Zelenin drops for bradycardia: how to use, contraindications

Combined Zelenin drops are used to treat many pathologies. The drug consists of several plant components. The therapeutic effect is due to the natural components included in its composition. The drug has a positive effect on the functioning of the heart and has a pronounced antispasmodic and calming effect.

Composition, dosage form

The medicinal solution is a yellowish-brown or clear liquid with a characteristic odor. The drops are packaged in glass bottles with a dropper stopper. A cardboard box contains one bottle of 15 or 25 ml. Each package comes with detailed instructions for use.

Zelenin drops contain only four active components. Tincture of belladonna leaf, tincture of lily of the valley, tincture of valerian rhizome and menthol are the active ingredients contained in the solution.

How do they work?

Zelenin drops for bradycardia and hypertension have an antispasmodic and sedative effect. They block acetylcholine, which transmits an excitatory signal to the brain. The active ingredients are infusions of belladonna (5 ml), valerian (10 ml), lily of the valley (10 ml) and menthol (200 mg). These plant components have a positive effect on the body, each of the components has the following effect:

Lily of the valley brings the human body into a state of calm.

Belladonna. Helps increase the activity of the salivary, lacrimal, bronchial, and pancreas glands, normalizes the functioning of the stomach, and has an antispasmodic effect.
Lily of the valley. Has a diuretic, sedative effect. Improves the general condition of the body.
Valerian. It normalizes sleep, calms the nerves, and stabilizes the heartbeat when the pulse is low.
Menthol. Eliminates pain and stagnation of blood in the veins, reduces the risk of ischemic disease, dilates the blood vessels of the myocardium.

pharmachologic effect

May lily of the valley has a cardiotonic effect - improves the functioning of the heart muscle (myocardium). As a result, the blood supply to the heart is normalized. Lily of the valley contains the following beneficial substances:

alkaloids;
flavonoids;
steroid saponins;
cardiac glycosides;
essential oil;
organic acids, etc.

Valerian is a famous medicinal plant.
The rhizome has many beneficial properties. The composition includes trace elements (copper, zinc, iron, calcium), tannins, alkaloids, saponins, vitamins. Affects the central nervous system, provides an antispasmodic, calming effect. The medicinal effect of belladonna vulgaris, or belladonna leaf, is due to the atropine group alkaloid contained in the plant. The substance relieves pain well and reduces the level of secretion of the body’s glands.

Menthol, or peppermint camphor, is a powerful natural analgesic. Quickly relieves pain, eliminates shortness of breath and difficulty breathing, which are characteristic of an attack of angina pectoris. It has anti-inflammatory, antibacterial, vasoconstrictor, antipruritic, analgesic, carminative, analgesic effects.

There are no data on the pharmacodynamics of Zelenin drops, because no research has been conducted in this direction. It is unknown how the drug, after administration, is distributed in tissues, absorbed into the blood, and excreted from the body.

Composition of Zelenin drops

The drug contains in one bottle 10 ml of tincture of lily of the valley and valerian roots, 5 ml of alcoholic extract from belladonna herb, 200 mg of menthol. The effect of Zelenin drops is manifested due to the total effect of these ingredients.

Lily of the valley tincture

Contains the cardiac glycoside convallatoxin, which is similar to strophanthin, flavonoids, saponins, and organic acids. Lily of the valley herb has the following effects on the heart:

the strength of contractions and stroke volume of blood increases;
ventricular emptying improves;
myocardial hypertrophy and its need for oxygen decreases;
coronary vessels dilate.

Lily of the valley tincture has a diuretic and mild choleretic effect. A feature of the glycosides of this plant is the speed of onset of the effect and its short duration, since these compounds are easily excreted from the body.

Valerian tincture

The main effect is sedative. Facilitates the process of falling asleep, the calming effect develops slowly, but it is stable. Under the influence of valerian, the secretion of bile and gastric juice accelerates, and blood vessels dilate. The effect on the myocardium is manifested both directly and through regulation by the nervous system.

