Medicine information
Berlipril for blood pressure is a German-made drug. Belongs to the pharmacological group of ACE inhibitors. It is used for therapeutic and prophylactic purposes, for pathologies with a concomitant increase in blood pressure.
Release form
The blood pressure drug Berlipril is presented on the pharmaceutical market in the form of tablets, convenient for use and calculation of the required dosage of the medication.
Compound
The main active component of the drug is enalapril maleate, presented in a dose of 5, 10 or 20 mg.
The composition of the tablets also includes auxiliary ingredients - magnesium stearate, gelatin, lactose monohydrate, silicon dioxide, magnesium carbonate.
Packaging of Berlipril tablets
Price and terms of sale
The cost of the drug is determined by factors such as the dosage of the main active ingredient and the number of tablets in the package. The average price for Berlipril varies from 90 to 200 rubles for 30 tablets. You can purchase the drug in pharmacy chains only after presenting an appropriate medical prescription.
Storage mode
It is recommended to store the drug in a place protected from exposure to ultraviolet radiation, inaccessible to children and pets. The optimal temperature should not exceed +25 °C.
Description and composition
The active substance is enalapril maleate. The shape of the tablets directly depends on the dosage of the active element.
5 mg tablets: flat-cylindrical, creamy-white tablets with a bevel and a separating stripe on one side.
Auxiliary components: lactose monohydrate, light basic magnesium carbonate, gelatin, magnesium stearate, highly dispersed silicon dioxide, sodium carboxymethyl starch.
10 mg tablets: flat-cylindrical tablets of beige-brown color with white inclusions, a chamfer and a separating strip on one side.
Auxiliary components: lactose monohydrate, light magnesium carbonate, gelatin, magnesium stearate, sodium carboxymethyl starch, brown iron oxide dye.
20 mg tablets: flat-cylindrical tablets of beige-pink color with slight white inclusions, a chamfer and a separating strip on one side.
Auxiliary components: lactose monohydrate, magnesium stearate, light basic magnesium carbonate, gelatin, carboxymethyl starch sodium salt, brown iron oxide pigment.
Pharmacodynamics: how it affects blood pressure
The blood pressure medicine Berlipril has a pronounced antihypertensive effect. The drug helps suppress the production of angiotensin and inhibits specific angiotensin-converting enzymes. Has a moderate diuretic effect.
Thanks to these properties, Berlipril helps with blood pressure, stabilizing diastolic and systolic indicators. It has an enhanced effect on the veins and significantly reduces the load on the myocardium.
By activating the processes of coronary and renal blood flow, Berlipril tablets do not affect cerebral circulation and do not provoke an increase in heart rate.
The drug has a positive effect on the heart and blood vessels, slowing down the progression of heart failure, reducing hypertrophy of the left cardiac ventricle, and helping to increase the life expectancy of patients with diagnosed cardiac pathologies.
Berlipril blood pressure tablets effectively combat the manifestations of intraglomerular hypertension and glomerulosclerosis.
To achieve the most pronounced, stable, positive result, it is recommended to take the tablets in a course.
Berlipril acts according to the scheme of ACE inhibitors, to the group of which it belongs
Overdose
If the medicine was prescribed by a doctor, an overdose does not occur. If the patient has exceeded the maximum possible dose per day, vascular insufficiency, myocardial infarction, convulsions, and impaired cerebral circulation may occur.
In this case, the victim is placed on the couch, his legs are raised, the stomach is washed and saline solutions are given.
The appearance of minor side effects is not a reason to stop using Berlipril.
Pharmacokinetics of the drug
The maximum concentrations of the active substances of the drug in the blood are observed after 3-4 hours from the moment of taking the tablets. However, the therapeutic effect manifests itself much faster, due to which Berlipril significantly reduces blood pressure an hour after taking the drug.
Once in the liver area, it is transformed into active metabolites. It has good bioavailability, being absorbed by the body by 60%, regardless of the meal schedule.
The half-life is approximately 11 hours. Most of the drug (about 60%) is excreted from the body through the kidneys, along with urine, and another 33-34% through the gastrointestinal tract with feces.
What does Berlipril help with?
Medical experts recommend that patients take Berlipril for high blood pressure if the following clinical indications exist:
- Arterial hypertension;
- Scleroderma;
- Symptomatic and renovascular form of hypertension;
- Chronic heart failure.
Berlipril for hypertension is also prescribed for preventive purposes to patients suffering from dysfunction of the left cardiac ventricle to prevent the development of coronary-ischemic processes.
