
Zocardis is a relatively inexpensive drug. However, if you wish, you can choose a domestic analogue at a lower price, but with absolutely the same level of efficiency.
Analogs of Zokardis:
- Accupro;
- Amprilan;
- Berlipril;
- Blockordil.
These products contain the same active ingredient. However, they may differ in quantity and additional ingredients. Therefore, they have different instructions for use, which must be prescribed by a doctor.
Zocardis is an antihypertensive drug that is an ACE inhibitor. It is highly effective. And it allows you to achieve stable normal indicators in a short course of use. However, this product has a lot of side effects and contraindications, so it is sold by prescription and can only be used as prescribed by a doctor.
Contraindications
Reviews from patients indicate that they often use the drug Zocardis, the instructions for use of which indicate that it is contraindicated for people who are intolerant to zofenopril. Zocardis Plus should not be taken if you are lactose deficient or intolerant or sensitive to hydrochlorothiazide. In addition, any Zocardis is contraindicated for:
- severe liver disorders;
- under 18 years of age;
- history of Quincke's edema;
- pathology of the renal arteries;
- postoperative period after kidney transplantation.
The drug is prescribed cautiously for:
- Conn's syndrome (primary aldosteronism);
- those on a salt-free diet or hemodialysis;
- psoriasis;
- diabetes mellitus;
- taking immunosuppressants;
- over 75 years of age;
- liver failure;
- cerebrovascular disorders.