Belladonna tincture

Inhibits the action of acetylcholine, reduces the secretion of the glands of the oral cavity, bronchi, sweat, lacrimal glands, as well as the pancreas, stimulates atrioventricular conduction within the myocardium.
With spasms of the bronchi and intestines, belladonna causes their expansion, stimulates the cerebral cortex, and impairs vision.

Menthol

Due to its irritating effect on receptors in the oral cavity, it reflexively dilates the coronary vessels of the heart, relieves an attack of angina, and relieves pain.

Indications for use

The herbal medicine is prescribed for the treatment of cardiac, neurological, and digestive diseases. Main indications for use:

signs of VSD (vegetative-vascular dystonia);
JVP (biliary dyskinesia);
cramping pain in the liver, kidneys;
spasm of the gastrointestinal tract;
small stones in the bile ducts;
gastritis with high acidity;
chronic cholecystitis;
tachycardia, temporary increase in heart rate;
cardiac neuroses accompanied by bradycardia;
severe heart failure;
depressive states;
increased nervousness, excitability;
lack of appetite;
sleep disturbance.

Zelenin drops increase blood pressure, so they are prescribed for bradycardia and low blood pressure. The medicine is used in the complex treatment of heart disease and pain caused by spinal pathologies.

Zelenin drops for bradycardia

One of the main functions of Zelenin drops is to get rid of bradycardia. There is a strong decrease in pulse due to a drop in pressure. You need to drink this remedy at least 30 minutes before meals. In this case, be sure to drink the product with a glass of water.

It is worth taking Zelenin drops for at least 10 days, 20 drops three times a day. After the course of treatment, take a break for 15 days. Treatment can then be repeated if necessary.

Indications for use of the product may be as follows:

Frequent dizziness, accompanied by a pulse less than 40 beats per minute;

Poor blood circulation, constant feeling of freezing of the extremities.

Contraindications for use

Zelenin drops should not be taken for certain conditions and health problems. Contraindications include:

hypersensitivity to at least one component of the drug;
disturbance of the outflow of urine caused by an enlarged prostate gland;
increased eye pressure;
angle-closure glaucoma;
inflammatory pathologies of the heart;
cardiosclerosis – disease of the heart muscle;
severe atherosclerosis of the heart vessels;
exacerbation of peptic ulcer disease.

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Take with caution for chronic alcoholism, pathologies of the brain and liver. Children under 12 years of age are another contraindication. Only a specialist should prescribe medicine. His consultation is a prerequisite for successful treatment.

Side effects, overdose

Zelenin drops are well tolerated by patients who rarely complain of side effects. But sometimes during treatment the following may occur:

allergic manifestations;
heartburn;
bloating;
nausea and vomiting;
diarrhea;
heart rhythm failure;
muscle pain, headache;
low blood pressure;
dizziness;
drowsiness;
muscle weakness;
loss of appetite;
stomach pain.

If these side effects occur, you should stop taking the drug for a while and consult your doctor. He will select a new dosage or an analogue of the drug.

In order to prevent the occurrence of undesirable consequences from the body, it is necessary to strictly adhere to the dosage (selected by the doctor) and not exceed the course of therapy. Compatibility with alcohol is unacceptable. There is no information about overdose.

Increase or decrease blood pressure

Getting rid of bradycardia is one of the main functions of the drug. Does this mean that when your heart rate increases, your blood pressure inevitably increases? The answer is negative. Direct drops of Zelenin at elevated pressure are not shown. Different mechanisms are responsible for regulating heart rate and increasing/decreasing blood pressure in the human body. The area where the vena cava enters the atrium on the right is called the 3rd reflexogenic area. It is she who regulates the heart rate. Pressure primarily depends on the vasomotor center, which is in the medulla oblongata. These mechanisms are not related to each other.

Instructions for use

The solution is diluted in a small amount of water. Frequency of administration – 3-4 times a day. The frequency and duration of therapy is determined by the attending physician, taking into account the patient’s condition and the course of the disease.

The instructions for use indicate the following standard dosages for taking the drops:

adults – 20-25 drops;
for children – one for each year of the child’s life.