When use is contraindicated
Berlipril for high blood pressure is strictly prohibited for use by patients who have the following clinical contraindications:
- Cerebrovascular diseases;
- Hypotonic disease (low blood pressure);
- Renal artery stenosis;
- Disruption of cerebral circulation processes;
- Scleroderma;
- Autoimmune systemic pathologies of connective tissue structures;
- Aortic stenosis;
- Diabetes;
- Lupus erythematosus;
- Hyperkalemia;
- Individual intolerance and hypersensitivity to the components contained in the tablets;
- Age category of the patient, under 18 years old;
- Ischemic disease;
- The patient has a history of edema of a hereditary, angioedema, or idiopathic nature.
Despite the fact that Berlipril lowers blood pressure effectively and quickly, the tablets are not used to treat the elderly, women expecting the birth of a baby, or during breastfeeding.
The drug is used with extreme caution when suppressing the hematopoietic functions of the bone marrow, renal dysfunction, liver failure, during the hemodialysis procedure, after undergoing surgery for a kidney transplant.
Berlipril is not used in the treatment of elderly people
Instructions for use and dosage for arterial hypertension
The instructions for use of Berlipril recommend selecting the optimal dose of the drug individually, taking into account the severity of the patient’s condition and other features of a particular clinical case.
The starting dosage for blood pressure is usually 5 mg throughout the day. In the absence of a proper therapeutic effect, the daily dose of the drug is increased by 50% over 1.5-2 weeks.
If the patient has low systolic pressure, then treatment begins with minimal dosages - from 1.25 mg per day.
If the patient tolerates the tablets well and does not experience any adverse reactions, I increase the dosage to 40 mg throughout the day. In this case, diuretic medications should be stopped several days before the start of the therapeutic course.
For moderate hypertension, tablets are prescribed in a daily dosage of 10 mg.
To achieve prolonged, positive results, it is recommended to drink Berlipril for blood pressure for 2 weeks to one month.
Video on the topic
Berlipril or Enalapril – which is better? If the article helped to understand the pharmacological characteristics of the first drug, then this video helped with the second:
The information on the MyMedNews.ru website is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment.
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Adverse reactions
Berlipril to reduce blood pressure may cause the following adverse reactions:
- Irregular heart rhythm (arrhythmia);
- Excessive decrease in blood pressure;
- Dry cough;
- Angina;
- Nausea;
- Dyspeptic disorders;
- Painful sensations localized in the chest area;
- Stool disorders (constipation or diarrhea);
- Permanent lack of appetite;
- Headache:
- Depressive states;
- Bradycardia (slow heartbeat);
- Deterioration of hearing function;
- Swelling;
- Allergic skin rashes;
- Paresthesia;
- Psycho-emotional instability, anxiety, nervousness, irritability;
- Attacks of dizziness;
- Chronic fatigue syndrome;
- Dysphonia;
- Stomatitis;
- Swelling of the larynx;
- Dyspnea;
- Bronchial spasms;
- Arthritis;
- Disturbances in the functioning of the renal apparatus.
Any unwanted reactions that occur while taking the pills must be reported to a specialist! You may need to adjust the dosage or select a more suitable analogue!
Berlipril is one of those blood pressure medications that can cause coughing.
Side effects
Berlipril can provoke some adverse reactions from various body systems:
- From the cardiovascular system: angina pectoris, orthostatic collapse, arrhythmia, hypotension, rapid heartbeat, chest pain, heart attack, fainting;
- From the central and peripheral nervous system: headache, weakness, insomnia, anxiety, confusion, drowsiness and fatigue; in rare cases, when using high doses - nervousness, depression and paresthesia;
- From the senses: hearing and vision impairment, tinnitus, disturbances in the vestibular apparatus;
- From the digestive system: vomiting, dry mouth, anorexia, nausea and diarrhea; sometimes - hepatitis, pancreatitis, jaundice, intestinal obstruction, abdominal pain, disruption of the biliary tract and liver;
- From the respiratory system: shortness of breath, bronchospasm, pharyngitis, rhinorrhea, dry non-productive cough, interstitial pneumonitis;
- Various allergic manifestations;
- From the urinary system: impaired renal function and proteinuria.
Sometimes taking Berlipril can lead to hot flashes, decreased libido and alopecia.
Drug overdose
The use of Berlipril tablets in high doses can cause the following alarming symptoms:
- Convulsive syndrome;
- A sharp decrease in blood pressure to critical levels (hypotonic crisis);
- Stupor;
- Myocardial infarction;
- Thromboembolism;
- Disorders of cerebral circulatory processes occurring in an acute form.