Method of administration and dosage regimen for the following pathological conditions:

Tachycardia. Requires taking 20 drops at a time. To stabilize the heart rhythm, 10-14 days of treatment are sufficient.
In case of malfunction of the myocardium (arrhythmia), drink no more than 50 drops per day. A positive effect is observed after 2 weeks from the start of therapy.
If your heart rate is low, you need to take the drug carefully, because... A larger dosage further reduces heart rate. No more than 30 drops per day will be required, duration of use - no more than 5 days.
Hypertension. Taken for prevention, because Drops cannot immediately lower blood pressure. For the first 3 days, take 6 drops 3 times a day, then the dosage is increased to 20.
Bradycardia is one of the main indications for use. For treatment, take 20 drops. The duration of the course is at least 10 days. Then you will need a break of 2 weeks. Therapy is repeated according to indications.
For VSD and panic attacks, you will need 20-30 drops per glass of water.

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Drug interactions

Zelenin drops should be taken with caution by patients with bronchial asthma who are taking medications to relieve bronchospasm: Ventolin, Salbutamol, Saltos, Berotek. This is because concomitant use may increase your heart rate. Taken together with other sedatives enhances the sedative effect of Zelenin. The same applies to drugs that depress the central nervous system.

It cannot be combined with antiarrhythmic drugs (Quinidine, Propranolol, Verapamil, etc.), which are prescribed for tachycardia. The effect of the latest medications is reduced.

Special Recommendations

The drug is prescribed with caution to elderly patients, children under 12 years of age, pregnant and lactating women. Treatment of these categories of patients is carried out under the strict supervision of a specialist. To enhance the effect of Zelenin solution, some doctors recommend drinking it with hawthorn-based medications. During the treatment period, you should refrain from driving vehicles and engaging in potentially hazardous activities.

Storage conditions and periods

The shelf life is 2 years from the date of manufacture. Store the drug in a dark place out of reach of children at a temperature not exceeding 25 degrees. Zelenin drops are dispensed from pharmacies without presenting a doctor's prescription.

Attention!

Those who regularly use the presented drug should know that:

With the systematic use of Zelenin drops in patients diagnosed with bronchial asthma with the simultaneous use of drugs “Izadrin”, “Salbutamol”, “Berotek”, etc. special care should be taken. This is because this combination of medications can cause a very rapid heart rate.
During the period of therapy, special care must be taken when driving vehicles, as well as engaging in other dangerous activities that require good vision, speed of psychomotor reactions and increased concentration.
Some consumers confuse Zelenin drops with the medicine Corvalol. In this regard, it should be remembered that the first drug is used for bradycardia, and the second - in the presence of tachycardia.

Analogs

At the pharmacy you can buy structural analogues for individual active ingredients:

Cardioviol. The composition includes valerian root, hawthorn fruits, motherwort, mint leaves. Indications for use: disorders of the cardiac and nervous system.
Herbion heart drops. Consists of aqueous-alcoholic extract of medicinal plants (hawthorn, valerian, mistletoe). Belongs to the group of cardiological combination drugs.
Cardiofit. Contains a complex of natural ingredients. Has a therapeutic effect on the cardiovascular system.
Tricardin. Includes valerian, motherwort, hawthorn. The medicine is effective for neurological disorders.
Lily of the valley-valerian drops. Tincture of valerian and lily of the valley are the active ingredients. Drops are classified as sedatives of plant origin.

The following medications can also be substitutes:

Validol;
Corvalment;
Corvalol;
Destion;
Valocordin.

Belladonna tincture is the only combined remedy that has a similar composition and properties.

The price of Zelenin's solution is 70-120 rubles per bottle of 25 ml, the cost of 15 ml is 35-60 rubles.

Further treatment: what do doctors prescribe?

Zelenin drops are a combination drug based on herbal components. They are necessary to regulate the heart rate, as well as the proper supply of blood and oxygen to all internal organs.

The drug is able to suppress muscle spasm of blood vessels, increasing the heart rate and intracranial pressure.

This medicine is classified as an M-anticholinergic, so it is able to block cholinergic receptors, which in turn increases the heart rate.

More drops can improve atrioventricular conduction, reduce the tone of the bronchial system, and significantly reduce the secretion of glands.

The effect of the drug on the body is characterized by the presence of the following components:

Belladonna leaf - relieves muscle spasms, it also has an anticholinergic effect. This substance prevents the stimulating effect of acetylcholine and reduces the degree of pancreas secretion. The action of belladonna is aimed at reducing the muscle tone of the gallbladder, gastrointestinal tract and bile ducts.
Lily of the valley infusion stimulates the activity of the heart muscle, increasing its frequency and tension. Also, with the help of lily of the valley, venous and pulmonary pressure is reduced.
Valerian with rhizome – relieves spasms of the heart vessels and has a calming effect on the body. This plant calms the nerves and fights insomnia. Valerian also has a choleretic effect, activating the secretion of the mucous membranes of the gastrointestinal tract. In addition, the plant can slow down the heartbeat and dilate blood vessels.
Lily of the valley (herb) – reduces the possibility of myocardial infarction and improves hemodynamics.
Menthol is a local dispensing agent that helps relieve pain and tonify the veins.

It is important to understand that the sedative effect is stable, but it does not occur instantly, but gradually.

This drug is widely used for the following pathologies:

hypoacid gastritis;
nervous imbalance;
colic in the liver;
arrhythmia (bradycardia);
vegetative-vascular dystonia;
spasms of the gastrointestinal tract;
colic in the liver;
biliary dyskinesia.

In addition, the drug is recommended for use in combination with other types of therapy. For example, with heart failure or severe excitability.

Taking drops in the presence of a disease such as bradycardia should be done in courses. The duration is determined by the therapist after a complete examination of the patient. The first three days you should take 3 drops in the morning and evening. Then increase the dose to 20 drops, dividing it into 2 doses.

Children over 12 years of age are prescribed drops using the following calculation: 1 drop of Zelenin per 1 year of life.

The product is taken diluted with water (a little) and drunk half an hour before meals. This remedy acts quickly and also significantly increases the pulse. You cannot increase the dose on your own, as this will only worsen the situation.

Contraindications

Zelenin drops are not recommended for use in the presence of a pathology such as tachycardia. In addition to this, drops are prohibited when:

angle-closure glaucoma;
high blood pressure (hypertension);
prostate hypertrophy;
cardiosclerosis;
individual intolerance to the leading components;
myocardial infarction;
duodenal ulcer;
endocarditis;
pregnancy and lactation;
atherosclerosis of the heart vessels.

You should also stop taking the medicine at the first sign of allergy, replacing Zelenin drops with another medicine.

Adverse reactions

If the drops are taken according to the instructions, there should be no adverse reactions. They can only be observed in case of overdose, which are expressed in:

dry mouth mucous membranes;
increased heart rate;
dizziness;
an increase in the size of the eye pupils.

As soon as the patient stops taking the drug, the symptoms disappear.

Also, if you take the drops longer than the course prescribed by the doctor, depression of the nerves occurs and the person may experience:

lethargy;
drowsiness;
prostration;
nausea and vomiting;
allergic manifestations;
heartburn;
stool disorder;
migraine;
loss of appetite.

The occurrence of at least one of the above symptoms indicates discontinuation of the drug.

Zelenin drops increase the effectiveness of drugs that are aimed at reducing muscle spasms and drugs that affect the nervous system. The effect of combined use of additional drugs that fight bradycardia also significantly increases the effect.

Experienced doctors believe that Zelenin’s drug is effective for pathologies such as bradycardia. There is only a small probability of individual intolerance to certain substances included in the product. Good effectiveness is noted for loss of strength, migraines and pressure surges.

The drug contains conditionally toxic substances, so they should not be taken without consulting a doctor. An additional “plus” of the drops is their pleasant smell; the only disadvantages include the high cost from certain manufacturers.