An overdose of Berlipril is very dangerous and can lead to the death of the patient! Therefore, with such a clinical picture, it is necessary to call an ambulance, and before the doctors arrive, lay the victim down with his head down, do a gastric lavage, and allow him to take a portion of saline solution.
In particularly severe clinical cases, hospitalization of the patient, hemodialysis, IV drips with sodium solution, and plasma substitutes are required in order to stabilize blood pressure.
Important points in the instructions for use of the drug
Despite the positive reviews about the drug "Berlipril", it must still be taken with caution, especially in combination with other drugs that have similar characteristics and effects on the sick human body. You can either enhance the effect of the product or weaken it. Therefore, there should be no talk of any amateur activity here at all.
The medicine is prescribed only by the attending physician!
Despite the prescriptions, many patients also bother to overdose on the drug. In this case, the most pronounced symptoms are convulsions, heart attacks, strokes, nervous stupor, and too sharp a drop in blood pressure.
There is no antidote. An urgent measure is gastric lavage and the appointment of special therapy.
Drug interactions
The combination of Berlipril with diuretics and potassium supplements increases the risk of developing hyperkalemia, which threatens the patient with bone marrow damage and neutropenia.
Combination with nonsteroidal anti-inflammatory drugs and estrogens significantly reduces the hypotensive effect of the drug.
The simultaneous use of Berlipril tablets with diuretics and other antihypertensive medications, on the contrary, increases the risks of an excessive decrease in blood pressure and the development of a hypotensive crisis.
Berlipril reduces the effectiveness of drugs containing theophylline, which should be taken into account when calculating the optimal dosage.
Analogs
Analogs of Berlipril are the drugs Enalapril, Enap, Bagopril, Renitek, Enam, Envas, but when replacing one drug with another, you should consult your doctor - their therapeutic effects and effects on the body may differ from each other.
Berlipril is an effective medication that gently lowers blood pressure and is well tolerated by the body, but its use requires compliance with medical recommendations and monitoring of the patient’s general condition.
Special instructions and recommendations
The drug should be stopped before a planned examination of the parathyroid gland or surgical interventions.
Particular care and constant medical supervision require the treatment of patients with chronic heart failure occurring in the stage of decompensation, ischemia, and pathologies of cerebral vessels, since in these diseases, an excessive decrease in blood pressure can provoke renal dysfunction, the development of a stroke or heart attack.
During the therapeutic course, it is recommended to refrain from driving, since the drug has a suppressive effect on the central nervous system and cognitive abilities of a person.
During treatment with the drug, you should be careful when performing work that requires concentration.
Side effects of Berlipril
- The following negative effects are observed in the cardiac system and blood vessels: too strong a decrease in pressure, angina pectoris (in rare cases), orthostatic collapse, atrial fibrillation, myocardial infarction due to a sharp drop in blood pressure, pain in the heart area. Quite rarely, a decrease in hemoglobin level, a high ESR, and agranulocytosis are observed;
- Nervous system: headaches, sleep disturbances, dizziness, lethargy, clouding of consciousness, fatigue. In rare cases, depression, neuroses, weakened hearing, visual and vestibular function are observed;
- Digestive system: loss of appetite, dry mouth, diarrhea and nausea, abdominal pain, constipation, hepatitis, gastritis, jaundice;
- Respiratory system: cough without sputum, pneumonitis, rhinorrhea, shortness of breath, bronchospasm;
- Allergies: neurotic swelling of the face, skin rash, polymorphic erythema, itching, arthritis, urticaria, vasculitis, etc.
Side effects of the medicine
Important! When taking the medicine, laboratory test results may change:
- The concentration of urea increases;
- Hypercreatinemia and hyperkalemia occur;
- The activity of liver transaminases increases;
- Sodium concentration decreases;
- Bilirubin increases;
- Rarely does the hematocrit value drop.
In a small number of patients, renal dysfunction occurs while using Berlipril.
How to replace Berlipril for high blood pressure
The following analogues of Berlipril are presented on the modern pharmaceutical market:
- Enalozide;
- Dilaprel;
- Invoril;
- Enam;
- Diroton;
- Renitek;
- Prenesa;
- Enagexal;
- Enalapril;
- Enap.
Berlipril for high blood pressure is a very effective drug that quickly improves the patient’s condition and reduces the risk of developing complications characteristic of hypertension. Like other antihypertensive drugs, you should take the tablets as prescribed by your doctor, following the recommended dosage!