Cardiologists say that the use of Zelenin should be quite long to obtain the desired result. With their help you can defeat neurosis, vegetative-vascular dystonia, insomnia, and bradycardia.

The approximate cost of Zelenin drops in Russia is 28 – 80 rubles per volume of 25 milliliters, depending on the developer. For example, Mospharma calls for purchasing the product for 67 rubles, when you can buy the same drug from the Tver company for 28 rubles.

There are also direct and indirect analogues of Zelenin drops, among the direct ones they note:

Valerian tincture is a sedative, hypnotic, analgesic and antispasmodic drug. Valerian is taken for increased excitability, sleep disturbances, heart rhythm problems, and gastrointestinal spasms. You need to take 25-30 drops three times a day until symptoms disappear. Price 30 – 45 rubles in Russia.
Motherwort tincture – has sedative, hypotensive, cardiotonic properties. Indications for use: nervousness, sleep disturbance, increased excitability, bradycardia. The tincture is taken orally, 40-50 drops three times a day; if necessary, it can be increased to 4 days. The average cost is 20 rubles.
Medicinal chamomile - calms the nervous system, has antimicrobial, antiallergic, and antipyretic properties. Chamomile herb is brewed according to the instructions and drunk as tea. The average cost is 45 rubles.
Novo-passit is a sedative and sedative. It is recommended to use for neurasthenia, heart rhythm disturbances, irritability, insomnia, and gastrointestinal diseases. Directions for use: a teaspoon of syrup three times a day, half an hour before meals. The medicine can also be mixed with a small amount of any liquid. The drug is not cheap, its average cost is 200-300 rubles.

Zelenin drops are effective at any age starting from 12 years. They are able to calm the nervous system, normalize the heartbeat, and they are not at all expensive. In some cases, drops are specifically prescribed to eliminate the symptoms of bradycardia.

If attacks of bradycardia occur frequently and are accompanied by severe discomfort, you should think about qualified help.

Indications for drug treatment of arrhythmia:

heart rate drops to 45 beats per minute;
bradycardia, which is accompanied by hypotension;
frequent loss of consciousness;
ECG revealed signs of ventricular arrhythmia;
acute period of myocardial infarction.

Rules for correcting bradycardia:

Discontinuation of the drug that provoked the attack (if the arrhythmia was caused by intoxication with beta-blockers or calcium antagonists, glucagon is administered in an individual dosage).
As an emergency aid for severe hemodynamic disturbances, intravenous administration of 0.5 mg of a 0.5% solution of “Atropine” is allowed.
To improve the contractility of the heart muscle, Isoprenaline is used intravenously at a dose of 2-3 mg per 1 kg of body weight.
If the slowing of the rhythm is complicated by asystole, resuscitation measures are performed:

indirect cardiac massage
electrical stimulation (endocardial or transcutaneous cardiac pacing).

Maintenance therapy to prevent attacks:

Beta-adrenergic agonists: “Isadrin” in tablets 2.5-5 mg 2-4 times a day. It must be taken sublingually (under the tongue). “Isadrin” acts similarly to “Adrenaline”, improving the ability of the heart to respond by contraction to stimulation. When an impulse passes through the sympathetic part of the autonomic nervous system, this medication enhances the desired response by the cells of the pathways. However, unlike catecholamines, it does not increase blood pressure.
Agents that improve metabolic processes in cardiomyocytes: “L-carnitine” (antihypoxant, anabolic), “Panangin”, “Asparkam” (contain potassium and magnesium, which are responsible for adequate contractions of the heart muscle). They have a weak evidence base.
Adaptogens: extracts of Leuzea, Eleutherococcus, Schisandra chinensis. The result of using such drugs will be an increase in the tone of the body as a whole (as an additional effect - an acceleration of the heartbeat). However, these drugs will not have a quick therapeutic effect for bradycardia with pronounced clinical symptoms.
Pacemaker. If there is a blockade of the conduction of excitation from the atria to the ventricles, electrical stimulation of the heart muscle from the outside is necessary. The impulse is transmitted by a special device - a pacemaker, fixed under the skin of the chest or implanted inside the chamber.